PAF receptor and tumor growth

Current Drug Targets

Volumn 15, Issue 10, 2014, Pages 982-987

  Jancar, Sonia ^a   Chammas, Roger ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chemotherapy; PAF receptor; Tumor growth; Tumor macrophages; Tumor microenvironment

Indexed keywords

CD36 ANTIGEN; CYCLOOXYGENASE 2; GALECTIN 3; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 33; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; SCAVENGER RECEPTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ADAPTIVE IMMUNITY; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER CHEMOTHERAPY; DENDRITIC CELL; DESENSITIZATION; HUMAN; HYPOXIA; LIPID PEROXIDATION; NONHUMAN; PHOTODYNAMIC THERAPY; SMOOTH MUSCLE CONTRACTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; WOUND HEALING; ANTAGONISTS AND INHIBITORS; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; METABOLISM; NEOPLASMS; PATHOLOGY;

ADAPTIVE IMMUNITY; HUMANS; IMMUNITY, INNATE; MACROPHAGES; NEOPLASMS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, G-PROTEIN-COUPLED; TUMOR MICROENVIRONMENT;

EID: 84925967957     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Ishii S, Nagase T, Shimizu T. Platelet-activating factor receptor. Prostaglandins Other Lipid Mediat 2002; 68-69: 599-609.
2. Honda Z, Nakamura M, Miki I, et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 1991; 349(6307): 342-6.
3. Chao W, Olson MS. Platelet-activating factor: receptors and signal transduction. Biochem J 1993; 292: 617-29.
4. Marreche AM, Gobeil F Jr, Bernier SG, et al. Pro-inflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. J Immunol 2002; 169(11): 6474-81.
5. Gobeil F, Fortier A, Zhu T, et al. G-protein-coupled receptors signaling at the cell nucleus: an emerging paradigm. Can J Physiol Pharmacol 2006; 84(3-4): 287-97.
6. Zhu T, Gobeil F, Vazquez-Tello A, et al. Intracrine signaling through lipid mediators and their cognate nuclear G-proteincoupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Can J Physiol Pharmacol 2006; 84(3-4): 377-91.
7. Dupré DJ, Chen Z, Le Gouill C, et al. Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor. J Biol Chem 2003; 278(48): 48228-35.
8. Benveniste J, Henson PM, Cochrane CG. Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J Exp Med 1972; 136(6): 1356-77.
9. Prescott SM, Zimmerman GA, Stafforini DM, McIntyre TM. Platelet-activating factor and related lipid mediators. Annu Rev Biochem 2000; 69: 419-45.
10. Zimmerman GA, Elstad MR, Lorant DE, et al. Platelet-activating factor (PAF): signaling and adhesion in cell-cell interactions. Adv Exp Med Biol 1996; 416: 297-304.
11. Smiley PL, Stremler SM, Prescott GA, et al. oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor. J Biol Chem 1991; 266: 11104-10.
12. McIntyre TM. Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: formation, targets and inactivation. Biochim Biophys Acta 2012; 1818(10): 2456-64.
13. Marathe GK, Johnson C, Billings SD, et al. Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem 2005; 280(42): 35448-57.
14. Sahu RP, Turner MJ, DaSilva SC, et al. The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis 2012; 33 (7): 1360-67.
15. Sahu RP, Petrache I, Van Demark MJ, et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of plateletactivating factor agonists. J Immunol 2013; 190(5): 2447-54.
16. Ferracini M, Sahu RP, Harrison KA, et al. Topical Photodynamic Therapy Induces Systemic Immunosuppression via Generation of Platelet-Activating Factor Receptor Ligands. J Invest Dermatol. 2014 Jul 22. [Epub ahead of print].
17. Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296(5566): 298-300.
18. Miller YI, Choi SH, Wiesner P. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res 2011; 108(2): 235-48.
19. Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2014; 25(12); 677-86.
20. MosserDM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8 (12): 958-69.
21. Lonardoni MV, Russo M, Jancar S. Essential role of plateletactivating factor in control of Leishmania (Leishmania) amazonensis infection. Infect Immun 2000; 68(11): 6355-61.
22. Aliberti JC, Machado FS, Gazzinelli RT, et al. Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. Infect Immun 1999; 67(6): 2810-4.
