Cell-based therapies for diabetic complications

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Secchiero, Paola ^a,b   Bernardi, Stella ^c   Severini, Giovanni Maria ^c   Zauli, Giorgio ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; GROWTH HORMONE; PLERIXAFOR; ROSIGLITAZONE;

ADULT STEM CELL; CELL THERAPY; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DIABETIC CARDIOMYOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; ENDOTHELIAL PROGENITOR CELL; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; REVIEW; THERAPY EFFECT; WOUND HEALING;

EID: 84926231717     PISSN: 16875214     EISSN: 16875303     Source Type: Trade Journal    
DOI: 10.1155/2012/872504     Document Type: Review

References (105)

1. Calcutt N. A., Cooper M. E., Kern T. S., Schmidt A. M., Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials Nature Reviews Drug Discovery 2009 8 5 417 429
2. Jarajapu Y. P., Grant M. B., The promise of cell-based therapies for diabetic complications: challenges and solutions Circulation Research 2010 106 5 854 869
3. Asahara T., Murohara T., Sullivan A., Silver M., Van Der Zee R., Li T., Witzenbichler B., Schatteman G., Isner J. M., Isolation of putative progenitor endothelial cells for angiogenesis Science 1997 275 5302 964 967 (Pubitemid 27087709)
4. Volarevic V., Arsenijevic N., Lukic M. L., Stojkovic M., Mesenchymal stem cell treatment of complications of diabetes mellitus Stem Cells 2011 29 1 5 10
5. Aggarwal S., Pittenger M. F., Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 2005 105 4 1815 1822 (Pubitemid 40223708)
6. Fiorina P., Jurewicz M., Augello A., Vergani A., Dada S., La Rosa S., Selig M., Godwin J., Law K., Placidi C., Smith R. N., Capella C., Rodig S., Adra C. N., Atkinson M., Sayegh M. H., Abdi R., Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes Journal of Immunology 2009 183 2 993 1004
7. Madec A. M., Mallone R., Afonso G., Abou Mrad E., Mesnier A., Eljaafari A., Thivolet C., Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells Diabetologia 2009 52 7 1391 1399
8. Zauli G., Toffoli B., Di Iasio M. G., Celeghini C., Fabris B., Secchiero P., Treatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes Diabetes 2010 59 5 1261 1265
9. Xie Q. P., Huang H., Xu B., Dong X., Gao S. L., Zhang BO., Wu YU. L., Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro Differentiation 2009 77 5 483 491
10. Dong Q. Y., Chen L., Gao G. Q., Wang L., Song J., Chen BO., Xu YU. X., Sun L., Allogeneic diabetic mesenchymal stem cells transplantation in streptozotocin-induced diabetic rat Clinical and Investigative Medicine 2008 31 6 E328 E337
11. Ito T., Itakura S., Todorov I., Rawson J., Asari S., Shintaku J., Nair I., Ferreri K., Kandeel F., Mullen Y., Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function Transplantation 2010 89 12 1438 1445
12. Schatteman G. C., Awad O., Hemangioblasts, angioblasts, and adult endothelial cell progenitors Anatomical RecordPart A Discoveries in Molecular, Cellular, and Evolutionary Biology 2004 276 1 13 21 (Pubitemid 38063874)
13. Fadini G. P., Sartore S., Schiavon M., Albiero M., Baesso I., Cabrelle A., Agostini C., Avogaro A., Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats Diabetologia 2006 49 12 3075 3084 (Pubitemid 44730312)
14. Loomans C. J. M., De Koning E. J. P., Staal F. J. T., Rookmaaker M. B., Verseyden C., De Boer H. C., Verhaar M. C., Braam B., Rabelink T. J., Van Zonneveld A. J., Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes Diabetes 2004 53 1 195 199 (Pubitemid 38044715)
