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Volumn 194, Issue 7, 2015, Pages 3035-3044

TLR7- and TLR9-responsive human B cells share phenotypic and genetic characteristics

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; CD40 LIGAND; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 21; MEMBRANE PROTEIN; PROTEIN CDR3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; COMPLEMENTARITY DETERMINING REGION; INTERLEUKIN DERIVATIVE; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84925851902     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402690     Document Type: Article
Times cited : (37)

References (69)
  • 3
    • 4644241216 scopus 로고    scopus 로고
    • CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10
    • He, B., X. Qiao, and A. Cerutti. 2004. CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J. Immunol. 173: 4479-4491.
    • (2004) J. Immunol. , vol.173 , pp. 4479-4491
    • He, B.1    Qiao, X.2    Cerutti, A.3
  • 4
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi, N. L., N. Onai, and A. Lanzavecchia. 2003. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 8
    • 84860337134 scopus 로고    scopus 로고
    • Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae
    • So, N. S., M. A. Ostrowski, and S. D. Gray-Owen. 2012. Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J. Immunol. 188: 4008-4022.
    • (2012) J. Immunol. , vol.188 , pp. 4008-4022
    • So, N.S.1    Ostrowski, M.A.2    Gray-Owen, S.D.3
  • 9
    • 33748505008 scopus 로고    scopus 로고
    • Evidence that marginal zone B cells possess an enhanced secretory apparatus and exhibit superior secretory activity
    • Gunn, K. E., and J. W. Brewer. 2006. Evidence that marginal zone B cells possess an enhanced secretory apparatus and exhibit superior secretory activity. J. Immunol. 177: 3791-3798.
    • (2006) J. Immunol. , vol.177 , pp. 3791-3798
    • Gunn, K.E.1    Brewer, J.W.2
  • 10
    • 0035013708 scopus 로고    scopus 로고
    • Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    • Martin, F., A. M. Oliver, and J. F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14: 617-629.
    • (2001) Immunity , vol.14 , pp. 617-629
    • Martin, F.1    Oliver, A.M.2    Kearney, J.F.3
  • 11
    • 34250192856 scopus 로고    scopus 로고
    • TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    • Genestier, L., M. Taillardet, P. Mondiere, H. Gheit, C. Bella, and T. Defrance. 2007. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J. Immunol. 178: 7779-7786.
    • (2007) J. Immunol. , vol.178 , pp. 7779-7786
    • Genestier, L.1    Taillardet, M.2    Mondiere, P.3    Gheit, H.4    Bella, C.5    Defrance, T.6
  • 12
    • 0033812335 scopus 로고    scopus 로고
    • Generation, expansion, migration and activation of mouse B1 cells
    • Fagarasan, S., N. Watanabe, and T. Honjo. 2000. Generation, expansion, migration and activation of mouse B1 cells. Immunol. Rev. 176: 205-215.
    • (2000) Immunol. Rev. , vol.176 , pp. 205-215
    • Fagarasan, S.1    Watanabe, N.2    Honjo, T.3
  • 13
    • 0019990962 scopus 로고
    • Migrant mu+ delta+ and static mu+ delta- B lymphocyte subsets
    • Gray, D., I. C. MacLennan, H. Bazin, and M. Khan. 1982. Migrant mu+ delta+ and static mu+ delta- B lymphocyte subsets. Eur. J. Immunol. 12: 564-569.
    • (1982) Eur. J. Immunol. , vol.12 , pp. 564-569
    • Gray, D.1    MacLennan, I.C.2    Bazin, H.3    Khan, M.4
  • 14
    • 0033563309 scopus 로고    scopus 로고
    • IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
    • Oliver, A. M., F. Martin, and J. F. Kearney. 1999. IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 162: 7198-7207.
    • (1999) J. Immunol. , vol.162 , pp. 7198-7207
    • Oliver, A.M.1    Martin, F.2    Kearney, J.F.3
  • 15
    • 15444378323 scopus 로고    scopus 로고
    • Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
    • Avery, D. T., J. I. Ellyard, F. Mackay, L. M. Corcoran, P. D. Hodgkin, and S. G. Tangye. 2005. Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J. Immunol. 174: 4034-4042.
    • (2005) J. Immunol. , vol.174 , pp. 4034-4042
    • Avery, D.T.1    Ellyard, J.I.2    Mackay, F.3    Corcoran, L.M.4    Hodgkin, P.D.5    Tangye, S.G.6
  • 17
    • 84867350002 scopus 로고    scopus 로고
    • IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
    • Alamyar, E., P. Duroux, M. P. Lefranc, and V. Giudicelli. 2012. IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS. Methods Mol. Biol. 882: 569-604.
