Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors

Molecular Nutrition and Food Research

Volumn 59, Issue 4, 2015, Pages 729-740

  Kondo, Kensuke ^a   Ishida, Tatsuro ^a   Yasuda, Tomoyuki ^a   Nakajima, Hideto ^a   Mori, Kenta ^a   Tanaka, Nobuaki ^a   Mori, Takeshige ^a   Monguchi, Tomoko ^a   Shinohara, Masakazu ^a   Irino, Yasuhiro ^a   Toh, Ryuji ^a   Rikitake, Yoshiyuki ^a   Kiyomizu, Kazunobu ^b   Tomiyama, Yoshiaki ^b,c   Yamamoto, Junichiro ^d   Hirata, Ken ichi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY HOSPITAL   (Japan)

^d KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Endothelial dysfunction; Inflammation; Thrombosis; Toll like receptor; Trans fatty acid

Indexed keywords

ANIMALIA; MUS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPROTEIN; LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THROMBOMODULIN; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANS FATTY ACID;

ANIMAL; C3H MOUSE; C57BL MOUSE; CHEMICALLY INDUCED; CYTOLOGY; DIET; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOSIS; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; VASCULAR ENDOTHELIUM;

ANIMALS; DIET; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPROTEINS; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THROMBOMODULIN; THROMBOSIS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRANS FATTY ACIDS; UP-REGULATION;

EID: 84926080893     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400537     Document Type: Article

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