Gene structure and function of the 2'-5'-oligoadenylate synthetase family

Cellular and Molecular Life Sciences

Volumn 57, Issue 11, 2000, Pages 1593-1612

  Justesen, J ^a   Hartmann, R ^a   Kjeldgaard, N O ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

2 5A; Chromosome 12; Exon structure; OAS; OAS genes; OASL; Oligoadenylate synthetase

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; INTERFERON; JANUS KINASE; PROTEIN TYROSINE KINASE; STAT PROTEIN;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; APOPTOSIS; CELL GROWTH; CHROMOSOMAL LOCALIZATION; CHROMOSOME 12; ENZYME ACTIVITY; ENZYME ISOLATION; EVOLUTION; EXPRESSED SEQUENCE TAG; GENE FUNCTION; GENE STRUCTURE; MULTIGENE FAMILY; PROMOTER REGION; REVIEW;

JANUS;

EID: 0033792511     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000644     Document Type: Review

References (81)

1. Constitutive expression of (2'-5') oligo A synthetase confers resistance to picornavirus infection
2. A mammalian 2-5A system functions as an antiviral pathway in transgenic plants
3. Virus-induced cell death in plants expressing the mammalian 2',5' oligoadenylate system
4. A bipartite model of 2-5A-dependent RNase L.
5. Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: A novel oligonucleotide synthesized by interferon-treated L cell extracts
6. Interferon action may be mediated by activation of a nuclease by pppA2'p5'A2'p5'A
7. Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
8. Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L
9. Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells
10. The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis
11. Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells
12. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies
13. Interferon action: Two (2'-5')(A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon
14. Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis
15. Two types of chicken 2',5'-oligoadenylate synthetase mRNA derived from alleles at a single locus
16. Origin of the interferon-inducible (2'-5')oligoadenylate synthetases: Cloning of the (2'-5')oligoadenylate synthetase from the marine sponge Geodia cydonium
17. p59OASL, A 2'-5' oligoadenylate synthetase like protein: A novel human gene related to the 2'-5' oligoadenylate synthetase family
18. Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase
19. M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells
20. Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences
21. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains
22. The human 2',5'-oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties
23. Human 2-5A synthetase: Characterization of a novel cDNA and corresponding gene structure
24. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus
25. The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms
26. Production, purification, and characterization of recombinant 2', 5'-oligoadenylate synthetases
27. How cells respond to interferons
28. Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis
29. Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA
30. Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells
31. pppA2'p5'A2'p5'A: An inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells
32. Isolation of two interferon-induced translational inhibitors: A protein kinase and an oligo-isoadenylate synthetase
33. Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase
34. Interferon, double-stranded RNA, and RNA degradation: Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells
35. Interferons, double-stranded RNA, and RNA degradation: Isolation and characterization of homogeneous human (2'-5')(A)n synthetase
36. Purification of 2',5'-oligoadenylate synthetase from rabbit reticulocytes
37. Interferon-induced enzymes: Microassays and their applications - Purification and assay of (2'-5')-oligoadenylate synthetase and assay of 2'-phosphodiesterase
38. Differential expression and distinct structure of 69-and 100-kDa forms of 2-5A synthetase in human cells treated with interferon
39. Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells
40. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein
41. The role of interferon-induced proteins, double-stranded RNA and 2',5'-oligoadenylate in the interferon-mediated inhibition of viral translation
42. Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase
43. 2'5' Oligoadenylate synthetase, an interferon induced enzyme: Direct assay methods for the products, 2'5' oligoadenylates and 2'5' cooligonucleotides
44. Spectrophotometric pyrophosphate assay of 2',5'-oligoadenylate synthetase
45. The 2'5' oligoadenylate synthetase has a multifunctional 2'5' nucleotidyl-transferase activity
46. Novel 2',5'-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells
47. Ap3A and Ap4A are primers for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase
48. 2'-Adenylated derivatives of Ap3A activate RNase L
49. Interferon action: Binding of viral RNA to the 40-kilodalton 2'-5'-oligoadenylate synthetase in interferon-treated HeLa cells infected with encephalomyocarditis virus
50. Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) poly(cytidylic acid): Correlations with interferon-inducing activity
51. Activation of 2-5 oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers
52. Structural requirements of double-stranded RNA for the activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells
53. Effects of varying lengths of double-stranded RNA on binding and activation of 2'-5'-oligoadenylate synthetase
54. Identification of the ATP binding domain of recombinant human 40-kDa 2',5'-oligoadenylate synthetase by photoaffinity labeling with 8-azido-[alpha-32P]ATP
55. The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases
56. Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases: Structure-function relationships
57. Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein
58. Effects of mutating specific residues present near the amino terminus of 2'-5'-oligoadenylate synthetase
59. Production and purification of recombinant 2'-5' oligoadenylate synthetase and its mutants using the baculovirus system
60. Cloning and characterization of a RNAse L inhibitor: A new component of the interferon-regulated 2-5A pathway
61. Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells
62. 3' End structure of the human (2'-5') oligo A synthetase gene: Prediction of two distinct proteins with cell type-specific expression
63. Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon
64. Cloning and chromosomal location of human genes inducible by type I interferon
65. Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene
66. Mouse 2-5A synthetase cDNA: Nucleotide sequence and comparison to human 2-5A synthetase
67. A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication
68. The p69/71 2-5A synthetase promoter contains multiple regulatory elements required for interferon-alpha-induced expression
69. The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains
70. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
71. Interferon regulatory factors: The next generation
72. An overview of the interferon system: Signal transduction and mechanisms of action
73. Enhancer-like interferon responsive sequences of the human and murine (2'-5') oligoadenylate synthetase gene promoters
74. Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene
75. Transcriptional induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha is stimulated by 12-O-tetradecanoyl phorbol-13-acetate through IRF/ISRE binding motifs
76. Protein synthesis-dependent and -independent induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha
77. The murine 2-5A synthetase locus: Three distinct transcripts from two linked genes
78. Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions
79. The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges: Demonstration of the existence and identification of its reaction products
80. Identification of the reaction products of (2'-5')oligoadenylate synthetase in the marine sponge
81. M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells