Phase I-II studies on accelerated IMRT in breast carcinoma: Technical comparison and acute toxicity in 332 patients

Radiotherapy and Oncology

Volumn 90, Issue 1, 2009, Pages 86-92

  Morganti, Alessio G ^a   Cilla, Savino ^a   Valentini, Vincenzo ^b   Digesu', Cinzia ^a   Macchia, Gabriella ^a   Deodato, Francesco ^a   Ferrandina, Gabriella ^a   Cece, M Grazia ^a   Cirocco, Massimo ^a   Garganese, Giorgia ^a   Lullo, Liberato Di ^c   Traficante, Divina ^c   Scarabeo, Francesca ^c   Panunzi, Simona ^d   Gaetano, Andrea De ^d   Sallustio, Giuseppina ^a   Cellini, Numa ^b   Sofo, Luigi ^a   Piermattei, Angelo ^a   Scambia, Giovanni ^a  

^a John Paul II Center for High Technology Research and Education in Biomedical Sciences   (Italy)

^b UOC Neuropsichiatria Infantile   (Italy)

^c General Hospital   (Italy)

^d CNR   (Italy)

Author keywords

Acute toxicity; Breast cancer; Dosimetry; IMRT

Indexed keywords

ANTHRACYCLINE; DOCETAXEL; TAXANE DERIVATIVE;

ADULT; ARTICLE; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSIMETRY; FEMALE; FOLLOW UP; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RADIATION DOSE; TOXICITY; TREATMENT DURATION;

AGED; ANALYSIS OF VARIANCE; BREAST NEOPLASMS; CHI-SQUARE DISTRIBUTION; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; TREATMENT OUTCOME;

EID: 58149477702     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2008.10.017     Document Type: Article

References (45)

