메뉴 건너뛰기




Volumn 95, Issue 4, 2015, Pages 422-431

MALDI Imaging mass spectrometry: Current frontiers and perspectives in pathology research and practice

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; PROTEIN;

EID: 84926339388     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.156     Document Type: Article
Times cited : (342)

References (106)
  • 1
    • 84890060782 scopus 로고    scopus 로고
    • Imaging mass spectrometry: A new tool for pathology in a molecular age
    • Norris JL, Caprioli RM. Imaging mass spectrometry: a new tool for pathology in a molecular age. Proteomics Clin Appl 2013;7:733-738.
    • (2013) Proteomics Clin Appl , vol.7 , pp. 733-738
    • Norris, J.L.1    Caprioli, R.M.2
  • 2
    • 84876099509 scopus 로고    scopus 로고
    • Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research
    • Norris JL, Caprioli RM. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev 2013;113:2309-2342.
    • (2013) Chem Rev , vol.113 , pp. 2309-2342
    • Norris, J.L.1    Caprioli, R.M.2
  • 3
    • 0031304362 scopus 로고    scopus 로고
    • Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS
    • Caprioli RM, Farmer TB, Gile J. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 1997;69:4751-4760.
    • (1997) Anal Chem , vol.69 , pp. 4751-4760
    • Caprioli, R.M.1    Farmer, T.B.2    Gile, J.3
  • 4
    • 0035048372 scopus 로고    scopus 로고
    • Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues
    • Stoeckli M, Chaurand P, Hallahan DE, et al. Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat Med 2001;7:493-496.
    • (2001) Nat Med , vol.7 , pp. 493-496
    • Stoeckli, M.1    Chaurand, P.2    Hallahan, D.E.3
  • 5
    • 77955952166 scopus 로고    scopus 로고
    • Molecular imaging by mass spectrometry-looking beyond classical histology
    • Schwamborn K, Caprioli RM. Molecular imaging by mass spectrometry-looking beyond classical histology. Nat Rev Cancer 2010;10:639-646.
    • (2010) Nat Rev Cancer , vol.10 , pp. 639-646
    • Schwamborn, K.1    Caprioli, R.M.2
  • 6
    • 0037329401 scopus 로고    scopus 로고
    • Ion formation in MALDI: The cluster ionization mechanism
    • Karas M, Kruger R. Ion formation in MALDI: the cluster ionization mechanism. Chem Rev 2003;103:427-440.
    • (2003) Chem Rev , vol.103 , pp. 427-440
    • Karas, M.1    Kruger, R.2
  • 7
    • 79955824911 scopus 로고    scopus 로고
    • Compelling evidence for Lucky Survivor and gas phase protonation: The unified MALDI analyte protonation mechanism
    • Jaskolla TW, Karas M. Compelling evidence for Lucky Survivor and gas phase protonation: the unified MALDI analyte protonation mechanism. J Am Soc Mass Spectrom 2011;22:976-988.
    • (2011) J Am Soc Mass Spectrom , vol.22 , pp. 976-988
    • Jaskolla, T.W.1    Karas, M.2
  • 8
    • 84878264150 scopus 로고    scopus 로고
    • Mass spectrometry imaging with high resolution in mass and space
    • Rompp A, Spengler B. Mass spectrometry imaging with high resolution in mass and space. Histochem Cell Biol 2013;139:759-783.
    • (2013) Histochem Cell Biol , vol.139 , pp. 759-783
    • Rompp, A.1    Spengler, B.2
  • 9
    • 77952664027 scopus 로고    scopus 로고
    • Histology by mass spectrometry: Label-free tissue characterization obtained from high-accuracy bioanalytical imaging
    • Rompp A, Guenther S, Schober Y, et al. Histology by mass spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging. Angew Chem Int Ed Engl 2010;49:3834-3838.
    • (2010) Angew Chem Int Ed Engl , vol.49 , pp. 3834-3838
    • Rompp, A.1    Guenther, S.2    Schober, Y.3
  • 10
    • 79960559981 scopus 로고    scopus 로고
    • Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level
    • Rompp A, Guenther S, Takats Z, et al. Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level. Anal Bioanal Chem 2011;401:65-73.
    • (2011) Anal Bioanal Chem , vol.401 , pp. 65-73
    • Rompp, A.1    Guenther, S.2    Takats, Z.3
  • 11
    • 56449125884 scopus 로고    scopus 로고
    • Protein fragment imaging using ink jet printing digestion technique
    • Komatsu M, Murayama Y, Hashimoto H. Protein fragment imaging using ink jet printing digestion technique. Appl Surf Sci 2008;255: 1162-1164.
    • (2008) Appl Surf Sci , vol.255 , pp. 1162-1164
    • Komatsu, M.1    Murayama, Y.2    Hashimoto, H.3
  • 12
    • 53049107066 scopus 로고    scopus 로고
    • Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: Bypassing formalin fixation
    • Chaurand P, Latham JC, Lane KB, et al. Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: bypassing formalin fixation. J Proteome Res 2008;7:3543-3555.
    • (2008) J Proteome Res , vol.7 , pp. 3543-3555
    • Chaurand, P.1    Latham, J.C.2    Lane, K.B.3
  • 13
    • 35848970035 scopus 로고    scopus 로고
    • MALDI imaging mass spectrometry: Molecular snapshots of biochemical systems
    • Cornett DS, Reyzer ML, Chaurand P, et al. MALDI imaging mass spectrometry: molecular snapshots of biochemical systems. Nat Methods 2007;4:828-833.
