CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds

Journal of Vascular Research

Volumn 40, Issue 4, 2003, Pages 368-377

  Sivan Loukianova, E ^a   Awad, O A ^a   Stepanovic, V ^a   Bickenbach, J ^b   Schatteman, Gina C ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Angiogenesis; Diabetes; Endothelial progenitor; Endothelium; Skin; Stem cell; Wound healing

Indexed keywords

CD34 ANTIGEN; STREPTOZOCIN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; CONTROLLED STUDY; EPIDERMIS; MALE; MONONUCLEAR CELL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; REVASCULARIZATION; SKIN BLOOD FLOW; SKIN INJURY; STEM CELL; STREPTOZOCIN DIABETES; WOUND HEALING;

ANIMALS; ANTIGENS, CD34; DIABETES MELLITUS, EXPERIMENTAL; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PHYSIOLOGIC; SKIN; SKIN ULCER; STEM CELL TRANSPLANTATION; STEM CELLS; WOUND HEALING;

EID: 0141728458     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072701     Document Type: Article

References (23)

1. Adler AI, Neil HA, Manley SE, Holman RR, Turner RC: Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47). Am Heart J 1999;138:S353-S359.
2. Akbari CM, Gibbons GW, Habershaw GM, LoGerfo FW, Veves A: The effect of arterial reconstruction on the natural history of diabetic neuropathy. Arch Surg 1997;132:148-152.
3. Ansel JC, Armstrong CA, Song I, Quinlan KL, Olerud JE, Caughman SW, Bunnett NW: Interactions of the skin and nervous system. J Invest Dermatol Symp Proc 1997;2:23-26.
4. Aronin N, Leeman SE, Clements RS Jr: Diminished flare response in neuropathic diabetic patients. Comparison of effects of substance P, histamine, and capsaicin. Diabetes 1987;36:1139-1143.
5. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
6. Cameron NE, Cotter MA: Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 1997;46(suppl 2):S31-S37.
7. Colville-Nash PR, Willoughby DA: Growth factors in angiogenesis: Current interest and therapeutic potential. Mol Med Today 1997;3:14-23.
8. Haegerstrand A, Dalsgaard CJ, Jonzon B, Larsson O, Nilsson J: Calcitonin gene-related peptide stimulates proliferation of human endothelial cells. Proc Natl Acad Sci USA 1990;87:3299-3303.
9. Harrington C, Zagari MJ, Corea J, Klitenic J: A cost analysis of diabetic lower-extremity ulcers. Diabetes Care 2000;23:1333-1338.
10. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-2756.
11. Kennedy WR, Wendelschafer-Crabb G: Utility of skin biopsy in diabetic neuropathy. Semin Neurol 1996;16:163-171.
12. Kunjathoor VV, Wilson DL, LeBoeuf RC: Increased atherosclerosis in streptozotocin-induced diabetic mice. J Clin Invest 1996;97:1767-1773.
13. Lawrence WT, Diegelmann RF: Growth factors in wound healing. Clin Dermatol 1994;12:157-169.
14. Newman PJ, Berndt MC, Gorski J, White GCD, Lyman S, Paddock C, Muller WA: PE-CAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990;247:1219-1222.
15. Nilsson J, von Euler AM, Dalsgaard CJ: Stimulation of connective tissue cell growth by substance P and substance K. Nature 1985;315:61-63.
16. Pecoraro RE, Reiber GE, Burgess EM: Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care 1990;13:513-521.
17. Reiber GE, Pecoraro RE, Koepsell TD: Risk factors for amputation in patients with diabetes mellitus. A case-control study. Ann Intern Med 1992;117:97-105.
18. Schatteman GC, Hanlon HD, Jiao C, Dodds SG, Christy BA: Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice. J Clin Invest 2000;106:571-578.
19. Schratzberger P, Schratzberger G, Silver M, Curry C, Kearney M, Magner M, Alroy J, Adelman LS, Weinberg DH, Ropper AH, Isner JM: Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat Med 2000;6:405-413.
20. Senapati A, Anand P, McGregor GP, Ghatei MA, Thompson RP, Bloom SR: Depletion of neuropeptides during wound healing in rat skin. Neurosci Lett 1986;71:101-105.
21. Servold SA: Growth factor impact on wound healing. Clin Podiatr Med Surg 1991;8:937-953.
22. Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, Fujita Y, Kothari S, Mohle R, Sauvage LR, Moore MA, Storb RF, Hammond WP: Evidence for circulating bone marrow-derived endothelial cells. Blood 1998;92:362-367.
23. Swift ME, Kleinman HK, DiPietro LA: Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 1999;79:1479-1487.