LGR5, a relevant marker of cancer stem cells, indicates a poor prognosis in colorectal cancer patients: A meta-analysis

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue 2, 2015, Pages 267-273

  Han, Ye ^a   Xue, Xiaofeng ^a   Jiang, Min ^a   Guo, Xiaobo ^b   Li, Pu ^c   Liu, Fei ^a   Yuan, Bin ^a   Shen, Yichen ^a   Guo, Xingpo ^a   Zhi, Qiaoming ^a   Zhao, Hong ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER STEM CELL; COLORECTAL CANCER; DISTANT METASTASIS; EMBASE; GENDER; HUMAN; LYMPH NODE METASTASIS; MEDLINE; META ANALYSIS; OVERALL SURVIVAL; PROTEIN EXPRESSION; SYSTEMATIC REVIEW; TUMOR INVASION; CHEMISTRY; COLORECTAL TUMOR; MORTALITY; PATHOLOGY; PROGNOSIS;

BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; HUMANS; NEOPLASTIC STEM CELLS; PROGNOSIS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84926349188     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2014.07.008     Document Type: Article

References (34)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J., Thun M.J. Cancer statistics, 2007. CA Cancer J Clin 2007, 57:43-66.
2. Kekelidze M., D'Errico L., Pansini M., Tyndall A., Hohmann J. Colorectal cancer: Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation. World J Gastroenterol 2013, 19:8502-8514.
3. Zafar S.Y., Malin J.L., Grambow S.C., Abbott D.H., Kolimaga J.T., Zullig L.L., et al. Chemotherapy use and patient treatment preferences in advanced colorectal cancer: a prospective cohort study. Cancer 2013, 119:854-862.
4. Kelley R.K., Wang G., Venook A.P. Biomarker use in colorectal cancer therapy. J Natl Compr Canc Netw 2011, 9:1293-1302.
5. Ping Y.F., Bian X.W. Consice review: Contribution of cancer stem cells to neovascularization. Stem Cells 2011, 29:888-894.
6. Odoux C., Fohrer H., Hoppo T., Guzik L., Stolz D.B., Lewis D.W., et al. A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res 2008, 68:6932-6941.
7. Wang C., Xie J., Guo J., Manning H.C., Gore J.C., Guo N. Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep 2012, 28:1301-1308.
8. Lugli A., Iezzi G., Hostettler I., Muraro M.G., Mele V., Tornillo L., et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer 2010, 103:382-390.
9. Su Y.J., Lai H.M., Chang Y.W., Chen G.Y., Lee J.L. Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J 2011, 30:3186-3199.
10. Hsu S.Y., Liang S.G., Hsueh A.J. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven transmembrane region. Mol Endocrinol 1998, 12:1830-1845.
11. Becker L., Huang Q., Mashimo H. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. Sci World J 2008, 8:1168-1176.
12. Sato T., Vries R.G., Snippert H.J., van de Wetering M., Barker N., Stange D.E., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459:262-265.
13. Barker N., van Es J.H., Kuipers J., Kujala P., van den Born M., Cozijnsen M., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
14. Kleist B., Xu L., Kersten C., Seel V., Li G., Poetsh M. Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer. Am J Transl Res 2012, 4:279-290.
15. Wu X.S., Xi H.Q., Chen L. Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. World J Surg Oncol 2012, 10:244.
16. Takeda K., Kinoshita I., Shimizu Y., Matsuno Y., Shichinohe T., Dosaka-Akita H. Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Anticancer Res 2011, 31:263-270.
17. Rao G.H., Liu H.M., Li B.W., Hao J.J., Yang Y.L., Wang M.R., et al. Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. Acta Pharmacol Sin 2013, 34:793-804.
18. Ziskin J.L., Dunlap D., Yaylaoglu M., Fodor I.K., Forrest W.F., Patel R., et al. In situ validation of an intestinal stem cell signature in colorectal cancer. Gut 2013, 62:1012-1023.
19. Parmar M.K., Torri V., Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998, 17:2815-2834.
20. Fan X.S., Wu H.Y., Yu H.P., Zhou Q., Zhang Y.F., Huang Q. Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin. Int J Colorectal Dis 2010, 25:583-590.
21. Takahashi H., Ishii H., Nishida N., Takemasa I., Mizushima T., Ikeda M., et al. Significance of Lgr5 (+ve) cancer stem cells in the colon and rectum. Ann Surg Oncol 2011, 18:1166-1174.
22. Saigusa S., Inoue Y., Tanaka K., Toiyama Y., Matsushita K., Okugawa M., et al. Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy. Int J Oncol 2012, 41:1643-1652.
23. Hsu H.C., Liu Y.S., Tseng K.C., Hsu C.L., Liang Y., Yang T.S., et al. Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer. Int J Colorectal Dis 2013, 28:1535-1546.
24. Liu Z., Dai W., Jiang L., Cheng Y. Overexpression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients. Neoplasma 2014, 61:177-185.
25. Fukuma M., Tanese K., Effendi K., Yamazaki K., Masugi Y., Suda M., et al. Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells. Exp Cell Res 2013, 319:113-121.
26. Yamanoi K., Fukuma M., Uchida H., Kushima R., Yamazaki K., Katai H., et al. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. Pathol Int 2013, 63:13-19.
27. McClanahan T., Koseoglu S., Smith K., Grein J., Gustafson E., Black S., et al. Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. Cancer Biol Ther 2006, 5:419-426.
28. Dirks P.B. Cancer: stem cells and brain tumours. Nature 2006, 444:687-688.
29. Becker L., Huang Q., Mashimo H. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. Dis Esophagus 2010, 23:168-174.
30. Kemper K., Prasetyanti P.R., De Lau W., Rodermond H., Clevers H., Medema J.P. Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem Cells 2012, 30:2378-2386.
31. Merlos-Suarez A., Barriga F.M., Jung P., Iglesias M., Cespedes M.V., Rossell D., et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 2011, 8:511-524.
32. Gerger A., Zhang W., Yang D., Bohanes P., Ning Y., Winder T., et al. Common cancer stem cell gene variants predict colon cancer recurrence. Clin Cancer Res 2011, 17:6934-6943.
33. Saigusa S., Inoue Y., Tanaka K., Toiyama Y., Kawamura M., Okugawa Y., et al. Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. J Cancer Res Clin Oncol 2013, 139:131-138.
34. Wan D., Gu W., Xu G., Shen C., Ding D., Shen S., et al. Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis. Clin Transl Oncol 2014, 16:792-800.