Long-term results of hypofractionated radiation therapy for breast cancer

New England Journal of Medicine

Volumn 362, Issue 6, 2010, Pages 513-520

  Whelan, Timothy J ^a   Pignol, Jean Philippe ^b   Levine, Mark N ^a   Julian, Jim A ^a   MacKenzie, Robert ^b   Parpia, Sameer ^a   Shelley, Wendy ^d   Grimard, Laval ^e   Bowen, Julie ^f   Lukka, Himu ^a   Perera, Francisco ^g   Fyles, Anthony ^c   Schneider, Ken ^h   Gulavita, Sunil ⁱ   Freeman, Carolyn ^j  

^a MCMASTER UNIVERSITY   (Canada)

^b DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d Cancer Centre of Southeastern Ontario   (Canada)

^e OTTAWA REGIONAL CANCER CENTRE   (Canada)

^f Northeastern Regional Cancer Centre   (Canada)

^g LONDON REGIONAL CANCER PROGRAM   (Canada)

^h Centre Regional De Cancerologie De Windsor   (Canada)

ⁱ Northwestern Ontario Regional Cancer Centre   (Canada)

^j MONTREAL GENERAL HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE; TAMOXIFEN;

ADJUVANT THERAPY; ADULT; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; BREAST SURGERY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CLINICAL TRIAL; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYPOFRACTIONATED RADIATION THERAPY; LONG TERM CARE; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; SKIN ULCER; TISSUE NECROSIS; TREATMENT DURATION;

EID: 76649099557     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa0906260     Document Type: Article

References (24)

1. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41.
2. Veronesi U, Luini A, Del Vecchio M, et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 1993;328:1587-91.
3. Clark RM, Whelan T, Levine M, et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. J Natl Cancer Inst 1996;88:1659-64.
4. Forrest AP, Stewart HJ, Everington D, et al. Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Lancet 1996; 348:708-13.
5. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;366:2087-106.
6. Virnig B, Habermann E, Al-Raie W, et al. Increased use of breast-conserving surgery: preferred treatment or failure to provide adequate local therapy? Breast Cancer Res Treat 2007;106:Suppl 1:S188. abstract.
7. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989;62:679-94.
8. Ash DV, Benson EA, Sainsbury JR, Round C, Head C. Seven-year follow-up on 334 patients treated by breast conserving surgery and short course radical postoperative radiotherapy: a report of the Yorkshire Breast Cancer Group. Clin Oncol (R Coll Radiol) 1995;7:93-6.
9. Olivotto IA, Weir LM, Kim-Sing C, et al. Late cosmetic results of short fractionation for breast conservation. Radiother Oncol 1996;41:7-13.
10. Shelley W, Brundage M, Hayter C, Paszat L, Zhou S, Mackillop W. A shorter fractionation schedule for postlumpectomy breast cancer patients. Int J Radiat Oncol Biol Phys 2000;47:1219-28.
11. Whelan T, MacKenzie R, Julian J, et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 2002;94:1143-50.
12. Curran D, van Dongen JP, Aaronson NK, et al. Quality of life of early-stage breast cancer patients treated with radical mastectomy or breast-conserving procedures: results of EORTC trial 10801. Eur J Cancer 1998;34:307-14.
13. Powell S, Cooke J, Parsons C. Radiation-induced brachial plexus injury: follow-up of two different fractionation schedules. Radiother Oncol 1990;18:213-20.
14. Harris J. Notes on the Ontario Trial in the context of breast-conserving therapy for early-stage breast cancer. J Clin Oncol 2000;18:Suppl:43S-44S.
15. Sartor CI, Tepper JE. Is less more? Lessons in radiation schedules in breast cancer. J Natl Cancer Inst 2002;94:1114-5.
16. Winchester DP, Cox JD. Standards for breast-conservation treatment. CA Cancer J Clin 1992;42:134-62.
17. Aaronson NK, Bartelink H, van Dongen JA, van Dam FS. Evaluation of breast conserving therapy: clinical, methodological and psychosocial perspectives. Eur J Surg Oncol 1988;14:133-40.
18. Dewar JA, Benhamou S, Benhamou E, et al. Cosmetic results following lumpectomy, axillary dissection and radiotherapy for small breast cancers. Radiother Oncol 1988;12:273-80.
19. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
20. Taylor CW, McGale P, Darby SC. Cardiac risks of breast-cancer radiotherapy: a contemporary view. Clin Oncol (R Coll Radiol) 2006;18:236-46.
21. START Trialists' Group, Bentzen SM, Agrawal RK, et al. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol 2008;9:331-41.
22. START Trialists' Group, Bentzen SM, Agrawal RK, et al. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 2008;371:1098-107.
23. Bartelink H, Horiot JC, Poortmans P, et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10822 trial. J Clin Oncol 2007;25:3259-65.
24. Romestaing P, Lehingue Y, Carrie C, et al. Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized trial in Lyon, France. J Clin Oncol 1997;15:963-8.