    • (2012) Methods Mol. Biol. , vol.882 , pp. 569-604
    • Alamyar, E.1    Duroux, P.2    Lefranc, M.P.3    Giudicelli, V.4
  • 18
    • 77951949737 scopus 로고    scopus 로고
    • SoDA2: A Hidden Markov Model approach for identification of immunoglobulin rearrangements
    • Munshaw, S., and T. B. Kepler. 2010. SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements. Bioinformatics 26: 867-872.
    • (2010) Bioinformatics , vol.26 , pp. 867-872
    • Munshaw, S.1    Kepler, T.B.2
  • 19
    • 84863304598 scopus 로고    scopus 로고
    • R Foundation for Statistical Computing, Vienna, Austria Available at
    • R Development Core Team. 2014. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available at: http://www.R-project.org.
    • (2014) R: A Language and Environment for Statistical Computing
  • 21
    • 79961232797 scopus 로고    scopus 로고
    • The Split-Apply-Combine Strategy for Data Analysis
    • Wickham, H. 2011. The Split-Apply-Combine Strategy for Data Analysis. J. Stat. Softw. 40: 1-29. Available at: http://www.jstatsoft.org/v40/i01.
    • (2011) J. Stat. Softw. , vol.40 , pp. 1-29
    • Wickham, H.1
  • 23
    • 37249026668 scopus 로고    scopus 로고
    • Reshaping data with the reshape package
    • Available at
    • Wickham, H. 2007. Reshaping data with the reshape package. J. Stat. Softw. 21: 1-29. Available at: http://www.jstatsoft.org/v21/i12.
    • (2007) J. Stat. Softw. , vol.21 , pp. 1-29
    • Wickham, H.1
  • 27
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson, T. A., L. Z. Rassenti, and T. J. Kipps. 1997. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J. Immunol. 158: 235-246.
    • (1997) J. Immunol. , vol.158 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 28
    • 58249117762 scopus 로고    scopus 로고
    • A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses
    • Seifert, M., S. A. Steimle-Grauer, T. Goossens, M. L. Hansmann, A. Bräuninger, and R. Küppers. 2009. A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses. Mol. Immunol. 46: 630-639.
    • (2009) Mol. Immunol. , vol.46 , pp. 630-639
    • Seifert, M.1    Steimle-Grauer, S.A.2    Goossens, T.3    Hansmann, M.L.4    Bräuninger, A.5    Küppers, R.6
  • 30
    • 0031939565 scopus 로고    scopus 로고
    • Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region
    • Thorpe, S. J., C. E. Turner, F. K. Stevenson, M. B. Spellerberg, R. Thorpe, J. B. Natvig, and K. M. Thompson. 1998. Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region. Immunology 93: 129-136.
    • (1998) Immunology , vol.93 , pp. 129-136
    • Thorpe, S.J.1    Turner, C.E.2    Stevenson, F.K.3    Spellerberg, M.B.4    Thorpe, R.5    Natvig, J.B.6    Thompson, K.M.7
  • 32
    • 84862782326 scopus 로고    scopus 로고
    • High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
    • Di Niro, R., L. Mesin, N. Y. Zheng, J. Stamnaes, M. Morrissey, J. H. Lee, M. Huang, R. Iversen, M. F. du Pré, S. W. Qiao, et al. 2012. High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat. Med. 18: 441-445.
    • (2012) Nat. Med. , vol.18 , pp. 441-445
    • Di Niro, R.1    Mesin, L.2    Zheng, N.Y.3    Stamnaes, J.4    Morrissey, M.5    Lee, J.H.6    Huang, M.7    Iversen, R.8    Du Pré, M.F.9    Qiao, S.W.10
  • 33
    • 0033711628 scopus 로고    scopus 로고
    • Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
    • Xu, J. L., and M. M. Davis. 2000. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 13: 37-45.
    • (2000) Immunity , vol.13 , pp. 37-45
    • Xu, J.L.1    Davis, M.M.2
  • 35
    • 0032476611 scopus 로고    scopus 로고
    • Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • Klein, U., K. Rajewsky, and R. Küppers. 1998. Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188: 1679-1689.
    • (1998) J. Exp. Med. , vol.188 , pp. 1679-1689
    • Klein, U.1    Rajewsky, K.2    Küppers, R.3
  • 36
    • 11144353781 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
    • Poeck, H., M. Wagner, J. Battiany, S. Rothenfusser, D. Wellisch, V. Hornung, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2004. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 103: 3058-3064.
    • (2004) Blood , vol.103 , pp. 3058-3064
    • Poeck, H.1    Wagner, M.2    Battiany, J.3    Rothenfusser, S.4    Wellisch, D.5    Hornung, V.6    Jahrsdorfer, B.7    Giese, T.8    Endres, S.9    Hartmann, G.10
  • 39
    • 77956551877 scopus 로고    scopus 로고
    • High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations
    • Wu, Y. C., D. Kipling, H. S. Leong, V. Martin, A. A. Ademokun, and D. K. Dunn-Walters. 2010. High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood 116: 1070-1078.
