메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

CXCL12 Modulates Prostate Cancer Cell Adhesion by Altering the Levels or Activities of β1-Containing Integrins

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; FIBRONECTIN; FOCAL ADHESION KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE SHP 2; STROMAL CELL DERIVED FACTOR 1; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5; VINCULIN;

EID: 84926351192     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2014/981750     Document Type: Article
Times cited : (17)

References (48)
  • 2
    • 0038360798 scopus 로고    scopus 로고
    • Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
    • Y.-X. Sun, J. Wang, C. E. Shelburne et al., "Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo," Journal of Cellular Biochemistry, vol. 89, no. 3, pp. 462-473, 2003.
    • (2003) Journal of Cellular Biochemistry , vol.89 , Issue.3 , pp. 462-473
    • Sun, Y.-X.1    Wang, J.2    Shelburne, C.E.3
  • 3
    • 34247881741 scopus 로고    scopus 로고
    • Prostate cancer: Epidemiology, screening, and biomarkers
    • G. Chodak, "Prostate cancer: epidemiology, screening, and biomarkers," Reviews in Urology, vol. 8, supplement 2, pp. S3-S8, 2006.
    • (2006) Reviews in Urology , vol.8 , pp. S3-S8
    • Chodak, G.1
  • 4
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • J. D. Hood and D. A. Cheresh, "Role of integrins in cell invasion and migration," Nature Reviews Cancer, vol. 2, no. 2, pp. 91-100, 2002.
    • (2002) Nature Reviews Cancer , vol.2 , Issue.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 5
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • W. Guo and F. G. Giancotti, "Integrin signalling during tumour progression," Nature Reviews Molecular Cell Biology, vol. 5, no. 10, pp. 816-826, 2004.
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.10 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 6
    • 48249157054 scopus 로고    scopus 로고
    • Type I collagen receptor (α2β1) signaling promotes prostate cancer invasion through RhoC GTPase
    • C. L. Hall, C. W. Dubyk, T. A. Riesenberger, D. Shein, E. T. Keller, and K. L. van Golen, "Type I collagen receptor (α2β1) signaling promotes prostate cancer invasion through RhoC GTPase," Neoplasia, vol. 10, no. 8, pp. 797-803, 2008.
    • (2008) Neoplasia , vol.10 , Issue.8 , pp. 797-803
    • Hall, C.L.1    Dubyk, C.W.2    Riesenberger, T.A.3    Shein, D.4    Keller, E.T.5    Van Golen, K.L.6
  • 8
    • 0028808210 scopus 로고
    • Fibronectin and integrins in invasion and metastasis
    • S. K. Akiyama, K. Olden, and M. Yamada, "Fibronectin and integrins in invasion and metastasis," Cancer and Metastasis Reviews, vol. 14, no. 3, pp. 173-189, 1995.
    • (1995) Cancer and Metastasis Reviews , vol.14 , Issue.3 , pp. 173-189
    • Akiyama, S.K.1    Olden, K.2    Yamada, M.3
  • 9
    • 84866313241 scopus 로고    scopus 로고
    • A new paradigm for mechanobiological mechanisms in tumor metastasis
    • P. A. Torzilli, J. W. Bourne, T. Cigler, and C. T. Vincent, "A new paradigm for mechanobiological mechanisms in tumor metastasis," Seminars in Cancer Biology, vol. 22, no. 5-6, pp. 385-395, 2012.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 385-395
    • Torzilli, P.A.1    Bourne, J.W.2    Cigler, T.3    Vincent, C.T.4
  • 10
    • 10044284415 scopus 로고    scopus 로고
    • CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    • S. Singh, U.P. Singh, W.E. Grizzle, and J.W. Lillard Jr., "CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion," Laboratory Investigation, vol. 84, no. 12, pp. 1666-1676, 2004.
