Biomarker-based asthma phenotypes of corticosteroid response

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 4, 2015, Pages 877-883.e1

  Cowan, Douglas C ^a   Taylor, D Robin ^a   Peterson, Laura E ^b   Cowan, Jan O ^a   Palmay, Rochelle ^a   Williamson, Avis ^a   Hammel, Jef ^b   Erzurum, Serpil C ^b   Hazen, Stanley L ^b   Comhair, Suzy A A ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Asthma; biomarker; clinical outcome; fraction of exhaled nitric oxide; inhaled corticosteroids; sputum eosinophils; urinary bromotyrosine

Indexed keywords

ADENOSINE PHOSPHATE; BIOLOGICAL MARKER; BROMOTYROSINE; CORTICOSTEROID; CREATININE; FLUTICASONE; IMMUNOGLOBULIN E; NITRIC OXIDE; UNCLASSIFIED DRUG; TYROSINE;

ADULT; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; CREATININE URINE LEVEL; ELECTROSPRAY; EOSINOPHIL COUNT; EXHALED NITRIC OXIDE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LUNG FUNCTION; MALE; PEAK EXPIRATORY FLOW; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT PARAMETERS; SPUTUM; TREATMENT RESPONSE; URINE LEVEL; ANALOGS AND DERIVATIVES; CASE CONTROL STUDY; EXHALATION; INHALATIONAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; LUNG FUNCTION TEST; ODDS RATIO; PHENOTYPE; PROGNOSIS; TREATMENT OUTCOME; URINE;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ASTHMA; BIOMARKERS; CASE-CONTROL STUDIES; EXHALATION; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; NITRIC OXIDE; ODDS RATIO; PHENOTYPE; PROGNOSIS; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME; TYROSINE;

EID: 84926137106     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.026     Document Type: Article

References (42)

