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Volumn 14, Issue , 2015, Pages 183-191

The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol

Author keywords

Bioavailability; Curcumin; Curcuminoids; Micelles; Pharmacokinetics; Phytochemicals

Indexed keywords


EID: 84926320018     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.01.045     Document Type: Article
Times cited : (67)

References (39)
  • 1
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal B.B., Sung B. Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets. Trends in Pharmacological Sciences 2009, 30(2):85-94. 10.1016/j.tips.2008.11.002.
    • (2009) Trends in Pharmacological Sciences , vol.30 , Issue.2 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 3
    • 58149084882 scopus 로고    scopus 로고
    • A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (biocurcumax), a novel bioenhanced preparation of curcumin
    • Antony B., Merina B., Iyer V.S., Judy N., Lennertz K., Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (biocurcumax), a novel bioenhanced preparation of curcumin. Indian Journal of Pharmaceutical Sciences 2008, 70(4):445-449. 10.4103/0250-474x.44591.
    • (2008) Indian Journal of Pharmaceutical Sciences , vol.70 , Issue.4 , pp. 445-449
    • Antony, B.1    Merina, B.2    Iyer, V.S.3    Judy, N.4    Lennertz, K.5    Joyal, S.6
  • 6
    • 33750353446 scopus 로고    scopus 로고
    • Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
    • Brand W., Schutte M.E., Williamson G., van Zanden J.J., Cnubben N.H., Groten J.P., van Bladeren P.J., Rietjens I.M. Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients. Biomedicine and Pharmacotherapy 2006, 60(9):508-519. 10.1016/j.biopha.2006.07.081.
    • (2006) Biomedicine and Pharmacotherapy , vol.60 , Issue.9 , pp. 508-519
    • Brand, W.1    Schutte, M.E.2    Williamson, G.3    van Zanden, J.J.4    Cnubben, N.H.5    Groten, J.P.6    van Bladeren, P.J.7    Rietjens, I.M.8
  • 13
    • 45749159289 scopus 로고    scopus 로고
    • Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects
    • Frank J., Lee S., Leonard S.W., Atkinson J.K., Kamal-Eldin A., Traber M.G. Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. The American Journal of Clinical Nutrition 2008, 87(6):1723-1729.
    • (2008) The American Journal of Clinical Nutrition , vol.87 , Issue.6 , pp. 1723-1729
    • Frank, J.1    Lee, S.2    Leonard, S.W.3    Atkinson, J.K.4    Kamal-Eldin, A.5    Traber, M.G.6
  • 14
    • 38749109673 scopus 로고    scopus 로고
    • Curcumin as "Curecumin": From kitchen to clinic
    • Goel A., Kunnumakkara A.B., Aggarwal B.B. Curcumin as "Curecumin": From kitchen to clinic. Biochemical Pharmacology 2008, 75(4):787-809. 10.1016/j.bcp.2007.08.016.
    • (2008) Biochemical Pharmacology , vol.75 , Issue.4 , pp. 787-809
    • Goel, A.1    Kunnumakkara, A.B.2    Aggarwal, B.B.3
  • 15
    • 77249131774 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers
    • Gota V.S., Maru G.B., Soni T.G., Gandhi T.R., Kochar N., Agarwal M.G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. Journal of Agricultural and Food Chemistry 2010, 58(4):2095-2099. 10.1021/jf9024807.
    • (2010) Journal of Agricultural and Food Chemistry , vol.58 , Issue.4 , pp. 2095-2099
    • Gota, V.S.1    Maru, G.B.2    Soni, T.G.3    Gandhi, T.R.4    Kochar, N.5    Agarwal, M.G.6
  • 16
    • 84899026008 scopus 로고    scopus 로고
    • Alpha-Tocopherol transfer protein is not required for the discrimination against gamma-tocopherol in vivo but protects it from side-chain degradation in vitro
    • Grebenstein N., Schumacher M., Graeve L., Frank J. alpha-Tocopherol transfer protein is not required for the discrimination against gamma-tocopherol in vivo but protects it from side-chain degradation in vitro. Molecular Nutrition and Food Research 2014, 58(5):1052-1060. 10.1002/mnfr.201300756.
    • (2014) Molecular Nutrition and Food Research , vol.58 , Issue.5 , pp. 1052-1060
    • Grebenstein, N.1    Schumacher, M.2    Graeve, L.3    Frank, J.4
  • 18
    • 34548065533 scopus 로고    scopus 로고
    • Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases
    • Hoehle S.I., Pfeiffer E., Metzler M. Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases. Molecular Nutrition and Food Research 2007, 51(8):932-938. 10.1002/mnfr.200600283.
    • (2007) Molecular Nutrition and Food Research , vol.51 , Issue.8 , pp. 932-938
    • Hoehle, S.I.1    Pfeiffer, E.2    Metzler, M.3
  • 19
    • 33244473463 scopus 로고    scopus 로고
    • Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver
    • Hoehle S.I., Pfeiffer E., Solyom A.M., Metzler M. Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. Journal of Agricultural and Food Chemistry 2006, 54(3):756-764. 10.1021/jf058146a.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.3 , pp. 756-764
