Radiotherapy breast boost with reduced whole-breast dose is associated with improved cosmesis: The results of a comprehensive assessment from the St. George and Wollongong randomized breast boost trial

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 2, 2012, Pages 682-689

  Hau, Eric ^a   Browne, Lois H ^a   Khanna, Sam ^a   Cail, Stacy ^a   Cert, Grad ^a   Chin, Yaw ^a   Clark, Catherine ^a   Inder, Stephanie ^a   Szwajcer, Alison ^a   Graham, Peter H ^a  

^a ST GEORGE HOSPITAL   (Australia)

Author keywords

Boost; Breast cancer; Cosmeis; Radiotherapy

Indexed keywords

BOOST; BREAST CANCER; BREAST CONSERVING SURGERY; BREAST RETRACTION ASSESSMENTS; COMPREHENSIVE ASSESSMENT; COSMEIS; COSMESIS; PATIENT SELF-ASSESSMENT;

PATIENT MONITORING; RADIOTHERAPY; RATING;

MEDICAL COMPUTING;

ARTICLE; BREAST BOOST; BREAST CARCINOMA; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ASSESSMENT; COMPUTER PROGRAM; CONTROLLED STUDY; ELECTRON; ESTHETICS; HUMAN; MAJOR CLINICAL STUDY; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RADIATION DOSE; RELATIVE BREAST RETRACTION ASSESSMENT; SELF EVALUATION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ALGORITHMS; BREAST; BREAST NEOPLASMS; CONTRACTURE; DIAGNOSTIC SELF EVALUATION; DOSE FRACTIONATION; ESTHETICS; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEW SOUTH WALES; OBSERVER VARIATION; PHOTOGRAPHY; RADIOTHERAPY DOSAGE; RETREATMENT; SOFTWARE;

EID: 84855847265     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.11.025     Document Type: Article

References (36)

