Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 2810-2814

  Aliberti, Júlio C S ^a   Machado, Fabiana S ^a   Gazzinelli, Ricardo T ^b   Teixeira, Mauro M ^b   Silva, João S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BEPAFANT; CYTOKINE; GAMMA INTERFERON; MONOCLONAL ANTIBODY; NITRIC OXIDE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; INFECTION RESISTANCE; INFECTION SENSITIVITY; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; RECEPTOR BLOCKING; SURVIVAL RATE; TRYPANOSOMA CRUZI;

EID: 0033052472     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2810-2814.1999     Document Type: Article

References (29)

1. Aliberti, J. C., M. A. Cardoso, G. A. Martins, R. T. Gazzinelli, L. Q. Vieira, and J. S. Silva. 1996. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect. Immun. 64:1961-1967.
2. Bussolati, B., F. Mariana, A. Cignetti, A. Guarini, V. Cambi, R. Foa, G. Piccoli, and G. Camussi. 1998. Platelet-activating factor synthesized by IL-12-stimulated polymorphonuclear neutrophils and NK cells mediates chemotaxis. J. Immunol. 161:1493-1500.
3. Braquet, P., L. Touqui, T. Y. Shen, and B. B. Vargaftig. 1987. Perspectives in platelet-activating factor research. Pharmacol. Rev. 39:97-145.
4. Camussi, G., M. Aglietta, R Coda, F. Bussolino, W. Piacibello, and C. Tetta. 1981. Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils. Immunology 42:191-199.
5. Cardillo, F., J. C. Voltarelli, S. G. Reed, and J. S. Silva. 1996. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infect. Immun. 64:128-134.
6. Chandrasekar, B., P. C. Melby, D. A. Trover, J. T. Colston, and G. L. Freeman. 1998. Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy. Am. J. Pathol. 152:925-934.
7. Chao, W., and M. S. Olson. 1993. Platelet-activating factor: receptors and signal transduction. Biochem. J. 292:617-629.
8. Chignardi, M., J. P. Le Couedic, M. Tence, B. B. Vargaftig, and J. Benreniste. 1979. The role of platelet-activating factor in platelet aggregation. Nature 279:799-800.
9. Ding, A., C. F. Nathan, and D. J. Stuher. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
10. Drapier, J. C., J. Wietzerbin, and J. B. Hibbs, Jr. 1988. Interferon-gamma and tumor necrosis factor induce the L-arginine dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1587-1592.
11. Dubois, C., E. Bissonnette, and M. Rola-Pleszczynski. 1989. Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. Prevention by PAF receptor antagonists and lipoxygenase inhibitors. J. Immunol. 143:964-970.
12. Gazzinelll, R. T., I. P. Oswald, S. Hienry, S. L. James, and A. Sher. 1992. The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. Eur. J. Immunol. 22:2501-2506.
13. Howard, A. D., and K. L. Erickson. 1995. The induction and augmentation of macrophage tumoricidal responses by platelet-activating factor. Cell. Immunol. 164:105-112.
14. Im, S.-Y., H.-M. Ko, Y.-S. Ko, J.-W. Kim, H.-K. Lee, T.-Y. Ha, H. B. Lee, S.-J. Oh, S. Bai, K.-C. Chung, Y.-B. Lee, H.-S. Kang, and S.-B. Chun. 1996. Augmentation of tumor metastasis by platelet-activating factor. Cancer Res. 56:2662-2665.
15. Im, S.-Y., J.-H. Choi, H.-M. Ko, S.-J. Han, S.-B. Chun, H.-K. Lee, and T.-Y. Ha. 1997. A protective role of platelet-activating factor in murine candidiasis. Infect. Immun. 65:1321-1326.
16. Ishii, S., T. Kuwaki, T. Nagase, K. Maki, F. Tashiro, S. Sunaga, W.-H. Cao, K. Kume, Y. Fukuchi, K. Ikuta, J.-I. Mivazaki, M. Kumada, and T. Shimizu. 1998. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187:1779-1788.
17. Melo, R. C., and Z. Brener. 1978. Tissue tropism of different Trypanosoma cruzi strains. J. Parasitol. 64:475-482.
18. Mencia-Huerta, J. M., and J. Benveniste. 1979. Platelet-activating factor and macrophage. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes. Eur. J. Immunol. 9:409-415.
19. Moncada, S., and A. Higgs. 1993. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 30:2002-2012.
20. Nathan, C., and Q.-W. Xie. 1994. Nitric oxide synthases: roles, tools and controls. Cell 78:915-918.
21. Nathan, C. 1993. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3064.
22. Negro-Alvarez, J. M., J. C. M. Lopez, J. L. O. Martinez, A. A. Aleman, and R. Rubio del Barrio. 1997. Platelet-activating factor antagonists. Allergol. Immunopathol. 25:249-258.
23. Petray, P., M. E. Rottenberg, S. Grinstein, and A. Orn. 1994. Release of nitric oxide during the experimental infection with Trypanosoma cruzi. Parasite Immunol. 16:193-199.
24. Plata, F., J. Wietzerbin, F. G. Ons, E. Falcoff, and H. Eisen. 1984. Synergistic protection by specific antibodies and interferon against infection by Trypanosoma cruzi in vitro. Eur. J. Immunol. 14:930-935.
25. Silva, J. S., G. N. R. Vespa, M. A. G. Cardoso. J. C. S. Aliberti, and F. Q. Cunha. 1995. Tumor necrosis factor alpha mediates resistance to Trypano-soma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect. Immun. 63:4862-4867.
26. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169-174.
27. Steil, A. A., M. C. Garcia Rodriguez, A. Alonso, M. S. Crespo, and L. Bosca. 1995. Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br. J. Pharmacol. 114:895-901.
28. Szabo, C., C. C. Wu, J. A. Mitchell, S. S. Gross, C. Thiemermann, and J. R. Vane. 1993. Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipolysaccharide. Circ. Res. 73:991-999.
29. Vespa, G. N. R., F. Q. Cunha, and J. S. Silva. 1994. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect. Immun. 62:5177-5182.