1. National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program Expert panel report 3: guidelines for the diagnosis and management of asthma 2007 National Heart, Lung, and Blood Institute Bethesda (MD) NIH publication no. 07-4051
2. A. Deykin, S.C. Lazarus, J.V. Fahy, M.E. Wechsler, H.A. Boushey, and V.M. Chinchilli Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids J Allergy Clin Immunol 115 2005 720 727
3. H.K. Reddel, D.R. Taylor, E.D. Bateman, L.P. Boulet, H.A. Boushey, and W.W. Busse An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice Am J Respir Crit Care Med 180 2009 59 99
4. R.S. Zeiger, S.J. Szefler, B.R. Phillips, M. Schatz, F.D. Martinez, and V.M. Chinchilli Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma J Allergy Clin Immunol 117 2006 45 52
5. S.J. Szefler, S. Wenzel, R. Brown, S.C. Erzurum, J.V. Fahy, and R.G. Hamilton Asthma outcomes: biomarkers J Allergy Clin Immunol 129 suppl 2012 S9 S23
6. M.A. Berry, D.E. Shaw, R.H. Green, C.E. Brightling, A.J. Wardlaw, and I.D. Pavord The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma Clin Exp Allergy 35 2005 1175 1179
7. A. Jatakanon, S. Lim, S.A. Kharitonov, K.F. Chung, and P.J. Barnes Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma Thorax 53 1998 91 95
8. R.A. Dweik, S.A. Comhair, B. Gaston, F.B. Thunnissen, C. Farver, and M.J. Thomassen NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response Proc Natl Acad Sci U S A 98 2001 2622 2627
9. R.A. Dweik, R.L. Sorkness, S. Wenzel, J. Hammel, D. Curran-Everett, and S.A. Comhair Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma Am J Respir Crit Care Med 181 2010 1033 1041
10. J. Bousquet, P. Chanez, J.Y. Lacoste, G. Barneon, N. Ghavanian, and I. Enander Eosinophilic inflammation in asthma N Engl J Med 323 1990 1033 1039
11. D. Giannini, A. Di Franco, S. Cianchetti, E. Bacci, F.L. Dente, and B. Vagaggini Analysis of induced sputum before and after withdrawal of treatment with inhaled corticosteroids in asthmatic patients Clin Exp Allergy 30 2000 1777 1784
12. P.G. Woodruff, R. Khashayar, S.C. Lazarus, S. Janson, P. Avila, and H.A. Boushey Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma J Allergy Clin Immunol 108 2001 753 758
13. J.C. MacPherson, S.A. Comhair, S.C. Erzurum, D.F. Klein, M.F. Lipscomb, and M.S. Kavuru Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species J Immunol 166 2001 5763 5772
14. W. Wu, M.K. Samoszuk, S.A. Comhair, M.J. Thomassen, C.F. Farver, and R.A. Dweik Eosinophils generate brominating oxidants in allergen-induced asthma J Clin Invest 105 2000 1455 1463
15. S.L. Jones, J. Kittelson, J.O. Cowan, E.M. Flannery, R.J. Hancox, and C.R. McLachlan The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control Am J Respir Crit Care Med 164 2001 738 743
16. C.E. Brightling, F.A. Symon, S.S. Birring, P. Bradding, A.J. Wardlaw, and I.D. Pavord Comparison of airway immunopathology of eosinophilic bronchitis and asthma Thorax 58 2003 528 532
17. P. Haldar, C.E. Brightling, B. Hargadon, S. Gupta, W. Monteiro, and A. Sousa Mepolizumab and exacerbations of refractory eosinophilic asthma N Engl J Med 360 2009 973 984
18. S.H. Wedes, S.B. Khatri, R. Zhang, W. Wu, S.A. Comhair, and S. Wenzel Noninvasive markers of airway inflammation in asthma Clin Transl Sci 2 2009 112 117
19. S.H. Wedes, W. Wu, S.A. Comhair, K.M. McDowell, J.A. DiDonato, and S.C. Erzurum Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children J Pediatr 159 2011 248 255.e1
20. D.C. Cowan, J.O. Cowan, R. Palmay, A. Williamson, and D.R. Taylor Effects of steroid therapy on inflammatory cell subtypes in asthma Thorax 65 2010 384 390
21. Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society Am Rev Respir Dis 144 1991 1202 1218
22. R. Polosa, G.D. Phillips, K. Rajakulasingam, and S.T. Holgate The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5′-monophosphate and histamine in asthma J Allergy Clin Immunol 87 1991 939 947
23. E.F. Juniper, P.M. O'Byrne, G.H. Guyatt, P.J. Ferrie, and D.R. King Development and validation of a questionnaire to measure asthma control Eur Respir J 14 1999 902 907
24. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 2005 912 930
25. J.V. Fahy, J. Liu, H. Wong, and H.A. Boushey Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects Am Rev Respir Dis 147 1993 1126 1131
26. M. Scott, A. Raza, W. Karmaus, F. Mitchell, J. Grundy, and R.J. Kurukulaaratchy Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study Thorax 65 2010 258 262
27. E.F. Juniper, K. Svensson, A.C. Mork, and E. Stahl Measurement properties and interpretation of three shortened versions of the asthma control questionnaire Respir Med 99 2005 553 558
28. S.D. Anderson, and J.D. Brannan Methods for "indirect" challenge tests including exercise, eucapnic voluntary hyperpnea, and hypertonic aerosols Clin Rev Allergy Immunol 24 2003 27 54
29. I.D. Pavord, C.E. Brightling, G. Woltmann, and A.J. Wardlaw Non-eosinophilic corticosteroid unresponsive asthma Lancet 353 1999 2213 2214
30. A. Michils, S. Baldassarre, and A. Van Muylem Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients Eur Respir J 31 2008 539 546
31. M. Wegmann Targeting eosinophil biology in asthma therapy Am J Respir Cell Mol Biol 45 2011 667 674
32. L. Fleming, N. Wilson, N. Regamey, and A. Bush Use of sputum eosinophil counts to guide management in children with severe asthma Thorax 67 2012 193 198
33. R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
34. C. Lemiere, P. Ernst, R. Olivenstein, Y. Yamauchi, K. Govindaraju, and M.S. Ludwig Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes J Allergy Clin Immunol 118 2006 1033 1039
35. C. Lane, D. Knight, S. Burgess, P. Franklin, F. Horak, and J. Legg Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath Thorax 59 2004 757 760
36. J.L. Puckett, and S.C. George Partitioned exhaled nitric oxide to non-invasively assess asthma Respir Physiol Neurobiol 163 2008 166 177
37. L. Fleming, L. Tsartsali, N. Wilson, N. Regamey, and A. Bush Longitudinal relationship between sputum eosinophils and exhaled nitric oxide in children with asthma Am J Respir Crit Care Med 188 2013 400 402
38. E. Bacci, S. Cianchetti, M. Bartoli, F.L. Dente, A. Di Franco, and B. Vagaggini Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients Chest 129 2006 565 572
39. H.M. Brown Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum Lancet 2 1958 1245 1247
40. J.D. Leuppi, C.M. Salome, C.R. Jenkins, S.D. Anderson, W. Xuan, and G.B. Marks Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids Am J Respir Crit Care Med 163 2001 406 412
41. E. Pizzichini, M.M. Pizzichini, A. Efthimiadis, S. Evans, M.M. Morris, and D. Squillace Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements Am J Respir Crit Care Med 154 1996 308 317
42. A. Jatakanon, S. Lim, and P.J. Barnes Changes in sputum eosinophils predict loss of asthma control Am J Respir Crit Care Med 161 2000 64 72