The novel derivatives of 3-(iminomethyl)-2H-chromen-2-one with thiourea and piperazine structural motive: Rationale, synthesis, antimicrobial and anti-tb evaluation

Letters in Drug Design and Discovery

Volumn 12, Issue 4, 2015, Pages 324-341

  Lakum, Harshad P ^a   Shah, Dhruvin R ^a   Chikhalia, Kishor H ^a  

^a GUJARAT UNIVERSITY   (India)

Author keywords

Antibacterial; Antifungal; Antituberculosis; Coumarin based schiff base; Thiourea

Indexed keywords

1 (2 CHLOROPHENYL) 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 (4 CHLOROPHENYL) 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 (4 FLUOROPHENYL) 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 ALLYL 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 CYCLOHEXYL 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 ETHYL 3 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]THIOUREA; 1 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL] 3 (ORTHO TOLYL)THIOUREA; 1 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL] 3 (PARA TOLYL)THIOUREA; 1 [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL] 3 PHENYLTHIOUREA; 3 (IMINOMETHYL) 2H CHROMEN 2 ONE; 3 [(CYCLOHEXYLIMINO)METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(3 CHLOROPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(3 HYDROXYPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(3 NITROPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(4 AMINOPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(4 CHLOROPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(4 FLUOROPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(4 HYDROXYPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 3 [[(4 NITROPHENYL)IMINO]METHYL] 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; 4 (4 PHENYLPIPERAZIN 1 YL) 3 [(ORTHO TOLYLIMINO)METHYL] 2H CHROMEN 2 ONE; ANTIFUNGAL AGENT; CIPROFLOXACIN; COUMARIN DERIVATIVE; ETHAMBUTOL; ISONIAZID PLUS RIFAMPICIN; N [4 [[[2 OXO 4 (4 PHENYLPIPERAZIN 1 YL) 2H CHROMEN 3 YL]METHYLENE]AMINO]PHENYL]ACETAMIDE; PIPERAZINE DERIVATIVE; PYRAZINAMIDE; THIOUREA DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS CLAVATUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BROTH DILUTION; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MICROFLORA; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84926429102     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/1570180811666141009234835     Document Type: Article

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