    • (2007) Nat Methods , vol.4 , pp. 828-833
    • Cornett, D.S.1    Reyzer, M.L.2    Chaurand, P.3
  • 14
    • 70349629991 scopus 로고    scopus 로고
    • Improving tissue preparation for matrix-assisted laser desorption ionization mass spectrometry imaging. Part 1: Using microspotting
    • Franck J, Arafah K, Barnes A, et al. Improving tissue preparation for matrix-assisted laser desorption ionization mass spectrometry imaging. Part 1: using microspotting. Anal Chem 2009;81:8193-8202.
    • (2009) Anal Chem , vol.81 , pp. 8193-8202
    • Franck, J.1    Arafah, K.2    Barnes, A.3
  • 16
    • 84877737720 scopus 로고    scopus 로고
    • Detection of high molecular weight proteins by MALDI imaging mass spectrometry
    • Mainini V, Bovo G, Chinello C, et al. Detection of high molecular weight proteins by MALDI imaging mass spectrometry. Mol Biosyst 2013;9:1101-1107.
    • (2013) Mol Biosyst , vol.9 , pp. 1101-1107
    • Mainini, V.1    Bovo, G.2    Chinello, C.3
  • 19
    • 84897396558 scopus 로고    scopus 로고
    • High-resolution metabolite imaging of light and dark treated retina using MALDI-FTICR mass spectrometry
    • Sun N, Ly A, Meding S, et al. High-resolution metabolite imaging of light and dark treated retina using MALDI-FTICR mass spectrometry. Proteomics 2014;14:913-923.
    • (2014) Proteomics , vol.14 , pp. 913-923
    • Sun, N.1    Ly, A.2    Meding, S.3
  • 20
    • 84885157789 scopus 로고    scopus 로고
    • Comprehensive identification of proteins from MALDI imaging
    • Maier SK, Hahne H, Gholami AM, et al. Comprehensive identification of proteins from MALDI imaging. Mol Cell Proteomics 2013;12: 2901-2910.
    • (2013) Mol Cell Proteomics , vol.12 , pp. 2901-2910
    • Maier, S.K.1    Hahne, H.2    Gholami, A.M.3
  • 21
    • 84893856169 scopus 로고    scopus 로고
    • MSiMass list: A public database of identifications for protein MALDI MS imaging
    • McDonnell LA, Walch A, Stoeckli M, et al. MSiMass list: a public database of identifications for protein MALDI MS imaging. J Proteome Res 2014;13:1138-1142.
    • (2014) J Proteome Res , vol.13 , pp. 1138-1142
    • McDonnell, L.A.1    Walch, A.2    Stoeckli, M.3
  • 22
    • 84883223403 scopus 로고    scopus 로고
    • Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas
    • Pote N, Alexandrov T, Le Faouder J, et al. Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas. Hepatology 2013;58: 983-994.
    • (2013) Hepatology , vol.58 , pp. 983-994
    • Pote, N.1    Alexandrov, T.2    Le Faouder, J.3
  • 23
    • 77951256401 scopus 로고    scopus 로고
    • Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array
    • Djidja MC, Claude E, Snel MF, et al. Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array. Anal Bioanal Chem 2010;397:587-601.
    • (2010) Anal Bioanal Chem , vol.397 , pp. 587-601
    • Djidja, M.C.1    Claude, E.2    Snel, M.F.3
  • 24
    • 53549111100 scopus 로고    scopus 로고
    • High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry
    • Groseclose MR, Massion PP, Chaurand P, et al. High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 2008;8:3715-3724.
    • (2008) Proteomics , vol.8 , pp. 3715-3724
    • Groseclose, M.R.1    Massion, P.P.2    Chaurand, P.3
  • 25
    • 71849100285 scopus 로고    scopus 로고
    • Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray
    • Morita Y, Ikegami K, Goto-Inoue N, et al. Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray. Cancer Sci 2010;101:267-273.
    • (2010) Cancer Sci , vol.101 , pp. 267-273
    • Morita, Y.1    Ikegami, K.2    Goto-Inoue, N.3
  • 26
    • 84884709219 scopus 로고    scopus 로고
    • MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer
    • Quaas A, Bahar AS, von Loga K, et al. MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer. Histopathology 2013;63: 455-462.
    • (2013) Histopathology , vol.63 , pp. 455-462
    • Quaas, A.1    Bahar, A.S.2    Von Loga, K.3
  • 27
    • 84878844720 scopus 로고    scopus 로고
    • MALDI mass spectrometric imaging based identification of clinically relevant signals in prostate cancer using large-scale tissue microarrays
    • Steurer S, Borkowski C, Odinga S, et al. MALDI mass spectrometric imaging based identification of clinically relevant signals in prostate cancer using large-scale tissue microarrays. Int J Cancer 2013;133: 920-928.
    • (2013) Int J Cancer , vol.133 , pp. 920-928
    • Steurer, S.1    Borkowski, C.2    Odinga, S.3
  • 28
    • 84902994401 scopus 로고    scopus 로고
    • MALDI imaging on tissue microarrays identifies molecular features associated with renal cell cancer phenotype
    • Steurer S, Seddiqi AS, Singer JM, et al. MALDI imaging on tissue microarrays identifies molecular features associated with renal cell cancer phenotype. Anticancer Res 2014;34:2255-2261.
