Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer

Pathology International

Volumn 63, Issue 1, 2013, Pages 13-19

  Yamanoi, Kazuhiro ^a,c   Fukuma, Mariko ^a   Uchida, Hiroshi ^b   Kushima, Ryoji ^c   Yamazaki, Ken ^a   Katai, Hitoshi ^a   Kanai, Yae ^c   Sakamoto, Michiie ^a  

^a KEIO UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Epithelial; Gastric cancer; LGR5; Lymphatic invasion

Indexed keywords

BETA CATENIN; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER;

ADENOCARCINOMA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84873080790     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12013     Document Type: Article

References (17)

1. Jemel A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66.
2. Matsuda T, Marugame T, Kamo K etal. Cancer incidence and incidence rates in Japan in 2003: Based on deta from 13 population-based canced registries in the monitoring of cancer incidence in Japan project. Jpn J Clin Oncol 2009; 39: 850-858.
3. Uchida H, Yamazaki K, Fukuma M etal. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer Sci 2010; 101: 1731-1737.
4. Schoneberg T, Schultz G, Gudermann T. Structural basis of G protein-coupled receptor function. Mol Cell Endocrinol 1999; 151: 181-193.
5. Tanese K, Fukuma M, Yamada T etal. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol 2008; 173: 835-843.
6. Yamamoto Y, Sakamoto M, Fujii G etal. Overexpression of orphan Gprotein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 2003; 37: 528-533.
7. Simon E, Petke D, Boger C, Behrens H-M, Warneke V, Ebert M. Christoph Roken The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS One 2012; 7: e35486.
8. Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Immunol Scand 1965; 64: 349-358.
9. Tsukamoto T, Yamamoto M, Ogasawara N etal. beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer Sci 2003; 94: 1046-1051.
10. Clements WM, Wang J, Sarnaik A, Kim OJ etal. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 2002; 62: 3503-3506.
11. Taketo MM. Wnt signaling and gastrointestinal tumorigenesis in mouse models. Oncogene 2006; 25: 7522-7530.
12. Van der Flier LG, Sabates-Bellver J, Oving I etal. The intestinal Wnt / TCF signature. Gastroenterology 2007; 132: 628-632.
13. Segditsas S, Sieber O, Deheragoda M etal. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet 2008; 17: 3864-3875.
14. Aokage K, Ishii G, Ohtaki Y etal. Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. Int J Cancer 2011; 128: 1585-1595.
15. Rosivatz E, Becker I, Specht K etal. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161: 1881-1891.
16. Barker N, Huch M, Kujala P etal. Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 2010; 6: 25-36.
17. Barker N, Huch M, Kujala P etal. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-1007.