Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis- khellactone analogues

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 664-671

  Xie, L ^a   Takeuchi, Y ^a   Cosentino, L M ^b   McPhail, A T ^c   Lee, K H ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b BBI Biotech Research Laboratories   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLORO 3',4' DI O CAMPHANOYL 4 METHYLKHELLACTONE; 3',4' DI O CAMPHANOYL 3,4 TETRAHYDROBENZOKHELLACTONE; 3',4' DI O CAMPHANOYL 5 METHOXY 4 METHYLKHELLACTONE; 3,4 DIMETHYL 3',4' DI O CAMPHANOYLKHELLACTONE; 3,5 DIMETHYL 3',4' DI O CAMPHANOYLKHELLACTONE; 4,5 DIMETHYL 3',4' DI O CAMPHANOYLKHELLACTONE; 4,6 DIMETHYL 3',4' DI O CAMPHANOYLKHELLACTONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; COUMARIN; KHELLACTONE; LACTONE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHOCYTE; REACTION ANALYSIS; STRUCTURE ANALYSIS; VIRUS REPLICATION;

ANTI-HIV AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 0035282630     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000070g     Document Type: Article

References (12)

1. Anti-AIDS 41. Synthesis and anti-HIV activity of 3′,4′-di-O(-)-camphanoyl-(+)-cis-khelloactone (DCK) lactam analogues
2. Anti-AIDS agents 15. Synthesis and anti-HIV activity of dihydroseselins and related analogues
3. Anti-AIDS agents 37. Synthesis and structure - Activity relationships of monosubstituted (+)-cis-khellactone derivatives as potent anti-HIV agents
4. A convenient synthesis of benzofuran-3-acetic acids
5. Indoles Part I. The formylation of indole and some reactions of 3-formylindole
6. Convenient synthesis of a simple coumarin from salicyaldehyde and Wittig reagent (III): Synthesis of nitrocoumarins
7. A convenient synthesis of a simple coumarin from salicyaldehyde and Wittig reagent (I): A synthesis of methoxy- and hydroxycoumarins
8. A new and convenient synthesis of 4-methyl-3-phenyl-coumarins and 3-phenylcoumarins
9. Asymmetric synthesis of 3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK), a potent anti-HIV agent
10. Synthesis of 1-aryl-3-methyl-but-2-en-1-ones intermediates for the synthesis of chromanone derivatives
11. Total synthesis of isoflavones: Jamaican, calopogonium isoflavone-B, pseudibaptigenin, and maxima substance-B. Friedel-Crafts acylation reactions with acid-sensitive substrates