Toll-like receptor 4 activation promotes cardiac arrhythmias by decreasing the transient outward potassium current (Ito) through an IRF3-dependent and MyD88-independent pathway

Current Therapeutic Research - Clinical and Experimental

Volumn 76, Issue , 2014, Pages 70-75

  Monnerat Cahli, Gustavo ^a   Alonso, Hiart ^b   Gallego, Monica ^b   Alarcón, Micaela Lopez ^a   Bassani, Rosana A ^c   Casis, Oscar ^b   Medei, Emiliano ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Calcium handling; Cardiac electrophysiology; Signal transduction; TLR's; Transient outward potassium current

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; KCHIP2 PROTEIN; KV4.3 PROTEIN; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; SHAL POTASSIUM CHANNEL; SODIUM CALCIUM EXCHANGE PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; LIPOPOLYSACCHARIDE; MYD88 PROTEIN, RAT; POTASSIUM; TLR4 PROTEIN, RAT;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CELL ISOLATION; CONTROLLED STUDY; EXTRASYSTOLE; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE; IN VITRO STUDY; INCUBATION TIME; MEMBRANE POTENTIAL; NONHUMAN; POTASSIUM CURRENT; RAT; SIGNAL TRANSDUCTION; TRANSIENT OUTWARD POTASSIUM CURRENT; ACTION POTENTIAL; AGONISTS; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; HEART CONTRACTION; IMMUNOLOGY; MALE; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM SIGNALING; CELLS, CULTURED; INTERFERON REGULATORY FACTOR-3; LIPOPOLYSACCHARIDES; MALE; MYELOID DIFFERENTIATION FACTOR 88; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; POTASSIUM; RATS, WISTAR; TOLL-LIKE RECEPTOR 4;

EID: 84925872429     PISSN: 0011393X     EISSN: 18790313     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.08.012     Document Type: Article

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