1. M. Clarke, R. Collins, and S. Darby Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials Lancet 366 2005 2087 2106
2. P. Romestaing, Y. Lehingue, and C. Carrie Role of a 10Gy boost in the conservative treatment of early breast cancer: Results of a randomized clinical trial in Lyon. France J Clin Oncol 15 1997 963 968
3. H. Bartelink, J.-C. Horiot, and P. Poortmans Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial J Clin Oncol 25 2007 3259 3265
4. C. Polgar, J. Fodor, and Z. Orosz Electron and brachytherapy boost in the conservative treatment of Stage I-II breast cancer: 5 year results of the randomized Budapest boost trial Radiother Oncol 64 Suppl. 1 2002 S15
5. C. Vrieling, L. Collette, and A. Fourquet The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC "boost versus no boost" trial Int J Radiat Oncol Biol Phys 45 1999 677 685
6. P.M. Poortmans, L. Collette, and H. Bartelink The addition of a boost dose to the primary tumor bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 "boost versus no boost" trial Cancer Radiotherapie 12 2008 565 570
7. A. Munshi, S. Kakkar, and R. Bhutani Factors influencing cosmetic outcome in breast conservation Clin Oncol 21 2009 285 293
8. E. Van Limbergen, E. van der Schueren, and K. Van Tongelen Cosmetic evaluation of breast conserving treatment for mammary cancer. 1. Proposal of a quantative scoring system Radiother Oncol 16 1989 159 167
9. L.I. Tsoukas, and I.S. Fentiman Breast compliance: A new method for evaluation of cosmetic outcome after conservative treatment of early breast cancer Breast Cancer Res Treat 15 1990 185 190
10. M. Noguchi, Y. Saito, and Y. Mizukami Breast deformity, its correction, and assessment of breast conserving surgery Breast Cancer Res Treat 18 1991 111 118
11. S.K. Al-Ghazal, R.W. Blamey, and J. Steward The cosmetic outcome in early breast cancer treated with breast conservation Eur J Surg Oncol 25 1999 566 570
12. S.K. Al-Ghazal, L. Fallowfield, and R.W. Blamey Patient evaluation of cosmetic outcome after conserving surgery for treatment of primary breast cancer Eur J Surg Oncol 25 1999 344 346
13. P. Graham, A. Capp, and C. Fox Why a breast boost should remain a controversial aspect of routine breast conservation management in Australia and New Zealand in 2002 Australasian Radiol 47 2003 44 49
14. G. Delaney, D. Blakey, and R. Drummond Breast radiotherapy: An Australasian survey of current treatment techniques Australas Radiol 45 2001 170 178
15. A. de la Rochefordiere, A.L. Abner, and B. Silver Are cosmetic results following conservative surgery and radiation therapy for early breast cancer dependent on technique? Int J Radiat Oncol Phys 23 1992 925 931
16. D. Christie, C. Sharpley, and T. Curtis Improving the accuracy of a photographic assessment system for breast cosmesis Clin Oncol 17 2005 27 31
17. C. Vrieling, L. Collette, and E. Bartelink Validation of the methods of cosmetic assessment after breast-conserving therapy in the EORTC "boost versus no boost" trial. EORTC Radiotherapy and Breast Cancer Cooperative Groups. European Organization for Research and Treatment of Cancer Trial Int J Radiat Oncol Biol Phys 45 1999 667 676
18. M.J. Cardoso, A.C. Santos, and J. Cardoso Choosing observers for evaluation of aesthetic results in breast cancer conservative treatment Int J Radiat Oncol Biol Phys 61 2005 879 881
19. J.R. Harris, M.B. Levene, and G. Svensson Analysis of cosmetic results following primary radiation therapy for Stages I and II carcinoma of the breast Int J Radiat Oncol Biol Phys 5 1979 257 261
20. J.S. Haviland, A. Ashton, and B. Broad Evaluation of a method for grading late photographic change in breast appearance after radiotherapy for early breast cancer Clin Oncol 20 2008 497 501
21. R.D. Pezner, M.P. Patterson, and L.R. Hill Breast retraction assessment: an objective evaluation of cosmetic results of patients treated conservatively for breast cancer Int J Radiat Oncol Biol Phys 11 1985 575 578
22. J.S. Cardoso, and M.J. Cardoso Towards and intelligent medical system for the aesthetic evaluation of breast cancer conservative treatment Artif Intelli Med 40 2007 115 126
23. M.J. Cardoso, J. Cardoso, and N. Amaral Turning subjective into objective: The BCCT.core software for evaluation of cosmetic results in breast cancer conservative treatment Breast 16 2007 456 461
24. M. Bland An introduction to medical statistics 2000 Oxford University Press New York p. 149-150
25. L. Livi, S. Borghesi, and C. Saieva Benefit of radiation boost after whole-breast radiotherapy Int J Radiat Oncol Biol Phys 75 2009 1029 1034
26. P. Graham, L. Browne, and A. Capp The St. George, Wollongong and Liverpool Breast Boost Trial: 1st planned analysis at 6 year mean follow-up Australas Radiol 51 Suppl 3 2007 A85
27. E.K. Millar, P.H. Graham, and S.A. O'Toole Prediction of local recurrence, distant metastases, and death following breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel J Clin Oncol 27 2009 4701 4708
28. R.D. Pezner, J.A. Lipsett, and N.L. Vora Limited usefulness of observer based cosmesis scales employed to evaluate patients treated conservatively for breast cancer Int J Radiat Biol Phys 11 1985 1117 1119
29. M.J. Cardoso, J. Cardoso, and A.C. Santos Interobserver agreement and consensus over the esthetic evaluation of conservative treatment for breast cancer Breast 15 2006 52 57
30. F. Fitzal, W. Krois, and H. Trischler The use of a breast symmetry index for objective evaluation of breast cosmesis Breast 16 2007 429 435
31. U. Hoeller, A. Kuhlmey, and A. Bajrovic Cosmesis from the patient's and doctor's view Int J Radiat Oncol Biol Phys 57 2003 345 354
32. J.H. Borger, and A.H. Keijser Conservative breast cancer treatment: Analysis of cosmetic results and the role of concomitant chemotherapy Int J Radiat Oncol Biol Phys 13 1987 1173 1177
33. K.C.A. Sneeuw, N.K. Aaronson, and J.R. Yarnold Cosmetic and functional outcomes of breast conserving treatment for early stage breast cancer.1. Comparison of patients' ratings, observers' ratings and objective assessments Radiother Oncol 25 1992 153 159
34. M.P. Patterson, R.D. Pezner, and L.R. Hill Patient self-evaluation of cosmetic outcome of breast-preserving cancer treatment Int J Radiat Oncol Biol Phys 11 1985 1849 1852
35. S. Vass, and I.A. Bairati Cosmetic evaluation of breast cancer treatment: A randomized study of radiotherapy boost technique Int J Radiat Oncol Biol Phys 62 2005 1274 1282
36. H. Kaija, S. Rauni, and I. Jorma Consistency of patient- and doctor-assessed cosmetic outcome after conservative treatment of breast cancer Breast Cancer Res Treat 45 1997 225 228