Tumor bed boost integration during whole breast radiotherapy: A review of the current evidence

Breast Care

Volumn 10, Issue 1, 2015, Pages 44-49

  Franco, Pierfrancesco ^a   Cante, Domenico ^b   Sciacero, Piera ^b   Girelli, Giuseppe ^b   La Porta, Maria Rosa ^b   Ricardi, Umberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b ASLTO4   (Italy)

Author keywords

Adjuvant whole breast radiotherapy; Breast cancer; Concomitant boost; Hypofractionation; IGRT; IMRT; Simultaneous integrated boost

Indexed keywords

COSMETIC;

CANCER RADIOTHERAPY; CLINICAL STUDY; HUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; REVIEW; TREATMENT OUTCOME; TUMOR BED BOOST INTEGRATION; WHOLE BREAST RADIOTHERAPY;

EID: 84926284167     PISSN: 16613791     EISSN: 16613805     Source Type: Journal    
DOI: 10.1159/000369845     Document Type: Review

References (51)

1. Poortmans P: Evidence based radiation oncology: breast cancer. Radiother Oncol 2007;84:84-101.
2. Graham P, Fourquet A: Placing the boost in the breast conservation radiotherapy: a review of the role, indications and techniques for breast boost radiotherapy. Clin Oncol (R Coll Radiol) 2006;18:210-219.
3. Freedman GM, White J, Arthur DW, et al.: Accelerated fractionation with a concurrent boost for early stage breast cancer. Radiother Oncol 2013;106:15-20.
4. Early Breast Cancer Trialists' Collaborative Group: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005;366:2087-2106.
5. Denham JW: The radiation dose-response relationship for control of primary breast cancer. Radiother Oncol 1986;7:107-123.
6. Holland R, Connolly JL, Gelman R, et al.: The presence of an extensive intraductal component (EIC) following a limited excision predicts for prominent residual disease in the remainder of the breast. J Clin Oncol 1990;8:113-118.
7. Freedman GM, Anderson PR, Hanlon AL, et al.: Pattern of local recurrence after conservative surgery and whole-breast irradiation. Int J Radiat Oncol Biol Phys 2005;61:1328-1336.
8. Polednack AP: Trends in, and predictors of, breast-conserving surgery and radiotherapy for breast cancer in Connecticut, 1988-1997. Int J Radiat Oncol Biol Phys 2002;53:157-63.
9. Lievens Y: Hypofractionated breast radiotherapy: financial and economic consequences. Breast 2010;19:192-7.
10. Bartelink H, Horiot J-C, Poortmans P, et al.; European Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups: Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001;345:1378-1387.
11. Bartelink H, Horiot J-C, Poortmans P, et al.: Impact of higher radiation dose on local control, survival in breast-conserving therapy of early breast cancer: 10 years results of the randomized boost versus no boost EORTC trial 22881-10882. J Clin Oncol 2007;25:3259-3265.
12. Romestaing P, Lehingue Y, Carrie C, et al.: Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol 1997;15:963-968.
13. Polgar C, Fodor J, Orosz Z, et al.: Electron and high-dose rate brachytherapy boost in the conservative treatment of stage I-II breast cancer. First results of the randomized Budapest Boost Trial. Strahelenther Onkol 2002;178:615-623.
14. Hau E, Browne LH, Khanna S, et al.: Radiotherapy breast boost with reduced whole-breast dose is associated with improved cosmesis: the results of a comprehensive assessment for the St. George and Wollongong randomized breast boost trial. Int J Radiat Oncol Biol Phys 2012;82:682-689.
15. Graham P, Browne LH, Capp A, et al.: The St George Wollongong and Liverpool Breast boost trial: 1st planned analysis at 6 year median follow-up. Australasian Radiology 2007;51(suppl 3):A85.
16. Coles CE, Brunt AM, Wheatley D, et al.: Breast radiotherapy: Less is more?. Clin Oncol 2013;25:127-134.
17. Holloway CL, Panet-Raymond V, Olivotto I: Hypofrac-tionation should be the new 'standard' for radiation therapy after breast conserving surgery. Breast 2010:19: 163-167.
18. Harnett A: Fewer fractions of adjuvant external beam radiotherapy for early breast cancer are safe and effective and can now be the standard of care. Why the UK's NICE accepts fewer fractions as the standard of care for adjuvant radiotherapy in early breast cancer. Breast 2010;19:159-162.
19. Smith BD, Bentzen SM, Correa CR, et al.: Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guidelines. Int J Radiat Oncol Biol Phys 2011;81:59-68.
20. Yarnold J, Ashton A, Bliss J, et al.: Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomized trial. Radiother Oncol 2005;75:9-17.
21. Bentzen SM, Agrawal RK, Aird EG, et al.; The START Trialists' Group: The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofrac-tionation for treatment of early breast cancer: a randomized trial. Lancet Oncol 2008;9:331-341.
22. Haviland JS, Owen JR, Dewar JA, et al.: The UK Standardisation of Breast Radiotherapy (START) Trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomized trials. Lancet Oncol 2013;14:1086-1094.
23. Whelan TJ, Pignol JP, Levine MN, et al.: Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010;362:513-520.
24. Singla R, King S, Abuquerque K, et al.: Simultaneous-integrated boost intensity-modulated radiation therapy (SIB-IMRT) in the treatment of early-stage left-sided breast carcinoma. Med Dosim 2006;31:190-196.
25. Hurkmans CW, Meijer GJ, van-Vliet-Vroegindeweij, et al.: High-dose simultaneously integrated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiat Oncol Biol Phys 2006;66:923-930.
