Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling

International Journal of Cancer

Volumn 137, Issue 7, 2015, Pages 1560-1573

  Takahashi, Kohta ^a,b   Hosono, Masahiro ^a   Sato, Ikuro ^c   Hata, Keiko ^a   Wada, Tadashi ^a   Yamaguchi, Kazunori ^c   Nitta, Kazuo ^b   Shima, Hiroshi ^b   Miyagi, Taeko ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

colon cancer; gangliosides; sialidase; stem cells; Wnt signaling

Indexed keywords

AXIN; BETA CATENIN; DICKKOPF 1 PROTEIN; DOXYCYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GANGLIOSIDE GM3; GLYCOGEN SYNTHASE KINASE 3BETA; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN C JUN; PROTEIN KINASE B; RAS PROTEIN; SHORT HAIRPIN RNA; SIALIDASE; SIALIDASE NEU3; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT3A PROTEIN; CTNNB1 PROTEIN, HUMAN; GANGLIOSIDE; LRP6 PROTEIN, HUMAN; NEU3 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CARCINOGENESIS; CELL EXPANSION; CELL FRACTIONATION; CELL SELF-RENEWAL; CLONOGENESIS; COLON CANCER; COLONY FORMATION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPHEROID CELL; THIN LAYER CHROMATOGRAPHY; TUMOR GROWTH; TUMOR SPHEROID; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; COLON TUMOR; ENZYMOLOGY; HCT116 CELL LINE; HEK293 CELL LINE; HT 29 CELL LINE; METABOLISM; NONOBESE DIABETIC MOUSE; NUDE MOUSE; PATHOLOGY; SCID MOUSE; WNT SIGNALING PATHWAY; XENOGRAFT;

ANIMALS; BETA CATENIN; COLONIC NEOPLASMS; GANGLIOSIDES; HCT116 CELLS; HEK293 CELLS; HETEROGRAFTS; HT29 CELLS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, NUDE; MICE, SCID; NEOPLASM PROTEINS; NEURAMINIDASE; PLURIPOTENT STEM CELLS; TCF TRANSCRIPTION FACTORS; WNT SIGNALING PATHWAY;

EID: 84925957244     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29527     Document Type: Article

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