    • (2014) Anticancer Res , vol.34 , pp. 2255-2261
    • Steurer, S.1    Seddiqi, A.S.2    Singer, J.M.3
  • 29
    • 84925940444 scopus 로고    scopus 로고
    • MALDI imaging-based identification of prognostically relevant signals in bladder cancer using large-scale tissue microarrays
    • Steurer S, Singer JM, Rink M, et al. MALDI imaging-based identification of prognostically relevant signals in bladder cancer using large-scale tissue microarrays. Urol Oncol 2014;32:1225-1233.
    • (2014) Urol Oncol , vol.32 , pp. 1225-1233
    • Steurer, S.1    Singer, J.M.2    Rink, M.3
  • 30
    • 84880090199 scopus 로고    scopus 로고
    • Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria
    • Aichler M, Elsner M, Ludyga N, et al. Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. J Pathol 2013;230:410-419.
    • (2013) J Pathol , vol.230 , pp. 410-419
    • Aichler, M.1    Elsner, M.2    Ludyga, N.3
  • 31
    • 1342344698 scopus 로고    scopus 로고
    • Cellular lipid metabolism and the role of lipids in progressive renal disease
    • Abrass CK. Cellular lipid metabolism and the role of lipids in progressive renal disease. Am J Nephrol 2004;24:46-53.
    • (2004) Am J Nephrol , vol.24 , pp. 46-53
    • Abrass, C.K.1
  • 32
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003;144:2201-2207.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.H.1    Olson, P.2    Evans, R.M.3
  • 33
    • 77953635903 scopus 로고    scopus 로고
    • Longitudinal changes of adiponectin, carbohydrate and lipid metabolism in pregnant women at high risk for gestational diabetes
    • Paradisi G, Ianniello F, Tomei C, et al. Longitudinal changes of adiponectin, carbohydrate and lipid metabolism in pregnant women at high risk for gestational diabetes. Gynecol Endocrinol 2010;26: 539-545.
    • (2010) Gynecol Endocrinol , vol.26 , pp. 539-545
    • Paradisi, G.1    Ianniello, F.2    Tomei, C.3
  • 34
    • 84863837081 scopus 로고    scopus 로고
    • Lipid metabolism in cancer
    • Santos CR, Schulze A. Lipid metabolism in cancer. FEBS J 2012;279: 2610-2623.
    • (2012) FEBS J , vol.279 , pp. 2610-2623
    • Santos, C.R.1    Schulze, A.2
  • 35
    • 78650031435 scopus 로고    scopus 로고
    • Mass-spectrometry based oxidative lipidomics and lipid imaging: Applications in traumatic brain injury
    • Sparvero LJ, Amoscato AA, Kochanek PM, et al. Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury. J Neurochem 2010;115:1322-1336.
    • (2010) J Neurochem , vol.115 , pp. 1322-1336
    • Sparvero, L.J.1    Amoscato, A.A.2    Kochanek, P.M.3
  • 36
    • 27844595844 scopus 로고    scopus 로고
    • In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS
    • Jackson SN, Wang HY, Woods AS. In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS. J Am Soc Mass Spectrom 2005;16:2052-2056.
    • (2005) J Am Soc Mass Spectrom , vol.16 , pp. 2052-2056
    • Jackson, S.N.1    Wang, H.Y.2    Woods, A.S.3
  • 37
    • 70349781660 scopus 로고    scopus 로고
    • MALDI reveals membrane lipid profile reversion in MDX mice
    • Benabdellah F, Yu H, Brunelle A, et al. MALDI reveals membrane lipid profile reversion in MDX mice. Neurobiol Dis 2009;36:252-258.
    • (2009) Neurobiol Dis , vol.36 , pp. 252-258
    • Benabdellah, F.1    Yu, H.2    Brunelle, A.3
  • 38
    • 84858843653 scopus 로고    scopus 로고
    • Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: Enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition
    • Thomas A, Charbonneau JL, Fournaise E, et al. Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. Anal Chem 2012;84:2048-2054.
    • (2012) Anal Chem , vol.84 , pp. 2048-2054
    • Thomas, A.1    Charbonneau, J.L.2    Fournaise, E.3
  • 39
    • 1442339662 scopus 로고    scopus 로고
    • In situ MALDI-TOF MS regional analysis of neutral phospholipids in lens tissue
    • Rujoi M, Estrada R, Yappert MC. In situ MALDI-TOF MS regional analysis of neutral phospholipids in lens tissue. Anal Chem 2004;76:1657-1663.
    • (2004) Anal Chem , vol.76 , pp. 1657-1663
    • Rujoi, M.1    Estrada, R.2    Yappert, M.C.3
  • 40
    • 0037378889 scopus 로고    scopus 로고
    • Isolation and lipid characterization of cholesterol-enriched fractions in cortical and nuclear human lens fibers
    • Rujoi M, Jin J, Borchman D, et al. Isolation and lipid characterization of cholesterol-enriched fractions in cortical and nuclear human lens fibers. Invest Ophthalmol Vis Sci 2003;44:1634-1642.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 1634-1642
    • Rujoi, M.1    Jin, J.2    Borchman, D.3
  • 41
    • 0038667898 scopus 로고    scopus 로고
    • Glycero-versus sphingophospholipids: Correlations with human and non-human mammalian lens growth
    • Yappert MC, Rujoi M, Borchman D, et al. Glycero-versus sphingophospholipids: correlations with human and non-human mammalian lens growth. Exp Eye Res 2003;76:725-734.
