Wnt signaling in lip and palate development

Frontiers of Oral Biology

Volumn 16, Issue , 2012, Pages 81-90

  He, Fenglei ^a   Chen, Yiping ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Tulane University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

CLEFT LIP; CLEFT PALATE; EMBRYO DEVELOPMENT; GENETICS; HUMAN; LIP; MUTATION; PALATE; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; WNT SIGNALING PATHWAY;

BETA CATENIN; CLEFT LIP; CLEFT PALATE; EMBRYONIC DEVELOPMENT; HUMANS; LIP; MUTATION; PALATE; WNT SIGNALING PATHWAY;

EID: 84925856248     PISSN: 14202433     EISSN: 16623770     Source Type: Book Series    
DOI: 10.1159/000337619     Document Type: Article

References (85)

1. Chiquet BT, Blanton SH, Burt A, Ma D, Stal S, Mulliken JB, Hecht JT: Variation in WNT genes is associated with nonsyndromic cleft lip with or without cleft palate. Hum Mol Genet 2008;17:2212-2218. (Pubitemid 351916577)
2. Menezes R, Letra A, Kim AH, Kuchler EC, Day A, Tannure PN, Gomes da Motta L, Paiva KB, Granjeiro JM, Vieira AR: Studies with Wnt genes and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol 2010;88:995-1000.
3. Nusse R, Varmus HE: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 1982;31:99-109.
4. Nusse R, Brown A, Papkoff J, Scambler P, Shackleford G, McMahon A, Moon R, Varmus H, Smolich BD, McMahon JA: A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 1991;64:231.
5. Liu F, Millar SE: Wnt/β-catenin signaling in oral tissue development and disease. J Dent Res 2010;89:318-330.
6. Klaus A, Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008;8:387-398. (Pubitemid 351589714)
7. Clevers H: Wnt/β-catenin signaling in development and disease. Cell 2006;127:469-480.
8. Logan CY, Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810. (Pubitemid 39488658)
9. Veeman MT, Axelrod JD, Moon RT: A second canon: functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003;5:367-377. (Pubitemid 37107667)
10. Nelson WJ, Nusse R: Convergence of Wnt, β-catenin, and cadherin pathways. Science 2004;303:1483-1487. (Pubitemid 38314410)
11. Grigoryan T, Wend P, Klaus A, Birchmeier W: Deciphering the function of canonical Wnt signals in development and disease: conditional loss-and gainof-function mutations of β-catenin in mice. Genes Dev 2008;22:2308-2341.
12. Sugimura R, Li L: Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases. Birth Defects Res C Embryo Today 2010;90:243-256.
13. Pandur P: Recent discoveries in vertebrate non-canonical Wnt signaling: towards a Wnt signaling network; in Marek M (ed): Advances in Developmental Biology. New York, Elsevier, 2005, pp 91-106. (Pubitemid 44725680)
14. Mlodzik M: Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 2002;18:564-571. (Pubitemid 35284649)
15. Wansleeben C, Meijlink F: The planar cell polarity pathway in vertebrate development. Dev Dyn 2011;240:616-626.
16. Church VL, Francis-West P: Wnt signalling during limb development. Int J Dev Biol 2002;46:927-936. (Pubitemid 35364641)
17. 2+/calmodulin- dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem 2000;275:12701-12711. (Pubitemid 30241421)
18. 2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 2000;16:279-283. (Pubitemid 30389591)
19. Slusarski DC, Corces VG, Moon RT: Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 1997;390:410-413. (Pubitemid 28027323)
20. 2+ signaling by Wnt-5A. Dev Biol 1997;182:114-120. (Pubitemid 27107320)
21. 2+ pathway to antagonize Wnt/β-catenin signaling. Mol Cell Biol 2003;23:131-139. (Pubitemid 36008507)
22. Miller JR: The Wnts. Genome Biol 2001;3:3001-3015.
23. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y: Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J Cell Biol 2003;162:899-908. (Pubitemid 37087729)
24. Wallingford JB, Mitchell B: Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev 2011;25:201.
25. Van Amerongen R, Mikels A, Nusse R: Alternative Wnt signaling is initiated by distinct receptors. Sci Signal 2008;1:re9.
26. Mikels AJ, Nusse R: Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. PLoS Biol 2006;4:e115.
27. Kawano Y, Kypta R: Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003;116:2627-2634. (Pubitemid 36857216)
28. Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol 2003;264:91-105. (Pubitemid 37393449)
29. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W: R-spondin2 is a secreted activator of Wnt/β-catenin signaling and is required for Xenopus myogenesis. Dev Cell 2004;7:525-534. (Pubitemid 39341838)
30. Kim K-A, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A: R-spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell 2008;19:2588-2596.
