Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration

Europace

Volumn 10, Issue 7, 2008, Pages 868-876

  Medei, Emiliano Horacio ^a   Nascimento, José H M ^a   Pedrosa, Roberto C ^a   Barcellos, Luciane ^a   Masuda, Masako O ^a,b   Sicouri, Serge ^c   Elizari, Marcelo V ^d   Campos De Carvalho, Antonio C ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Centro de Cincias e Educacao a Distancia do Estado do Rio de Janeiro   (Brazil)

^c MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^d HOSPITAL RAMOS MEJÍA   (Argentina)

Author keywords

Antibodies; Chagas' disease; Electrophysiology; M cells; QT interval

Indexed keywords

ATENOLOL; IMMUNOGLOBULIN G; ISOPRENALINE;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CALCIUM CURRENT; CHAGAS DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; HUMAN; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; RABBIT; RAT;

EID: 45849125698     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eun138     Document Type: Article

References (43)

1. Borda E, Pascual J, Cossio P, De La Vega M, Arana R, Sterin-Borda L. A circulating IgG in Chagas' disease which binds to beta-adrenoceptors of myocardium and modulates their activity. Clin Exp Immunol 1984;57:679-86.
2. Limas CJ, Goldenberg IF, Limas C. Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 1989;64:97-103.
3. Costa PC, Fortes FS, Machado AB, Almeida NA, Olivares EL, Cabral PR et al. Sera from chronic chagasic patients depress cardiac electrogenesis and conduction. Braz J Med Biol Res 2000;33:439-46.
4. Iwata M, Yoshikawa T, Baba A, Anzai T, Mitamura H, Ogawa S. Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2001;37:418- 24.
5. Chiale PA, Rosenbaum MB, Elizari MV, Hjalmarson A, Magnusson Y, Wallukat G et al. High prevalence of antibodies against beta 1- and beta 2-adrenoceptors in patients with primary electrical cardiac abnormalities. J Am Coll Cardiol 1995;26:864-9.
6. Rassi A Jr, Rassi SG, Rassi A. Sudden death in Chagas' disease. Arq Bras Cardiol 2001;76:75-96.
7. Yan GX, Antzelevitch C. Cellular basis for the normal Twave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998;98:1928-36.
8. Lowry OH, Rosebrough NJ, Farr AL, Randall RL. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:267-75.
9. Masuda MO, Engel GM, Moreira APB. Characterization of isolated ventricular myocytes: two levels of resting potential. J Mol Cell Cardiol 1987;19:831-9.
10. Sicouri S, Quist M, Antzelevitch C. Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol 1996;7:503-11.
11. Fozzard HA. Afterdepolarisations and triggered activity. Basic Res Cardiol 1992;87:105-13.
12. Priori SG, Corr Pb. Mechanisms underlying early and delayed after depolarisations induced by sarcocatecholamines. Am J Physiol 1990;258:h1796-805.
13. Tweedie D, Harding SE, MacLeod KT. Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol 2000;32:261-72.
14. Salles G, Xavier S, Sousa A, Hasslocher-Moreno A, Cardoso C. Prognostic value of QT interval parameters for mortality risk stratification in Chagas' disease: results of a long-term follow-up study. Circulation 2003;108:305-12.
15. Extramiana F, Antzelevitch C. Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome. Circulation 2004;110:3661-6.
16. Medei E, Pedrosa RC, Benchimol Barbosa PR, Costa PC, Hernandez CC, Chaves EA et al. Human antibodies with muscarinic activity modulate ventricular repolarization: basis for electrical disturbance. Int J Cardiol 2007;115:373-80.
17. Christ T, Wettwer E, Dobrev D, Adolph E, Knaut M, Wallukat G et al. Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes. J Mol Cell Cardiol 2001;33:1515-25.
18. Dorian P, Dunnmon P, Elstun L, Newman D. The effect of isoproterenol on the class III effect of azimilide in humans. J Cardiovasc Pharmacol Ther 2002;7:211-7.
19. Litovsky SH, Antzelevitch C. Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol: a direct effect of acetylcholine in ventricular myocardium. Circ Res 1990;67:615-27.