15. Tepper O. M., Galiano R. D., Capla J. M., Kalka C., Gagne P. J., Jacobowitz G. R., Levine J. P., Gurtner G. C., Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures Circulation 2002 106 22 2781 2786 (Pubitemid 35396976)
16. Kusuyama T., Omura T., Nishiya D., Enomoto S., Matsumoto R., Takeuchi K., Yoshikawa J., Yoshiyama M., Effects of treatment for diabetes mellitus on circulating vascular progenitor cells Journal of Pharmacological Sciences 2006 102 1 96 102 (Pubitemid 44440972)
17. Fadini G. P., Pucci L., Vanacore R., Baesso I., Penno G., Balbarini A., Di Stefano R., Miccoli R., De Kreutzenberg S., Coracina A., Tiengo A., Agostini C., Del Prato S., Avogaro A., Glucose tolerance is negatively associated with circulating progenitor cell levels Diabetologia 2007 50 10 2156 2163 (Pubitemid 47373839)
18. Egan C. G., Lavery R., Caporali F., Fondelli C., Laghi-Pasini F., Dotta F., Sorrentino V., Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes Diabetologia 2008 51 7 1296 1305
19. Busik J. V., Tikhonenko M., Bhatwadekar A., Opreanu M., Yakubova N., Caballero S., Player D., Nakagawa T., Afzal A., Kielczewski J., Sochacki A., Hasty S., Li Calzi S., Kim S., Duclas S. K., Segal M. S., Guberski D. L., Esselman W. J., Boulton M. E., Grant M. B., Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock Journal of Experimental Medicine 2009 206 13 2897 2906
20. Thum T., Fraccarollo D., Schultheiss M., Froese S., Galuppo P., Widder J. D., Tsikas D., Ertl G., Bauersachs J., Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes Diabetes 2007 56 3 666 674 (Pubitemid 46348461)
21. Heissig B., Hattori K., Dias S., Friedrich M., Ferris B., Hackett N. R., Crystal R. G., Besmer P., Lyden D., Moore M. A. S., Werb Z., Raf S. II, Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand Cell 2002 109 5 625 637 (Pubitemid 34628725)
22. Segal M. S., Shah R., Afzal A., Perrault C. M., Chang K., Schuler A., Beem E., Shaw L. C., Calzi S. L., Harrison J. K., Tran-Son-Tay R., Grant M. B., Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes Diabetes 2006 55 1 102 109 (Pubitemid 43343304)
23. Browner W. S., Lui L. Y., Cummings S. R., Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women Journal of Clinical Endocrinology and Metabolism 2001 86 2 631 637 (Pubitemid 32207471)
24. Candido R., Toffoli B., Corallini F., Bernardi S., Zella D., Voltan R., Grill V., Celeghini C., Fabris B., Human full-length osteoprotegerin induces the proliferation of rodent vascular smooth muscle cells both in vitro and in vivo Journal of Vascular Research 2010 47 3 252 261
25. Toffoli B., Bernardi S., Candido R., Sabato N., Carretta R., Corallini F., Secchiero P., Zauli G., Fabris B., Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets Molecular and Cellular Endocrinology 2011 331 1 136 142
26. Secchiero P., Melloni E., Corallini F., Beltrami A. P., Alviano F., Milani D., D'Aurizio F., Di Iasio M. G., Cesselli D., Bagnara G. P., Zauli G., Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells Stem Cells 2008 26 11 2955 2963
27. Corallini F., Secchiero P., Beltrami A. P., Cesselli D., Puppato E., Ferrari R., Beltrami C. A., Zauli G., TNF- modulates the migratory response of mesenchymal stem cells to TRAIL Cellular and Molecular Life Sciences 2010 67 8 1307 1314
28. Kuki S., Imanishi T., Kobayashi K., Matsuo Y., Obana M., Akasaka T., Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase Circulation Journal 2006 70 8 1076 1081 (Pubitemid 44161749)
