Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

Applied Physiology, Nutrition and Metabolism

Volumn 40, Issue 4, 2015, Pages 393-400

  Alves, Naiane F B ^a   Porpino, Suênia K P ^a   Monteiro, Matheus M O ^a   Gomes, Enéas R M ^a   Braga, Valdir A ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Antioxidant; Baroreflex; Hypertension; Swimming; Virgin coconut oil

Indexed keywords

COCONUT OIL; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; VEGETABLE OIL;

ANIMAL; ANIMAL EXPERIMENT; BLOOD PRESSURE; DRUG EFFECTS; HEART RATE; HYPERTENSION; LIPID PEROXIDATION; MALE; METABOLISM; OXIDATIVE STRESS; PRESSORECEPTOR REFLEX; RAT; SENSITIVITY AND SPECIFICITY; SPONTANEOUSLY HYPERTENSIVE RAT; WEIGHT GAIN; WISTAR KYOTO RAT;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; HEART RATE; HYPERTENSION; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PLANT OILS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SENSITIVITY AND SPECIFICITY; SUPEROXIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WEIGHT GAIN;

EID: 84925933942     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2014-0351     Document Type: Article

References (45)

1. Abate, D.T., Barbosa Neto, O., Rossi e Silva, R.C., Faleiros, A.C., Correa, R.R., da Silva, V.J., et al. 2012. Exercise-training reduced blood pressure and improve placental vascularization in pregnant spontaneously hypertensive rats–pilot study. Fetal Pediatr. Pathol. 31(6): 423–431. doi:10.3109/15513815.2012.659535. PMID:22506932.
2. Appel, L.J., Brands, M.W., Daniels, S.R., Karanja, N., Elmer, P.J., and Sacks, F.M. 2006. Dietary approaches to prevent and treat hypertension a scientific statement from the American Heart Association. Hypertension, 47(2): 296–308. doi:10.1161/01.HYP.0000202568.01167.B6. PMID:16434724.
3. Arunima, S., and Rajamohan, T. 2013. Effect of virgin coconut oil enriched diet on the antioxidant status and paraoxonase 1 activity in ameliorating the oxidative stress in rats - a comparative study. Food Funct. 4(9): 1402–1409. doi:10.1039/c3fo60085h. PMID:23892389.
4. Assunção, M.L., Ferreira, H.S., dos Santos, A.F., Cabral, C.R., Jr., and Florêncio, T.M.M.T. 2009. Effects of dietary coconut oil on the biochemical and anthropometric profiles of women presenting abdominal obesity. Lipids, 44(7): 593–601. doi:10.1007/s11745-009-3306-6. PMID:19437058.
5. Botelho-Ono, M.S., Pina, H.V., Sousa, K.H.F., Nunes, F.C., Medeiros, I.A., and Braga, V.A. 2011. Acute superoxide scavenging restores depressed baroreflex sensitivity in renovascular hypertensive rats. Auton. Neurosci. 159(1–2): 38–44. doi:10.1016/j.autneu.2010.07.025. PMID:20719579.
6. Braga, V.A. 2010. Dietary salt enhances angiotensin-II-induced superoxide formation in the rostral ventrolateral medulla. Auton. Neurosci. 155(1–2): 14–18. doi:10.1016/j.autneu.2009.12.007. PMID:20053589.
7. Braga, V.A., Burmeister, M.A., Sharma, R.V., and Davisson, R.L. 2008. Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry. Am. J. Physiol. Regul., Integr. Comp. Physiol. 295(4): R1168–R1174. doi:10.1152/ajpregu.90375.2008. PMID:18667715.
8. Braga, V.A., Medeiros, I.A., Ribeiro, T.P., França-Silva, M.S., Botelho-Ono, M.S., and Guimarães, D.D. 2011. Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension. Braz. J. Med. Biol. Res. 44(9): 871–876. doi:10.1590/S0100-879X2011007500088. PMID:21755262.
9. Burneiko, R.C.M., Diniz, Y.S., Galhardi, C.M., Rodrigues, H.G., Ebaid, G.M.X., Faine, L.A., et al. 2006. Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses. Food Chem. Toxicol. 44(7): 1167–1172. doi:10.1016/j.fct.2006.01.004. PMID:16516366.
10. Cheng, Q., Law, P.K., de Gasparo, M., and Leung, P.S. 2008. Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo] acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2=-(1H-tetrazol-5-yl)-[1,1=-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. J. Pharmacol. Exp. Ther. 327(3): 683–691. doi:10.1124/jpet.108.142703. PMID:18787107.
11. Choi, E.Y., and Cho, Y.O. 2014. The influence of different durations of aerobic exercise on fuel utilization, lactate level and antioxidant defense system in trained rats. Nutr. Res. Pract. 8(1): 27–32. doi:10.4162/nrp.2014.8.1.27. PMID: 24611102.