    • (2010) Blood , vol.116 , pp. 1070-1078
    • Wu, Y.C.1    Kipling, D.2    Leong, H.S.3    Martin, V.4    Ademokun, A.A.5    Dunn-Walters, D.K.6
  • 41
    • 78650660388 scopus 로고    scopus 로고
    • TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells
    • Aranburu, A., S. Ceccarelli, E. Giorda, R. Lasorella, G. Ballatore, and R. Carsetti. 2010. TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J. Immunol. 185: 7293-7301.
    • (2010) J. Immunol. , vol.185 , pp. 7293-7301
    • Aranburu, A.1    Ceccarelli, S.2    Giorda, E.3    Lasorella, R.4    Ballatore, G.5    Carsetti, R.6
  • 42
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers, M., H. Fukuyama, T. L. McGaha, A. Aderem, and J. V. Ravetch. 2006. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203: 553-561.
    • (2006) J. Exp. Med. , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 43
    • 84866735326 scopus 로고    scopus 로고
    • TLR7 and TLR9 in SLE: When sensing self goes wrong
    • Celhar, T., R. Magalhães, and A. M. Fairhurst. 2012. TLR7 and TLR9 in SLE: when sensing self goes wrong. Immunol. Res. 53: 58-77.
    • (2012) Immunol. Res. , vol.53 , pp. 58-77
    • Celhar, T.1    Magalhães, R.2    Fairhurst, A.M.3
  • 44
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen, S. R., J. Shupe, K. Nickerson, M. Kashgarian, R. A. Flavell, and M. J. Shlomchik. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25: 417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 45
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson, K. M., S. R. Christensen, J. Shupe, M. Kashgarian, D. Kim, K. Elkon, and M. J. Shlomchik. 2010. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J. Immunol. 184: 1840-1848.
    • (2010) J. Immunol. , vol.184 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3    Kashgarian, M.4    Kim, D.5    Elkon, K.6    Shlomchik, M.J.7
  • 46
    • 84879226183 scopus 로고    scopus 로고
    • Distinct auto-antibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation
    • Chauhan, S. K., V. V. Singh, R. Rai, M. Rai, and G. Rai. 2013. Distinct auto-antibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation. J. Clin. Immunol. 33: 954-964.
    • (2013) J. Clin. Immunol. , vol.33 , pp. 954-964
    • Chauhan, S.K.1    Singh, V.V.2    Rai, R.3    Rai, M.4    Rai, G.5
  • 47
    • 84890913903 scopus 로고    scopus 로고
    • Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females
    • Laska, M. J., A. Troldborg, B. Hansen, K. Stengaard-Pedersen, P. Junker, B. A. Nexø, and A. Voss. 2014. Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females. Rheumatology (Oxford) 53: 48-55.k
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 48-55
    • Laska, M.J.1    Troldborg, A.2    Hansen, B.3    Stengaard-Pedersen, K.4    Junker, P.5    Nexø, B.A.6    Voss, A.7
  • 48
    • 84865395359 scopus 로고    scopus 로고
    • Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population
    • Mu, R., X. Y. Sun, L. T. Lim, C. H. Xu, C. X. Dai, Y. Su, R. L. Jia, and Z. G. Li. 2012. Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population. Chin. Med. J. (Engl.) 125: 2873-2877.
    • (2012) Chin. Med. J. (Engl.) , vol.125 , pp. 2873-2877
    • Mu, R.1    Sun, X.Y.2    Lim, L.T.3    Xu, C.H.4    Dai, C.X.5    Su, Y.6    Jia, R.L.7    Li, Z.G.8
  • 52
    • 84860324057 scopus 로고    scopus 로고
    • Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival
    • Mannoor, K., A. Matejuk, Y. Xu, M. Beardall, and C. Chen. 2012. Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival. J. Immunol. 188: 3628-3638.
    • (2012) J. Immunol. , vol.188 , pp. 3628-3638
    • Mannoor, K.1    Matejuk, A.2    Xu, Y.3    Beardall, M.4    Chen, C.5
  • 53
    • 84877697551 scopus 로고    scopus 로고
    • Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: Involvement of electronegative potential of antigens
    • Chikazawa, M., N. Otaki, T. Shibata, H. Miyashita, Y. Kawai, S. Maruyama, S. Toyokuni, Y. Kitaura, T. Matsuda, and K. Uchida. 2013. Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. J. Biol. Chem. 288: 13204-13214.
