Simultaneous quantitation of five flavonoid glycosides in herba Epimedii by high-performance liquid chromatography-tandem mass spectrometry

Phytochemical Analysis

Volumn 19, Issue 1, 2008, Pages 71-77

  Islam, Nural M ^a   Yoo, Hye Hyun ^a   Lee, Min Woo ^a   Dong, Mi Sook ^b   Park, Young In ^b   Jeong, Ha Sook ^c   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c Duksung Women's University   (South Korea)

Author keywords

Flavonoid glycosides; Herba Epimedii; HPLC MS MS; Quantitative analysis

Indexed keywords

ELECTROSPRAY IONIZATION; FLAVONOIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POSITIVE IONS; SUGARS;

CONCENTRATION RANGES; FLAVONOID GLYCOSIDES; HERBA EPIMEDII; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS-MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; QUANTITATIVE DETERMINATIONS; REVERSED PHASE LIQUID-CHROMATOGRAPHY; REVERSED-PHASE LIQUID CHROMATOGRAPHY;

MASS SPECTROMETRY;

ACETONITRILE; AMMONIUM FORMATE; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; FLAVONOID; FLAVONOID GLYCOSIDE; HERBA EPIMEDII EXTRACT; HYPERIN; ICARIIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; BERBERIDACEAE; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY; HERBA EPIMEDII; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SOLVENT EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 39049132012     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.1018     Document Type: Article

References (22)

1. Bramati L, Minoggio M, Gardana C, Simonetti P, Mauri P, Pietta P. 2002. Quantitative characterization of flavonoids compounds in rooibos tea ( Aspalathuts linearis) by LC-UV/DAD. J Agric Food Chem 50: 5513-5519.
2. Butterweck V, Jurgenliemk G, Nahrstedt A, Winterhoff H. 2000. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med 66: 3-6.
3. Carini M, Aldini G, Furlanetto S, Stefani R, Facino RM. 2001. LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechas. J Pharm Biomed Anal 24: 517-526.
4. Chen M, Song F, Guo M, Liu Z, Liu S. 2002. Analysis of flavonoids constituents from leaves of Acanthopanax senticosus Harms by electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 16: 264-271.
5. Guo BL, Xiao PG. 2003. Comment on main species of herba epimedil. Zhongguo Zhong Yao Za Zhi 28: 303-307.
6. Hu P, Liang Q-L, Luo G-A, Zhao Z-Z, Jiang Z-H. 2005. Multicomponent HPLC fingerprinting of Radix Salviae Miltiorrhizae and its LC-MS-MS identification. Chem Pharm Bull 53: 677-683.
7. Jensen AG, Ndjoko K, Wolfender JL, Hostettmann K. Camponovo F, Soldati F. 2002. Liquid chromatography-atmospheric pressure chemical ionization/ mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals. Phytochem Anal 13: 31-38.
8. Justesen U, Knuthsen P, Leth T. 1998. Quantitative analysis of flavonols, flavones and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array mass spectrometric detection. J Chromatogr A 799: 101-110.
9. Lee MK, Choi YJ. Sung SH, Shin DI, Kim JW, Kim YC. 1995. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med 61: 523-526.
10. Li Y, Xiong Z, Li F. 2005. Determination of epimedin C in rat plasma by reversed-phase high-performance chromatography after oral administration of Herba Epimedii extract. J Chromatogr B 821: 235-239.
11. Liang HR, Vuorela P, Vuorela H, Hiltunen R. 1997a. Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Planta Med 63: 316-319.
12. Liang HR, Siren H, Jyske P, Reikkola ML. 1997b. Characterization of flavonoids in extracts from four species of Epimedium by micellar electrokinetic capillary chromatography with diode-array detection. J Chromatogr Sci 35: 117-125.
13. Liu J, Lou YJ. 2004. Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin. J Pharm Biomed Anal 36: 365-370.
14. Liu JJ, Li SP, Wang YT. 2006. Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with dyad array detection using central composite design. J Chromatogr A 1103: 344-349.
15. Liu R, Ye M, Guo H, Bi K, Guo D-A. 2005a. Liquid chromatography/ electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera. Rapid Commun Mass Spectrom 19: 1557-1565.
16. Liu W-J, Xin Z-C, Xin H, Yuan Y-M. Tian L, Guo Y-L. 2005b. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl 7: 381-388.
17. Pan Y, Kong L, Xia X, Zhang W, Xia Z, Jiang F. 2005. Antidepressantlike effect of icariin and its possible mechanism in mice. Pharmacol Biochem Behav 82: 686-694.
18. Schmidt TJ, Merfort I. 1993. Resolution of complex mixtures of flavonoid aglycones by analysis of gas chromatographic-mass spectrometric data. J Chromatogr 634: 350-355.
19. Sha M, Cao A, Yang S. 1995. Determination of hyperin in Epimedium koreanum Nakai by HPLC. Zhongguo Zhong Yao Za Zhi 20: 357-358.
20. Sun P, Ye W, Zhao J, Pei Y, Wang Z, Chen Y, Ogihara Y, Takeda T. 1995. Studies on the constituents of Epimedium koreanum. Chem Pharm Bull 43: 703--704.
21. Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. 2003. Effect of icariin on cGMP-specific PDE5 and cAMP-specific PDE activities. Asian J Androl 5: 15-18.
22. Zheng HZ, Dong ZH, She Q. 1998. Modern Research and Application of Traditional Chinese Medicine. Xueyuan Press: Beijing; 4225.