    • (2003) Exp Eye Res , vol.76 , pp. 725-734
    • Yappert, M.C.1    Rujoi, M.2    Borchman, D.3
  • 42
    • 72849123745 scopus 로고    scopus 로고
    • Mass spectrometry imaging of rat brain sections: Nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS
    • Benabdellah F, Seyer A, Quinton L, et al. Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS. Anal Bioanal Chem 2010;396:151-162.
    • (2010) Anal Bioanal Chem , vol.396 , pp. 151-162
    • Benabdellah, F.1    Seyer, A.2    Quinton, L.3
  • 43
    • 1542617951 scopus 로고    scopus 로고
    • Tissue molecular ion imaging by gold cluster ion bombardment
    • Touboul D, Halgand F, Brunelle A, et al. Tissue molecular ion imaging by gold cluster ion bombardment. Anal Chem 2004;76:1550-1559.
    • (2004) Anal Chem , vol.76 , pp. 1550-1559
    • Touboul, D.1    Halgand, F.2    Brunelle, A.3
  • 44
    • 57449121806 scopus 로고    scopus 로고
    • Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix
    • Astigarraga E, Barreda-Gomez G, Lombardero L, et al. Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix. Anal Chem 2008;80:9105-9114.
    • (2008) Anal Chem , vol.80 , pp. 9105-9114
    • Astigarraga, E.1    Barreda-Gomez, G.2    Lombardero, L.3
  • 45
    • 70350359832 scopus 로고    scopus 로고
    • Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation
    • Burnum KE, Cornett DS, Puolitaival SM, et al. Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J Lipid Res 2009;50:2290-2298.
    • (2009) J Lipid Res , vol.50 , pp. 2290-2298
    • Burnum, K.E.1    Cornett, D.S.2    Puolitaival, S.M.3
  • 46
    • 77952865171 scopus 로고    scopus 로고
    • Localization and imaging of sialylated glycosphingolipids in brain tissue sections by MALDI mass spectrometry
    • Colsch B, Woods AS. Localization and imaging of sialylated glycosphingolipids in brain tissue sections by MALDI mass spectrometry. Glycobiology 2010;20:661-667.
    • (2010) Glycobiology , vol.20 , pp. 661-667
    • Colsch, B.1    Woods, A.S.2
  • 47
    • 74949129649 scopus 로고    scopus 로고
    • Lipid geographical analysis of the primate macula by imaging mass spectrometry
    • Garrett TJ, Dawson WW. Lipid geographical analysis of the primate macula by imaging mass spectrometry. Methods Mol Biol 2009;579:247-260.
    • (2009) Methods Mol Biol , vol.579 , pp. 247-260
    • Garrett, T.J.1    Dawson, W.W.2
  • 48
    • 70349243081 scopus 로고    scopus 로고
    • Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo
    • Hayasaka T, Goto-Inoue N, Zaima N, et al. Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo. Lipids 2009;44:837-848.
    • (2009) Lipids , vol.44 , pp. 837-848
    • Hayasaka, T.1    Goto-Inoue, N.2    Zaima, N.3
  • 49
    • 70449794095 scopus 로고    scopus 로고
    • Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS
    • Landgraf RR, Prieto Conaway MC, Garrett TJ, et al. Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS. Anal Chem 2009;81: 8488-8495.
    • (2009) Anal Chem , vol.81 , pp. 8488-8495
    • Landgraf, R.R.1    Prieto Conaway, M.C.2    Garrett, T.J.3
  • 50
    • 77950519952 scopus 로고    scopus 로고
    • Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids
    • Meriaux C, Franck J, Wisztorski M, et al. Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids. J Proteomics 2010;73:1204-1218.
    • (2010) J Proteomics , vol.73 , pp. 1204-1218
    • Meriaux, C.1    Franck, J.2    Wisztorski, M.3
  • 51
    • 58249131629 scopus 로고    scopus 로고
    • Imaging of phosphatidylcholines in the adult rat brain using MALDI-TOF MS
    • Mikawa S, Suzuki M, Fujimoto C, et al. Imaging of phosphatidylcholines in the adult rat brain using MALDI-TOF MS. Neurosci Lett 2009;451:45-49.
    • (2009) Neurosci Lett , vol.451 , pp. 45-49
    • Mikawa, S.1    Suzuki, M.2    Fujimoto, C.3
  • 52
    • 66349085913 scopus 로고    scopus 로고
    • Imaging of lipid species by MALDI mass spectrometry
    • Murphy RC, Hankin JA, Barkley RM. Imaging of lipid species by MALDI mass spectrometry. J Lipid Res 2009;50(Suppl):S317-S322.