    • (2004) Laboratory Investigation , vol.84 , Issue.12 , pp. 1666-1676
    • Singh, S.1    Singh, U.P.2    Grizzle, W.E.3    Lillard, J.W.4
  • 11
    • 47749109823 scopus 로고    scopus 로고
    • The role of CXC chemokines and their receptors in cancer
    • J. Vandercappellen, J. van Damme, and S. Struyf, "The role of CXC chemokines and their receptors in cancer," Cancer Letters, vol. 267, no. 2, pp. 226-244, 2008.
    • (2008) Cancer Letters , vol.267 , Issue.2 , pp. 226-244
    • Vandercappellen, J.1    Van Damme, J.2    Struyf, S.3
  • 12
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • B. A. Teicher and S. P. Fricker, "CXCL12 (SDF-1)/CXCR4 pathway in cancer," Clinical Cancer Research, vol. 16, no. 11, pp. 2927-2931, 2010.
    • (2010) Clinical Cancer Research , vol.16 , Issue.11 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 13
    • 35448994852 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells
    • J. Jones, D. Marian, E. Weich et al., "CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells," Experimental Cell Research, vol. 313, no. 19, pp. 4051-4065, 2007.
    • (2007) Experimental Cell Research , vol.313 , Issue.19 , pp. 4051-4065
    • Jones, J.1    Marian, D.2    Weich, E.3
  • 14
    • 33846058844 scopus 로고    scopus 로고
    • The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
    • J. Wang, R. Loberg, and R. S. Taichman, "The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis," Cancer and Metastasis Reviews, vol. 25, no. 4, pp. 573-587, 2006.
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.4 , pp. 573-587
    • Wang, J.1    Loberg, R.2    Taichman, R.S.3
  • 15
    • 0037085938 scopus 로고    scopus 로고
    • Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    • R. S. Taichman, C. Cooper, E. T. Keller, K. J. Pienta, N. S. Taichman, and L. K. McCauley, "Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone," Cancer Research, vol. 62, no. 6, pp. 1832-1837, 2002.
    • (2002) Cancer Research , vol.62 , Issue.6 , pp. 1832-1837
    • Taichman, R.S.1    Cooper, C.2    Keller, E.T.3    Pienta, K.J.4    Taichman, N.S.5    McCauley, L.K.6
  • 18
    • 0033621689 scopus 로고    scopus 로고
    • Significance of integrin alpha5 gene expression as a prognostic factor in node-negative non-small cell lung cancer
    • M. Adachi, T. Taki, M. Higashiyama, N. Kohno, H. Inufusa, and M. Miyake, "Significance of integrin alpha5 gene expression as a prognostic factor in node-negative non-small cell lung cancer," Clinical Cancer Research, vol. 6, no. 1, pp. 96-101, 2000.
    • (2000) Clinical Cancer Research , vol.6 , Issue.1 , pp. 96-101
    • Adachi, M.1    Taki, T.2    Higashiyama, M.3    Kohno, N.4    Inufusa, H.5    Miyake, M.6
  • 19
    • 33846003850 scopus 로고    scopus 로고
    • The wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the α4integrin gene
    • K. M. Kirschner, N. Wagner, K.-D. Wagner, S. Wellmann, and H. Scholz, "The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the α4integrin gene," The Journal of Biological Chemistry, vol. 281, no. 42, pp. 31930-31939, 2006.
    • (2006) The Journal of Biological Chemistry , vol.281 , Issue.42 , pp. 31930-31939
    • Kirschner, K.M.1    Wagner, N.2    Wagner, K.-D.3    Wellmann, S.4    Scholz, H.5
  • 20
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • A. Müller, B. Homey, H. Soto et al., "Involvement of chemokine receptors in breast cancer metastasis," Nature, vol. 410, no. 6824, pp. 50-56, 2001.
    • (2001) Nature , vol.410 , Issue.6824 , pp. 50-56
    • Müller, A.1    Homey, B.2    Soto, H.3
  • 21
    • 67349107150 scopus 로고    scopus 로고
    • Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
    • S. M. Potter, R. M. Dwyer, C. E. Curran et al., "Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones," Breast Cancer Research and Treatment, vol. 115, no. 2, pp. 279-287, 2009.
