Creatine supplementation reduces increased homocysteine concentration induced by acute exercise in rats

European Journal of Applied Physiology

Volumn 111, Issue 11, 2011, Pages 2663-2670

  Deminice, Rafael ^a   Vannucchi, Helio ^a   Simões Ambrosio, Lívia Maria ^a   Jordao, Alceu Afonso ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute exercise; Amino acids; Creatine supplementation; Homocysteine

Indexed keywords

AMINO ACID; CREATINE; HOMOCYSTEINE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MODEL; BLOOD; DIET SUPPLEMENTATION; DOWN REGULATION; DRUG EFFECT; EVALUATION; MALE; OSMOLARITY; PHYSIOLOGY; RAT; TIME; UPREGULATION; WISTAR RAT;

AMINO ACIDS; ANIMALS; CREATINE; DIETARY SUPPLEMENTS; DOWN-REGULATION; HOMOCYSTEINE; MALE; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; TIME FACTORS; UP-REGULATION;

EID: 84855673708     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-1891-6     Document Type: Article

References (30)

1. Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, Gekeler F, Müller-Myhsok B, Gasser T, Tatsch K, Klopstock T (2006) Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology 67:1262-1264 (Pubitemid 44563840)
2. Brosnan JT, Brosnan ME (2007) Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr 27:241-261 (Pubitemid 351373357)
3. De Crée C, Whiting PH, Cole H (2000) Interactions between homocyst(e)ine and nitric oxide during acute submaximal exercise in adult males. Int J Sports Med 21(4):256-262 (Pubitemid 30311477)
4. Deminice R, Portari GV, Vannucchi H, Jordao AA (2009) Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats. Br J Nutr 102:110-116
5. Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247-248
6. Edison EE, Brosnan ME, Meyer C, Brosnan JT (2007) Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo. Am J Physiol Renal Physiol 293:F1799-F1804 (Pubitemid 350179604)
7. Harbor-Gonçalves L, Vaz LS, Bezzi M (2005) Associação entre ń?veis plasmáticos de homocisté?na e acidente vascular cerebral isquêmico. Arq Neuropsiquiatr 63:97-103 (Pubitemid 40543425)
8. Herrmann M, Schorr H, Obeid R, Scharhag J, Urhausen A, Kindermann W, Herrmann W (2003a) Homocysteine increases during endurance exercise. Clin Chem Lab Med 41:1518-1524 (Pubitemid 37493570)
9. Herrmann M, Wilkinson J, Schorr H, Obeid R, Georg T, Urhausen A, Scharhag J, Kindermann W, Herrmann W (2003b) Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers. Clin Chem Lab Med 41:1525-1531 (Pubitemid 37493571)
10. Joubert LM, Manore MM (2006) Exercise, nutrition, and homocys-teine. Int J Sport Nutr Exerc Metab 16(4):341-361
11. König D, Bissé E, Deibert P, Müller HM, Wieland H, Berg A (2003) Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12. Ann Nutr Metab 47:114-118 (Pubitemid 36578801)
12. Korzun WJ (2004) Oral creatine supplements lower plasma homo-cysteine concentrations in humans. Clin Lab Sci 17(2):102-106
13. Likogianni V, Janel N, Ledru A, Beaune P, Paul JL, Demuth K (2006) Thiol compounds metabolism in mice, rats and humans: comparative study and potential explanation of rodents protec-tion against vascular diseases. Clin Chim Acta 372:140-146 (Pubitemid 44286770)
14. Obeid R, Herrmann W (2006) Mechanisms of homocysteine neuro-toxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 580:2994-3005 (Pubitemid 43744523)
15. Real JT, Merchante A, Gómez JL, Chaves FJ, Ascaso JF, Carmena R (2005) Effects of marathon running on plasma total homocys-teine concentrations. Nutr Metab Cardiovasc Dis 15:134-139 (Pubitemid 40712477)
16. Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 23(11):1939-1951 (Pubitemid 23342492)
17. Rennie MJ, Tipton KD (2000) Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr 20:457-483
18. Sotgia S, Carru C, Caria MA, Tadolini B, Deiana L, Zinellu A (2007) Acute variations in homocysteine levels are related to creatine changes induced by physical activity. Clin Nutr 26:444-449 (Pubitemid 47091489)
19. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT (2001) Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 281:E1095-E1100
20. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL (2006) Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 83:5-10 (Pubitemid 44699227)
21. Steenge GR, Verhoef P, Greenhaff PL (2001) The effect of creatine and resistance training on plasma homocysteine concentration in healthy volunteers. Arch Intern Med 161:1455-1456 (Pubitemid 32681168)
22. Taes YE, Delanghe JR, De Vriese AS, Rombait R, Vam Camp J, Lameire NH (2003) Creatine supplementation decrease homo-cysteine in an animal model of uremia. Kidney Int 64:1331-1337 (Pubitemid 37153798)
23. Taes YE, Delanghe JR, De Bacquer D, Langlois M, Stevens L, Geerolf I, Lameire NH, De Vriese AS (2004) Creatine supple-mentation does not decrease total plasma homocysteine in chronic hemodialysis patients. Kidney Int 66:2422-2428
24. Van Hall G, Saltin B, Wagenmakers AJ (1999) Muscle protein degradation and amino acid metabolism during prolonged knee-extensor exercise in humans. Clin Sci 97(5):557-567 (Pubitemid 29527834)
25. Venta R, Cruz E, Valcárcel G, Terrados N (2009) Plasma vitamins, amino acids, and renal function in postexercise hyperhomocy-steinemia. Med Sci Sports Exerc 41:1645-1651
26. Voltarelli FA, Gobatto CA, de Mello MA (2002) Determination of anaerobic threshold in rats using the lactate minimum test. Braz J Med Biol Res 35(11):1389-1394 (Pubitemid 36013591)
27. Wijekoon EP, Brosnan ME, Brosnan JT (2007) Homocysteine metabolism in diabetes. Biochem Soc Trans 35:1175-1179 (Pubitemid 350206455)
28. Wright M, Francis K, Cornwell P (1998) Effect of acute exercise on plasma homocysteine. J Sports Med Phys Fitness 38(3):262-265 (Pubitemid 28530153)
29. Wyss M, Schulze A (2002) Health implications of creatine: can oral creatine supplementation protect against neurological and ath-erosclerotic disease? Neuroscience 112:243-260 (Pubitemid 34607009)
30. Zinellu A, Sotgia S, Caria MA, Tangianu F, Casu G, Deiana L, Carru C (2007) Effect of acute exercise on low molecular weight thiols in plasma. Scand J Med Sci Sports 17(4):452-456