Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs

Acta Pharmacologica Sinica

Volumn 34, Issue 6, 2013, Pages 793-804

  Rao, Guan Hua ^b   Liu, Hong Min ^c   Li, Bao Wei ^a   Hao, Jia Jie ^d   Yang, Yan Lei ^a   Wang, Ming Rong ^d   Wang, Xiao Hui ^a   Wang, Jun ^a   Jin, Hai Jing ^a   Du, Lei ^a   Chen, Quan ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b NANKAI UNIVERSITY   (China)

^c HEBEI UNITED UNIVERSITY   (China)

^d CANCER HOSPITAL   (China)

Author keywords

5 fluorouracil; Camptothecin; cancer stem cell; CD44 antigens; colorectal cancer; drug resistance; Oct3 4; self renewal

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; FLUOROURACIL; HERMES ANTIGEN; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LGR5; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER STEM CELL; CANCER TISSUE; CARCINOGENICITY; CELL CLONE; CELL DIVISION; CELL PROLIFERATION; CELL RENEWAL; CLINICAL ARTICLE; COLON; COLONY FORMATION; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE C MYC; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NEOPLASTIC STEM CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84881432119     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.56     Document Type: Article

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