    • (2009) Breast Cancer Research and Treatment , vol.115 , Issue.2 , pp. 279-287
    • Potter, S.M.1    Dwyer, R.M.2    Curran, C.E.3
  • 22
    • 70249132586 scopus 로고    scopus 로고
    • Gleason score and lethal prostate cancer: Does 3 + 4 = 4 + 3?
    • J. R. Stark, S. Perner, M. J. Stampfer et al., "Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?" Journal of Clinical Oncology, vol. 27, no. 21, pp. 3459-3464, 2009.
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.21 , pp. 3459-3464
    • Stark, J.R.1    Perner, S.2    Stampfer, M.J.3
  • 23
    • 40349087130 scopus 로고    scopus 로고
    • Pilot and feasibility study of serum chemokines as markers to distinguish prostatic disease in men with low total serum PSA
    • J. A. Macoska, L. A. Begley, R. L. Dunn, J. Siddiqui, J. T. Wei, and A. V. Sarma, "Pilot and feasibility study of serum chemokines as markers to distinguish prostatic disease in men with low total serum PSA," Prostate, vol. 68, no. 4, pp. 442-452, 2008.
    • (2008) Prostate , vol.68 , Issue.4 , pp. 442-452
    • Macoska, J.A.1    Begley, L.A.2    Dunn, R.L.3    Siddiqui, J.4    Wei, J.T.5    Sarma, A.V.6
  • 24
    • 29344451650 scopus 로고    scopus 로고
    • CXCL12/CXCR4 signaling activates akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12
    • S. R. Chinni, S. Sivalogan, Z. Dong et al., "CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12," Prostate, vol. 66, no. 1, pp. 32-48, 2006.
    • (2006) Prostate , vol.66 , Issue.1 , pp. 32-48
    • Chinni, S.R.1    Sivalogan, S.2    Dong, Z.3
  • 25
    • 33845769269 scopus 로고    scopus 로고
    • Expression and activation of αvβ3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells
    • Y.-X. Sun, M. Fang, J. Wang, C. R. Cooper, K. J. Pienta, and R. S. Taichman, "Expression and activation of αvβ3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells," Prostate, vol. 67, no. 1, pp. 61-73, 2007.
    • (2007) Prostate , vol.67 , Issue.1 , pp. 61-73
    • Sun, Y.-X.1    Fang, M.2    Wang, J.3    Cooper, C.R.4    Pienta, K.J.5    Taichman, R.S.6
  • 26
    • 33646422999 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor mediates prostate tumor cell adhesion through α5 and β3 integrins
    • T. Engl, B. Relja, D. Marian et al., "CXCR4 chemokine receptor mediates prostate tumor cell adhesion through α5 and β3 integrins," Neoplasia, vol. 8, no. 4, pp. 290-301, 2006.
    • (2006) Neoplasia , vol.8 , Issue.4 , pp. 290-301
    • Engl, T.1    Relja, B.2    Marian, D.3
  • 27
    • 52449124146 scopus 로고    scopus 로고
    • Cadherin-11 promotes the metastasis of prostate cancer cells to bone
    • K. Chu, C.-J. Cheng, X. Ye et al., "Cadherin-11 promotes the metastasis of prostate cancer cells to bone," Molecular Cancer Research, vol. 6, no. 8, pp. 1259-1267, 2008.
    • (2008) Molecular Cancer Research , vol.6 , Issue.8 , pp. 1259-1267
    • Chu, K.1    Cheng, C.-J.2    Ye, X.3
  • 28
    • 36849069902 scopus 로고    scopus 로고
    • Vinculin controls focal adhesion formation by direct interactions with talin and actin
    • J.D. Humphries, P. Wang, C. Streuli, B. Geiger, M. J. Humphries, and C. Ballestrem, "Vinculin controls focal adhesion formation by direct interactions with talin and actin," Journal of Cell Biology, vol. 179, no. 5, pp. 1043-1057, 2007.
