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Volumn 46, Issue 2, 2013, Pages 138-147

Natural autoantibodies and associated B cells in immunity and autoimmunity

Author keywords

Autoantibodies; Autoimmunity; B cells; Natural antibodies

Indexed keywords

AUTOANTIBODY; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; PHOSPHORYLCHOLINE ANTIBODY; UNCLASSIFIED DRUG;

EID: 84873673878     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.748753     Document Type: Review
Times cited : (48)

References (142)
  • 1
    • 0020040257 scopus 로고
    • Naturally occuring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization
    • Guilbert, B., G. Dighiero, and S. Avrameas. 1982. Naturally occuring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization. J. Immunol 128: 2779-2787
    • (1982) J. Immunol , vol.128 , pp. 2779-2787
    • Guilbert, B.1    Dighiero, G.2    Avrameas, S.3
  • 2
    • 0021084192 scopus 로고
    • Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens
    • Dighiero, G., P. Lymberi, J. C. Mazie, et al. 1983. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J. Immunol 131: 2267-2272
    • (1983) J. Immunol , vol.131 , pp. 2267-2272
    • Dighiero, G.1    Lymberi, P.2    Mazie, J.C.3
  • 3
    • 0022556758 scopus 로고
    • Natural autoantibodies constitute a substantial part of normal circulating immunoglobulin
    • Dighiero, G., P. Lymberi, B. Guilbert, T. Ternynck, and S. Avrameas. 1986. Natural autoantibodies constitute a substantial part of normal circulating immunoglobulin. Ann. N.Y. Acad. Sci 475: 135-145
    • (1986) Ann. N.Y. Acad. Sci , vol.475 , pp. 135-145
    • Dighiero, G.1    Lymberi, P.2    Guilbert, B.3    Ternynck, T.4    Avrameas, S.5
  • 5
    • 0025905663 scopus 로고
    • Natural autoantibodies: From horror autotoxicus to gnothi seauton
    • Avrameas, S. 1991. Natural autoantibodies: from horror autotoxicus to gnothi seauton. Immunol. Today 12: 54
    • (1991) Immunol. Today , vol.12 , pp. 54
    • Avrameas, S.1
  • 6
    • 0020622027 scopus 로고
    • Virus-induced autoimmunity: Monoclonal antibodies that react with endocrine tissues
    • Haspel, M. V., T. Onodera, B. S. Prabhakar, et al. 1983. Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues. Science 220: 304-306
    • (1983) Science , vol.220 , pp. 304-306
    • Haspel, M.V.1    Onodera, T.2    Prabhakar, B.S.3
  • 7
    • 0020577078 scopus 로고
    • Multiple organ-reactive monoclonal autoantibodies
    • Haspel, M. V., T. Onodera, B. S. Prabhakar, et al. 1983. Multiple organ-reactive monoclonal autoantibodies. Nature 304: 73-76
    • (1983) Nature , vol.304 , pp. 73-76
    • Haspel, M.V.1    Onodera, T.2    Prabhakar, B.S.3
  • 9
    • 0024425654 scopus 로고
    • CD5 B lymphocytes, polyreactive antibodies and the human B-cell repertoire
    • Casali, P., and A. Notkins. 1989. CD5 B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunol. Today 10: 364-368
    • (1989) Immunol. Today , vol.10 , pp. 364-368
    • Casali, P.1    Notkins, A.2
  • 10
    • 0029008056 scopus 로고
    • Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults
    • Mouthon, L., A. Nobrega, N. Nicolas, et al. 1995. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc. Natl. Acad. Sci. USA 92: 3839-3843
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3839-3843
    • Mouthon, L.1    Nobrega, A.2    Nicolas, N.3
  • 11
    • 0031905272 scopus 로고    scopus 로고
    • Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire
    • Chen, Z. J., C. J. Wheeler, W. Shi, et al. 1998. Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire. Eur. J. Immunol 28: 989-994
    • (1998) Eur. J. Immunol , vol.28 , pp. 989-994
    • Chen, Z.J.1    Wheeler, C.J.2    Shi, W.3
  • 12
    • 33847343450 scopus 로고    scopus 로고
    • Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics
    • Merbl, Y., M. Zucker-Toledano, F. Quintana, and I. Cohen. 2007. Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J. Clin. Invest 117: 712-718
    • (2007) J. Clin. Invest , vol.117 , pp. 712-718
    • Merbl, Y.1    Zucker-Toledano, M.2    Quintana, F.3    Cohen, I.4
  • 13
    • 0021953397 scopus 로고
    • High frequency of natural autoantibodies in normal newborn mice
    • Dighiero, G., P. Lymberi, D. Holmberg, et al. 1985. High frequency of natural autoantibodies in normal newborn mice. J. Immunol 134: 765-771
    • (1985) J. Immunol , vol.134 , pp. 765-771
    • Dighiero, G.1    Lymberi, P.2    Holmberg, D.3
  • 14
    • 0021699786 scopus 로고
    • Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered "antigenfree" diet
    • Hooijkaas, H., R. Benner, J. R. Pleasants, and B. S. Wostmann. 1984. Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered "antigenfree" diet. Eur. J. Immunol 14: 1127-1130
    • (1984) Eur. J. Immunol , vol.14 , pp. 1127-1130
    • Hooijkaas, H.1    Benner, R.2    Pleasants, J.R.3    Wostmann, B.S.4
  • 15
    • 0041689676 scopus 로고    scopus 로고
    • Predominant autoantibody production by early human B cell precursors
    • Wardemann, H., S. Yurasov, A. Schaefer, et al. 2003. Predominant autoantibody production by early human B cell precursors. Science 301(5638): 1374-1377
    • (2003) Science , vol.301 , Issue.5638 , pp. 1374-1377
    • Wardemann, H.1    Yurasov, S.2    Schaefer, A.3
  • 16
    • 0023900691 scopus 로고
    • Specificity of natural serum antibodies present in phylogenetically distinct fish species
    • Gonzalez, R., J. Charlemagne,W. Mahana, and S. Avrameas. 1988. Specificity of natural serum antibodies present in phylogenetically distinct fish species. Immunology 63: 31-36
    • (1988) Immunology , vol.63 , pp. 31-36
    • Gonzalez, R.1    Charlemagne, J.2    Mahana, W.3    Avrameas, S.4
  • 17
    • 0033767186 scopus 로고    scopus 로고
    • Early and natural antibodies in non-mammalian vertebrates
    • Flajnik, M., and L. Rumfelt. 2000. Early and natural antibodies in non-mammalian vertebrates. Curr. Top. Microbiol. Immunol 252: 233-240
    • (2000) Curr. Top. Microbiol. Immunol , vol.252 , pp. 233-240
    • Flajnik, M.1    Rumfelt, L.2
  • 18
    • 0023800017 scopus 로고
    • Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice
    • Souroujon, M., M. E. White-Scharf, J. Andreschwartz, M. L. Gefter, and R. S. Schwartz. 1988. Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice. J. Immunol 140: 4173-4179
    • (1988) J. Immunol , vol.140 , pp. 4173-4179
    • Souroujon, M.1    White-Scharf, M.E.2    Andreschwartz, J.3    Gefter, M.L.4    Schwartz, R.S.5
  • 19
    • 1642315560 scopus 로고    scopus 로고
    • Polyreactivity of antibody molecules
    • Notkins, A. L. 2004. Polyreactivity of antibody molecules. Trends Immunol. 25: 174-179
    • (2004) Trends Immunol. , vol.25 , pp. 174-179
    • Notkins, A.L.1
  • 20
    • 0026040197 scopus 로고
    • Natural auto-and polyreactive antibodies differing from antigen-induced antibodies in theHchain CDR3
    • Chen, C., M. P. Stenzel-Poore, and M. B. Rittenberg. 1991. Natural auto-and polyreactive antibodies differing from antigen-induced antibodies in theHchain CDR3. J. Immunol 147: 2359-2367
    • (1991) J. Immunol , vol.147 , pp. 2359-2367
    • Chen, C.1    Stenzel-Poore, M.P.2    Rittenberg, M.B.3
  • 21
    • 0023714236 scopus 로고
    • Immunochemical studies of polyspecific natural autoantibodies: Charge, lipid reactivity, Fab'2 fragment activity and complement fixation
    • Poncet, P., T. Matthes, A. Billecocq, and G. Dighiero. 1988. Immunochemical studies of polyspecific natural autoantibodies: charge, lipid reactivity, Fab'2 fragment activity and complement fixation. Mol. Immunol 25: 981
    • (1988) Mol. Immunol , vol.25 , pp. 981
    • Poncet, P.1    Matthes, T.2    Billecocq, A.3    Dighiero, G.4
  • 22
    • 0024336835 scopus 로고
    • Immunochemical studies of a murine polyreactive IgG2b autoantibody with rheumatoid factor activity
    • Fernandez, P.-A., T. Ternynck, and S. Avrameas. 1989. Immunochemical studies of a murine polyreactive IgG2b autoantibody with rheumatoid factor activity. Mol. Immunol 26: 539
    • (1989) Mol. Immunol , vol.26 , pp. 539
    • Fernandez, P.-A.1    Ternynck, T.2    Avrameas, S.3
  • 23
    • 0024146603 scopus 로고
    • V genes encoding autoantibodies: Molecular and phenotypic characteristics
    • Bona, C. A. 1988. V genes encoding autoantibodies: molecular and phenotypic characteristics. Ann. Rev. Immunol 6: 327
    • (1988) Ann. Rev. Immunol , vol.6 , pp. 327
    • Bona, C.A.1
  • 26
    • 0024563709 scopus 로고
    • Organ reactive autoantibodies from non-immunized adult BALB/c mice are polyreactive and express non-biased VH gene usage
    • Hartman, A. B., C. P. Mallett, J. Srinivasappa, et al. 1989. Organ reactive autoantibodies from non-immunized adult BALB/c mice are polyreactive and express non-biased VH gene usage. Mol. Immunol 26: 359-370
