Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 13, 2015, Pages 3949-3954

  Donovan, Jesse ^a   Whitney, Gena ^a   Rath, Sneha ^a   Korennykh, Alexei ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

2 5A; DsRNA; Interferon; OAS3; RNase L

Indexed keywords

ASPARTIC ACID; DOUBLE STRANDED RNA; MANGANESE; OLIGOADENYLATE SYNTHETASE 3; POLYINOSINIC POLYCYTIDYLIC ACID; RNA POLYMERASE; SYNTHETASE; UNCLASSIFIED DRUG; 2',5' OLIGOADENYLATE SYNTHETASE; 2',5'-OLIGOADENYLATE; 2-5A-DEPENDENT RIBONUCLEASE; ADENINE NUCLEOTIDE; INTERFERON; OAS1 PROTEIN, HUMAN; OAS3 PROTEIN, HUMAN; OLIGORIBONUCLEOTIDE; PROTEIN BINDING; RIBONUCLEASE;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HELA CELL LINE; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; RNA BINDING; RNA STRUCTURE; SYNTHESIS; CHEMISTRY; INNATE IMMUNITY; MOLECULAR MODEL; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

2',5'-OLIGOADENYLATE SYNTHETASE; ADENINE NUCLEOTIDES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENDORIBONUCLEASES; HELA CELLS; HUMANS; IMMUNITY, INNATE; INTERFERONS; MODELS, MOLECULAR; OLIGORIBONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, DOUBLE-STRANDED;

EID: 84926059445     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419409112     Document Type: Article

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