29. Rosso A., Balsamo A., Gambino R., Dentelli P., Falcioni R., Cassader M., Pegoraro L., Pagano G., Brizzi M. F., p53 mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes Journal of Biological Chemistry 2006 281 7 4339 4347 (Pubitemid 43847865)
30. Balestrieri M. L., Rienzo M., Felice F., Rossiello R., Grimaldi V., Milone L., Casamassimi A., Servillo L., Farzati B., Giovane A., Napoli C., High glucose downregulates endothelial progenitor cell number via SIRT1 Biochimica et Biophysica Acta 2008 1784 6 936 945
31. Vasa M., Breitschopf K., Zeiher A. M., Dimmeler S., Nitric oxide activates telomerase and delays endothelial cell senescence Circulation Research 2000 87 7 540 542
32. Di Stefano V., Cencioni C., Zaccagnini G., Magenta A., Capogrossi M. C., Martelli F., P66 ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose Cardiovascular Research 2009 82 3 421 429
33. Fadini G. P., Boscaro E., De Kreutzenberg S., Agostini C., Seeger F., Dimmeler S., Zeiher A., Tiengo A., Avogaro A., Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes Diabetes Care 2010 33 5 1097 1102
34. Ishizuka T., Hinata T., Watanabe Y., Superoxide induced by a high-glucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells Journal of Endocrinology 2011 208 2 147 159
35. Chen Q., Dong L., Wang L., Kang L., Xu B., Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2 Biochemical and Biophysical Research Communications 2009 381 2 192 197
36. Sun C., Liang C., Ren Y., Zhen Y., He Z., Wang H., Tan H., Pan X., Wu Z., Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways Basic Research in Cardiology 2009 104 1 42 49
37. Scheubel R. J., Kahrstedt S., Weber H., Holtz J., Friedrich I., Borgermann J., Silber R. E., Simm A., Depression of progenitor cell function by advanced glycation endproducts (AGEs): potential relevance for impaired angiogenesis in advanced age and diabetes Experimental Gerontology 2006 41 5 540 548 (Pubitemid 43765896)
38. Stolzing A., Sellers D., Llewelyn O., Scutt A., Diabetes induced changes in rat mesenchymal stem cells Cells Tissues Organs 2010 191 6 453 465
39. Kume S., Kato S., Yamagishi S. I., Inagaki Y., Ueda S., Arima N., Okawa T., Kojiro M., Nagata K., Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone Journal of Bone and Mineral Research 2005 20 9 1647 1658 (Pubitemid 41243553)
40. Beckman J. A., Creager M. A., Libby P., Diabetes and atherosclerosis epidemiology, pathophysiology, and management Journal of the American Medical Association 2002 287 19 2570 2581 (Pubitemid 34517204)
41. Secchiero P., Candido R., Corallini F., Zacchigna S., Toffoli B., Rimondi E., Fabris B., Giacca M., Zauli G., Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice Circulation 2006 114 14 1522 1530 (Pubitemid 44527008)
42. Schmidt-Lucke C., Rssig L., Fichtlscherer S., Vasa M., Britten M., Kmper U., Dimmeler S., Zeiher A. M., Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair Circulation 2005 111 22 2981 2987 (Pubitemid 40814192)
43. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., Bhm M., Nickenig G., Circulating endothelial progenitor cells and cardiovascular outcomes The New England Journal of Medicine 2005 353 10 999 1007 (Pubitemid 41262334)
44. Fadini G. P., Maruyama S., Ozaki T., Taguchi A., Meigs J., Dimmeler S., Zeiher A. M., de Kreutzenberg S., Avogaro A., Nickenig G., Schmidt-Lucke C., Werner N., Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis PLoS ONE 2010 5 7
45. Fadini G. P., Sartore S., Albiero M., Baesso I., Murphy E., Menegolo M., Grego F., De Kreutzenberg S. V., Tiengo A., Agostini C., Avogaro A., Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 9 2140 2146 (Pubitemid 44253800)
