In vitro phase II metabolism of xanthohumol by human UDP- glucuronosyltransferases and sulfotransferases

Molecular Nutrition and Food Research

Volumn 49, Issue 9, 2005, Pages 851-856

  Ruefer, Corinna E ^a   Gerhäuser, Clarissa ^b   Frank, Norbert ^b   Becker, Hans ^c   Kulling, Sabine E ^d  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Phase II metabolism; Sulfotransferase (SULT); UDP glucuronosyltransferase (UGT); Xanthohumol

Indexed keywords

GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; PROPIOPHENONE DERIVATIVE; RECOMBINANT PROTEIN; SULFATE; SULFOTRANSFERASE; XANTHOHUMOL;

ARTICLE; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER; MASS SPECTROMETRY; METABOLISM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GASTROINTESTINAL TRACT; GLUCURONIC ACIDS; GLUCURONOSYLTRANSFERASE; HUMANS; LIVER; MASS SPECTROMETRY; PROPIOPHENONES; RECOMBINANT PROTEINS; SULFATES; SULFOTRANSFERASES;

HUMULUS LUPULUS;

EID: 26244462955     PISSN: 16134125     EISSN: None     Source Type: Journal    
DOI: 10.1002/mnfr.200500057     Document Type: Article

References (22)

1. Stevens, J. F., Ivanic, M., Hsu, V. L., Deinzer, M. L., Phytochemistry 1997, 44, 1575-1585.
2. Tagashira, M., Uchiyama, K., Yoshimura, T., Shirota, M., et al., Biosci. Biotechnol. Biochem. 1997, 61, 332-335.
3. Gerhäuser, C., Alt, A., Heiss, E., Gamal-Eldeen, A., et al., Mol. Cancer. Ther. 2002, 1, 959-969.
4. Miranda, C. L., Aponso, G. L., Stevens, J. F., Deinzer, M. L., et al., Cancer Lett. 2000, 149, 21-29.
5. Tabata, N., Ito, M., Comoda, H., Omura, S., Phytochemistry 1997, 46, 683-687.
6. Tobe, H., Muraki, Y., Kitamura, K., Komiyama, O., et al., Biosci. Biotechnol. Biochem. 1997, 61, 158-159.
7. Yilmazer, M., Stevens, J. F., Buhler, D. R., FEBS Lett. 2001, 491, 252-256.
8. Yilmazer, M., Stevens, J. F., Deinzer, M. L., Buhler, D. R., Drug Metab. Dispos. 2001, 29, 223-231.
9. Nookandeh, A., Frank, N., Steiner, F., Ellinger, R., et al., Phytochemistry 2004, 65, 561-570.
10. Avula, B., Ganzera, M., Warnick, J. E., Feltenstein, M. E., et al., J. Chromatogr. Sci. 2004, 42, 378-382.
11. Nikolic, D., Li, Y., Chadwick, L. R., Pauli, G. F., et al., J. Mass Spectrom. 2005, 40, 289-299.
12. Ireson, C. R., Jones, D. J., Orr, S., Coughtrie, M. W., et al., Cancer Epidemiol. Biomarkers Prev. 2002, 11, 105-111.
13. Dutton, G. J., Glucuronidation of Drugs and Other Compounds, CRC Press, Boca Raton, Florida 1980.
14. Tukey, R. H., Strassburg, C. P., Annu. Rev. Pharmacol. Toxicol. 2000, 40, 581-616.
15. Glatt, H., Meinl, W., Naunyn-Schmiedeberg's Arch. Pharmacol. 2004, 369, 55-68.
16. Glatt, H., Boeing, H., Engelke, C. E., Ma, L., et al., Mutat. Res. 2001, 482, 27-40.
17. Adlercreutz, H., Fotsis, T., Kurzer, M. S., Wähälä, K., et al., Anal. Biochem. 1995, 225, 101-108.
18. Shelnutt, S. R., Cimino, C. O., Wiggins, P. A., Ronis, M. J. J., et al., Am. J. Clin. Nutr. 2002, 76, 588-594.
19. Rimbach, G., De Pascual-Teresa, S., Ewins, B. A., Matsugo, S., et al., Xenobiotica 2003, 33, 913-925.
20. Turner, R., Baron, T., Wolffram, S., Minihane, A. M., et al., Free Radic. Res. 2004, 382, 209-216.
21. Janisch, K. M., Williamson, G., Needs, P., Plumb, G. W., Free Radic. Res. 2004, 38, 877-884.
22. Lu, H., Meng, X., Li, C., Sang, S., et al., Drug Metab. Dispos. 2003, 31, 452-441.