Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 2, 1998, Pages 316-322

  Turpeinen, Anu M ^a   Wübert, Joachim ^b   Aro, Antti ^c   Lorenz, Reinhard ^b   Mutanen, Marja ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

2,3 Dinor 6 keto PGF(1 ); 2,3 Dinor TXB2; Platelet activation; Stearic acid; Trans fatty acids

Indexed keywords

2,3 DINOR 6 OXOPROSTAGLANDIN F1 ALPHA; 2,3 DINORTHROMBOXANE B2; BETA THROMBOGLOBULIN; FATTY ACID; PROSTACYCLIN; STEARIC ACID; THROMBOXANE B2;

ADULT; ARTICLE; CORONARY ARTERY DISEASE; FEMALE; HUMAN; LIPID DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; VASCULAR ENDOTHELIUM;

EID: 0031837240     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.2.316     Document Type: Article

References (20)

1. Mensink RP, Katan MB. Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. Engl J Med. 1990:323:439-445.
2. Zock PL, Katan MB. Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. J Lipid Res. 1992;33:399-410.
3. Mensink RP, Zock PL, Katan MB, Hornstra GJ. Effect of dietary cis and trans fatty acids on serum lipoprotein (a) levels in humans. J Lipid Res. 1992:33:1493-1501.
4. Nestel P, Noakes M, Belling B, McAnhur R, Clifton P, Janus E, Abbey M. Plasma lipoprotein lipid and Lp(a) changes with substitution of elaidic acid for oleic acid in the diet. J Lipid Res. 1992;33:1029-1036.
5. Lichtenstein AH, Ausman LM, Carrasco W, Jenner JL, Ordovas JM, Schaefer EJ. Hydrogenation impairs the hypolipidemic effect of corn oil in humans. Arterioscler Thromb. 1993;13:154-161.
6. Clevidence BA, Judd JT, Schaefer EJ, McNamara JR, Muesing RA, Wittes J, Sunkin ME. Plasma lipoprotein(a) levels in subjects consuming trans fatty acids. FASEB J. 1995;9:A579. Abstract.
7. Hwang DH, Chanmugam P, Anding R. Effects of dietary 9-trans, 12-trans linoleate on arachidonic acid metabolism in rat platelets. Lipids. 1982;17: 307-313.
8. Peacock LIL, Wahle KWJ. Isomeric cis and trans fatty acids and porcine platelet reactivity to collagen in vitro. Biochem Soc Trans. 1988:16:291.
9. MacIntyre DE, Hoover RL, Smith M, Steer M, Lynch C, Kamovsky MJ, Sakman EW. Inhibition of platelet function by cis-unsaturated fatty acids. Blood. 1984;63:848-857.
10. Bonanome A, Grundy SM. Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med. 1988;318:1244-1248.
11. Denke MA, Grundy SM. Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. Am J Clin Nutr. 1991;54:1036-1040.
12. Detr J, Kris-Etherton PM, Pearson TA, Seligson FH. The role of fatty acid saturation on plasma lipids, lipoproteins, and apoproteins, II: the plasma total and low-density lipoprotein cholesterol response of individual fatty acids. Metabolism. 1993:42:130-134.
13. Renaud S, Dumont E, Godsey F, Suplisson A, Thevenon C. Platelet function in relation to dietary fats in farmers from two regions of France. Thromb Haemost. 1978;40:518-531.
14. Hornstra G. Dietary Fats, Prostanoids and Arterial Thrombosis. The Hague, Netherlands: Martinus Nijhof Publishers; 1982:44-62.
15. Hoak JC. Stearic acid, clotting, and thrombosis. Am J Clin Mitr. 1994; 60(suppl):1050S-1053S.
16. Blair IA, Dougherty RM, Iacono JM. Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. Am J Clin Nutr. 1994;60(suppl):1054S-1058S.
17. Aro A, Jauhiainen M, Partanen R, Salminen I, Mutanen M. Dairy fat, stearic acid, and trans fatty acids: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins of healthy subjects. Am J Clin Mur. 1997;65:1419-1426.
18. Mutanen M, Aro A. Coagulation and fibrinolysis factors in healthy subjects consuming high stearic or trans fatty acid diets. Thromb Haemost. 1997;77: 99-104.
19. Zock PL, Blijlevens RAMT, de Vries JHM, Katan MB. Effect of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. Eur J Clin Nutr. 1993;47:437-444.
20. 2 generation and altered membrane fatty acid composition in platelets from patients with active angina pectoris. Thromb Res. 1986;44:101-102.