20. Lu HR, Vlaminckx E, Van De Water A, Gallacher DJ. Both beta-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of I(Ks) channel blockers in vitro. J Pharmacol Toxicol Methods 2005;51:81-90.
21. Salata JJ, Jurkiewicz NK, Wang J, Evans BE, Orme HT, Sanguinetti MC. A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Mol Pharmacol 1998;54:220-30.
22. Song Y, Shryock JC, Belardinelli L. Potentiating effect of acetylcholine on stimulation by isoproterenol of L-type Ca2+ current and arrhythmogenic triggered activity in guinea pig ventricular myocytes. J Cardiovasc Electrophysiol 1998;9:718-26.
23. Thomas D, Zhang W, Karle CA, Kathöfer S, Schöls W, Kübler W et al. Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J Biol Chem 1999;274:27457-62.
24. Findlay I. Is there an A-type K+ current in guinea pig ventricular myocytes? Am J Physiol Heart Circ Physiol 2003;284:H598-604.
25. Gallego M, Setien R, Puebla L, Boyano-Adanez M del C, Arilla E, Casis O. alpha1-Adrenoceptors stimulate a Galphas protein and reduce the transient outward K+ current via a cAMP/PKA-mediated pathway in the rat heart. Am J Physiol Cell Physiol 2005;288:C577-85.
26. Pacioretty LM, Gilmour RF Jr. Restoration of transient outward current by norepinephrine in cultured canine cardiac myocytes. Am J Physiol 1998;275:H1599-605.
27. + channels. Channels 2007;2:124-34.
28. Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res 2005;96:e25-34.
29. Christ T, Schindelhauer S, Wettwer E, Wallukat G, Ravens U. Interaction between autoantibodies against the beta1-adrenoceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes. J Mol Cell Cardiol 2006;41:716-23.
30. Christ T, Adolph E, Schindelhauer S,Wettwer E, Dobrev D,Wallukat G et al. Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. Basic Clin Pharmacol Toxicol 2005;96:445-52.
31. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G et al. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004;113:1419-29.
32. Tutor AS, Penela P, Mayor F Jr. Anti-beta(1)-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells. Cardiovasc Res 2007;76:51-60.
33. Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P et al. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation 2007;116:399-410.
34. Chen J, Larsson L, Haugen E, Fedorkova O, Angwald E, Waagstein F et al. Effects of autoantibodies removed by immunoadsorption from patients with dilated cardiomyopathy on neonatal rat cardiomyocytes. Eur J Heart Fail 2006;8:460-7.
35. Tsui Y, Opthof T, Kamiya K, Yasui K, Liu W, Lu Z et al. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res 2000;48:300-9.
36. Li GR, Lau CP, Ducharme A, Tardif JC, Nattel S. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. Am J Physiol 2002;283:H1031-41.
37. Volders PG, Stengl M, van Opstal JM, Gerlach U, Spätjens RL, Beekman JD et al. Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 2003;107:2753-60.
38. Stengl M, Ramakers C, Donker DW, Nabar A, Rybin AV, Spätjens RL et al. Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation blunted beta-adrenergic activation. Cardiovasc Res 2006;72:90-100.
39. Stengl M, Volders PG, Thomsen MB, Spätjens RL, Sipido KR, Vos MA. Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes. J Physiol 2003;551:777-86.
40. Felix SB, Staudt A, Dörffel WV, Stangl V, Merkel K, Pohl M et al. Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol 2000;35:1590-8.
41. Labovsky V, Smulski CR, Gomez K, Levy G, Levin MJ. Anti-beta1-adrenergic receptor autoantibodies in patients with chronic Chagas heart disease. Clin Exp Immunol 2007;148:440-9.
42. Liu K, Liao YH, Wang ZH, Li SL, Wang M, Zeng LL et al. Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. World J Gastroenterol 2004;10:1171-5.
43. Machida CA, Bunzow JR, Searles RP, Van Tol H, Tester B, Neve KA et al. Molecular cloning and expression of the rat beta 1-adrenergic receptor gene. J Biol Chem 1990;265:12960-5.