Role of a 10-Gy boost in the conservative treatment of early breast cancer: Results of a randomized clinical trial in Lyon, France

Journal of Clinical Oncology

Volumn 15, Issue 3, 1997, Pages 963-968

  Romestaing, P ^a   Lehingue, Y ^a   Carrie, C ^a   Coquard, R ^a   Montbarbon, X ^a   Ardiet, J M ^a   Mamelle, N ^a   Gerard J P ^a  

^a CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER RECURRENCE; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EARLY CANCER; FEMALE; FRANCE; HUMAN; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MASTECTOMY; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; TELANGIECTASIA;

EID: 0031059354     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.3.963     Document Type: Article

References (48)

1. Fisher B, Bauer M, Margolese R, et al: Five year results of a randomized clinical trial comparing total mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 312:665-673, 1985
2. Sarrazin D, Le MG, Arriagada R, et al: Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol 14:177-184, 1989
3. Veronesi U, Saccozzi R, Del Vecchio M, et al: Comparing radical mastectomy with quadrantectomy, axillary dissection and radiotherapy in patients with small cancers of the breast. N Engl J Med 305:6-11, 1981
4. Kurtz JM, Amalric R, Delouche G, et al: The second ten years: Long time risks of breast conservation in early breast cancer. Int J Radiat Oncol Biol Phys 13:1327-1332, 1987
5. Calle R, Pilleron JP, Schlienger P, et al: Conservative management of operable breast cancer. Ten years experience at the Fondation Curie. Cancer 42:2045-2053, 1978
6. Harris JR, Recht A, Almaric R, et al: Time course and prognosis of local recurrence following primary radiation therapy for early breast cancer. J Clin Oncol 2:37-45, 1984
7. Fletcher G: Textbook of Radiotherapy. Philadelphia, PA, Lea & Febiger, 1980, p 563
8. Clark CM, Sarrazin C, Fontaine F, et al: Analysis of local regional relapses in patients with early breast cancers treated by excision and radiotherapy: Experience of the I.G. Roussy. Int J Radiat Oncol Biol Phys 11:137-145, 1985
9. Fowble B: The relationship between local relapse and distant metastases revisited. Int J Radiat Oncol Biol Phys 30:237-239, 1994
10. Veronesi U, Volterrani F, Luini A, et al: Quadrantectomy versus lumpectomy for small size breast cancer. Eur J Cancer 26:671-673, 1990
11. Arriagada R, Mouriesse H, Sarrazin D: Radiotherapy alone in breast cancer. Analysis of tumor parameters, tumor dose and local control in the experience of the G. Roussy Institute and the Princess Margaret Hospital. Int J Radiat Oncol Biol Phys 11:1751-1758, 1985
12. Touboul E, Belkacemi Y, Lefranc JP, et al: Early breast cancer: Influence of type of boost (electrons vs iridium-192) on local control and cosmesis after conservative surgery and radiation therapy. Radiother Oncol 34:105-113, 1995
13. Fisher B, Anderson S, Fisher ER, et al: Significance of ipsilateral breast tumour recurrence after lumpectomy. Lancet 338:327-331, 1991
14. Papillon J, Montbarbon JF, Ingels J: Le traitement conservateur du cancer du sein par association tumorectomie-irradiation. J Belge Radiol 55:129-137, 1972
15. Gérard JP, Montbarbon JF, Chassard JL, et al: Conservative treatment of early carcinoma of the breast: Significance of axillary dissection and iridium implant. Radiother Oncol 3:17-22, 1985
16. International Commission of Radiation Units and Measurements: Report No 50. Prescribing. Recording and Reporting Photon Beam Therapy. Bethesda, MD, 1993
17. SAS Institute Inc: SAS/STAT User's Guide, Version 6, vol 1 and 2 (ed 4). Cary, NC, 1989
18. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
19. Kalbfeisch JE, Prentice RL: The Statistical Analysis of Failure Time Data. New York, NY, Wiley, 1980
20. Rothman KF: Estimation of confidence limits for the cumulative probability of survival in life table analysis. J Chronic Dis 31:557-560, 1978
21. Abner AL, Recht A, Eberlein T, et al: Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early stage breast cancer. J Clin Oncol 11:44-48, 1993
22. Gelman R, Gelber R, Henderson C, et al: Improved methodology for analyzing local and distant recurrence. J Clin Oncol 8:548-555, 1990
23. Clark RM, McCulloch PB, Levine MN, et al: Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node negative breast cancer. J Natl Cancer Inst 84:683-689, 1992
