Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes

Diabetologia

Volumn 51, Issue 7, 2008, Pages 1296-1305

  Egan, C G ^a   Lavery, R ^a   Caporali, F ^a,b   Fondelli, C ^a   Laghi Pasini, F ^b   Dotta, F ^a   Sorrentino, V ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Chemokine (C X C motif) receptor 4; CXCR4; Endothelial progenitor cells; EPC; Microvascular disease; PBMCs; Peripheral blood mononuclear cells; Stem cells; Surface marker; Type 2 diabetes

Indexed keywords

BIOLOGICAL MARKER; CD34 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CXCR4;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CELL MOTILITY; CELL POPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; STEM CELL;

ANTIGENS, CD; ANTIGENS, CD31; ANTIGENS, CD34; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; ENDOTHELIAL CELLS; FEMALE; FLOW CYTOMETRY; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MIDDLE AGED; PEPTIDES; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, CXCR4; SEVERITY OF ILLNESS INDEX; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 44749087657     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-0939-6     Document Type: Article

References (47)

1. Waltenberger J (2001) Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications. Cardiovasc Res 16:554-560
2. St Clair L, Ballantyne CM (2007) Biological surrogates for enhancing cardiovascular risk prediction in type 2 diabetes mellitus. Am J Cardiol 99:80-88
3. Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333-1346
4. Landmesser U, Drexler H (2005) The clinical significance of endothelial dysfunction. Curr Opin Cardiol 20:547-551
5. Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115:1285-1295
6. Vita JA (2005) Endothelial function and clinical outcome. Heart 91:1278-1279
7. Takahashi T, Kalka C, Masuda H et al (1999) Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5:434-438
8. Asahara T, Murohara T, Sullivan A et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-967
9. Hristov M, Wolfgang W, Weber PC (2003) Endothelial progenitor cells-mobilization differentiation and homing. Arterioscler Thromb Vasc Biol 23:1185-1189
10. Ingram DA, Caplice NM, Yoder MC (2005) Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood 106:1525-1531
11. Case J, Mead LE, Bessler WK et al (2007) Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 35:1109-1118
12. Hur J, Yoon CH, Kim HS et al (2004) Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 24:288-293
13. Urbich C, Dimmeler S (2004) Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 95:343-353
14. Vasa M, Fichtlscherer S, Aicher A et al (2001) Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89:E1-E7
15. Shantsila E, Watson T, Lip GY (2007) Endothelial progenitor cells in cardiovascular disorders. J Am Coll Cardiol 49:741-752
16. Grisar J, Aletaha D, Steiner CW et al (2005) Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritis. Circulation 111:204-211
17. Fadini GP, Schiavon M, Cantini M et al (2006) Circulating progenitor cells are reduced in patients with severe lung disease. Stem Cells 24:1806-1813
18. Fadini GP, Miorin M, Facco M et al (2005) Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 45:1449-1457
19. Tepper OMGR, Capla JM, Kalka C et al (2002) Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation adhesion and incorporation into vascular structures. Circulation 106:2781-2786
20. Loomans CJ, de Koning EJ, Staal FJ et al (2004) Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53:195-199
21. Massa M, Rosti V, Ferrario M et al (2005) Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infaction. Blood 105:199-205
22. Isner JM, Asahara T (1999) Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest 103:1231-1236
23. Kucia M, Ratajczak J, Ratajczak MZ (2005) Bone marrow as a source of circulating CXCR4 + tissue-committed stem cells. Biol Cell 97:133-146
24. Ceradini DJ, Gurtner GC (2005) Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc Med 15:57-63
25. Ruiz de Almodovar C, Luttun A, Carmeliet P (2006) An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 124:18-21
26. Yamaguchi J, Kusano KF, Masuo O et al (2003) Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107:1322-1328
27. Walter DH, Haendeler J, Reinhold J et al (2005) Impaired CXCR4 signaling contributes to the reduced neovascularisation capacity of endothelial progenitor cells from patients with coronary artery disease. Circ Res 97:1142-1151
28. American Diabetes Association (2007) Standards of medical care in diabetes-2007. Diabetes Care 30(Suppl 1):S4-S41
29. Grundy SM, Cleeman JI, Merz CN et al (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110:227-239
30. Miller DD, Shaw LJ (2006) Foreword: cardiovascular disease: diagnostic, prognostic, and measurement paradigms for reducing patient risk. J Cardiovasc Nurs 21(6 Suppl 1):S1
31. Devendra D, Farmer K, Bruce G, Hughes P, Vivian G, Millward BA (2001) Diagnosing osteomyelitis in patients with diabetic neuropathic osteoarthropathy. Diabetes Care 24:2154-2155
32. Cypress M, Tomky D (2006) Microvascular complications of diabetes. Nurs Clin North Am 41:719-736 ix
33. Molitch ME, DeFronzo RA, Franz MJ et al (2004) American Diabetes Association. Nephropathy in diabetes. Diabetes Care Suppl 1:S79-S83
34. Rogler G, Hausmann M, Vogl D et al (1998) Isolation and phenotypic characterization of colonic macrophages. Clin Exp Immunol 112:205-215
35. Wang XX, Zhang FR, Shang YP et al (2007) Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J Am Coll Cardiol 49:1566-1571
36. Fadini GP, Sartore S, Agostini C, Avogaro A (2007) Significance of endothelial progenitor cells in subjects with diabetes. Diabetes Care 30:1305-1313
37. Kusuyama T, Omura T, Nishiya D et al (2006) Effects of treatment for diabetes mellitus on circulating vascular progenitor cells. J Pharmacol Sci 102:96-102
38. Naruse K, Hamada Y, Nakashima E et al (2005) Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes 54:1823-1828
39. Fadini GP, Sartore S, Baesso I et al (2006) Endothelial progenitor cells and the diabetic paradox. Diabetes Care 29:714-716
40. Lee IG, Chae SL, Kim JC (2006) Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy. Eye 20:546-552
41. Butler JM, Guthrie SM, Koc M et al (2005) SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest 115:86-93
42. Damas JK, Waehre T, Yndestad A et al (2002) Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects. Circulation 106:36-42
43. Honold J, Lehmann R, Heeschen C et al (2006) Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease. Arterioscler Thromb Vasc Biol 26:2238-2243
44. Segal MS, Shah R, Afzal A et al (2006) Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes 55:102-109
45. Humpert PM, Neuwirth R, Battista MJ et al (2005) SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes. Diabetes Care 28:934-936
46. Fadini GP, Sartore S, Schiavon M et al (2006) Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats. Diabetologia 49:3075-3084
47. Gallagher KA, Liu ZJ, Xiao M et al (2007) Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1. J Clin Invest 117:1249-1259