    • (2009) J Lipid Res , vol.50 , pp. S317-S322
    • Murphy, R.C.1    Hankin, J.A.2    Barkley, R.M.3
  • 53
    • 77951835487 scopus 로고    scopus 로고
    • High-spatial resolution matrix-assisted laser desorption ionization imaging analysis of glucosylceramide in spleen sections from a mouse model of Gaucher disease
    • Snel MF, Fuller M. High-spatial resolution matrix-assisted laser desorption ionization imaging analysis of glucosylceramide in spleen sections from a mouse model of Gaucher disease. Anal Chem 2010;82:3664-3670.
    • (2010) Anal Chem , vol.82 , pp. 3664-3670
    • Snel, M.F.1    Fuller, M.2
  • 54
    • 84862757634 scopus 로고    scopus 로고
    • Mapping of phospholipids by MALDI imaging (MALDI-MSI): Realities and expectations
    • Sparvero LJ, Amoscato AA, Dixon CE, et al. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. Chem Phys Lipids 2012;165:545-562.
    • (2012) Chem Phys Lipids , vol.165 , pp. 545-562
    • Sparvero, L.J.1    Amoscato, A.A.2    Dixon, C.E.3
  • 55
    • 70350379611 scopus 로고    scopus 로고
    • Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry
    • Sugiura Y, Konishi Y, Zaima N, et al. Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J Lipid Res 2009;50:1776-1788.
    • (2009) J Lipid Res , vol.50 , pp. 1776-1788
    • Sugiura, Y.1    Konishi, Y.2    Zaima, N.3
  • 56
    • 77956838048 scopus 로고    scopus 로고
    • Visualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry
    • Vidova V, Pol J, Volny M, et al. Visualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry. J Lipid Res 2010;51:2295-2302.
    • (2010) J Lipid Res , vol.51 , pp. 2295-2302
    • Vidova, V.1    Pol, J.2    Volny, M.3
  • 57
    • 84891798349 scopus 로고    scopus 로고
    • Comprehensive imaging of porcine adrenal gland lipids by MALDI-FTMS using quercetin as a matrix
    • Wang X, Han J, Pan J, et al. Comprehensive imaging of porcine adrenal gland lipids by MALDI-FTMS using quercetin as a matrix. Anal Chem 2014;86:638-646.
    • (2014) Anal Chem , vol.86 , pp. 638-646
    • Wang, X.1    Han, J.2    Pan, J.3
  • 58
    • 84884987139 scopus 로고    scopus 로고
    • Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; Possible involvement of LPCAT4
    • Kurabe N, Hayasaka T, Ogawa M, et al. Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4. Cancer Sci 2013;104:1295-1302.
    • (2013) Cancer Sci , vol.104 , pp. 1295-1302
    • Kurabe, N.1    Hayasaka, T.2    Ogawa, M.3
  • 59
    • 78649699613 scopus 로고    scopus 로고
    • Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors
    • Miura D, Fujimura Y, Yamato M, et al. Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors. Anal Chem 2010;82:9789-9796.
    • (2010) Anal Chem , vol.82 , pp. 9789-9796
    • Miura, D.1    Fujimura, Y.2    Yamato, M.3
  • 60
    • 77956325355 scopus 로고    scopus 로고
    • Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry
    • Hattori K, Kajimura M, Hishiki T, et al. Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. Antioxid Redox Signal 2010;13:1157-1167.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1157-1167
    • Hattori, K.1    Kajimura, M.2    Hishiki, T.3
  • 61
    • 84884470533 scopus 로고    scopus 로고
    • Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo
    • Bao Y, Mukai K, Hishiki T, et al. Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. Mol Cancer Res 2013;11:973-985.
    • (2013) Mol Cancer Res , vol.11 , pp. 973-985
    • Bao, Y.1    Mukai, K.2    Hishiki, T.3
  • 62
    • 77955372862 scopus 로고    scopus 로고
    • Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue microcompartments using imaging mass spectrometry
    • Nilsson A, Fehniger TE, Gustavsson L, et al. Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue microcompartments using imaging mass spectrometry. PLoS One 2010; 5:e11411.
    • (2010) PLoS One , vol.5 , pp. e11411
    • Nilsson, A.1    Fehniger, T.E.2    Gustavsson, L.3
  • 63
    • 84883062905 scopus 로고    scopus 로고
    • Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging
    • Morosi L, Spinelli P, Zucchetti M, et al. Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging. PLoS One 2013; 8:e72532.
    • (2013) PLoS One , vol.8 , pp. e72532
    • Morosi, L.1    Spinelli, P.2    Zucchetti, M.3
  • 64
    • 84872586328 scopus 로고    scopus 로고
    • Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard
    • Pirman DA, Reich RF, Kiss A, et al. Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard. Anal Chem 2013;85:1081-1089.
    • (2013) Anal Chem , vol.85 , pp. 1081-1089
    • Pirman, D.A.1    Reich, R.F.2    Kiss, A.3
  • 65
    • 84865200761 scopus 로고    scopus 로고
    • Mass spectrometry imaging for drug distribution studies
    • Prideaux B, Stoeckli M. Mass spectrometry imaging for drug distribution studies. J Proteomics 2012;75:4999-5013.
    • (2012) J Proteomics , vol.75 , pp. 4999-5013
    • Prideaux, B.1    Stoeckli, M.2
  • 66
    • 33846888780 scopus 로고    scopus 로고
    • MALDI-MS-based imaging of small molecules and proteins in tissues
    • Reyzer ML, Caprioli RM. MALDI-MS-based imaging of small molecules and proteins in tissues. Curr Opin Chem Biol 2007;11:29-35.
