Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: First in vivo data

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 1, 2009, Pages 392-398

  Brunner, Simon ^a,b   Schernthaner, Gerit Holger ^c   Satler, Miriam ^c   Elhenicky, Marie ^c   Hoellerl, Florian ^c   Schmid Kubista, Katharina E ^a,b   Zeiler, Florian ^a,b   Binder, Susanne ^a,b   Schernthaner, Guntram ^a  

^a KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

^b Ludwig Boltztmann Institute for Retinology and Biomicroscopic Laser Surgery   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CD34 ANTIBODY; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

ARTICLE; CASE CONTROL STUDY; CELL MATURATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE CLASSIFICATION; EYE; FLOW CYTOMETRY; HIGH RISK POPULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; STEM CELL; ADULT; BLOOD; HEMATOPOIETIC STEM CELL; PATHOLOGY; VASCULAR ENDOTHELIUM;

ADULT; ANTIGENS, CD; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS;

EID: 58249083287     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1748     Document Type: Article

References (58)

1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications, I: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539 -553.
2. Fong DS, Aiello LP, Ferris FL 3rd, Klein R. Diabetic retinopathy. Diabetes Care. 2004;27(10):2540-2553.
3. Foster A, Resnikoff S. The impact of Vision 2020 on global blindness. Eye. 2005;19(10):1133-1135.
4. Nordwall M, Bojestig M, Arnqvist HJ, Ludviqsson J, Linköping Diabetes Complications Study. Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of type 1 diabetes-the Linköping Diabetes Complications Study. Diabetologia. 2004;47(7):1266-1272.
5. Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy, XVII: the 14-year incidence and progression of diabetic retinopathy and associated risk factors in type I diabetes. Ophthalmology. 1998;105(10):1801-1815.
6. Antonetti DA, Barber AJ, Bronson SK, et al. JDRF Diabetic Retinopathy Center Group: diabetic retinopathy: seeing beyond glucoseinduced microvascular disease. Diabetes. 2006;55(9):2401-2411.
7. Spranger J, Pfeiffer AF. New concepts in pathogenesis and treatment of diabetic retinopathy. Exp Clin Endocrinol Diabetes. 2001;109(suppl 2):S438 -S450.
8. Merimee TJ. Diabetic retinopathy: a synthesis of perspectives. N Engl J Med. 1990;332(14):978 -983.
9. Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening and novel therapies. Diabetes Care. 2003;26(9):2653-2664.
10. Tong PC, Lee KF, So WY, et al. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care. 2004;27(1):216 -222.
11. Schram MT, Chaturvedi N, Schalwijk C, et al. Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care. 2003;26(7):2165-2173.
12. Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18(12):1450-142.
13. Otani A, Friedlander M. Retinal vascular regeneration. Semin Ophthalmol. 2005;20(1):43-50.
14. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001;22(1):36-52.
15. Clermont AC, Aiello LP, Mori F, Aiello LM, Bursell SE. Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy. Am J Ophthalmol. 1997;124(4):433-446.
16. Wiedemann P. [What is the etiology of diabetic retinopathy?]. Ophthalmologe. 1993;90(5):426-433.
17. Yilmaz G, Esser P, Kociek N, Aydin P, Heiman K. Elevated nitric oxide levels in patients with proliferative diabetic retinopathy. Am J Ophthalmol. 2000;130(1):87-90.
18. Garner A. Histopathology of diabetic retinopathy in man. Eye. 1993;7(pt 2):250 -253.
19. Kalka C, Masuda H, Takahashi T, et al. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res. 2000;86(12):1198-1202.
20. Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85(3):221-228.
21. Kalka C, Asahara T, Krone W, et al. [Angiogenesis and vasculogenesis: therapeutic strategies for stimulation of postnatal neovascularization] Herz. 2000;25(6):611- 622.
22. Yodoi Y, Sasahara M, Kameda T, Yoshimura N, Otani A. Circulating hematopoietic stem cells in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2007;48:5464-5472.
23. Sheridan CM, Rice D, Hiscott PS, Wong D, Kent DL. The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2006;47:1642-1645.
24. Sengupta N, Caballero S, Mames RN, Timmers AM, Saban D, Grant MB. Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. Invest Ophthalmol Vis Sci. 2005;46:343-348.
25. Lee IG, Chae SL, Kim JC. Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy. Eye. 2006;20(5):546 -552.
26. Fadini GP, Sartore S, Baesso I, et al. Endothelial progenitor cells and the diabetic paradox. Diabetes Care. 2006;29(3):714 -716.
27. Asnaghi V, Lattanzio R, Mazzolari G, et al. Increased clonogenic potential of circulating endothelial progenitor cells in patients with type 1 diabetes and proliferative retinopathy. Diabetologia. 2006;49(5):1109-1111.