24. Fowble B, Solin L, Schultz DJ, et al: Frequency, sites of relapse, and outcome of regional node failures following conservative surgery and radiation for early breast cancer. Int J Radiat Oncol Biol Phys 17:703-710, 1989
25. Fowble B, Solin LJ, Schultz DJ, et al: Breast recurrence following conservative surgery and radiation: Patterns of failure, prognosis, and pathologic findings from mastectomy specimens with implications for treatment. Int J Radiat Oncol Biol Phys 19:833-842, 1990
26. Haffty BG, Fischer D, Rose M, et al: Prognostic factors for local recurrence in the conservatively treated breast cancer patient: A cautious interpretation of the data. J Clin Oncol 9:997-1003, 1991
27. Kurtz JM, Jacquemier J, Amalric R, et al: Risk factors for breast recurrence in premenopausal and postmenopausal patients with ductal cancers treated by conservation therapy. Cancer 65:1867-1878, 1990
28. Solin LJ, Fowble B, Schultz DJ, et al: Age as a prognostic factor for patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 16:373-381, 1989
29. Schnitt SJ, Abner A, Gelman R, et al: The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast conserving surgery and radiation therapy. Cancer 74:1746-1751, 1994
30. Bartelink H, Borger JH, Van Dongen JA, et al: The impact of tumor size and histology on local control after breast conserving therapy. Radiother Oncol 11:297-303, 1988
31. Pezner RD, Lipsett JA, Desai K, et al: To boost or not to boost: Decreasing radiation therapy in conservative breast cancer treatment when 'inked' tumor resection margins are pathologically free of cancer. Int J Radiat Oncol Biol Phys 14:873-877, 1988
32. Pezner RD, Luk KH, Lipsett JA: To boost or not to boost: Aye. There's the rub! Int J Radiat Oncol Biol Phys 21:529-530, 1991
33. Recht A, Harris JR: To boost or not to boost, and how to do it. Int J Radiat Oncol Biol Phys 20:177-178, 1991
34. Recht A: When is more better? Int J Radiat Oncol Biol Phys 27:749-751, 1993
35. Abner AL, Recht A, Vicini FA, et al: Cosmetic results after surgery, chemotherapy, and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys 21:331-338, 1991
36. Borger JH, Kemperman H, Smitt HS, et al: Dose and volume effects on fibrosis after breast conservation therapy. Int J Radiat Oncol Biol Phys 30:1073-1081, 1994
37. Moody AM, Mayles WPM, Bliss JM, et al: The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity. Radiother Oncol 33:106-112, 1994
38. Pezner RD: Cosmetic breast fibrosis: It's the local boost! Int J Radiat Oncol Biol Phys 30:1251-1252, 1994
39. Wazer D, Dipetrillo T, Schmidt-Ullrich R, et al: Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early stage breast carcinoma. J Clin Oncol 10:356-363, 1992
40. Turesson I, Thames HD: Repair capacity and kinetics of human skin during fractionated radiotherapy: Erythema desquamation, and telangiectasia after 3 and 5 years' follow up. Radiother Oncol 15:169-188, 1989
41. Beadle GF, Silver B, Botnick L, et al: Cosmetic results following primary radiation therapy for early breast cancer. Cancer 54:2911-2918, 1984
42. Dewar JA, Benhamou S, Benhamou E, et al: Cosmetic results following lumpectomy, axillary dissection and radiotherapy for small breast cancers. Radiother Oncol 12:273-280, 1988
43. Fourquet A, Campana F, Mosseri V, et al: Iridium 192 versus cobalt 60 boost in 3-7 cm breast cancer treated by irradiation alone: Final results of a randomized trial. Radiother Oncol 34:114-120, 1995
44. Machtay M, Lanciano R, Hoffman J, et al: Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma. Int J Radiat Oncol Biol Phys 30:43-48, 1994
45. Whelan T, Clark R, Roberts R, et al: Ipsilateral breast tumor recurrence postlumpectomy is predictive of subsequent mortality: Results from a randomized trial. Int J Radiat Oncol Biol Phys 30:11-16, 1994
46. Overgaard M, Christensen JJ, Johansen H, et al: Evaluation of radiotherapy in high-risk breast cancer patients: Report from the Danish Breast Cancer Cooperative Group (DBCG 82) Trial. Int J Radiat Oncol Biol Phys 19:1121-1124, 1990
47. Kemperman H, Borger J, Hart A, et al: Prognostic factors for survival after breast conserving therapy for stage I and II breast cancer. The role of local recurrence. Eur J Cancer 31:690-698, 1995
48. Suit HD: Local control and patient survival. Int J Radiat Oncol Biol Phys 12:453-458, 1986