    • (1989) Mol. Immunol , vol.26 , pp. 359-370
    • Hartman, A.B.1    Mallett, C.P.2    Srinivasappa, J.3
  • 27
    • 0028101448 scopus 로고
    • Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain v segments
    • Ichiyoshi, Y., and P. Casali. 1994. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J. Exp. Med 180: 885-895
    • (1994) J. Exp. Med , vol.180 , pp. 885-895
    • Ichiyoshi, Y.1    Casali, P.2
  • 28
    • 0029553152 scopus 로고
    • Analysis of the structural correlates for self-antigen binding by natural and diseaserelated autoantibodies. in vitro expression of recombinant and/or mutagenized human IgG
    • Ichiyoshi, Y., and P. Casali. 1995. Analysis of the structural correlates for self-antigen binding by natural and diseaserelated autoantibodies. In vitro expression of recombinant and/or mutagenized human IgG. Ann N Y Acad Sci 764: 328-341
    • (1995) Ann N y Acad Sci , vol.764 , pp. 328-341
    • Ichiyoshi, Y.1    Casali, P.2
  • 30
    • 0028307808 scopus 로고
    • Structure-function studies on a polyreactive [natural] autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain
    • Martin, T., R. Crouzier, J. C. Weber, T. J. Kipps, and J. L. Pasquali. 1994. Structure-function studies on a polyreactive [natural] autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J. Immunol 152: 5988-5996
    • (1994) J. Immunol , vol.152 , pp. 5988-5996
    • Martin, T.1    Crouzier, R.2    Weber, J.C.3    Kipps, T.J.4    Pasquali, J.L.5
  • 31
    • 0033979707 scopus 로고    scopus 로고
    • Molecular determinants of polyreactive antibody binding:HCDR3and cyclic peptides
    • Deng, Y. J., and A. L. Notkins. 2000. Molecular determinants of polyreactive antibody binding:HCDR3and cyclic peptides. Clin. Exp. Immunol 119: 69-76
    • (2000) Clin. Exp. Immunol , vol.119 , pp. 69-76
    • Deng, Y.J.1    Notkins, A.L.2
  • 32
    • 0022519337 scopus 로고
    • Three-dimensional structure of an antigen-antibody complex at 2 8 A resolution
    • Amit, A. G., R. A. Mariuzza, S. E. Phillips, and R. J. Poljak. 1986. Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution. Science 233: 747-753
    • (1986) Science , vol.233 , pp. 747-753
    • Amit, A.G.1    Mariuzza, R.A.2    Phillips, S.E.3    Poljak, R.J.4
  • 33
    • 0013484210 scopus 로고
    • The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site
    • Segal, D. M., E. A. Padlan, G. H. Cohen, et al. 1974. The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. Proc. Natl. Acad. Sci. USA 71: 4298-4302
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 4298-4302
    • Segal, D.M.1    Padlan, E.A.2    Cohen, G.H.3
  • 35
    • 0020681403 scopus 로고
    • The "Ly-1" B cell subpopulation in normal, immunodefective, and autoimmune mice
    • Hayakawa, K., R. R. Hardy, D. R. Parks, and L. A. Herzenberg. 1983. The "Ly-1" B cell subpopulation in normal, immunodefective, and autoimmune mice. J. Exp. Med 157: 202-218
    • (1983) J. Exp. Med , vol.157 , pp. 202-218
    • Hayakawa, K.1    Hardy, R.R.2    Parks, D.R.3    Herzenberg, L.A.4
  • 36
  • 37
    • 78650600361 scopus 로고    scopus 로고
    • The double life of a B-1 cell: Self-reactivity selects for protective effector functions
    • Baumgarth, N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11: 34-46
    • Nat. Rev. Immunol. , vol.11 , pp. 34-46
    • Baumgarth, N.1
  • 38
    • 0033973585 scopus 로고    scopus 로고
    • Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
    • Martin, F., and J. F. Kearney. 2000. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12: 39-49
    • (2000) Immunity , vol.12 , pp. 39-49
    • Martin, F.1    Kearney, J.F.2
  • 39
    • 0023685871 scopus 로고
    • Restricted Ig variable region gene expression among Ly-1 B cell hybridomas
    • Pennell, C. A., L.W. Arnold,G. Haughton, and S. H. Clarke. 1988. Restricted Ig variable region gene expression among Ly-1 B cell hybridomas. J. Immunol 141: 2788-2796
    • (1988) J. Immunol , vol.141 , pp. 2788-2796
    • Pennell, C.A.1    Arnold, L.W.2    Haughton, G.3    Clarke, S.H.4
  • 40
    • 0024198976 scopus 로고
    • Repetitive usage of immunoglobulin VH and D gene segments in CD5 Ly-1 B clones of [NZB x NZW]F1 mice