28. World Medical Association. Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Helsinki, Finland, 1964; amended in Tokyo, Japan, 1975; Venice, Italy, 1983; Hong Kong, 1989; Somerset West, South Africa, 1996; Edinburgh, Scotland, 2000; Washington, USA, 2002; Tokyo, Japan, 2004. http://www.wma.net/e/policy/b3.htm. Accessed September 25, 2008.
29. US Food and Drug Administration. Guidances, Information Sheets, and Important Notices on Good Clinical Practice in FDA-Regulated Clinical Trials. ICH Harmonised Tripartite Guideline for Good Clinical Practice. http://www.fda.gov/oc/gcp/guidance.html. Accessed September 25, 2008.
30. Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. Official Journal of the European Communities L/21/34 1.5.2001 and the EudraCT Supporting Documentation updated 04/08/05. http://eudract.emea. europa.eu/document.html.
31. Early Treatment Diabetic Retinopathy Study Research Group. ETDRS study design and baseline patient characteristics: ETDRS report number 7. Ophthalmology. 1991;98(suppl):741-756.
32. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy: ETDRS report number 12. Ophthalmology. 1991;98(suppl):823- 833.
33. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from fundus photographs: an extension of the modified Airlie House classification: ETDRS report number 10. Ophthalmology. 1991,98(suppl):786-806.
34. Davis MD, Fisher MR, Gangnon RE, et al. Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: ETDRS report number 18. Invest Ophthalmol Vis Sci. 1998;39(2):233-252.
35. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275(5302):964-967.
36. Gehling UM, Ergün S, Schumacher U, et al. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood. 2000;95(10):3106-3112.
37. + cells identifies a population of functional endothelial precursors. Blood. 2000;95(3):952-958.
38. Blann AD, Pretorius A. Circulating endothelial cells and endothelial progenitor cells: two sides of the same coin, or two different coins? Atherosclerosis. 2006;188:12-18.
39. Stevens T, Rosenberg R, Aird W, et al. NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Am J Physiol Cell Physiol. 2001;281:C1422-C1433.
40. Sutherland DR, Anderson L, Keeney M, Nayar Chin-Yee I. The ISHAGE guidelines for CD34/ cell determination by flow cytometry. J Hematother. 1996;5:213.
41. To LB, Haylock DN, Simmons PJ, Juttner CA. The biology and clinical uses of blood stem cells. Blood. 1997;89(7):2233-2258.
42. + haematopoietic stem cell working party: General Haematology Task Force of the British Committee for Standards in Haematology. Clin Lab Haematol. 1999;21(5):301-308.
43. Rohde E, Bartmann C, Schallmoser K, et al. Immune cells mimic the morphology of endothelial progenitor colonies in vitro. Stem Cells. 2007;25(7):1746-1752.
44. Rohde E, Malischnik C, Thaler D, et al. Blood monocytes mimic endothelial progenitor cells. Stem Cells. 2006;24(2):357-367.
45. Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG. Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension. 2005;46(1):7-18.
46. Rehman J, Li J, Orschell CM, March KL. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107(8):1164-1169.
47. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 2004;95(4):343-353.
48. Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89(1):e:1-7.
49. Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331(22):1480-1487.
50. Wasada T, Kawahara R, Katsumori K, Naruse M, Omori Y. Plasma concentration of immunoreactive vascular endothelial growth factor and its relation to smoking. Metabolism. 1998;47(1):27-30.
51. Chaturvedi N, Fuller JH, Pokras F, Rottiers R, Papazoglou N, Aiello LP. Circulating plasma vascular endothelial growth factor and microvascular complications of type 1 diabetes mellitus: the influence of ACE inhibition (EUCLID). Diabet Med. 2001;18(4):288-294.
52. Watanabe D, Suzuma K, Matsui S, et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med. 2005;353:782-792.
53. Brooks HL Jr, Caballero S Jr, Newell CK, et al. Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch Ophthalmol. 2004;122(12):1801-1807.
54. Eicher A, Zeiher HM, Dimmeler S. Mobilizing endothelial progenitor cells. Hypertension. 2005 45(3):321-325.
55. Tepper OM, Galiano RD, Capla JM, et al. Human endothelial progenitor cells from type II diabetes exhibit impaired proliferation, adhesion and incorporation into vascular structures. Circulation. 2002;106(22):2781- 2786.
56. Caballero S, Sengupta N, Afzal A, et al. Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes. 2007;56(4):960 -967.
57. Klein BE, Klein R, McBride PE, et al. Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin epidemiologic study of diabetic retinopathy. Arch Intern Med. 2004;164(17):1917-1924.
58. van Hecke MV, Dekker JM, Stehouwer CD, et al. Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications study. Diabetes Care. 2005;28(6):1383-1389.