26. Van der Laan HP, Dolsma WV, Maduro JH, et al.: Three dimensional conformal simultaneously integrated boost technique for breast-conserving radiotherapy. Int J Radiat Oncol Biol Phys 2007;68:1018-1023.
27. Hijal T, Fourniez-Bodoz N, Castro-Pena P, et al.: Simultaneous integrated boost in breast conserving treatment of the breast: a dosimetric comparison of helical and three-dimensional conformal radiotherapy. Radio-ther Oncol 2010;94:300-306.
28. Franco P, Zeverino M, Migliaccio F, et al.: Intensity-modulated adjuvant whole breast radiation delivered with static angle tomotherapy (TomoDirect): a prospective case series. J Cancer Res Clin Oncol 2013;139:1927-1936.
29. Franco P, Zeverino M, Migliaccio F, et al.: Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of tomotherapy (TomoDirect): a prospective phase II trial. J Cancer Res Clin Oncol 2014;140:167-177.
30. Dellas K, Vonthein R, Zimmer J, et al.: Hypofractiona-tion with simultaneous integrated boost for early breast cancer: results of the German multicentre phase II trial (ARO-2010-01). Strahlenther Onkol 2014;190:646-653.
31. Freedman GM, Anderson PR, Bleicher RJ, et al.: Five-year local control in a phase II study of hypofraction-ated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer. Int J Ra-diat Oncol Biol Phys 2012;84:888-893.
32. Chadha M, Woode R, Sillanpaa J, et al.: Early-stage breast cancer treated with 3-week accelerated whole-breast radiation therapy and concomitant boost. Int J Radiat Oncol Biol Phys 2013;86:40-44.
33. Formenti SC, Gidea-Addeo D, Goldberg JD, et al.: Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. J Clin Oncol 2007;25:2236-2242.
34. McDonald MW, Godette KD, Whitaker DJ, et al.: Three-year outcomes of breast intensity-modulated radiation therapy with simultaneous integrated boost. Int J Radiat Oncol Biol Phys 2010;77:523-530.
35. Bantema-Joppe EJ, van der Laan HP, deBock GH, et al.: Three-dimensional conformal hypofractionated simultaneous integrated boost in breast conserving therapy: results on local control and survival. Radiother Oncol 2011;100;215-220.
36. Bantema-Joppe EJ, Vredeveld EJ, deBock GH, et al.: Five year outcome of hypofractionated simultaneous integrated boost irradiation in breast conserving therapy: patterns of recurrence. Radiother Oncol 2013;108: 269-272.
37. Bantema-Joppe EJ, Schilstra C, de Bock GH, et al.: Simultaneous integrated boost irradiation after breast-conserving surgery: physician-rated toxicity and cosmetic outcome at 30 months' follow up. Int J Radiat Oncol Biol Phys 2012;83:e471-477.
38. Cante D, Rosa La Porta M, Casanova-Borca V, et al.: Accelerated hypofractionated adjuvant whole breast radiotherapy with concomitant photon boost after conserving surgery for early breast cancer: a prospective evaluation on 463 patients. Breast J 2011;17:586-593.
39. Cante D, Franco P, Sciacero P, et al.: Five-year results of a prospective case series of accelerated hypofraction-ated whole breast radiation with concomitant boost to the tumor bed after conserving surgery for early breast cancer. Med Oncol 2013;30:518.
40. RTOG 1005: A Phase III trial of accelerated whole breast irradiation with hypofractionation plus concurrent boost versus standard whole breast irradiation plus sequential boost for early-stage breast cancer. www. rtog.org, accessed March 3rd, 2014.
41. Coles C, Yarnold J; IMPORT Trials Management Group: The IMPORT trials are launched (September 2006). Clin Oncol 2006;18:587-590.
42. Import High trial. www.icr.ac.uk, accessed March 3rd, 2014.
43. Askoxylakis V, Jensen AD, Hafner MF, et al.: Simultaneous integrated boost for adjuvant treatment of breast cancer-intensity modulated vs. conventional radiotherapy: the IMRT-MC2 trial. BMC Cancer 2011;11:249.
44. Van Parijs H, Miedema G, Vinh-Hung V, et al.: Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized trial. Radiat Oncol 2012;7:80.
45. Souchon R, Sautter-Bihl ML, Sedlmayer F, et al.; on behalf of the Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO): Radiation oncologists' view on the Zurich consensus. Breast Care (Basel) 2013;8:448-452.
46. Sedlmayer F, Sautter-Bihl ML, Budach W, et al.; Breast Cancer Panel of the German Society of Radiation Oncology (DEGRO): Is the simultaneously integrated boost (SIB) technique for early breast cancer ready to be adopted for routine adjuvant radiotherapy? Statement of the German and the Austrian Societies of Radiooncology (DEGRO/ÖGRO). Strahlenther Onkol 2013;189:193-196.
47. Untch M, Gerber B, Harbeck N, et al.: 13th St. Gallen International Breast Conference 2013: primary therapy for early breast cancer evidence, controversies, consensus-opinion of a German team of experts (Zurich 2013). Breast Care 2013;8:221-229.
48. Owen JR, Ashton A, Bliss JM, et al.: Effect of radiotherapy fraction size on tumor control in patients with early-stage breast cancer after local tumor excision: long-term results of a randomized trial. Lancet Oncol 2006;7:467-471.
49. Corvo R, Ricchetti F, Doino D, et al.: Adjuvant hypof-ractionated radiotherapy with weekly concomitant boost for women with early breast cancer: the clinical experience at Genoa university. Anticancer Res 2010; 30:4749-4753.
50. Morganti AG, Cilla S, Valentini V, et al.: Phase I-II studies on accelerated IMRT in breast carcinoma: technical comparison and acute toxicity in 332 patients. Radiother Oncol 2009;90:86-92.
51. Formenti SC, Gidea-Addeo D, Goldberg JD, et al.: Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. J Clin Oncol 2007;25:2236-42.