Protective mechanism of sulindac in an animal model of ischemic stroke

Brain Research

Volumn 1576, Issue , 2014, Pages 91-99

  Modi, Jigar Pravinchandra ^a,b   Gharibani, Payam M ^a,d   Ma, Zhiyuan ^a   Tao, Rui ^a,b   Menzie, Janet ^b   Prentice, Howard ^a,b   Wu, Jang Yen ^a,b,c  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt Bcl2; Grp 78; Hsp 27; Stroke Sulindac

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 27; PROTEIN BAK; PROTEIN BCL 2; PROTEIN KINASE B; PUMA PROTEIN; SULINDAC; AKT1 PROTEIN, RAT; HEAT SHOCK PROTEIN; HSPA5 PROTEIN, RAT; HSPB1 PROTEIN, RAT; NERVE PROTEIN; NEUROPROTECTIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; FUNCTIONAL DISEASE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; PREMEDICATION; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HSP27 HEAT-SHOCK PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PREMEDICATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SULINDAC; UP-REGULATION;

EID: 84926126497     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.06.019     Document Type: Article

References (45)

1. Badin, R.A., Lythgoe, M.F., van der Weerd, L., Thomas, D.L., Gadian, D.G., Latchman, D.S., 2006. Neuroprotective effects of virally delivered HSPs in experimental stroke. J. Cereb. Blood Flow Metab. 26, 371-381.
2. Bederson, J.B., Pitts, L.H., Germano, S.M., Nishimura, M.C., Davis, R.L., Bartkowski, H.M., 1986. Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17, 1304-1308.
3. Buddhala, C., Suarez, M., Modi, J., Prentice, H., Ma, Z., Tao, R., et al., 2012. Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission. PLoS One 7, e33002.
4. Chen, J., Graham, S.H., Nakayama, M., Zhu, R.L., Jin, K., Stetler, R. A., et al., 1997. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J. Cereb. Blood Flow Metab. 17, 2-10.
5. Chen, Y., Ito, A., Takai, K., Saito, N., 2008. Blocking pterygopalatine arterial blood flow decreases infarct volume variability in a mouse model of intraluminal suture middle cerebral artery occlusion. J. Neurosci. Methods 174, 18-24.
6. Concannon, C.G., Gorman, A.M., Samali, A., 2003. On the role of Hsp27 in regulating apoptosis. Apoptosis 8, 61-70.
7. Davies, A.M., 1995. The Bcl-2 family of proteins, and the regulation of neuronal survival. Trends Neurosci. 18, 355-358.
8. Efthymiou, C.A., Mocanu, M.M., de Belleroche, J., Wells, D.J., Latchmann, D.S., Yellon, D.M., 2004. Heat shock protein 27 protects the heart against myocardial infarction. Basic Res. Cardiol. 99, 392-394.
9. Etienne, F., Resnick, L., Sagher, D., Brot, N., Weissbach, H., 2003. Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system. Biochem. Biophys. Res. Commun. 312, 1005-1010.
10. Gabai, V.L., Sherman, M.Y., 2002. Invited review: interplay between molecular chaperones and signaling pathways in survival of heat shock. J. Appl. Physiol. 92, 1743-1748.
11. Gharibani, P.M., Modi, J., Pan, C., Menzie, J., Ma, Z., Chen, P.-C., et al., 2013. The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture. Adv. Exp. Med. Biol. 776, 241-258.
12. Hayashi, T., Saito, A., Okuno, S., Ferrand-Drake, M., Chan, P.H., 2003. Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death. J. Cereb. Blood Flow Metab. 23, 949-961.
13. Hennekens, C.H., Borzak, S., 2008. Cyclooxygenase-2 inhibitors and most traditional nonsteroidal anti-inflammatory drugs cause similar moderately increased risks of cardiovascular disease. J. Cardiovasc. Pharmacol. Ther. 13, 41-50.
14. Henshall, D.C., Engel, T., 2013. Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts. Front. Cell. Neurosci. 7, 110.
15. Hollander, J.M., Martin, J.L., Belke, D.D., Scott, B.T., Swanson, E., Krishnamoorthy, V., et al., 2004. Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation 110, 3544-3552.
16. Hong, L.-Z., Zhao, X.-Y., Zhang, H.-L., 2010. p53-Mediated neuronal cell death in ischemic brain injury. Neurosci. Bull. 26, 232-240.
17. Kuroki, K., Virard, I., Concannon, C.G., Engel, T., Woods, I., Taki, W., et al., 2009. Effects of transient focal cerebral ischemia in mice deficient in puma. Neurosci. Lett. 451, 237-240.
18. Li, F., Irie, K., Anwer, M.S., Fisher, M., 1997. Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model. J. Cereb. Blood Flow Metab. 17, 1132-1135.
19. Linnik, M.D., Zahos, P., Geschwind, M.D., Federoff, H.J., 1995. Expression of bcl-2 from a defective herpes simplex virus 1 vector limits neuronal death in focal cerebral ischemia. Stroke 26, 1670-1675.