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 29-35
    • Reyzer, M.L.1    Caprioli, R.M.2
  • 67
    • 0242606377 scopus 로고    scopus 로고
    • Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry
    • Reyzer ML, Hsieh Y, Ng K, et al. Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom 2003;38:1081-1092.
    • (2003) J Mass Spectrom , vol.38 , pp. 1081-1092
    • Reyzer, M.L.1    Hsieh, Y.2    Ng, K.3
  • 68
    • 34047187431 scopus 로고    scopus 로고
    • Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ ionisation mass spectrometry
    • Atkinson SJ, Loadman PM, Sutton C, et al. Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ ionisation mass spectrometry. Rapid Commun Mass Spectrom 2007; 21:1271-1276.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 1271-1276
    • Atkinson, S.J.1    Loadman, P.M.2    Sutton, C.3
  • 69
    • 33947268472 scopus 로고    scopus 로고
    • Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues
    • Drexler DM, Garrett TJ, Cantone JL, et al. Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues. J Pharmacol Toxicol Methods 2007; 55:279-288.
    • (2007) J Pharmacol Toxicol Methods , vol.55 , pp. 279-288
    • Drexler, D.M.1    Garrett, T.J.2    Cantone, J.L.3
  • 70
    • 34447304613 scopus 로고    scopus 로고
    • Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry
    • Signor L, Varesio E, Staack RF, et al. Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry. J Mass Spectrom 2007;42:900-909.
    • (2007) J Mass Spectrom , vol.42 , pp. 900-909
    • Signor, L.1    Varesio, E.2    Staack, R.F.3
  • 71
    • 33748865022 scopus 로고    scopus 로고
    • Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
    • Khatib-Shahidi S, Andersson M, Herman JL, et al. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal Chem 2006;78:6448-6456.
    • (2006) Anal Chem , vol.78 , pp. 6448-6456
    • Khatib-Shahidi, S.1    Andersson, M.2    Herman, J.L.3
  • 72
    • 79955802352 scopus 로고    scopus 로고
    • Direct molecular analysis of whole-body animal tissue sections by MALDI imaging mass spectrometry
    • Reyzer ML, Chaurand P, Angel PM, et al. Direct molecular analysis of whole-body animal tissue sections by MALDI imaging mass spectrometry. Methods Mol Biol 2010;656:285-301.
    • (2010) Methods Mol Biol , vol.656 , pp. 285-301
    • Reyzer, M.L.1    Chaurand, P.2    Angel, P.M.3
  • 73
    • 10944222054 scopus 로고    scopus 로고
    • MALDI mass spectrometric imaging of biological tissue sections
    • Rohner TC, Staab D, Stoeckli M. MALDI mass spectrometric imaging of biological tissue sections. Mech Ageing Dev 2005;126:177-185.
    • (2005) Mech Ageing Dev , vol.126 , pp. 177-185
    • Rohner, T.C.1    Staab, D.2    Stoeckli, M.3
  • 74
    • 77249156030 scopus 로고    scopus 로고
    • Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: Toward in situ pharmacometabolomes
    • Sugiura Y, Setou M. Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes. J Neuroimmune Pharmacol 2010;5:31-43.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 31-43
    • Sugiura, Y.1    Setou, M.2
  • 75
    • 79959429712 scopus 로고    scopus 로고
    • Applications of MALDI-MSI to pharmaceutical research
    • Prideaux B, Staab D, Stoeckli M. Applications of MALDI-MSI to pharmaceutical research. Methods Mol Biol 2010;656:405-413.
    • (2010) Methods Mol Biol , vol.656 , pp. 405-413
    • Prideaux, B.1    Staab, D.2    Stoeckli, M.3
  • 76
    • 79957632743 scopus 로고    scopus 로고
    • Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging
    • Marko-Varga G, Fehniger TE, Rezeli M, et al. Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging. J Proteomics 2011;74:982-992.
    • (2011) J Proteomics , vol.74 , pp. 982-992
    • Marko-Varga, G.1    Fehniger, T.E.2    Rezeli, M.3
  • 77
    • 84881223277 scopus 로고    scopus 로고
    • Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels
    • Sun N, Walch A. Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels. Histochem Cell Biol 2013;140:93-104.
    • (2013) Histochem Cell Biol , vol.140 , pp. 93-104
    • Sun, N.1    Walch, A.2
  • 78
    • 81055140601 scopus 로고    scopus 로고
    • Mass spectrometry imaging for drugs and metabolites
    • Greer T, Sturm R, Li L. Mass spectrometry imaging for drugs and metabolites. J Proteomics 2011;74:2617-2631.
    • (2011) J Proteomics , vol.74 , pp. 2617-2631
    • Greer, T.1    Sturm, R.2    Li, L.3
  • 79
    • 81055144381 scopus 로고    scopus 로고
    • MALDI imaging mass spectrometry: Bridging biology and chemistry in drug development
    • Castellino S, Groseclose MR, Wagner D. MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis 2011;3:2427-2441.