12. Costa, C.A., Amaral, T.A.S., Carvalho, L.C.R.M., Ognibene, D.T., da Silva, A.F.E., Moss, M.B., et al. 2009. Antioxidant treatment with tempol and apocynin prevents endothelial dysfunction and development of renovascular hypertension. Am. J. Hypertens. 22(12): 1242–1249. doi:10.1038/ajh.2009.186. PMID: 19779472.
13. Costford, S.R., Bajpeyi, S., Pasarica, M., Albarado, D.C., Thomas, S.C., Xie, H., et al. 2010. Skeletal muscle NAMPT is induced by exercise in humans. Am. J. Physiol. Endocrinol. Metab. 298(1): E117–E126. doi:10.1152/ajpendo.00318.2009. PMID:19887595.
14. Deminice, R., Vannucchi, H., Simões-Ambrosio, L.M., and Jordao, A.A. 2011. Creatine supplementation reduces increased homocysteine concentration induced by acute exercise in rats. Eur. J. Appl. Physiol. 111(11): 2663–2670. doi:10.1007/s00421-011-1891-6. PMID:21394640.
15. Enig, M.G. 2000. Know your fats: the complete primer for understanding the nutrition of fats, oils and cholesterol. Bethesda Pr, Silver Spring, Md., USA.
16. Gauthier, M.S., Couturier, K., Latour, J.G., and Lavoie, J.M. 2003. Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis. J. Appl. Physiol. 94(6): 2127–2134. doi:10.1152/japplphysiol.01164.2002. PMID: 12547845.
17. Guimarães, D.D., Carvalho, C.C., and Braga, V.A. 2012. Scavenging of NADPH oxidase-derived superoxide anions improves depressed baroreflex sensitivity in spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 39(4): 373–378. doi:10.1111/j.1440-1681.2012.05679.x. PMID:22283703.
18. Gutteridge, J.M.C. 1986. Aspects to consider when detecting and measuring lipid peroxidation. Free Radic. Res. Commun. 1(3): 173–184. doi:10.3109/10715768609083149. PMID:2577734.
19. Horta, P.P., de Carvalho, J.J., and Mandarim-de-Lacerda, C.A. 2005. Exercise training attenuates blood pressure elevation and adverse remodeling in the aorta of spontaneously hypertensive rats. Life Sci. 77(26): 3336–3343. doi:10.1016/j.lfs.2005.05.044. PMID:15964024.
20. Intahphuak, S., Khonsung, P., and Panthong, A. 2010. Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharm. Biol. 48(2): 151–157. doi:10.3109/13880200903062614. PMID:20645831.
21. Kishi, T., Hirooka, Y., Katsuki, M., Ogawa, K., Shinohara, K., Isegawa, K., and Sunagawa, K. 2012. Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats. Clin. Exp. Hypertens. 34(4): 278–283. doi:10.3109/10641963.2012.681084. PMID: 22578069.
22. Kosugi, H., Kato, T., and Kikugawa, K. 1987. Formation of yellow, orange and red pigments in the reaction of alk-2-enals with 2-thiobarbituric acid. Anal. Biochem. 165(2): 456–464. doi:10.1016/0003-2697(87)90296-X. PMID:3425914.
23. Kumar, S.N. 2011. Variability in coconut (Cocos nucifera L.) germplasm and hybrids for fatty acid profile of oil. J. Agric. Food Chem. 59(24): 13050–13058. doi:10.1021/jf203182d. PMID:22118628.
24. Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M.D., and Sadoshima, J. 2010. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc. Natl. Acad. Sci. 107(35): 15565–15570. doi:10.1073/pnas.1002178107. PMID:20713697.
25. Lee, F.T., Kuo, T.Y., Liou, S.Y., and Chien, C.T. 2009. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am. J. Chin. Med. 37(3): 557–572. doi:10.1142/S0192415X09007053. PMID:19606515.
26. Masson, G.S., Costa, T.S.R., Yshii, L., Fernandes, D.C., Soares, P.P.S., Laurindo, F.R., et al. 2014. Time-dependent effects of training on cardiovascular control in spontaneously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity. PloS One 9(5): e94927. doi:10.1371/journal.pone.0094927.
27. Mei, Y., Thompson, M.D., Cohen, R.A., and Tong, X. 2014. Autophagy and oxidative stress in cardiovascular diseases. Biochim. Biophys. Acta, 1852(2): 243–251. doi:10.1016/j.bbadis.2014.05.005. PMID:24834848.
28. Mendes-Junior, L.G., Monteiro, M.M.O., Carvalho, A.S., Queiroz, T.M., and Braga, V.A. 2013. Oral supplementation with the rutin improves cardiovagal baroreflex sensitivity and vascular reactivity in hypertensive rats. Appl. Physiol. Nutr. Metab. 38(11): 1099–1106. doi:10.1139/apnm-2013-0091. PMID: 24053516.