    • Tarlinton, D., A. M. Stall, and L. A. Herzenberg. 1988. Repetitive usage of immunoglobulin VH and D gene segments in CD5 Ly-1 B clones of [NZB x NZW]F1 mice. EMBO J 7: 3705-3710
    • (1988) EMBO J , vol.7 , pp. 3705-3710
    • Tarlinton, D.1    Stall, A.M.2    Herzenberg, L.A.3
  • 41
    • 0029034242 scopus 로고
    • B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressure
    • Tornberg, U. C., and D. Holmberg. 1995. B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressure. EMBO J 14: 1680-1689
    • (1995) EMBO J , vol.14 , pp. 1680-1689
    • Tornberg, U.C.1    Holmberg, D.2
  • 42
    • 0031065192 scopus 로고    scopus 로고
    • An unbiased analysis of VH-D-JH sequences from B-1a, B-1b and conventional B cells
    • Kantor, A. B., C. E. Merrill, L. A. Herzenberg, and J. L. Hillson. 1997. An unbiased analysis of VH-D-JH sequences from B-1a, B-1b and conventional B cells. J. Immunol 158: 1175-1186
    • (1997) J. Immunol , vol.158 , pp. 1175-1186
    • Kantor, A.B.1    Merrill, C.E.2    Herzenberg, L.A.3    Hillson, J.L.4
  • 43
    • 0025335392 scopus 로고
    • Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cells and B-CLL progenitor generation
    • Gu, H., I. Forster, and K. Rajewsky. 1990. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cells and B-CLL progenitor generation. EMBO J 9: 2133
    • (1990) EMBO J , vol.9 , pp. 2133
    • Gu, H.1    Forster, I.2    Rajewsky, K.3
  • 44
    • 3042697408 scopus 로고    scopus 로고
    • Polyreactive antigenbinding B [PAB-] cells are widely distributed and the PAB population consists of both B-1 and B-1-phenotypes
    • Zhou, Z. H., and A. L. Notkins. 2004. Polyreactive antigenbinding B [PAB-] cells are widely distributed and the PAB population consists of both B-1 and B-1-phenotypes. Clin. Exp. Immunol 137: 88-100
    • (2004) Clin. Exp. Immunol , vol.137 , pp. 88-100
    • Zhou, Z.H.1    Notkins, A.L.2
  • 45
    • 0037408501 scopus 로고    scopus 로고
    • B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice
    • Thurnheer, M. C., A.W. Zuercher, J. J. Cebra, andN. A. Bos. 2003. B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice. J. Immunol 170: 4564-4571
    • (2003) J. Immunol , vol.170 , pp. 4564-4571
    • Thurnheer, M.C.1    Zuercher, A.W.2    Cebra, J.J.3    Bos, A.A.4
  • 46
    • 0037105484 scopus 로고    scopus 로고
    • Regeneration of natural antibody repertoire after massive ablation of lymphoid system: Robust selection mechanisms preserve antigen binding specificities
    • Nobrega, A., B. Stransky, N. Nicolas, and A. Coutinho. 2002. Regeneration of natural antibody repertoire after massive ablation of lymphoid system: robust selection mechanisms preserve antigen binding specificities. J. Immunol 169: 2971-2978
    • (2002) J. Immunol , vol.169 , pp. 2971-2978
    • Nobrega, A.1    Stransky, B.2    Nicolas, N.3    Coutinho, A.4
  • 47
    • 33746908192 scopus 로고    scopus 로고
    • B cells expressing a natural polyreactive autoantibody have a distinct phenotype and are overrepresented in immunoglobulin heavy chain transgenic mice
    • Tian, Q., M. Beardall, Y. Xu, et al. 2006. B cells expressing a natural polyreactive autoantibody have a distinct phenotype and are overrepresented in immunoglobulin heavy chain transgenic mice. J. Immunol 177: 2412-2422
    • (2006) J. Immunol , vol.177 , pp. 2412-2422
    • Tian, Q.1    Beardall, M.2    Xu, Y.3
  • 48
    • 0037240911 scopus 로고    scopus 로고
    • Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    • Hayakawa, K., M. Asano, S. A. Shinton, et al. 2003. Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J. Exp. Med 197: 87-99
    • (2003) J. Exp. Med , vol.197 , pp. 87-99
    • Hayakawa, K.1    Asano, M.2    Shinton, S.A.3
  • 49
  • 50
    • 0032787091 scopus 로고    scopus 로고
    • Control of early viral and bacterial distribution and disease by natural antibodies
    • Ochsenbein, A. F., T. Fehr, and C. Lutz, 1999. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286: 2156-2159
    • (1999) Science , vol.286 , pp. 2156-2159
    • Ochsenbein, A.F.1    Fehr, T.2    Lutz, C.3
  • 51
    • 0034679710 scopus 로고    scopus 로고
    • B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection
    • Baumgarth, N., O. C. Herman, G. C. Jager, et al. 2000. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J. Exp. Med 192: 271-280
    • (2000) J. Exp. Med , vol.192 , pp. 271-280
    • Baumgarth, N.1    Herman, O.C.2    Jager, G.C.3