1. Evans P.M., Donovan E.M., Partridge M., et al. The delivery of intensity modulated radiotherapy to the breast using multiple static fields. Radiother Oncol 57 (2000) 79-89
2. Baillet F., Housset M., Maylin C., et al. The use of a specific hypofractionated radiation therapy regimen versus classical fractionation in the treatment of breast cancer: a randomized study of 230 patients. Int J Radiat Oncol Biol Phys 19 (1990) 1131-1133
3. Vicini F.A., Chen P., Wallace M., Mitchell C., Hasan Y., Grills I., et al. Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 69 (2007) 1124-1130
4. Whelan T., MacKenzie R., Julian J., Levine M., Shelley W., Grimard L., et al. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 94 (2002) 1143-1150
5. START Trialist' Group. The UK standardisation of breast radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomized trial. Lancet Oncol 9 (2008) 331-341
6. START Trialists' Group. The UK standardization of breast radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomized trial. Lancet 371 (2008) 1098-1107
7. Bhatnagar A.K., Brandner E., Sonnik D., et al. Intensity-modulated radiation therapy (IMRT) reduces the dose to the controlateral breast when compared to conventional tangential fields for primary breast irradiation: initial report. Cancer J 10 (2004) 381-385
8. Guerrero M., Li X.A., Earl M.A., et al. Simultaneous integrated boost for breast cancer using IMRT: a radiobiological and treatment planning study. Int J Radiat Oncol Biol Phys 59 (2004) 1513-1522
9. Hong L., Hunt M., Chui C., et al. Intensity-modulated tangential beam irradiation of the intact breast. Int J Radiat Oncol Biol Phys 44 (1999) 1155-1164
10. Kestin L.L., Sharpe M.B., Frazier R.C., et al. Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience. Int J Radiat Oncol Biol Phys 48 (2000) 1559-1568
11. Landau D., Adams E.J., Webb S., and Ross G. Cardiac avoidance in breast radiotherapy: a comparison of simple shielding techniques with intensity-modulated radiotherapy. Radiother Oncol 60 (2001) 247-255
12. Marcenaro M., Sacco S., Pentimalli S., et al. Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. Tumori 90 (2004) 586-591
13. Mayo C., Lo Y.C., Fitzgerald T.J., and Urie M. Forward-planned, multiple-segment, tangential fields with concomitant boost in the treatment of breast cancer. Med Dosim 29 (2004) 265-270
14. Mihai A., Rakovitch E., Sixel K., et al. Inverse vs. Forward breast IMRT planning. Med Dosim 30 (2005) 149-154
15. Plataniotis G.A., Theofanopoulou M.E., Sotiriadou K., et al. High resolution computed tomography findings on the lung of early breast-cancer patients treated by postoperative breast irradiation with a hypofractionated radiotherapy schedule. Indian J Cancer 42 (2005) 191-196
16. Probst H., and Griffiths S. Moving to a high-tech approach to the irradiation of early breast cancer: is it possible to balance efficacy, morbidity and resource use?. Clin Oncol (R Coll Radiol) 18 (2006) 268-275
17. Singla R., King S., Albuquerque K., et al. Simultaneous-integrated boost intensity-modulated radiation therapy (SIB-IMRT) in the treatment of early-stage left-sided breast carcinoma. Med Dosim 31 (2006) 190-196
18. Suh W.W., Pierce L.J., Vicini F.A., and Hayman J.A. A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer. Int J Radiat Oncol Biol Phys 62 (2005) 790-796
19. Thilmann C., Zabel A., Milker-Zabel S., et al. Number and orientation of beams in inversely planned intensity-modulated radiotherapy of the female breast and the parasternal lymph nodes. Am J Clin Oncol 26 (2003) e136-e143
20. Thilmann C., Zabel A., Nill S., et al. Intensity-modulated radiotherapy of the female breast. Med Dosim 27 (2002) 79-90
21. van Asselen B., Schwarz M., van Vliet-Vroegindeweij C., et al. Intensity-modulated radiotherapy of breast cancer using direct aperture optimization. Radiother Oncol 79 (2006) 162-169
22. van Asselen B., Raaijmakers C.P., Hofman P., and Lagendijk J.J. An improved breast irradiation technique using three-dimensional geometrical information and intensity modulation. Radiother Oncol 58 (2001) 341-347
23. Vicini F.A., Sharpe M., Kestin L., et al. Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 54 (2002) 1336-1344
24. Woo T.C., Pignol J.P., Rakovitch E., et al. Body radiation exposure in breast cancer radiotherapy: impact of breast IMRT and virtual wedge compensation techniques. Int J Radiat Oncol Biol Phys 65 (2006) 52-58
25. Hurkmans C.W., Cho B.C., Damen E., et al. Reduction of cardiac and lung complication probabilities after breast irradiation using conformal radiotherapy with or without intensity modulation. Radiother Oncol 62 (2002) 163-171
26. Li J.S., Freedman G.M., Price R., et al. Clinical implementation of intensity-modulated tangential beam irradiation for breast cancer. Med Phys 31 (2004) 1023-1031
27. Hurkmans C.W., Meijer G.J., van Vliet-Vroegindeweij C., et al. High-dose simultaneously integrated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiat Oncol Biol Phys 66 (2006) 923-930
28. Ortholan C., Hannoun-Levi J.M., Ferrero J.M., et al. Long-term results of adjuvant hypofractionated radiotherapy for breast cancer in elderly patients. Int J Radiat Oncol Biol Phys 61 (2005) 154-1262
29. Pignol J.P., Olivotto I., Rakovitch E., Gardner S., Sixel K., Beckham W., et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 26 (2008) 2085-2092
30. Donovan E., Bleakley N., Denholm E., et al. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 82 (2007) 254-264
31. Owen J.R., Ashton A., Bliss J.M., et al. Effect of radiotherapy fraction size on tumor control in patients with early-stage breast cancer after local tumor excision: long-term results of a randomized trial. Lancet Oncol 7 (2006) 467-471
32. Antonini N., Jones H., Horiot J.C., et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882. Radiother Oncol 82 (2007) 265-271
33. Livi L., Paiar F., Saieva C., Scoccianti S., Dicosmo D., Borghesi S., et al. Survival and breast relapse in 3834 patients with T1-T2 breast cancer after conserving surgery and adjuvant treatment. Radiother Oncol 82 (2007) 287-293
34. Armitage P., and Berry G. Statistical methods in medical research (1994), Blackwell, Oxford p. 585
35. Bortfeld T., Schlegel W., and Rhein B. Decomposition of pencil beam kernels for fast dose calculations in three-dimensional treatment planning. Med Phys 20 2 Pt. 1 (1993) 311-318
36. Oken M.M., Creech R.H., Thormey D.C., et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5 (1982) 649-655
37. UICC. TNM classification of malignant tumors. 6th ed. (1997), Springer-Verlag, Berlin
38. Cox D.R. Regression model and life tables. J R Stat Soc Ser B34 (1972) 187-220
39. Perez C.A., and Brady L.W. Overview. In: Perez C.A., and Brady L.W. (Eds). Principles and practices of radiation oncology. 2nd ed. (1992), Lippincott Company, Philadelphia, PA 1-63
40. Chui C.S., Hong L., and McCormick B. Intensity-modulated radiotherapy technique for three-field breast treatment. Int J Radiat Oncol Biol Phys 62 (2005) 1217-1223
41. Chui C.S., Hong L., Hunt M., and McCormick B. A simplified intensity modulated radiation therapy technique for the breast. Med Phys 29 (2002) 522-529
42. Cho B.C., Schwarz M., Mijnheer B.J., and Bartelink H. Simplified intensity-modulated radiotherapy using pre-defined segments to reduce cardiac complications in left-sided breast cancer. Radiother Oncol 70 (2004) 231-241
43. Harsolia A., Kestin L., Grills I., Wallace M., Jolly S., Jones C., et al. Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy. Int J Radiat Oncol Biol Phys 68 (2007) 1375-1380
44. Horton J.K., Halle J.S., Chang S.X., and Sartor C.I. Comparison of three concomitant boost techniques for early-stage breast cancer. Int J Radiat Oncol Biol Phys 64 (2006) 168-175
45. Buijsen J., Jager J.J., Boverdeerd J., et al. Prone breast irradiation for pendulous breasts. Radiother Oncol 82 (2007) 337-340