    • (2013) J. Biol. Chem. , vol.288 , pp. 13204-13214
    • Chikazawa, M.1    Otaki, N.2    Shibata, T.3    Miyashita, H.4    Kawai, Y.5    Maruyama, S.6    Toyokuni, S.7    Kitaura, Y.8    Matsuda, T.9    Uchida, K.10
  • 54
    • 84873673878 scopus 로고    scopus 로고
    • Natural autoantibodies and associated B cells in immunity and autoimmunity
    • Mannoor, K., Y. Xu, and C. Chen. 2013. Natural autoantibodies and associated B cells in immunity and autoimmunity. Autoimmunity 46: 138-147.
    • (2013) Autoimmunity , vol.46 , pp. 138-147
    • Mannoor, K.1    Xu, Y.2    Chen, C.3
  • 55
    • 41149150143 scopus 로고    scopus 로고
    • Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    • Gururajan, M., J. Jacob, and B. Pulendran. 2007. Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS ONE 2: e863.
    • (2007) PLoS One , vol.2 , pp. e863
    • Gururajan, M.1    Jacob, J.2    Pulendran, B.3
  • 56
    • 0029034242 scopus 로고
    • B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures
    • Tornberg, U. C., and D. Holmberg. 1995. B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures. EMBO J. 14: 1680-1689.
    • (1995) EMBO J. , vol.14 , pp. 1680-1689
    • Tornberg, U.C.1    Holmberg, D.2
  • 57
    • 0027531439 scopus 로고
    • Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice
    • Reap, E. A., E. S. Sobel, P. L. Cohen, and R. A. Eisenberg. 1993. Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. J. Exp. Med. 177: 69-78.
    • (1993) J. Exp. Med. , vol.177 , pp. 69-78
    • Reap, E.A.1    Sobel, E.S.2    Cohen, P.L.3    Eisenberg, R.A.4
  • 58
    • 84855499464 scopus 로고    scopus 로고
    • A human equivalent of mouse B-1 cells?
    • author reply 2566-2569
    • Descatoire, M., J. C. Weill, C. A. Reynaud, and S. Weller. 2011. A human equivalent of mouse B-1 cells? J. Exp. Med. 208: 2563-2564, author reply 2566-2569.
    • (2011) J. Exp. Med. , vol.208 , pp. 2563-2564
    • Descatoire, M.1    Weill, J.C.2    Reynaud, C.A.3    Weller, S.4
  • 60
    • 78651509914 scopus 로고    scopus 로고
    • Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-
    • Griffin, D. O., N. E. Holodick, and T. L. Rothstein. 2011. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-. J. Exp. Med. 208: 67-80.
    • (2011) J. Exp. Med. , vol.208 , pp. 67-80
    • Griffin, D.O.1    Holodick, N.E.2    Rothstein, T.L.3
  • 61
    • 84860355430 scopus 로고    scopus 로고
    • - B1 cell subsets reveals potential cell sorting artifacts
    • author reply 434-436
    • - B1 cell subsets reveals potential cell sorting artifacts. J. Exp. Med. 209: 433-434, author reply 434-436.
    • (2012) J. Exp. Med. , vol.209 , pp. 433-434
    • Reynaud, C.A.1    Weill, J.C.2
  • 62
    • 84884182136 scopus 로고    scopus 로고
    • To B1 or not to B1: That really is still the question!
    • Tangye, S. G. 2013. To B1 or not to B1: that really is still the question! Blood 121: 5109-5110.
    • (2013) Blood , vol.121 , pp. 5109-5110
    • Tangye, S.G.1
  • 64
    • 84872946832 scopus 로고    scopus 로고
    • Marginal zone B cells: Virtues of innate-like antibody-producing lymphocytes
    • Cerutti, A., M. Cols, and I. Puga. 2013. Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes. Nat. Rev. Immunol. 13: 118-132.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 118-132
    • Cerutti, A.1    Cols, M.2    Puga, I.3
  • 65
    • 61749098024 scopus 로고    scopus 로고
    • Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
    • Vollmer, J., and A. M. Krieg. 2009. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv. Drug Deliv. Rev. 61: 195-204.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 195-204
    • Vollmer, J.1    Krieg, A.M.2
  • 68
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper, C. L., H. L. Davis, M. L. Morris, S. M. Efler, M. A. Adhami, A. M. Krieg, D. W. Cameron, and J. Heathcote. 2004. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. J. Clin. Immunol. 24: 693-701.
    • (2004) J. Clin. Immunol. , vol.24 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 69
    • 25844484501 scopus 로고    scopus 로고
    • CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults
    • Cooper, C. L., H. L. Davis, J. B. Angel, M. L. Morris, S. M. Elfer, I. Seguin, A. M. Krieg, and D. W. Cameron. 2005. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS 19: 1473-1479.
    • (2005) AIDS , vol.19 , pp. 1473-1479
    • Cooper, C.L.1    Davis, H.L.2    Angel, J.B.3    Morris, M.L.4    Elfer, S.M.5    Seguin, I.6    Krieg, A.M.7    Cameron, D.W.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.