  • 52
    • 0032445137 scopus 로고    scopus 로고
    • A critical role of natural immunoglobulinMin immediate defense against systemic bacterial infection
    • Boes, M., A. P. Prodeus, T. Schmidt, M. C. Carroll, and J. Chen. 1998. A critical role of natural immunoglobulinMin immediate defense against systemic bacterial infection. J. Exp. Med 188: 2380-2386
    • (1998) J. Exp. Med , vol.188 , pp. 2380-2386
    • Boes, M.1    Prodeus, A.P.2    Schmidt, T.3    Carroll, M.C.4    Chen, J.5
  • 53
    • 0347593991 scopus 로고    scopus 로고
    • A critical role for induced IgM in the protection against West Nile virus infection
    • Diamond, M. S., E. M. Sitati, L. D. Friend, et al. 2003. A critical role for induced IgM in the protection against West Nile virus infection. J. Exp. Med 198: 1853-1862
    • (2003) J. Exp. Med , vol.198 , pp. 1853-1862
    • Diamond, M.S.1    Sitati, E.M.2    Friend, L.D.3
  • 54
    • 22544482306 scopus 로고    scopus 로고
    • Critical role for IgM in host protection in experimental filarial infection
    • Rajan, B., T. Ramalingam, and T. V. Rajan. 2005. Critical role for IgM in host protection in experimental filarial infection. J Immunol 175: 1827-1833
    • (2005) J Immunol , vol.175 , pp. 1827-1833
    • Rajan, B.1    Ramalingam, T.2    Rajan, T.V.3
  • 55
    • 33947721996 scopus 로고    scopus 로고
    • The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies
    • Zhou, Z. H., Y. Zhang, Y. F. Hu, et al. 2007. The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe 1: 51-61
    • (2007) Cell Host Microbe , vol.1 , pp. 51-61
    • Zhou, Z.H.1    Zhang, Y.2    Hu, Y.F.3
  • 56
    • 33947434002 scopus 로고    scopus 로고
    • Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity
    • Jayasekera, J. P., E. A. Moseman, and M. C. Carroll. 2007. Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J. Virol 81: 3487-3494
    • (2007) J. Virol , vol.81 , pp. 3487-3494
    • Jayasekera, J.P.1    Moseman, E.A.2    Carroll, M.C.3
  • 57
    • 78650396484 scopus 로고    scopus 로고
    • Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina
    • Rapaka, R. R., D. M. Ricks, J. F. Alcorn, et al. Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina. J. Exp. Med 207: 2907-2919
    • J. Exp. Med , vol.207 , pp. 2907-2919
    • Rapaka, R.R.1    Ricks, D.M.2    Alcorn, J.F.3
  • 58
    • 68149178666 scopus 로고    scopus 로고
    • IgM in microbial infections taken for granted?
    • Racine, R., and G. M. Winslow. 2009. IgM in microbial infections: taken for granted? Immunol. Lett 125: 79-85
    • (2009) Immunol. Lett , vol.125 , pp. 79-85
    • Racine, R.1    Winslow, G.M.2
  • 59
    • 0034936968 scopus 로고    scopus 로고
    • Role of natural and immune IgM antibodies in immune responses
    • Boes, M. 2000. Role of natural and immune IgM antibodies in immune responses. Mol. Immunol 37: 1141-1149
    • (2000) Mol. Immunol , vol.37 , pp. 1141-1149
    • Boes, M.1
  • 60
    • 67649223624 scopus 로고    scopus 로고
    • Exclusion of natural autoantibody-producing B cells from IgG memory B cell compartment during T cell-dependent immune responses
    • Matejuk, A., M. Beardall, Y. Xu, et al. 2009. Exclusion of natural autoantibody-producing B cells from IgG memory B cell compartment during T cell-dependent immune responses. J. Immunol 182: 7634-7643
    • (2009) J. Immunol , vol.182 , pp. 7634-7643
    • Matejuk, A.1    Beardall, M.2    Xu, Y.3
  • 61
    • 0026782875 scopus 로고
    • Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
    • Chen, C., V. Roberts, and M. Rittenberg. 1992. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J. Exp. Med 176: 855-866
    • (1992) J. Exp. Med , vol.176 , pp. 855-866
    • Chen, C.1    Roberts, V.2    Rittenberg, M.3
  • 62
    • 0029047689 scopus 로고
    • Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by v gene combinatorial associations
    • Chen, C., V. Roberts, S. Stevens, et al. 1995. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J 14: 2784-2794
    • (1995) EMBO J , vol.14 , pp. 2784-2794
    • Chen, C.1    Roberts, V.2    Stevens, S.3
  • 63
    • 0037884814 scopus 로고    scopus 로고
    • Repertoire shift in the humoral response to phosphocholine-keyhole limpet hemocyanin: VH somatic mutation in germinal center B cells impairs T15 Ig function