    • Hoehle, S.I.1    Pfeiffer, E.2    Solyom, A.M.3    Metzler, M.4
  • 22
    • 0034066998 scopus 로고    scopus 로고
    • Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats
    • Kamal-Eldin A., Frank J., Razdan A., Tengblad S., Basu S., Vessby B. Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 2000, 35(4):427-435.
    • (2000) Lipids , vol.35 , Issue.4 , pp. 427-435
    • Kamal-Eldin, A.1    Frank, J.2    Razdan, A.3    Tengblad, S.4    Basu, S.5    Vessby, B.6
  • 23
    • 84856725493 scopus 로고    scopus 로고
    • Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
    • Kanai M., Imaizumi A., Otsuka Y., Sasaki H., Hashiguchi M., Tsujiko K., Matsumoto S., Ishiguro H., Chiba T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemotherapy and Pharmacology 2012, 69(1):65-70. 10.1007/s00280-011-1673-1.
    • (2012) Cancer Chemotherapy and Pharmacology , vol.69 , Issue.1 , pp. 65-70
    • Kanai, M.1    Imaizumi, A.2    Otsuka, Y.3    Sasaki, H.4    Hashiguchi, M.5    Tsujiko, K.6    Matsumoto, S.7    Ishiguro, H.8    Chiba, T.9
  • 24
    • 84857690182 scopus 로고    scopus 로고
    • An enhanced bioavailable formulation of curcumin using fenugreek-derived soluble dietary fibre
    • Krishnakumar I.M., Ravi A., Kumar D., Kuttan R., Maliakel B. An enhanced bioavailable formulation of curcumin using fenugreek-derived soluble dietary fibre. Journal of Functional Foods 2012, 4(1):348-357.
    • (2012) Journal of Functional Foods , vol.4 , Issue.1 , pp. 348-357
    • Krishnakumar, I.M.1    Ravi, A.2    Kumar, D.3    Kuttan, R.4    Maliakel, B.5
  • 25
    • 84883309280 scopus 로고    scopus 로고
    • Novel curcumin oral delivery systems
    • Kurita T., Makino Y. Novel curcumin oral delivery systems. Anticancer Research 2013, 33(7):2807-2821.
    • (2013) Anticancer Research , vol.33 , Issue.7 , pp. 2807-2821
    • Kurita, T.1    Makino, Y.2
  • 27
    • 84871586770 scopus 로고    scopus 로고
    • Bioavailability of a lipidic formulation of curcumin in healthy human volunteers
    • Pawar Y.B., Munjal B., Arora S., Karwa M., Kohli G., Paliwal J.K., Bansal A.K. Bioavailability of a lipidic formulation of curcumin in healthy human volunteers. Pharmaceutics 2012, 4(4):517-530. 10.3390/pharmaceutics4040517.
    • (2012) Pharmaceutics , vol.4 , Issue.4 , pp. 517-530
    • Pawar, Y.B.1    Munjal, B.2    Arora, S.3    Karwa, M.4    Kohli, G.5    Paliwal, J.K.6    Bansal, A.K.7
  • 30
    • 26244462955 scopus 로고    scopus 로고
    • In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases
    • Ruefer C.E., Gerhauser C., Frank N., Becker H., Kulling S.E. In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases. Molecular Nutrition and Food Research 2005, 49(9):851-856. 10.1002/mnfr.200500057.
    • (2005) Molecular Nutrition and Food Research , vol.49 , Issue.9 , pp. 851-856
    • Ruefer, C.E.1    Gerhauser, C.2    Frank, N.3    Becker, H.4    Kulling, S.E.5
  • 32
    • 77953807390 scopus 로고    scopus 로고
    • A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection
    • Schiborr C., Eckert G.P., Rimbach G., Frank J. A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Analytical and Bioanalytical Chemistry 2010, 397(5):1917-1925. 10.1007/s00216-010-3719-3.
    • (2010) Analytical and Bioanalytical Chemistry , vol.397 , Issue.5 , pp. 1917-1925
    • Schiborr, C.1    Eckert, G.P.2    Rimbach, G.3    Frank, J.4
  • 33
    • 84897584012 scopus 로고    scopus 로고
    • The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes
    • Schiborr C., Kocher A., Behnam D., Jandasek J., Toelstede S., Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Molecular Nutrition and Food Research 2014, 58(3):516-527. 10.1002/mnfr.201300724.
    • (2014) Molecular Nutrition and Food Research , vol.58 , Issue.3 , pp. 516-527
    • Schiborr, C.1    Kocher, A.2    Behnam, D.3    Jandasek, J.4    Toelstede, S.5    Frank, J.6
  • 34
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998, 64(4):353-356. 10.1055/s-2006-957450.
    • (1998) Planta Medica , vol.64 , Issue.4 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.6
  • 38
    • 0036843701 scopus 로고    scopus 로고
    • Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
    • Williams J.A., Ring B.J., Cantrell V.E., Campanale K., Jones D.R., Hall S.D., Wrighton S.A. Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2002, 30(11):1266-1273.
    • (2002) Drug Metabolism and Disposition: The Biological Fate of Chemicals , vol.30 , Issue.11 , pp. 1266-1273
    • Williams, J.A.1    Ring, B.J.2    Cantrell, V.E.3    Campanale, K.4    Jones, D.R.5    Hall, S.D.6    Wrighton, S.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.