Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis

Journal of Urology

Volumn 191, Issue 4, 2014, Pages 1153-1158

  Wang, Zun Yi ^a   Wang, Peiqing ^a   Bjorling, Dale E ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

cannabinoid receptor agonists; cystitis; interstitial; mice; N (piperidin 1 yl) 1 (2,4 dichlorophenyl) 1,4 dihydro 6 methylindeno(1,2 c) pyrazole 3 carboxamide; urinary bladder

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ACROLEIN; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; N (PIPERIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 1,4 DIHYDRO 6 METHYLINDENO[1,2 C]PYRAZOLE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GP 1A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLADDER; BLADDER WEIGHT; CONTROLLED STUDY; CYSTITIS; DISEASE SEVERITY; EDEMA; FEMALE; HISTOPATHOLOGY; HYPERALGESIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MECHANICAL SENSITIVITY; MECHANICS; MICTURITION; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; REFERRED PAIN; URINARY FREQUENCY; UROTHELIUM; BLADDER FUNCTION; DRUG EFFICACY; URINE;

CANNABINOID RECEPTOR AGONISTS; CYSTITIS; INTERSTITIAL; MICE; N-(PIPERIDIN-1-YL)-1-(2,4-DICHLOROPHENYL)-1,4-DIHYDRO-6-METHYLINDENO(1,2-C)PYRAZOLE-3-CARBOXAMIDE; URINARY BLADDER;

ANIMALS; CYSTITIS; FEMALE; INDENES; MICE; MICE, INBRED C57BL; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; SEVERITY OF ILLNESS INDEX;

EID: 84898435492     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.10.102     Document Type: Article

References (30)

1. N. Clayton, F.H. Marshall, and C. Bountra et al. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain Pain 96 2002 253
2. D.G. Demuth, and A. Molleman Cannabinoid signalling Life Sci 78 2006 549
3. S.J. Elmes, L.A. Winyard, and S.J. Medhurst et al. Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat Pain 118 2005 327
4. 1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents Mol Pain 7 2011 31
5. P. Dinis, A. Charrua, and A. Avelino et al. Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis J Neurosci 24 2004 11253
6. C. Gratzke, T. Streng, and A. Park et al. Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder J Urol 181 2009 1939
7. M.H. Hayn, I. Ballesteros, and F. de Miguel et al. Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder Urology 72 2008 1174
8. V. Tyagi, B.J. Philips, and R. Su et al. Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium J Urol 181 2009 1932
9. C. Gratzke, T. Streng, and C.G. Stief et al. Effects of cannabinor, a novel selective cannabinoid 2 receptor agonist, on bladder function in normal rats Eur Urol 57 2010 1093
10. C. Gratzke, T. Streng, and C.G. Stief et al. Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction J Urol 185 2011 731
11. S.H. Berry, M.N. Elliott, and M. Suttorp et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States J Urol 186 2011 540
12. Z.Y. Wang, P. Wang, and D.E. Bjorling Activation of cannabinoid receptor 2 inhibits experimental cystitis Am J Physiol Regul Integr Comp Physiol 304 2013 R846
13. D.E. Bjorling, J.E. Elkahwaji, and W. Bushman et al. Acute acrolein-induced cystitis in mice BJU Int 99 2007 1523
14. O. Ofek, M. Karsak, and N. Leclerc et al. Peripheral cannabinoid receptor, CB2, regulates bone mass Proc Natl Acad Sci U S A 103 2006 696
15. S.R. Chaplan, F.W. Bach, and J.W. Pogrel et al. Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1999 55
16. L.L. Cornelissen, B. Misajet, and D.P. Brooks et al. Influence of genetic background and gender on bladder function in the mouse Auton Neurosci 140 2008 53
17. A. Quartilho, H.P. Mata, and M.M. Ibrahim et al. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors Anesthesiology 99 2003 955
18. L. Hanus, A. Breuer, and S. Tchilibon et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor Proc Natl Acad Sci U S A 96 1999 14228
19. S.G. Kinsey, A. Mahadevan, and B. Zhao et al. The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects Neuropharmacology 60 2011 244
20. B. Horváth, L. Magid, and P. Mukhopadhyay et al. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury Br J Pharmacol 165 2012 2462
21. F. Montecucco, S. Lenglet, and V. Braunersreuther et al. CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion J Mol Cell Cardiol 46 2009 612
22. P. Mukhopadhyay, M. Rajesh, and B. Horváth et al. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death Free Radic Biol Med 50 2011 1368
23. M.M. Ibrahim, H. Deng, and A. Zvonok et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS Proc Natl Acad Sci U S A 100 2003 10529
24. A.N. Lozano-Ondoua, C. Wright, and A. Vardanyan et al. A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss Life Sci 86 2010 646
25. A.G. Nackley, A.M. Zvonok, and A. Makriyannis et al. Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation J Neurophysiol 92 2004 3562
26. M. Beltramo, N. Bernardini, and R. Bertorelli et al. CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms Eur J Neurosci 23 2006 1530
27. T. Gutierrez, J.N. Farthing, and A.M. Zvonok et al. Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis Br J Pharmacol 150 2007 153
28. L. Birder, and K.E. Andersson Urothelial signaling Physiol Rev 93 2013 653
29. A. Klegeris, C.J. Bissonnette, and P.L. McGeer Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor Br J Pharmacol 139 2003 775
30. D.R. Sagar, S. Kelly, and P.J. Millns et al. Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats Eur J Neurosci 22 2005 371