29. Mizuno, M., Iwamoto, G.A., Vongpatanasin, W., Mitchell, J.H., and Smith, S.A. 2014. Exercise training improves functional sympatholysis in spontaneously hypertensive rats through a nitric oxide dependent mechanism. Am. J. Physiol. Heart Circ. Physiol. 307(2): H242–H251. doi:10.1152/ajpheart.00103.2014. PMID:24816260.
30. Monteiro, M.M.O., França-Silva, M.S., Alves, N.F.B., Porpino, S.K.P., and Braga, V.A. 2012. Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats. Molecules, 17(11): 12997–13008. doi:10.3390/molecules171112997. PMID:23117438.
31. Mousa, T.M., Liu, D., Cornish, K.G., and Zucker, I.H. 2008. Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure. J. Appl. Physiol. 104(3): 616–624. doi:10.1152/japplphysiol.00601.2007. PMID:18079268.
32. Nandakumaran, M., Angelaki, E., Al-Azemi, N., Al-Sarraf, H., and Al-Saleh, E. 2011. Influence of coconut oil administration on some hematologic and metabolic parameters in pregnant rats. J. Matern-Fetal Neonatal Med. 24(10): 1254–1258. doi:10.3109/14767058.2011.572308. PMID:21736409.
33. Nevin, K.G., and Rajamohan, T. 2004. Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin. Biochem. 37(9): 830–835. doi:10.1016/j.clinbiochem.2004.04.010. PMID:15329324.
34. Nevin, K.G., and Rajamohan, T. 2006. Virgin coconut oil supplemented diet increases the antioxidant status in rats. Food Chem. 99(2): 260–266. doi:10.1016/j.foodchem.2005.06.056.
35. Nishi, E.E., Bergamaschi, C.T., Oliveira-Sales, E.B., Simon, K.A., and Campos, R.R. 2013. Losartan reduces oxidative stress within the rostral ventrolateral medulla of rats with renovascular hypertension. Am. J. Hypertens. 26(7): 858–865. doi:10.1093/ajh/hpt037. PMID:23485486.
36. Nurul-Iman, B.S., Kamisah, Y., Jaarin, K., and Qodriyah, H.M.S. 2013. Virgin coconut oil prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil. Evid.-Based Compl. Alt. Med. 2013: 629329. doi:10.1155/2013/629329.
37. Queiroz, T.M., Guimarães, D.D., Mendes-Junior, L.G., and Braga, V.A. 2012. α-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats. Molecules, 17(11): 13357–13367. doi:10.3390/molecules171113357. PMID:23143148.
38. Queiroz, T.M., Monteiro, M.M.O., and Braga, V.A. 2013. Angiotensin-II-derived reactive oxygen species on baroreflex sensitivity during hypertension: new perspectives. Front. Physiol. 4. doi:10.3389/fphys.2013.00105. PMID:23717285.
39. Rech, A., Radaelli, R., De Assis, A.M., Fernandes, J.R., Longoni, A., Vozari-Hampe, M.M., et al. 2014. The effects of strength, aerobic, and concurrent exercise on skeletal muscle damage in rats. Muscle Nerve, 50(1): 79–86. doi:10.1002/mus.24091. PMID:24123151.
40. Roque, F.R., Briones, A.M., García-Redondo, A.B., Galán, M., Martínez-Revelles, S., Avendaño, M.S., et al. 2013. Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension. Br. J. Pharmacol. 168(3): 686–703. doi:10.1111/j.1476-5381.2012.02224.x. PMID:22994554.
41. Rossi, N.F., Chen, H., and Maliszewska-Scislo, M. 2013. Paraventricular nucleus control of blood pressure in two-kidney, one-clip rats: effects of exercise training and resting blood pressure. Am. J. Physiol.: Regul., Integr. Comp. Physiol. 305(11): R1390–R1400. doi:10.1152/ajpregu.00546.2012. PMID:24089375.
42. Schrauwen, P., and Westerterp, K.R. 2000. The role of high-fat diets and physical activity in the regulation of body weight. Br. J. Nutr. 84(4): 417–427. doi:10.1017/S0007114500001720. PMID:11103212.
43. Soares, E.R., Lima, W.G., Machado, R.P., Carneiro, C.M., Silva, M.E., Rodrigues, M.C., et al. 2011. Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats. Braz. J. Med Biol. Res. 44(6): 573–582. doi:10.1590/S0100-879X2011007500049. PMID:21519638.
44. Traustadóttir, T., Davies, S.S., Su, Y., Choi, L., Brown-Borg, H.M., Roberts, L.J., 2nd, and Harman, S.M. 2012. Oxidative stress in older adults: effects of physical fitness. Age (Dordr., Neth.), 34(4): 969–982. doi:10.1007/s11357-011-9277-6. PMID:21671197.
45. Vysakh, A., Ratheesh, M., Rajmohanan, T.P., Pramod, C., Premlal, S., Girish Kumar, B., and Sibi, P.I. 2014. Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action. Int. Immunopharmacol. 20(1): 124–130. doi:10.1016/j.intimp.2014.02.026. PMID:24613207.