46. Fadini G. P., Miorin M., Facco M., Bonamico S., Baesso I., Grego F., Menegolo M., Vigili De Kreutzenberg S., Tiengo A., Agostini C., Avogaro A., Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus Journal of the American College of Cardiology 2005 45 9 1449 1457 (Pubitemid 40615617)
47. Ma Z. L., Mai X. L., Sun J. H., Ju S. H., Yang X., Ni Y., Teng G. J., Inhibited atherosclerotic plaque formation by local administration of magnetically labeled endothelial progenitor cells (EPCs) in a rabbit model Atherosclerosis 2009 205 1 80 86
48. Silvestre J. S., Gojova A., Brun V., Potteaux S., Esposito B., Duriez M., Clergue M., Le Ricousse-Roussanne S., Barateau V., Merval R., Groux H., Tobelem G., Levy B., Tedgui A., Mallat Z., Transplantation of bone marrow-derived mononuclear cells in ischemic apolipoprotein e-Knockout mice accelerates atherosclerosis without altering plaque composition Circulation 2003 108 23 2839 2842 (Pubitemid 37517809)
49. Westerweel P. E., van Velthoven C. T. J., Nguyen T. Q., den Ouden K., de Kleijn D. P. V., Goumans M. J., Goldschmeding R., Verhaar M. C., Modulation of TGF- /BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model Cardiovascular Diabetology 2010 9 55
50. Kang H. J., Kim H. S., Zhang S. Y., Park K. W., Cho H. J., Koo B. K., Kim Y. J., Lee D. S., Sohn D. W., Han K. S., Oh B. H., Lee M. M., Park Y. B., Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial The Lancet 2004 363 9411 751 756 (Pubitemid 38315164)
51. Menasché P., Stem cell therapy for heart failure: are arrhythmias a real safety concern? Circulation 2009 119 20 2735 2740
52. Dimmeler S., Burchfield J., Zeiher A. M., Cell-based therapy of myocardial infarction Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 2 208 216 (Pubitemid 351161191)
53. Hare J. M., Traverse J. H., Henry T. D., Dib N., Strumpf R. K., Schulman S. P., Gerstenblith G., DeMaria A. N., Denktas A. E., Gammon R. S., Hermiller J. B., Reisman M. A., Schaer G. L., Sherman W., A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Journal of the American College of Cardiology 2009 54 24 2277 2286
54. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., Magner M., Isner J. M., Asahara T., Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization Nature Medicine 1999 5 4 434 438 (Pubitemid 29180584)
55. Murohara T., Ikeda H., Duan J., Shintani S., Sasaki K. I., Eguchi H., Onitsuka I., Matsui K., Imaizumi T., Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization Journal of Clinical Investigation 2000 105 11 1527 1536 (Pubitemid 30390303)
56. Kalka C., Masuda H., Takahashi T., Kalka-Moll W. M., Silver M., Kearney M., Li T., Isner J. M., Asahara T., Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization Proceedings of the National Academy of Sciences of the United States of America 2000 97 7 3422 3427 (Pubitemid 30183318)
57. Fadini G. P., Agostini C., Avogaro A., Autologous stem cell therapy for peripheral arterial disease. Meta-analysis and systematic review of the literature Atherosclerosis 2010 209 1 10 17
58. Schatteman G. C., Hanlon H. D., Jiao C., Dodds S. G., Christy B. A., Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice Journal of Clinical Investigation 2000 106 4 571 578 (Pubitemid 30666390)
59. Hirata K., Li T. S., Nishida M., Ito H., Matsuzaki M., Kasaoka S., Hamano K., Autologous bone marrow cell implantation as therapeutic angiogenesis for ischemic hindlimb in diabetic rat model American Journal of Physiology 2003 284 1 H66 H70