20. Ma, Y., Hendershot, L.M., 2001. The unfolding tale of the unfolded protein response. Cell 107, 827-830.
21. Macrae, I.M., 2011. Preclinical stroke research - advantages and disadvantages of the most common rodent models of focal ischaemia. Br. J. Pharmacol. 164, 1062-1078.
22. Marchetti, M., Resnick, L., Gamliel, E., Kesaraju, S., Weissbach, H., Binninger, D., 2009. Sulindac enhances the killing of cancer cells exposed to oxidative stress. PLoS One 4, e5804.
23. Moench, I., Prentice, H., Rickaway, Z., Weissbach, H., 2009. Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms. Proc. Natl. Acad. Sci. USA 106, 19611-19616.
24. Mohammad-Gharibani, P., Tiraihi, T., Delshad, A., Arabkheradmand, J., Taheri, T., 2013. Improvement of contusive spinal cord injury in rats by co-transplantation of gamma-aminobutyric acid-ergic cells and bone marrow stromal cells. Cytotherapy, http://dxdoi.org/10.1016/j.jcyt.2013.05.002.
25. Mohammad-Gharibani, P., Modi, J., Menzie, J., Genova, R., Ma, Z., Tao, R., et al., 2014. Mode of action of S-methyl-N, N-diethylthiocarbamate sulfoxide (DETC-MeSO) as a novel therapy for stroke in a rat model. Mol. Neurobiol., http://dxdoi.org/10.1007/s12035-014-8658-0.
26. Morris, J.A., Dorner, A.J., Edwards, C.A., Hendershot, L.M., Kaufman, R.J., 1997. Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins. J. Biol. Chem. 272, 4327-4334.
27. Niizuma, K., Endo, H., Nito, C., Myer, D.J., Chan, P.H., 2009. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke 40, 618-625.
28. O'Neill, M.J., Clemens, J.A., 2001. Rodent models of focal cerebral ischemia. Curr. Protoc. Neurosci. Chapter 9: Unit 9.6.
29. Popp, A., Jaenisch, N., Witte, O.W., Frahm, C., 2009.Identification of ischemic regions in a rat model of stroke. PLoS One 4, e4764.
30. Prasad, S.S., Russell, M., Nowakowska, M., 2011. Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways. J. Mol. Neurosci. 43, 428-442.
31. Rane, M.J., Klein, J.B., 2009. Regulation of neutrophil apoptosis by modulation of PKB/Akt activation. Front. Biosci. 14, 2400-2412.
32. Rane, M.J., Pan, Y., Singh, S., Powell, D.W., Wu, R., Cummins, T., et al., 2003. Heat shock protein 27 controls apoptosis by regulating Akt activation. J. Biol. Chem. 278, 27828-27835.
33. Rich, P.R., Mischis, L.A., Purton, S., Wiskich, J.T., 2001. The sites of interaction of triphenyltetrazolium chloride with mitochondrial respiratory chains. FEMS Microbiol. Lett. 202, 181-187.
34. Srinivasan, K., Sharma, S.S., 2011. Augmentation of endoplasmic reticulum stress in cerebral ischemia/reperfusion injury associated with comorbid type 2 diabetes. Neurol. Res. 33, 8.
35. Steckley, D., Karajgikar, M., Dale, L.B., Fuerth, B., Swan, P., Drummond-Main, C., et al., 2007. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J. Neurosci. 27, 12989-12999.
36. Stetler, R.A., Cao, G., Gao, Y., Zhang, F., Wang, S., Weng, Z., et al., 2008. Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling. J. Neurosci. 28, 13038-13055.
37. Stetler, R.A., Gao, Y., Signore, A.P., Cao, G., Chen, J., 2009. HSP27: mechanisms of cellular protection against neuronal injury. Curr. Mol. Med. 9, 863-872.
38. Sun, B., Chen, L., Wei, X., Xiang, Y., Liu, X., Zhang, X., 2011. The Akt/GSK-3p pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem. Biophys. Res. Commun. 409, 808-813.
39. Taketo, M.M., 1998. Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I). J. Natl. Cancer. Inst. 90, 1529-1536.
40. Vane, J.R., 1971. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat.: New Biol. 231, 232-235.
41. Virtanen, T., Sivenius, J., Jolkkonen, J., 2003. Dehydration and stress do not explain severe weight loss after experimental stroke in rats. J. Anim. Veterinary Adv. 2 (4), 247-252.
42. Xu, X.-H., Zhang, H.-L., Han, R., Gu, Z.-L., Qin, Z.-H., 2006. Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Brain Res. 1102, 154-162.
43. Ye, Z., Wang, N., Xia, P., Wang, E., Liao, J., Guo, Q., 2013. Parecoxib suppresses CHOP and Foxo1 nuclear translocation, but increases GRP78 levels in a rat model of focal ischemia. Neurochem. Res. 38, 686-693.
44. Yu, Z., Luo, H., Fu, W., Mattson, M.P., 1999. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp. Neurol. 155, 302-314.
45. Van der Weerd, L., Tariq Akbar, M., Aron Badin, R., Valentim, L.M., Thomas, D.L., Wells, D.J., et al., 2010. Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia. J. Cereb. Blood Flow Metab. 30, 849-856.