31. Johnson EB, Hammer RE, Herz J: Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7deficient mice. Hum Mol Genet 2005;14:3523.
32. Ohazama A, Johnson EB, Ota MS, Choi HJ, Porntaveetus T, Oommen S, Itoh N, Eto K, Gritli-Linde A, Herz J: Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One 2008;3:e4092.
33. Wharton K: Vertebrate proteins related to Drosophila naked cuticle bind dishevelled and antagonize Wnt signaling. Dev Biol 2001;234:93-106.
34. Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H: The TAK1-NLK-MAPKrelated pathway antagonizes signalling between β-catenin and transcription factor TCF. Nature 1999;399:798-802. (Pubitemid 29293177)
35. Carinci P, Becchetti E, Baroni T, Carinci F, Pezzetti F, Stabellini G, Locci P, Scapoli L, Tognon M, Volinia S, Bodo M: Extracellular matrix and growth factors in the pathogenesis of some craniofacial malformations. Eur J Histochem 2007;51(suppl 1):105-115.
36. Niemann S, Zhao C, Pascu F, Stahl U, Aulepp U, Niswander L, Weber J, Muller U: Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet 2004;74:558-563. (Pubitemid 38325926)
37. Person AD, Beiraghi S, Sieben CM, Hermanson S, Neumann AN, Robu ME, Schleiffarth JR, Billington CJ Jr, van Bokhoven H, Hoogeboom JM, Mazzeul JF, Petryk A, Schimmenti LA, Brunner HG, Ekker SC, Lohr JL: WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn 2010;239:327-337.
38. Blanton SH, Bertin T, Serna M, Stal S, Mulliken JB, Hecht JT: Association of chromosomal regions 3p21.2, 10p13, and 16p13.3 with nonsyndromic cleft lip and palate. Am J Med Genet A 2004; 125A:23-27. (Pubitemid 38166529)
39. Watanabe A, Akita S, Tin NTD, Natsume N, Nakano Y, Niikawa N, Uchiyama T, Yoshiura K: A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. Cleft Palate Craniofac J 2006;43:310-316. (Pubitemid 43787780)
40. Jiang R, Bush JO, Lidral AC: Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn 2006;235:1152-1166. (Pubitemid 43843904)
41. Ferguson MWJ: Palate development. Development 1988;103(suppl):41-60.
42. Mani P, Jarrell A, Myers J, Atit R: Visualizing canonical Wnt signaling during mouse craniofacial development. Dev Dyn 2010;239:354-363.
43. Lan Y, Ryan R, Zhang Z, Bullard S, Bush J, Maltby K, Lidral A, Jiang R: Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn 2006;235: 1448-1454. (Pubitemid 43843925)
44. Song L, Li Y, Wang K, Wang Y-Z, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ: Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development 2009;136:3161-3171.
45. Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K: Craniofacial malformation in R-spondin2 knockout mice. Biochem Biophys Res Commun 2009;381:453-458.
46. Reid BS, Yang H, Melvin VS, Taketo MM, Williams T: Ectodermal Wnt/β-catenin signaling shapes the mouse face. Dev Biol 2011;349:261-269.
47. Carroll TJ, Park J-S, Hayashi S, Majumdar A, McMahon AP: Wnt9b Plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005;9:283-292. (Pubitemid 41051746)
48. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ: Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 2009;41:793-799.
49. Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C, Birchmeier W: Requirement for β-catenin in anteriorposterior axis formation in mice. J Cell Biol 2000;148:567-578.
50. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon A P, Sommer L, Boussadia O, Kemler R: Inactivation of the β-catenin gene by Wnt1-Cremediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 2001;128:1253-1264. (Pubitemid 32409648)
51. Wang Y, Song L, Zhou CJ: The canonical Wnt/β-catenin signaling pathway regulates Fgf signaling for early facial development. Dev Biol 2011;349:250-260.
52. He F, Xiong W, Wang Y, Li L, Liu C, Yamagami T, Taketo MM, Zhou C, Chen YP: Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfb3 expression. Dev Biol 2010;350;511-519.
53. He F, Popkie A P, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y: Gsk3β is required in the epithelium for palatal elevation in mice. Dev Dyn 2010;239:3235-3246.
54. He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y: Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development 2008;135:3871-3879.
55. Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA: Wnt signaling mediates regional specification in the vertebrate face. Development 2007;134:3283-3295. (Pubitemid 350018429)
56. Kaartinen V, Voncken J W, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J: Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelialmesenchymal interaction. Nat Genet 1995;11:415-421.