60. Amin A. H., Abd Elmageed Z. Y., Nair D., Partyka M. I., Kadowitz P. J., Belmadani S., Matrougui K., Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice Laboratory Investigation 2010 90 7 985 996
61. Gehling U. M., Ergn S., Schumacher U., Wagener C., Pantel K., Otte M., Schuch G., Schafhausen P., Mende T., Kilic N., Kluge K., Schfer B., Hossfeld D. K., Fiedler W., In vitro differentiation of endothelial cells from AC133-positive progenitor cells Blood 2000 95 10 3106 3112 (Pubitemid 30321161)
62. Comerota A. J., Link A., Douville J., Burchardt E. R., Upper extremity ischemia treated with tissue repair cells from adult bone marrow Journal of Vascular Surgery 2010 52 3 723 729
63. Lee J. S., Hong J. M., Moon G. J., Lee P. H., Ahn Y. H., Bang O. Y., A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke Stem Cells 2010 28 6 1099 1106
64. Toffoli B., Bernardi S., Candido R., Zacchigna S., Fabris B., Secchiero P., TRAIL shows potential cardioprotective activity. Investigational New Drugs. In press
65. Rota M., LeCapitaine N., Hosoda T., Boni A., De Angelis A., Padin-Iruegas M. E., Esposito G., Vitale S., Urbanek K., Casarsa C., Giorgio M., Lscher T. F., Pelicci P. G., Anversa P., Leri A., Kajstura J., Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene Circulation Research 2006 99 1 42 52 (Pubitemid 44297054)
66. Yoon Y. S., Uchida S., Masuo O., Cejna M., Park J. S., Gwon H. C., Kirchmair R., Bahlman F., Walter D., Curry C., Hanley A., Isner J. M., Losordo D. W., Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor Circulation 2005 111 16 2073 2085 (Pubitemid 40577902)
67. Zhang N., Li J., Luo R., Jiang J., Wang J. A., Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy Experimental and Clinical Endocrinology and Diabetes 2008 116 2 104 111 (Pubitemid 351363380)
68. Shabbir A., Zisa D., Suzuki G., Lee T., Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen American Journal of Physiology 2009 296 6 H1888 H1897
69. Cooper M. E., Pathogenesis, prevention, and treatment of diabetic nephropathy Lancet 1998 352 9123 213 219 (Pubitemid 28327814)
70. Abe-Yoshio Y., Abe K., Miyazaki M., Furusu A., Nishino T., Harada T., Koji T., Kohno S., Involvement of bone marrow-derived endothelial progenitor cells in glomerular capillary repair in habu snake venom-induced glomerulonephritis Virchows Archiv 2008 453 1 97 106
71. Ronconi E., Sagrinati C., Angelotti M. L., Lazzeri E., Mazzinghi B., Ballerini L., Parente E., Becherucci F., Gacci M., Carini M., Maggi E., Serio M., Vannelli G. B., Lasagni L., Romagnani S., Romagnani P., Regeneration of glomerular podocytes by human renal progenitors Journal of the American Society of Nephrology 2009 20 2 322 332
72. Ezquer F. E., Ezquer M. E., Parrau D. B., Carpio D., Yaez A. J., Conget P. A., Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice Biology of Blood and Marrow Transplantation 2008 14 6 631 640
73. Ezquer F., Ezquer M., Simon V., Pardo F., Yaez A., Carpio D., Conget P., Endovenous administration of bone marrow-derived multipotent mesenchymal stromal cells prevents renal failure in diabetic mice Biology of Blood and Marrow Transplantation 2009 15 11 1354 1365
74. Lee R. H., Seo M. J., Reger R. L., Spees J. L., Pulin A. A., Olson S. D., Prockop D. J., Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice Proceedings of the National Academy of Sciences of the United States of America 2006 103 46 17438 17443 (Pubitemid 44788987)