    • (2011) Bioanalysis , vol.3 , pp. 2427-2441
    • Castellino, S.1    Groseclose, M.R.2    Wagner, D.3
  • 80
    • 84881028758 scopus 로고    scopus 로고
    • Qualitative and quantitative mass spectrometry imaging of drugs and metabolites
    • Lietz CB, Gemperline E, Li L. Qualitative and quantitative mass spectrometry imaging of drugs and metabolites. Adv Drug Deliv Rev 2013;65:1074-1085.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1074-1085
    • Lietz, C.B.1    Gemperline, E.2    Li, L.3
  • 81
    • 84908583707 scopus 로고    scopus 로고
    • A novel approach of MALDI drug imaging, immunohistochemistry, and digital image analysis for drug distribution studies in tissues
    • Huber K, Feuchtinger A, Borgmann D, et al. A novel approach of MALDI drug imaging, immunohistochemistry, and digital image analysis for drug distribution studies in tissues. Anal Chem 2014;86: 10568-10575.
    • (2014) Anal Chem , vol.86 , pp. 10568-10575
    • Huber, K.1    Feuchtinger, A.2    Borgmann, D.3
  • 82
    • 81255214562 scopus 로고    scopus 로고
    • MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer
    • Balluff B, Rauser S, Meding S, et al. MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Am J Pathol 2011;179:2720-2729.
    • (2011) Am J Pathol , vol.179 , pp. 2720-2729
    • Balluff, B.1    Rauser, S.2    Meding, S.3
  • 83
    • 74549178443 scopus 로고    scopus 로고
    • Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation
    • Bauer JA, Chakravarthy AB, Rosenbluth JM, et al. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin Cancer Res 2010;16:681-690.
    • (2010) Clin Cancer Res , vol.16 , pp. 681-690
    • Bauer, J.A.1    Chakravarthy, A.B.2    Rosenbluth, J.M.3
  • 84
    • 77957602511 scopus 로고    scopus 로고
    • Application of MALDI imaging for the diagnosis of classical Hodgkin lymphoma
    • Schwamborn K, Krieg RC, Jirak P, et al. Application of MALDI imaging for the diagnosis of classical Hodgkin lymphoma. J Cancer Res Clin Oncol 2010;136:1651-1655.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1651-1655
    • Schwamborn, K.1    Krieg, R.C.2    Jirak, P.3
  • 86
    • 84859625307 scopus 로고    scopus 로고
    • Cancer of unknown primary site
    • Pavlidis N, Pentheroudakis G. Cancer of unknown primary site. Lancet 2012;379:1428-1435.
    • (2012) Lancet , vol.379 , pp. 1428-1435
    • Pavlidis, N.1    Pentheroudakis, G.2
  • 87
    • 0011760741 scopus 로고    scopus 로고
    • Summary of the Standards, Options and Recommendations for the management of patients with carcinoma of unknown primary site (2002)
    • Bugat R, Bataillard A, Lesimple T, et al. Summary of the Standards, Options and Recommendations for the management of patients with carcinoma of unknown primary site (2002). Br J Cancer 2003;89(Suppl 1): S59-S66.
    • (2003) Br J Cancer , vol.89 , pp. S59-S66
    • Bugat, R.1    Bataillard, A.2    Lesimple, T.3
  • 88
    • 84857824513 scopus 로고    scopus 로고
    • Tumor classification of six common cancer types based on proteomic profiling by MALDI imaging
    • Meding S, Nitsche U, Balluff B, et al. Tumor classification of six common cancer types based on proteomic profiling by MALDI imaging. J Proteome Res 2012;11:1996-2003.
    • (2012) J Proteome Res , vol.11 , pp. 1996-2003
    • Meding, S.1    Nitsche, U.2    Balluff, B.3
  • 89
    • 78649877261 scopus 로고    scopus 로고
    • Classification of HER2/neu status in gastric cancer using a breast-cancer derived proteome classifier
    • Balluff B, Elsner M, Kowarsch A, et al. Classification of HER2/neu status in gastric cancer using a breast-cancer derived proteome classifier. J Proteome Res 2010;9:6317-6322.
    • (2010) J Proteome Res , vol.9 , pp. 6317-6322
    • Balluff, B.1    Elsner, M.2    Kowarsch, A.3
  • 90
    • 77950661168 scopus 로고    scopus 로고
    • Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry
    • Rauser S, Marquardt C, Balluff B, et al. Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry. J Proteome Res 2010;9:1854-1863.
    • (2010) J Proteome Res , vol.9 , pp. 1854-1863
    • Rauser, S.1    Marquardt, C.2    Balluff, B.3
  • 91
    • 84897423154 scopus 로고    scopus 로고
    • Imaging mass spectrometry to discriminate breast from pancreatic cancer metastasis in formalin-fixed paraffin-embedded tissues
    • Casadonte R, Kriegsmann M, Zweynert F, et al. Imaging mass spectrometry to discriminate breast from pancreatic cancer metastasis in formalin-fixed paraffin-embedded tissues. Proteomics 2014;14:956-964.
    • (2014) Proteomics , vol.14 , pp. 956-964
    • Casadonte, R.1    Kriegsmann, M.2    Zweynert, F.3
  • 92
    • 84856228044 scopus 로고    scopus 로고
    • Imaging mass spectrometry-A new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas
    • Lazova R, Seeley EH, Keenan M, et al. Imaging mass spectrometry-a new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas. Am J Dermatopathol 2012;34:82-90.