    • (2007) Journal of Cell Biology , vol.179 , Issue.5 , pp. 1043-1057
    • Humphries, J.D.1    Wang, P.2    Streuli, C.3    Geiger, B.4    Humphries, M.J.5    Ballestrem, C.6
  • 29
    • 84877157661 scopus 로고    scopus 로고
    • Two modes of integrin activation form a binary molecular switch in adhesion maturation
    • H.-S. Lee, P. Anekal, C. J. Lim, C.-C. Liu, and M. H. Ginsberg, "Two modes of integrin activation form a binary molecular switch in adhesion maturation," Molecular Biology of the Cell, vol. 24, no. 9, pp. 1354-1362, 2013.
    • (2013) Molecular Biology of the Cell , vol.24 , Issue.9 , pp. 1354-1362
    • Lee, H.-S.1    Anekal, P.2    Lim, C.J.3    Liu, C.-C.4    Ginsberg, M.H.5
  • 31
    • 78149471066 scopus 로고    scopus 로고
    • Effect of collagen I and fibronectin on the adhesion, elasticity and cytoskeletal organization of prostate cancer cells
    • D. Docheva, D. Padula, M. Schieker, and H. Clausen-Schaumann, "Effect of collagen I and fibronectin on the adhesion, elasticity and cytoskeletal organization of prostate cancer cells," Biochemical and Biophysical Research Communications, vol. 402, no. 2, pp. 361-366, 2010.
    • (2010) Biochemical and Biophysical Research Communications , vol.402 , Issue.2 , pp. 361-366
    • Docheva, D.1    Padula, D.2    Schieker, M.3    Clausen-Schaumann, H.4
  • 32
    • 33749000912 scopus 로고    scopus 로고
    • Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone
    • C. L. Hall, J. Dai, K. L. van Golen, E. T. Keller, and M.W. Long, "Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone," Cancer Research, vol. 66, no. 17, pp. 8648-8654, 2006.
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8648-8654
    • Hall, C.L.1    Dai, J.2    Van Golen, K.L.3    Keller, E.T.4    Long, M.W.5
  • 33
    • 0035018353 scopus 로고    scopus 로고
    • Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
    • Z. Lu, G. Jiang, P. Blume-Jensen, and T. Hunter, "Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase," Molecular and Cellular Biology, vol. 21, no. 12, pp. 4016-4031, 2001.
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.12 , pp. 4016-4031
    • Lu, Z.1    Jiang, G.2    Blume-Jensen, P.3    Hunter, T.4
  • 34
    • 57249111842 scopus 로고    scopus 로고
    • Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
    • S. Zhang, L. Qi, M. Li et al., "Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer," Journal of Experimental and Clinical Cancer Research, vol. 27, article 62, 2008.
    • (2008) Journal of Experimental and Clinical Cancer Research , vol.27
    • Zhang, S.1    Qi, L.2    Li, M.3
  • 35
    • 56449111353 scopus 로고    scopus 로고
    • Tumor cell-specific blockade of CXCR4/SDF-1 interactions in prostate cancer cells by hTERT promoter induced CXCR4 knockdown: A possible metastasis preventing and minimizing approach
    • Y. Xing, M. Liu, Y. Du et al., "Tumor cell-specific blockade of CXCR4/SDF-1 interactions in prostate cancer cells by hTERT promoter induced CXCR4 knockdown: a possible metastasis preventing and minimizing approach," Cancer Biology & Therapy, vol. 7, no. 11, pp. 1839-1848, 2008.
    • (2008) Cancer Biology & Therapy , vol.7 , Issue.11 , pp. 1839-1848
    • Xing, Y.1    Liu, M.2    Du, Y.3
  • 36
    • 38849173663 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
    • C.H. Tang, T. W. Tan, W. M. Fu, and R. S. Yang, "Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis," Carcinogenesis, vol. 29, no. 1, pp. 35-43, 2008.
    • (2008) Carcinogenesis , vol.29 , Issue.1 , pp. 35-43
    • Tang, C.H.1    Tan, T.W.2    Fu, W.M.3    Yang, R.S.4
  • 37
    • 36049020021 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NFkappaB-dependent pathway in human lung cancer cells
    • Y.-C. Huang, Y.-C. Hsiao, Y.-J. Chen, Y.-Y. Wei, T.-H. Lai, and C.-H. Tang, "Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NFkappaB-dependent pathway in human lung cancer cells," Biochemical Pharmacology, vol. 74, no. 12, pp. 1702-1712, 2007.