75. Naruse K., Hamada Y., Nakashima E., Kato K., Mizubayashi R., Kamiya H., Yuzawa Y., Matsuo S., Murohara T., Matsubara T., Oiso Y., Nakamura J., Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy Diabetes 2005 54 6 1823 1828 (Pubitemid 40770773)
76. Jeong J. O., Kim M. O., Kim H., Lee M. Y., Kim S. W., Ii M. II, Lee J. U., Lee J., Choi Y. J., Cho H. J., Lee N., Silver M., Wecker A., Kim D. W., Yoon Y. S., Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy Circulation 2009 119 5 699 708
77. Shibata T., Naruse K., Kamiya H., Kozakae M., Kondo M., Yasuda Y., Nakamura N., Ota K., Tosaki T., Matsuki T., Nakashima E., Hamada Y., Oiso Y., Nakamura J., Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats Diabetes 2008 57 11 3099 3107
78. Brunner S., Schernthaner G. H., Satler M., Elhenicky M., Hoellerl F., Schmid-Kubista K. E., Zeiler F., Binder S., Schernthaner G., Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: first in vivo data Investigative Ophthalmology and Visual Science 2009 50 1 392 398
79. Lee I. G., Chae S. L., Kim J. C., Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy Eye 2006 20 5 546 552 (Pubitemid 43674990)
80. Grant M. B., May W. S., Caballero S., Brown G. A. J., Guthrie S. M., Mames R. N., Byrne B. J., Vaught T., Spoerri P. E., Peck A. B., Scott E. W., Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization Nature Medicine 2002 8 6 607 612 (Pubitemid 34633439)
81. Ritter M. R., Banin E., Moreno S. K., Aguilar E., Dorrell M. I., Friedlander M., Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy Journal of Clinical Investigation 2006 116 12 3266 3276 (Pubitemid 44878641)
82. Yang Z., Li K., Yan X., Dong F., Zhao C., Amelioration of diabetic retinopathy by engrafted human adipose-derived mesenchymal stem cells in streptozotocin diabetic rats Graefe's Archive for Clinical and Experimental Ophthalmology 2010 248 10 1415 1422
83. Albiero M., Menegazzo L., Boscaro E., Agostini C., Avogaro A., Fadini G. P., Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice Diabetologia 2011 54 4 945 953
84. Wu Y., Zhao R. C. H., Tredget E. E., Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration Stem Cells 2010 28 5 905 915
85. Gill M., Dias S., Hattori K., Rivera M. L., Hicklin D., Witte L., Girardi L., Yurt R., Himel H., Raf S. II, Vascular trauma induces rapid but transient mobilization of VEGFR2 + AC133 + endothelial precursor cells Circulation Research 2001 88 2 167 174 (Pubitemid 32147304)
86. Suh W., Kim K. L., Kim J. M., Shin I. S., Lee Y. S., Lee J. Y., Jang H. S., Lee J. S., Byun J., Choi J. H., Jeon E. S., Kim D. K., Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes/macrophages and neovascularization Stem Cells 2005 23 10 1571 1578 (Pubitemid 41741006)
87. Rehman J., Li J., Orschell C. M., March K. L., Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors Circulation 2003 107 8 1164 1169 (Pubitemid 36297209)
88. Wu Y., Chen L., Scott P. G., Tredget E. E., Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis Stem Cells 2007 25 10 2648 2659 (Pubitemid 47582758)
89. Kwon D. S., Gao X., Liu Y. B., Dulchavsky D. S., Danyluk A. L., Bansal M., Chopp M., McIntosh K., Arbab A. S., Dulchavsky S. A., Gautam S. C., Treatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats International Wound Journal 2008 5 3 453 463 (Pubitemid 351874520)
90. Vojtak J., Daniovi L., Kube M., Bako D., Jarbek L., Ulin M., Blako M., Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot Neuroendocrinology Letters 2006 27 supplement 2 134 137
