Protective effect of palmitoylethanolamide in a rat model of cystitis

Journal of Urology

Volumn 193, Issue 4, 2015, Pages 1401-1408

  Pessina, Federica ^a   Capasso, Raffaele ^b,c,e,g   Borrelli, Francesca ^b,c,e,g   Aveta, Teresa ^c,d,e,g   Buono, Lorena ^c,e,g   Valacchi, Giuseppe ^f   Fiorenzani, Paolo ^a   Di Marzo, Vincenzo ^c,d,e,g   Orlando, Pierangelo ^c,e,g   Izzo, Angelo A ^b,c,e,g  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^d CNR   (Italy)

^e ISTITUTO NAZIONALE DI OTTICA   (Italy)

^f UNIVERSITY OF FERRARA   (Italy)

^g Endocannabinoid Research Group   (Italy)

Author keywords

cannabinoid; cyclophosphamide; cystitis; interstitial; palmidrol; receptors; urinary bladder

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOPHOSPHAMIDE; MESSENGER RNA; MYELOPEROXIDASE; PALMIDROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RIMONABANT; ETHANOLAMINE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PALMITIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYSTITIS; DOWN REGULATION; ENZYME ACTIVITY; EXPERIMENTAL CYSTITIS; EXPERIMENTAL DISEASE; FEMALE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICTURITION; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOPHOSPHAMIDE; CYSTITIS; DISEASE MODELS, ANIMAL; ETHANOLAMINES; FEMALE; PALMITIC ACIDS; RATS; RATS, WISTAR;

EID: 84926419481     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.11.083     Document Type: Article

References (31)

1. S. Mukhtar, and C. Woodhouse The management of cyclophosphamide-induced haematuria BJU Int 105 2010 908
2. H. Payne, A. Adamson, and A. Bahl Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges BJU Int 112 2013 885
3. A. Kilaru, E.B. Blancaflor, and B.J. Venables The N-acylethanolamine-mediated regulatory pathway in plants Chem Biodivers 4 2007 1933
4. E. Esposito, and S. Cuzzocrea Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries CNS Neurol Disord Drug Targets 12 2013 55
5. S. Petrosino, T. Iuvone, and V. Di Marzo N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities Biochimie 92 2010 724
6. S.D. Skaper, L. Facci, and P. Giusti Mast cells, glia and neuroinflammation: partners in crime? Immunology 141 2014 314
7. J. LoVerme, G. La Rana, and R. Russo The search for the palmitoylethanolamide receptor Life Sci 77 2005 1685
8. D. Smart, K.O. Jonsson, and S. Vandevoorde 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism Br J Pharmacol 136 2002 452
9. L. De Petrocellis, T. Bisogno, and A. Ligresti Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems Fundam Clin Pharmacol 16 2002 297
10. W.P. Farquhar-Smith, and A.S. Rice Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder Anesthesiology 94 2001 507
11. W.P. Farquhar-Smith, S.I. Jaggar, and A.S. Rice Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors Pain 97 2002 11
12. 2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain Pain 76 1998 189
13. M. Boucher, M. Meen, and J.P. Codron Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioural approach to a new model of visceral pain J Urol 164 2000 203
14. K.J. Gray, U.H. Engelmann, and E.H. Johnson Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy J Urol 136 1986 497
15. R. Capasso, A.A. Izzo, and F. Fezza Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice Br J Pharmacol 134 2001 945
16. F. Navarrete, M. Rodríguez-Arias, and E. Martín-García Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine Neuropsychopharmacology 38 2013 2515
17. R. Capasso, P. Orlando, and E. Pagano Ultramicronized palmitoylethanolamide normalizes intestinal motility in a murine model of post-inflammatory accelerated transit: involvement of CB(1)receptors and TRPV1 Br J Pharmacol 2014 Epub ahead of print
18. A.A. Izzo, R. Capasso, and G. Aviello Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice Br J Pharmacol 166 2012 1444
19. 2 receptor in mouse spermatogenesis Proc Natl Acad Sci U S A 106 2009 11131
20. M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 30 2002 e36
21. A. Calignano, G. La Rana, and A. Giuffrida Control of pain initiation by endogenous cannabinoids Nature 394 1998 277
22. J. Lo Verme, J. Fu, and G. Astarita The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide Mol Pharmacol 67 2005 15
23. B. Costa, F. Comelli, and I. Bettoni The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors Pain 139 2008 541
24. M.G. Balvers, K.C. Verhoeckx, and J. Meijerink Measurement of palmitoylethanolamide and other N-acylethanolamines during physiological and pathological conditions CNS Neurol Disord Drug Targets 12 2013 23
25. F.V. Merriam, Z.Y. Wang, and C.J. Hillard Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation BJU Int 108 2011 1145
26. S.E. O'Sullivan, and D.A. Kendall Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease Immunobiology 215 2010 611
27. C. Gratzke, T. Streng, and C.G. Stief Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction J Urol 185 2011 731
28. C. Füllhase, L. Campeau, and A. Sibaev Bladder function in a cannabinoid receptor type 1 knockout mouse BJU Int 113 2014 144
29. Y. Li, Y. Sun, and Z. Zhang Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model BJU Int 112 2013 E143
30. Z.Y. Wang, P. Wang, and D.E. Bjorling Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis J Urol 191 2014 1153
31. S. Tambaro, M.A. Casu, and A. Mastinu Evaluation of selective cannabinoid CB(1) and CB(2) receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis Eur J Pharmacol 729 2014 67