    • (2007) Biochemical Pharmacology , vol.74 , Issue.12 , pp. 1702-1712
    • Huang, Y.-C.1    Hsiao, Y.-C.2    Chen, Y.-J.3    Wei, Y.-Y.4    Lai, T.-H.5    Tang, C.-H.6
  • 38
    • 21744433347 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
    • T.N. Hartmann, J. A. Burger, A. Glodek, N. Fujii, and M. Burger, "CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells," Oncogene, vol. 24, no. 27, pp. 4462-4471, 2005.
    • (2005) Oncogene , vol.24 , Issue.27 , pp. 4462-4471
    • Hartmann, T.N.1    Burger, J.A.2    Glodek, A.3    Fujii, N.4    Burger, M.5
  • 39
    • 62149091091 scopus 로고    scopus 로고
    • Signal co-operation between integrins and other receptor systems
    • C. H. Streulli and N. Akhtar, "Signal co-operation between integrins and other receptor systems," Biochemical Journal, vol. 418, no. 3, pp. 491-506, 2009.
    • (2009) Biochemical Journal , vol.418 , Issue.3 , pp. 491-506
    • Streulli, C.H.1    Akhtar, N.2
  • 40
    • 67651085772 scopus 로고    scopus 로고
    • Signal transduction by focal adhesion kinase in cancer
    • J. Zhao and J.-L. Guan, "Signal transduction by focal adhesion kinase in cancer," Cancer and Metastasis Reviews, vol. 28, no. 1-2, pp. 35-49, 2009.
    • (2009) Cancer and Metastasis Reviews , vol.28 , Issue.1-2 , pp. 35-49
    • Zhao, J.1    Guan, J.-L.2
  • 41
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-src signaling in normal and cancer cells
    • S. K. Mitra and D. D. Schlaepfer, "Integrin-regulated FAK-Src signaling in normal and cancer cells," Current Opinion in Cell Biology, vol. 18, no. 5, pp. 516-523, 2006.
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.5 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 44
    • 0141429921 scopus 로고    scopus 로고
    • A novel mode for integrin-mediated signaling: Tethering is required for phosphorylation of FAK Y397
    • Q. Shi and D. Boettiger, "A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397," Molecular Biology of the Cell, vol. 14, no. 10, pp. 4306-4315, 2003.
    • (2003) Molecular Biology of the Cell , vol.14 , Issue.10 , pp. 4306-4315
    • Shi, Q.1    Boettiger, D.2
  • 47
    • 74049094447 scopus 로고    scopus 로고
    • Aberrant DNA methylation of integrin α4: A potential novel role for metastasis of cholangio carcinoma
    • K.-O. Uhm, J. O. Lee, Y. M. Lee, E. S. Lee, H. S. Kim, and S.-H. Park, "Aberrant DNA methylation of integrin α4: a potential novel role for metastasis of cholangio carcinoma," Journal of Cancer Research and Clinical Oncology, vol. 136, no. 2, pp. 187-194, 2010.
    • (2010) Journal of Cancer Research and Clinical Oncology , vol.136 , Issue.2 , pp. 187-194
    • Uhm, K.-O.1    Lee, J.O.2    Lee, Y.M.3    Lee, E.S.4    Kim, H.S.5    Park, S.-H.6
  • 48
    • 2442652651 scopus 로고    scopus 로고
    • Aberrant methylation of integrin α4 gene in human gastric cancer cells
    • J. Park, S. H. Song, T. Y. Kim et al., "Aberrant methylation of integrin α4 gene in human gastric cancer cells," Oncogene, vol. 23, no. 19, pp. 3474-3480, 2004.
    • (2004) Oncogene , vol.23 , Issue.19 , pp. 3474-3480
    • Park, J.1    Song, S.H.2    Kim, T.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.