    • Wiens, G., M. Brown, and M. Rittenberg. 2003. Repertoire shift in the humoral response to phosphocholine-keyhole limpet hemocyanin: VH somatic mutation in germinal center B cells impairs T15 Ig function. J. Immunol 170: 5095-5102
    • (2003) J. Immunol , vol.170 , pp. 5095-5102
    • Wiens, G.1    Brown, M.2    Rittenberg, M.3
  • 64
    • 0028357638 scopus 로고
    • Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2
    • Chen, C., T. Martin, S. Stevens, and M. Rittenberg. 1994. Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2. J. Exp. Med 180: 577-586
    • (1994) J. Exp. Med , vol.180 , pp. 577-586
    • Chen, C.1    Martin, T.2    Stevens, S.3    Rittenberg, M.4
  • 65
    • 38049012778 scopus 로고    scopus 로고
    • Regulation of aicda expression and AID activity: Relevance to somatic hypermutation and class switch DNA recombination
    • Xu, Z., E. J. Pone, A. Al-Qahtani, et al. 2007. Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit. Rev. Immunol 27: 367-397
    • (2007) Crit. Rev. Immunol , vol.27 , pp. 367-397
    • Xu, Z.1    Pone, E.J.2    Al-Qahtani, A.3
  • 66
    • 57749191326 scopus 로고    scopus 로고
    • Regulation of class switch recombination and somatic mutation by AID phosphorylation
    • McBride, K. M., A. Gazumyan, E. M. Woo, et al. 2008. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J. Exp. Med 205: 2585-2594
    • (2008) J. Exp. Med , vol.205 , pp. 2585-2594
    • McBride, K.M.1    Gazumyan, A.2    Woo, E.M.3
  • 67
    • 84860324057 scopus 로고    scopus 로고
    • Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival
    • Mannoor, K., A. Matejuk, Y. Xu, M. Beardall, and C. Chen. Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival. J. Immunol 188: 3628-3638
    • J. Immunol , vol.188 , pp. 3628-3638
    • Mannoor, K.1    Matejuk, A.2    Xu, Y.3    Beardall, M.4    Chen, C.5
  • 68
    • 0033611469 scopus 로고    scopus 로고
    • Secondary V[D]J recombination in B1 cells
    • Qin, X. F., S. Schwers, W. Yu, et al. 1999. Secondary V[D]J recombination in B1 cells. Nature 397: 355-359
    • (1999) Nature , vol.397 , pp. 355-359
    • Qin, X.F.1    Schwers, S.2    Yu, W.3
  • 69
    • 15444365480 scopus 로고    scopus 로고
    • Defective B cell tolerance checkpoints in systemic lupus erythematosus
    • Yurasov, S., H. Wardemann, J. Hammersen, et al. 2005. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J. Exp. Med 201: 703-711
    • (2005) J. Exp. Med , vol.201 , pp. 703-711
    • Yurasov, S.1    Wardemann, H.2    Hammersen, J.3
  • 70
    • 19344374510 scopus 로고    scopus 로고
    • Impaired early B cell tolerance in patients with rheumatoid arthritis
    • Samuels, J., Y. Ng, C. Coupillaud, D. Paget, and E. Meffre. 2005. Impaired early B cell tolerance in patients with rheumatoid arthritis. J. Exp. Med 201: 1659-1667
    • (2005) J. Exp. Med , vol.201 , pp. 1659-1667
    • Samuels, J.1    Ng, Y.2    Coupillaud, C.3    Paget, D.4    Meffre, E.5
  • 71
    • 0018883090 scopus 로고
    • Antigen binding variants of the S107 mouse myeloma cell line
    • Cook, W. D., S. Rudikoff, A. M. Giusti, et al. 1980. Antigen binding variants of the S107 mouse myeloma cell line. Prog. Clin. Biol. Res 42: 217-230
    • (1980) Prog. Clin. Biol. Res , vol.42 , pp. 217-230
    • Cook, W.D.1    Rudikoff, S.2    Giusti, A.M.3
  • 72
    • 0022555558 scopus 로고
    • A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
    • Napastek, Y., J. Andre-Schwartz, T. Manser, et al. 1986. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus. J. Exp. Med 164: 614-626
    • (1986) J. Exp. Med , vol.164 , pp. 614-626
    • Napastek, Y.1    Andre-Schwartz, J.2    Manser, T.3
  • 73
    • 0027338331 scopus 로고
    • Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection
    • Ikematsu, H., M. T. Kasaian, E. W. Schettino, and P. Casali. 1993. Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection. J. Immunol 151: 3604-3616
    • (1993) J. Immunol , vol.151 , pp. 3604-3616
    • Ikematsu, H.1    Kasaian, M.T.2    Schettino, E.W.3    Casali, P.4
  • 74
    • 0032525007 scopus 로고    scopus 로고
    • Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM
    • Boes, M., C. Esau, M. B. Fischer, et al. 1998. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J. Immunol 160: 4776-4787
    • (1998) J. Immunol , vol.160 , pp. 4776-4787
    • Boes, M.1    Esau, C.2    Fischer, M.B.3
  • 75
    • 0032544110 scopus 로고    scopus 로고
    • Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
    • Ehrenstein, M. R., T. L. O'Keefe, S. L. Davies, and M. S. Neuberger. 1998. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc. Natl. Acad. Sci. USA 95: 10089-10093
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10089-10093
    • Ehrenstein, M.R.1    O'Keefe, T.L.2    Davies, S.L.3    Neuberger, M.S.4
  • 76
    • 0034599499 scopus 로고    scopus 로고
    • Deficiency in serum immunoglobulin [Ig]M predisposes to development of IgG autoantibodies
    • Ehrenstein, M. R., H. T. Cook, and M. S. Neuberger. 2000. Deficiency in serum immunoglobulin [Ig]M predisposes to development of IgG autoantibodies. J. Exp. Med 191: 1253-1258
    • (2000) J. Exp. Med , vol.191 , pp. 1253-1258
    • Ehrenstein, M.R.1    Cook, H.T.2    Neuberger, M.S.3
  • 77
    • 0033961425 scopus 로고    scopus 로고
    • Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM
    • Boes, M., T. Schmidt, K. Linkemann, et al. 2000. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc. Natl. Acad. Sci. USA 97: 1184-1189
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1184-1189
    • Boes, M.1    Schmidt, T.2    Linkemann, K.3
  • 78
    • 34249826624 scopus 로고    scopus 로고
    • Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    • Jiang, C., J. Foley, N. Clayton, et al. 2007. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J. Immunol 178: 7422-7431
    • (2007) J. Immunol , vol.178 , pp. 7422-7431
    • Jiang, C.1    Foley, J.2    Clayton, N.3
  • 79
    • 79953692402 scopus 로고    scopus 로고
    • Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
    • Jiang, C., M. L. Zhao, R. M. Scearce, and M. Diaz. Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis. Arthritis Rheum 63: 1086-1096
    • Arthritis Rheum , vol.63 , pp. 1086-1096
    • Jiang, C.1    Zhao, M.L.2    Scearce, R.M.3    Diaz, M.4
  • 80
    • 27744470366 scopus 로고    scopus 로고
    • Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the [NZB x NZW]F1 mouse
    • Werwitzke, S., D. Trick, K. Kamino, et al. 2005. Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the [NZB x NZW]F1 mouse. Arthritis Rheum 52: 3629-3638
    • (2005) Arthritis Rheum , vol.52 , pp. 3629-3638
    • Werwitzke, S.1    Trick, D.2    Kamino, K.3
  • 81
    • 70249140955 scopus 로고    scopus 로고
    • Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis
    • Chen, Y., S. Khanna, C. S. Goodyear, et al. 2009. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J. Immunol 183: 1346-1359
    • (2009) J. Immunol , vol.183 , pp. 1346-1359
    • Chen, Y.1    Khanna, S.2    Goodyear, C.S.3
  • 82
    • 7844248266 scopus 로고    scopus 로고
    • IgM anti-dsDNA antibodies in systemic lupus erythematosus: Negative association with nephritis
    • Witte, T., K. Hartung, C. Sachse, et al. 1998. IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. SLE Study Group. Rheumatol. Int 18: 85-91
    • (1998) SLE Study Group. Rheumatol. Int , vol.18 , pp. 85-91
    • Witte, T.1    Hartung, K.2    Sachse, C.3
  • 83
    • 16744362427 scopus 로고    scopus 로고
    • Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis
    • Forger, F., T. Matthias, M. Oppermann, H. Becker, and K. Helmke. 2004. Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis. Lupus 13: 36-44
    • (2004) Lupus , vol.13 , pp. 36-44
    • Forger, F.1    Matthias, T.2    Oppermann, M.3    Becker, H.4    Helmke, K.5
  • 84
    • 84857362706 scopus 로고    scopus 로고
    • IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE
    • Gronwall, C., E. Akhter, C. Oh, et al. IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE. Clin. Immunol 142: 390-398
    • Clin. Immunol , vol.142 , pp. 390-398
    • Gronwall, C.1    Akhter, E.2    Oh, C.3
  • 85
    • 47849104754 scopus 로고    scopus 로고
    • Natural antibodies against phosphorylcholine as potential protective factors in SLE
    • Su, J., X. Hua, H. Concha, et al. 2008. Natural antibodies against phosphorylcholine as potential protective factors in SLE. Rheumatology [Oxford] 47: 1144-1150
    • (2008) Rheumatology [Oxford] , vol.47 , pp. 1144-1150
    • Su, J.1    Hua, X.2    Concha, H.3
  • 86
    • 31044440224 scopus 로고    scopus 로고
    • Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays
    • Li, Q. Z., C. Xie, T. Wu, et al. 2005. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J. Clin. Invest 115: 3428-3439
