Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats

Diabetes

Volumn 62, Issue 10, 2013, Pages 3582-3588

  Mahadevan, Jana ^a   Parazzoli, Susan ^a   Oseid, Elizabeth ^a   Hertzel, Ann V ^b   Bernlohr, David A ^b   Vallerie, Sara N ^a   Liu, Chang Qin ^a   Lopez, Melissa ^a   Harmon, Jamie S ^a   Robertson, R Paul ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; EBSELEN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PROTEIN A; PROTEIN V MAF; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; ANTIOXIDANT; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLYCOSYLATED HEMOGLOBIN; KLRG1 PROTEIN, RAT; LECTIN; MEMBRANE PROTEIN; ORGANOSELENIUM DERIVATIVE; PYRROLE DERIVATIVE; GLUCOSE BLOOD LEVEL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DENSITY; CELL DIVISION; CELL FUNCTION; CELL LEVEL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DETERIORATION; DIET RESTRICTION; EARLY INTERVENTION; GENE LOCATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; LIPID PEROXIDATION; MALE; NONHUMAN; ONCOGENE; OPTIMAL DRUG DOSE; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; ZUCKER DIABETIC FATTY RAT; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; ZUCKER RAT; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS;

ADIPOCYTES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; AZOLES; BLOOD GLUCOSE; BODY WEIGHT; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLUTATHIONE PEROXIDASE; HEMOGLOBIN A, GLYCOSYLATED; INSULIN-SECRETING CELLS; LECTINS, C-TYPE; MALE; MEMBRANE GLYCOPROTEINS; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; RATS; RATS, ZUCKER;

EID: 84886721959     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0357     Document Type: Article

References (26)

1. Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest 1992;90: 320-325
2. Olson LK, Redmon JB, Towle HC, Robertson RP. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest 1993;92:514-519
3. Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 1999;48: 1995-2000
4. Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci USA 1999;96:10857-10862
5. Tanaka Y, Tran PO, Harmon J, Robertson RP. A role for glutathione peroxidase in protecting pancreatic b cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci USA 2002;99:12363-12368
6. Kaneto H, Kajimoto Y, Miyagawa J, et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic b-cells against glucose toxicity. Diabetes 1999;48:2398-2406
7. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet b cells in diabetes. J Biol Chem 2004;279: 42351-42354
8. Harmon JS, Bogdani M, Parazzoli SD, et al. b-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology 2009;150:4855-4862
9. Grankvist K, Marklund SL, Täljedal IB. CuZn-superoxide dismutase, Mnsuperoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 1981;199:393-398
10. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996;20:463-466
11. Müller A, Cadenas E, Graf P, Sies H. A novel biologically active selenoorganic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochem Pharmacol 1984;33: 3235-3239
12. Brodsky SV, Gealekman O, Chen J, et al. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res 2004;94:377-384
13. Maiorino M, Roveri A, Ursini F. Antioxidant effect of Ebselen (PZ 51): peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity. Arch Biochem Biophys 1992; 295:404-409
14. Lynch E, Kil J. Development of ebselen, a glutathione peroxidase mimic, for the prevention and treatment of noise-induced hearing loss. Semin Hear 2009;30:47-55.
15. Yamaguchi T, Sano K, Takakura K, et al. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 1998;29:12-17
16. Ogawa A, Yoshimoto T, Kikuchi H, et al. Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial. Cerebrovasc Dis 1999;9:112-118
17. Saito I, Asano T, Sano K, et al. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 1998;42:269-277; discussion 277-278
18. Tokuyama Y, Sturis J, DePaoli AM, et al. Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 1995;44:1447-1457
19. Pick A, Clark J, Kubstrup C, et al. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 1998;47:358-364
20. Mahadevan J, Parazolli SD, Oseid EA, et al. Ebselen, a glutathione peroxidase mimetic, prevents fasting hyperglycemia, loss of insulin secretion, increases beta-cell mass, and preserves intranuclear MafA and PDX-1 in ZDF rats (Abstract 994-P). Diabetes 2011;60(Suppl. 1):A273
21. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
22. Poitout V, Olson LK, Robertson RP. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J Clin Invest 1996;97:1041-1046.
23. Ardestani A, Sauter NS, Paroni F, et al. Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization. J Biol Chem 2011;286:17144-17155
24. Brissova M, Blaha M, Spear C, et al. Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am J Physiol Endocrinol Metab 2005;288:E707-E714
25. Kawamori D, Kajimoto Y, Kaneto H, et al. Oxidative stress induces nucleocytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 2003;52:2896-2904
26. Johnson JD, Ahmed NT, Luciani DS, et al. Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 2003;111:1147-1160