    • (2012) Am J Dermatopathol , vol.34 , pp. 82-90
    • Lazova, R.1    Seeley, E.H.2    Keenan, M.3
  • 93
    • 79952480645 scopus 로고    scopus 로고
    • Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides
    • M'Koma AE, Seeley EH, Washington MK, et al. Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides. Inflamm Bowel Dis 2011;17:875-883.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 875-883
    • M'koma, A.E.1    Seeley, E.H.2    Washington, M.K.3
  • 94
    • 83255177150 scopus 로고    scopus 로고
    • Single-cell dissection of transcriptional heterogeneity in human colon tumors
    • Dalerba P, Kalisky T, Sahoo D, et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol 2011;29:1120-1127.
    • (2011) Nat Biotechnol , vol.29 , pp. 1120-1127
    • Dalerba, P.1    Kalisky, T.2    Sahoo, D.3
  • 95
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012;366:883-892.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 96
    • 33645396945 scopus 로고    scopus 로고
    • Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    • Maley CC, Galipeau PC, Finley JC, et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet 2006;38:468-473.
    • (2006) Nat Genet , vol.38 , pp. 468-473
    • Maley, C.C.1    Galipeau, P.C.2    Finley, J.C.3
  • 97
    • 77951938263 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer
    • Wu JM, Halushka MK, Argani P. Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer. Hum Pathol 2010;41:914-917.
    • (2010) Hum Pathol , vol.41 , pp. 914-917
    • Wu, J.M.1    Halushka, M.K.2    Argani, P.3
  • 98
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. Clonal evolution in cancer. Nature 2012;481: 306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 99
    • 84859113048 scopus 로고    scopus 로고
    • Genetic heterogeneity and cancer drug resistance
    • Turner NC, Reis-Filho JS. Genetic heterogeneity and cancer drug resistance. Lancet Oncol 2012;13:e178-e185.
    • (2012) Lancet Oncol , vol.13 , pp. e178-e185
    • Turner, N.C.1    Reis-Filho, J.S.2
  • 100
    • 77957758578 scopus 로고    scopus 로고
    • Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity
    • Willems SM, van Remoortere A, van Zeijl R, et al. Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity. J Pathol 2010;222:400-409.
    • (2010) J Pathol , vol.222 , pp. 400-409
    • Willems, S.M.1    Van Remoortere, A.2    Van Zeijl, R.3
  • 101
    • 80053325115 scopus 로고    scopus 로고
    • Multiple statistical analysis techniques corroborate intratumor heterogeneity in imaging mass spectrometry datasets of myxofibrosarcoma
    • Jones EA, van Remoortere A, van Zeijl RJ, et al. Multiple statistical analysis techniques corroborate intratumor heterogeneity in imaging mass spectrometry datasets of myxofibrosarcoma. PLoS One 2011;6:e24913.
    • (2011) PLoS One , vol.6 , pp. e24913
    • Jones, E.A.1    Van Remoortere, A.2    Van Zeijl, R.J.3
  • 102
    • 84916200561 scopus 로고    scopus 로고
    • De novo discovery of phenotypic intra-tumor heterogeneity using imaging mass spectrometry
    • Balluff B, Frese CK, Maier SK, et al. De novo discovery of phenotypic intra-tumor heterogeneity using imaging mass spectrometry. J Pathol 2014;235:3-13.
    • (2014) J Pathol , vol.235 , pp. 3-13
    • Balluff, B.1    Frese, C.K.2    Maier, S.K.3
  • 103
    • 79952729319 scopus 로고    scopus 로고
    • Matrix-assisted laser-desorption/ionization biotyper: Experience in the routine of a University hospital
    • Bessede E, Angla-Gre M, Delagarde Y, et al. Matrix-assisted laser-desorption/ionization biotyper: experience in the routine of a University hospital. Clin Microbiol Infect 2011;17:533-538.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 533-538
    • Bessede, E.1    Angla-Gre, M.2    Delagarde, Y.3
  • 104
    • 79953869376 scopus 로고    scopus 로고
    • Performance and cost analysis of matrix-assisted laser desorption ionization-time of flight mass spectrometry for routine identification of yeast
    • Dhiman N, Hall L, Wohlfiel SL, et al. Performance and cost analysis of matrix-assisted laser desorption ionization-time of flight mass spectrometry for routine identification of yeast. J Clin Microbiol 2011; 49:1614-1616.
    • (2011) J Clin Microbiol , vol.49 , pp. 1614-1616
    • Dhiman, N.1    Hall, L.2    Wohlfiel, S.L.3
  • 105
    • 84855218451 scopus 로고    scopus 로고
    • Investigative pathology: Leading the post-genomic revolution
    • Berman DM, Bosenberg MW, Orwant RL, et al. Investigative pathology: leading the post-genomic revolution. Lab Invest 2012; 92:4-8.
    • (2012) Lab Invest , vol.92 , pp. 4-8
    • Berman, D.M.1    Bosenberg, M.W.2    Orwant, R.L.3
  • 106
    • 85027931087 scopus 로고    scopus 로고
    • Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI
    • e-pub ahead of print
    • Buck A, Halbritter S, Spath C, et al. Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI. Anal Bioanal Chem 2015; e-pub ahead of print.
    • (2015) Anal Bioanal Chem
    • Buck, A.1    Halbritter, S.2    Spath, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.