Impact of postsurgical opioid use and ileus on economic outcomes in gastrointestinal surgeries

Current Medical Research and Opinion

Volumn 31, Issue 4, 2015, Pages 677-686

  Gan, Tong J ^a   Robinson, Scott B ^b   Oderda, Gary M ^c   Scranton, Richard ^d   Pepin, Jodie ^e   Ramamoorthy, Sonia ^f  

^a STONY BROOK UNIVERSITY   (United States)

^b Premier Consulting Solutions   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d Pacira Pharmaceuticals Inc   (United States)

^e Seton Medical Center Austin   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cholecystectomy; Colectomy; Healthcare and economic outcomes; Ileus; Morphine equivalent dose; Opioid; Postoperative pain

Indexed keywords

OPIATE; NARCOTIC ANALGESIC AGENT;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; CHOLECYSTECTOMY; COLON RESECTION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GASTROINTESTINAL SURGERY; HEALTH CARE COST; HIGH RISK PATIENT; HOSPITAL COST; HOSPITAL READMISSION; HUMAN; INCIDENCE; LAPAROSCOPIC SURGERY; LAPAROTOMY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POSTOPERATIVE ILEUS; POSTOPERATIVE PAIN; ADVERSE EFFECTS; COST; ECONOMICS; ILEUS; LAPAROSCOPY; MIDDLE AGED; PAIN, POSTOPERATIVE; PROCEDURES; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; UNITED STATES;

AGED; ANALGESICS, OPIOID; CHOLECYSTECTOMY; COLECTOMY; COSTS AND COST ANALYSIS; FEMALE; HUMANS; ILEUS; INCIDENCE; LAPAROSCOPY; LAPAROTOMY; LENGTH OF STAY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PAIN, POSTOPERATIVE; PATIENT READMISSION; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 84926370880     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2015.1005833     Document Type: Article

References (35)

1. Chamberlain RS, Martindale RG. Evidence-based management of postoperative ileus. Issue 1: The role of the surgeons and the surgical care team: proactive strategies for preventing postoperative ileus. Available at: http://www.ce-university.org/surgery [Last accessed 1 October 2012]
2. Litkouhi B. Postpoerative ileus. UpToDate. Available at: http://www.uptodate.com/contents/ postoperative-ileus [Last accessed 27 September 2012]
3. Augestad KM, Delaney CP. Postoperative ileus: impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World J Gastroenterol 2010;16:2067-74
4. Erowele GI. Treatment options for postoperative ileus. US Pharmacist 2010;35:55-73
5. Salvador CG, Sikirica M, Evans A, et al. Clinical and economic outcomes of prolonged postoperative ileus in patients undergoing hysterectomy and hemicolectomy. Pharm Therapeut 2005;30:590-5
6. Johnson MD, Walsh RM. Current therapies to shorten postoperative ileus. Cleveland Clinic J Med 2009;76:641-8
7. Doyle E. The search for a therapy to prevent and treat postoperative ileus. Available at: http://www.todayshospitalist.com/index.php?b=articles-read&cnt=227 [Last accessed 15 October 2012]
8. Senagore, AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm 2007;64(Suppl 13):S3-7
9. Senagore, AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Clin Exp Gastroenterol 2010;3:87-9
10. Holzer P. Treatment of opioid-induced gut dysfunction. Expert Opin Investig Drugs 2007;16:181-94
11. Wheeler M, Oderda GM, Ashburn MA, Lipman AG. Adverse effects associated with postoperative opioid analgesia: a systematic review. J Pain 2002;3:159-80
12. Oderda GM, Gan TJ, Johnson BH, Robinson SB. Effect of opioid-related adverse events on outcomes in selected surgical patients. J Pain Palliative Care Pharmacother 2013;27:62-70
13. Mills JR, Robinson SB, Knudson R. Addressing the Need for Safe and Effective Postsurgical Pain Management: Survey Results from Hospital Pharmacy Practitioners. Premier Healthcare Alliance, Internal document, August 2012
14. Ay AA, Kutun S, Ulucanlar H, et al. Risk factors for postoperative ileus. J Korean Surg Soc 2011;81:242-9
15. Holte K, Kehlet H. Postoperative ileus. Progress towards effective management. Drug 2002;62:2603-15
16. Bream-Rouwenhorst H, Cantrell MA. Alvimopan for postoperative ileus. Am J Health Syst Pharm 2009;66:1267-77
17. Bashankaev B, Daniel M, Khaikin M, Wexner SD. Postoperative ileus: an algorithm for prevention and management. Pharmacy Practice News Special Edition 2009;30:71-8
18. Lubawski J, Saclarides T. Postoperative ileus: strategies for reduction. Therapeut Clin Risk Manag 2008;4:913-17
19. Chamberlain RS, Rathmell J. Evidence-based management of postoperative ileus. Issue 2, Preventing postoperative ileus: the use of epidural analgesia and opioid antagonists to ameliorate adverse effects. Available at: http://www.ce-university.org/surgery [Last accessed 1 October 2012]
20. U.S. Department of Health and Human Services. Management of Cancer Pain: Adults. AHCPR Pub. No. 94-0593. Rockville, MD: Agency for Health Care Policy and Research, 1994
21. Luckey A, Livingston E, Taché Y. Mechanism and treatment of postoperative ileus. Arch Surg 2003;138:206-14
22. Viscusi ER, Gan TJ, Leslie JB, et al. Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth Analg 2009;108:1811-22
23. Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm 2009;15:485-94
24. Goldstein JL, Matuszewski KA, Delaney CP, et al. Inpatient economic burden of postoperative ileus associated with abdominal surgery in the United States. P&T 2007;32:82-90
25. Garcia-Caballero M, Vara-Thorbeck C. The evolution of postoperative ileus after laparoscopic cholecystectomy. A comparative study with conventional cholecystectomy and sympathetic blockade treatment. Surg Endosc 1993;7:416-19
26. Draganic BD, Reece-Smith H. Gallstone ileus without a gallbladder. Ann Roy Coll Surg Engl 1997;79:231-2
27. Ivanov I, Beuran M, Venter MD, et al. Gallstone ileus after laparoscopic cholecystectomy. J Med Life 2012;15:335-41
28. Pavoor R, Milsom J. Postoperative ileus after laparoscopic colectomy: elusive and expensive. Letter to the Editor. Ann Surg 2011;254:1057
29. Cali RL, Meade PG, Swanson MS, Freeman C. Effect of morphine and incision length on bowel function after colectomy. Dis Colon Rectum 2000;43:163-8
30. Goettsch WG, Sukel MP, van der Peet DL, et al. In-hospital use of opioids increases rate of coded postoperative paralytic ileus. Pharmacoepidemiol Drug Saf 2007;16:668-74
31. Kodali B-S, Oberoi JS. Management of postoperative pain. UpToDate. Available at: http://www.uptodate.com/contents/management-of-postoperative-pain [Last accessed 27 September 2012]
32. Barletta JF, Asgeirsson T, Senagore AJ. Influence of intravenous opioid dose on postoperative ileus. Ann Pharmacother 2011;45:916-23
33. Kraft MD. Emerging pharmacologic options for treating postoperative ileus. Am J Health Syst Pharm 2007;64:S13-20
34. Barzoi G, Carluccio S, Bianchi B, et al. Morphine plus bupivacaine vs morphine peridural analgesia in abdominal surgery: The effects of postoperative course in major hepatobiliary surgery. HPB Surgery 2000;11:393-9
35. Kehlet H. Postoperative ileus. Gut 2000;47(Suppl IV):iv85-6