23. Soares AC, Pinho VS, Souza DG, et al. Role of the plateletactivating factor (PAF) receptor during pulmonary infection with gram negative bacteria. Br J Pharmacol 2002; 137(5): 621-8.
24. Talvani A, Santana G, Barcelos LS, et al. Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. Microbes Infect. 2003; 5(9): 789-96.
25. Korns D, Frasch SC, Fernandez-Boyanapalli R, Henson PM, Bratton DL. Modulation of macrophage efferocytosis in inflammation. Front Immunol 2011; 2: 57.
26. Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest 2001; 108(7): 957-62.
27. de Oliveira SI, Fernandes PD, Amarante-Mendes JG, et al. Phagocytosis of apoptotic and necrotic thymocytes is inhibited by PAFreceptor antagonists and affects LPS-induced COX2 expression in murine macrophages. Prostaglandins Other Lipid Mediators 2006; 80 (1-2): 62-73.
28. Freire de Lima CG, Xiao YQ, Gardai SJ, et al. Apoptotic cells, through transforming growth facto beta, coordinately induce antiinflammatory and suppress pro-inflammatory eicosanois and NO synthesis in murine macrophages. J Biol Chem 2006; 281 (50): 38376-84.
29. Ferracini M, Rios FJ, Pecenin M, Jancar S. Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of CD36 and platelet-activating factor receptor. Mediators Inflamm 2013; 2013: e950273.
30. Hazen SI. Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity. J Biol Chem 2008; 283(23): 15527-31.
31. Rios FJ, Koga MM, Ferracini M, Jancar S. Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation. PLoS One 2012; 7(5): e36632.
32. Koga MM, Bizzarro B, Sa-Nunes A, et al. Activation of PAFreceptor induces regulatory dendritic cells through PGE2 and IL-10. Prostaglandins Leukot Essent Fatty Acids 2013; 89(5): 319-26.
33. Mantovani A, Sozzani S, Locati M, et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes, Trends Immunol 2002; 23 (11): 549-55.
34. Noy R, Pollard JW. Tumor-Associated Macrophages: From Mechanisms to Therapy. Immunity. 2014; 41(1): 49-61.
35. Fecchio D, Sirois P, Russo M, Jancar S. Studies on inflammatory response induced by Ehrlich tumor in mice peritoneal cavity. Inflammation 1990; 14(1): 125-32.
36. Fecchio D, Russo M, Sirois P, Braquet P, Jancar S. Inhibition of Ehrlich ascites tumor in vivo by PAF-antagonists. Int J Immunopharmacol 1990; 12(1): 57-65.
37. de Oliveira SI, Andrade LN, Onuchic AC, et al. Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy. BMC Cancer 2010; 10: e200.
38. MacKinnon AC, Farnworth SL, Hodkinson PS, et al. Regulation of alternative macrophage activation by galectin-3. J Immunol 2008; 180(4): 2650-8.
39. Ishii S, Nagase T, Tashiro F, et al. Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J 1997; 16(1): 133-42.
40. Correa M, Machado J, Jr., Carneiro CR, et al. Transient inflammatory response induced by apoptotic cells is an important mediator of melanoma cell engraftment and growth. Int J Cancer 2005; 114(3): 356-63.
41. Bachi AL, Dos Santos LC, Nonogaki S, et al. Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. Mediators Inflamm 2012; 2012: e610371.
42. Bussolati B, Biancone L, Cassoni P, et al. PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. Am J Pathol 2000; 157(5): 1713-25.
43. Biancone L, Cantaluppi V, Del Sorbo L, et al. Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. Clin Cancer Res 2003; 9(11): 4214-20.
44. Zhang L, Wang D, Jiang W, et al. Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrinol 2010; 8: 74.
45. Braeuer RR, Zigler M, Villares GJ, et al. Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment. Semin Cancer Biol 2011; 21(2): 83-8.
46. Im SY, Ko HM, Kim JW. Augmentation of tumor metastasis by platelet-activating factor. Cancer Res 1996; 56(11): 2662-5.
47. Melnikova VO, Villares GJ, Bar-Eli M. Emerging roles of PAR-1 and PAFR in melanoma metastasis. Cancer Microenviron 2008; 1(1): 103-11.
48. Onuchic AC, Machado CM, Saito RF, et al. Expression of PAFR as part of a pro-survival response to chemotherapy: a novel target for combination therapy in melanoma. Mediators Inflamm 2012; 2012: 175408.
49. Heon Seo K, Ko HM, Kim HA, et al. Platelet-activating factor induces up-regulation of anti-apoptotic factors in a melanoma cell line through nuclear factor-kappaB activation. Cancer Res 2006; 66(9): 4681-6.
50. Huang Q, Li F, Liu X, et al. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med 2011; 17(7): 860-6.