57. Taya Y, O'Kane S, Ferguson MW: Pathogenesis of cleft palate in TGF-β3 knockout mice. Development 1999;126:3869-3879. (Pubitemid 29440484)
58. Proetzel G, Pawlowski SA, Wiles M V, Yin M, Boivin G P, Howles PN, Ding J, Ferguson MWJ, Doetschman T: Transforming growth factor-β3 is required for secondary palate fusion. Nat Genet 1995;11: 409-414. (Pubitemid 3007193)
59. Medici D, Hay ED, Olsen BR: Snail and Slug promote epithelial-mesenchymal transition through β-catenin-T-cell factor-4-dependent expression of transforming growth factor-β3. Mol Biol Cell 2008;19:4875-4887.
60. Pantalacci S, Prochazka J, Martin A, Rothova M, Lambert A, Bernard L, Charles C, Viriot L, Peterkova R, Laudet V: Patterning of palatal rugae through sequential addition reveals an anterior/ posterior boundary in palatal development. BMC Dev Biol 2008;8:1-17.
61. Welsh IC, O'Brien TP: Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol 2009;336:53-67.
62. Gritli-Linde A: Molecular control of secondary palate development. Dev Biol 2007;301:309-326. (Pubitemid 46073971)
63. Lan Y, Jiang R: Sonic hedgehog signaling regulates reciprocal epithelialmesenchymal interactions controlling palatal outgrowth. Development 2009;136:1387-1396.
64. Maretto S, Cordenonsi M, Dupont S, Braghetta P, Broccoli V, Hassan AB, Volpin D, Bressan GM, Piccolo S: Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 2003;100:3299-3304. (Pubitemid 36356577)
65. Lin C, Fisher AV, Yin Y, Maruyama T, Veith GM, Dhandha M, Huang GJ, Hsu W, Ma L: The inductive role of Wnt-βcatenin signaling in the formation of oral apparatus. Dev Biol 2011;356:40-50.
66. Ohazama A, Porntaveetus T, Ota M, Herz J, Sharpe P: Lrp4: a novel modulator of extracellular signaling in craniofacial organogenesis. Am J Med Genet A 2010;152:2974-2983.
67. Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT: Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice. Nature 2007;446: 79-82. (Pubitemid 46348041)
68. Chen J, Lan Y, Baek J-A, Gao Y, Jiang R: Wnt/β-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol 2009;334:174-185.
69. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT: Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol 1996;133:1123-1137. (Pubitemid 26172516)
70. Kilian B, Mansukoski H, Barbosa FC, Ulrich F, Tada M, Heisenberg CP: The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev 2003;120:467-476. (Pubitemid 36379262)
71. Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S: Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development 1993;119:97-111. (Pubitemid 23279130)
72. Yamaguchi T P, Bradley A, McMahon A P, Jones S: A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 1999; 126:1211-1223. (Pubitemid 29182117)
73. -/-) are infertile and exhibit impaired corpora lutea formation and function. Biol Reprod 2005;73:1135-1146. (Pubitemid 41698603)
74. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y: The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 2003;8:645-654. (Pubitemid 36880848)
75. Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S: Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn 2004;229:400-410. (Pubitemid 38140480)
76. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM: Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002;1:279-288. (Pubitemid 41039152)
77. Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC: Wnt5 signaling in vertebrate pancreas development. BMC Biol 2005;3:23.
78. Jopling C, den Hertog J: Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep 2005;6:426.
79. Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG: Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 2008;320:365.
80. Halford MM, Armes J, Buchert M, Meskenaite V, Grail D, Hibbs ML, Wilks AF, Farlie PG, Newgreen DF, Hovens CM: Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nat Genet 2000;25:414-418. (Pubitemid 32983433)
81. Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM: The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci 2006;26: 5840-5848. (Pubitemid 44315278)
82. Lee J-M, Kim J-Y, Cho K-W, Lee M-J, Cho S-W, Kwak S, Cai J, Jung H-S: Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev Biol 2008;314:341-350. (Pubitemid 351200508)
83. Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP: Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003;130:3175-3185. (Pubitemid 36926955)
84. Abdul-Ghani M, Dufort D, Stiles R, De Repentigny Y, Kothary R, Megeney LA: Wnt11 Promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol 2011;31:163-178.
85. Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J: Frizzled 1 and Frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 2010;137:3707-3717.