91. Sivan-Loukianova E., Awad O. A., Stepanovic V., Bickenbach J., Schatteman G. C., CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds Journal of Vascular Research 2003 40 4 368 377 (Pubitemid 37188106)
92. Barcelos L. S., Duplaa C., Krnkel N., Graiani G., Invernici G., Katare R., Siragusa M., Meloni M., Campesi I., Monica M., Simm A., Campagnolo P., Mangialardi G., Stevanato L., Alessandri G., Emanueli C., Madeddu P., Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling Circulation Research 2009 104 9 1095 1102
93. Marrotte E. J., Chen D. D., Hakim J. S., Chen A. F., Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice Journal of Clinical Investigation 2010 120 12 4207 4219
94. Murasawa S., Llevadot J., Silver M., Isner J. M., Losordo D. W., Asahara T., Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells Circulation 2002 106 9 1133 1139 (Pubitemid 34970856)
95. Choi J. H., Hurt J., Yoon C. H., Kim J. H., Lee C. S., Youn S. W., Oh I. Y., Skurk C., Murohara T., Park Y. B., Walsh K., Kim H. S., Augmentation of therapeutic augiogenesis using genetically modified human endothelial progenitor cells with altered glycogen synthase kinase-3 activity Journal of Biological Chemistry 2004 279 47 49430 49438 (Pubitemid 39625829)
96. Li H., Zuo S., He Z., Yang Y., Pasha Z., Wang Y., Xu M., Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival American Journal of Physiology 2010 299 6 H1772 H1781
97. Zhang D., Fan G. C., Zhou X., Zhao T., Pasha Z., Xu M., Zhu Y., Ashraf M., Wang Y., Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium Journal of Molecular and Cellular Cardiology 2008 44 2 281 292
98. Mangi A. A., Noiseux N., Kong D., He H., Rezvani M., Ingwall J. S., Dzau V. J., Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts Nature Medicine 2003 9 9 1195 1201 (Pubitemid 37173705)
99. Sasaki K. I., Heeschen C., Aicher A., Ziebart T., Honold J., Urbich C., Rossig L., Koehl U., Koyanagi M., Mohamed A., Brandes R. P., Martin H., Zeiher A. M., Dimmeler S., Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy Proceedings of the National Academy of Sciences of the United States of America 2006 103 39 14537 14541 (Pubitemid 44484785)
100. Thum T., Fleissner F., Klink I., Tsikas D., Jakob M., Bauersachs J., Stichtenoth D. O., Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I Journal of Clinical Endocrinology and Metabolism 2007 92 11 4172 4179 (Pubitemid 350074728)
101. Ceolotto G., Gallo A., Papparella I., Franco L., Murphy E., Iori E., Pagnin E., Fadini G. P., Albiero M., Semplicini A., Avogaro A., Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 12 2627 2633 (Pubitemid 350158915)
102. Sorrentino S. A., Bahlmann F. H., Besler C., Mller M., Schulz S., Kirchhoff N., Doerries C., Horvth T., Limbourg A., Limbourg F., Fliser D., Haller H., Drexler H., Landmesser U., Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor- agonist rosiglitazone Circulation 2007 116 2 163 173 (Pubitemid 47057522)
103. Seeger F. H., Haendeler J., Walter D. H., Rochwalsky U., Reinhold J., Urbich C., Rssig L., Corbaz A., Chvatchko Y., Zeiher A. M., Dimmeler S., p38 mitogen-activated protein kinase downregulates endothelial progenitor cells Circulation 2005 111 9 1184 1191 (Pubitemid 40365481)
104. Khan M., Akhtar S., Mohsin S., Khan N., Riazuddin S., Growth factor preconditioning increases the function of diabetes-impaired mesenchymal stem cells Stem Cells and Development 2011 20 1 67 75
105. Jiao C., Fricker S., Schatteman G. C., The chemokine (C-X-C motif) receptor 4 inhibitor AMD3100 accelerates blood flow restoration in diabetic mice Diabetologia 2006 49 11 2786 2789