    • (2005) J. Clin. Invest , vol.115 , pp. 3428-3439
    • Li, Q.Z.1    Xie, C.2    Wu, T.3
  • 87
    • 37849186218 scopus 로고    scopus 로고
    • Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs
    • Neeli, I., M. M. Richardson, S. N. Khan, et al. 2007. Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs. Mol. Immunol 44: 1914-1921
    • (2007) Mol. Immunol , vol.44 , pp. 1914-1921
    • Neeli, I.1    Richardson, M.M.2    Khan, S.N.3
  • 88
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen, L. A., G. Anhalt, and A. Rosen. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med 179: 1317-1330
    • (1994) J. Exp. Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 89
    • 0036644073 scopus 로고    scopus 로고
    • Blebs and apoptotic bodies are B cell autoantigens
    • Cocca, B. A., A. M. Cline, and M. Z. Radic. 2002. Blebs and apoptotic bodies are B cell autoantigens. J. Immunol 169: 159-166
    • (2002) J. Immunol , vol.169 , pp. 159-166
    • Cocca, B.A.1    Cline, A.M.2    Radic, M.Z.3
  • 90
    • 33947660078 scopus 로고    scopus 로고
    • Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    • Kalaaji, M., K. A. Fenton, E. S. Mortensen, et al. 2007. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int 71: 664-672
    • (2007) Kidney Int , vol.71 , pp. 664-672
    • Kalaaji, M.1    Fenton, K.A.2    Mortensen, E.S.3
  • 91
    • 0031778836 scopus 로고    scopus 로고
    • HomozygousC1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto, M., C. Dell'Agnola, A. E. Bygrave, et al. 1998. HomozygousC1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet 19: 56-59
    • (1998) Nat. Genet , vol.19 , pp. 56-59
    • Botto, M.1    Dell'Agnola, C.2    Bygrave, A.E.3
  • 92
    • 0034618113 scopus 로고    scopus 로고
    • A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
    • Taylor, P. R., A. Carugati, V. A. Fadok, et al. 2000. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med 192: 359-366
    • (2000) J. Exp. Med , vol.192 , pp. 359-366
    • Taylor, P.R.1    Carugati, A.2    Fadok, V.A.3
  • 93
    • 0033954220 scopus 로고    scopus 로고
    • Negative selection of B lymphocytes: A novel role for innate immunity
    • Gommerman, J. L., and M. C. Carroll. 2000. Negative selection of B lymphocytes: a novel role for innate immunity. Immunol. Rev 173: 120-130
    • (2000) Immunol. Rev , vol.173 , pp. 120-130
    • Gommerman, J.L.1    Carroll, M.C.2
  • 94
    • 0035837323 scopus 로고    scopus 로고
    • Phagocytosis and clearance of apoptotic cells is mediated by MER
    • Scott, R. S., E. J. McMahon, S. M. Pop, et al. 2001. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411: 207-211
    • (2001) Nature , vol.411 , pp. 207-211
    • Scott, R.S.1    McMahon, E.J.2    Pop, S.M.3
  • 95
    • 2342517413 scopus 로고    scopus 로고
    • Murine lupus autoantibodies identify distinct subsets of apoptotic bodies
    • Cline, A. M., and M. Z. Radic. 2004. Murine lupus autoantibodies identify distinct subsets of apoptotic bodies. Autoimmunity 37: 85-93
    • (2004) Autoimmunity , vol.37 , pp. 85-93
    • Cline, A.M.1    Radic, M.Z.2
  • 96
    • 3042753858 scopus 로고    scopus 로고
    • Apoptosis, subcellular particles, and autoimmunity
    • Cline, A. M., and M. Z. Radic. 2004. Apoptosis, subcellular particles, and autoimmunity. Clin. Immunol 112: 175-182
    • (2004) Clin. Immunol , vol.112 , pp. 175-182
    • Cline, A.M.1    Radic, M.Z.2
  • 97
    • 2442707797 scopus 로고    scopus 로고
    • Nucleosomes are exposed at the cell surface in apoptosis
    • Radic, M., T. Marion, and M. Monestier. 2004. Nucleosomes are exposed at the cell surface in apoptosis. J. Immunol 172: 6692-6700
    • (2004) J. Immunol , vol.172 , pp. 6692-6700
    • Radic, M.1    Marion, T.2    Monestier, M.3
  • 98
    • 12344327400 scopus 로고    scopus 로고
    • Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro
    • Quartier, P., P. K. Potter, M. R. Ehrenstein, M. J. Walport, and M. Botto. 2005. Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur. J. Immunol 35: 252-260
    • (2005) Eur. J. Immunol , vol.35 , pp. 252-260
    • Quartier, P.1    Potter, P.K.2    Ehrenstein, M.R.3    Walport, M.J.4    Botto, M.5
  • 99
    • 0036719167 scopus 로고    scopus 로고
    • I-PLA[2] activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation
    • Kim, S. J., D. Gershov, X. Ma, N. Brot, and K. B. Elkon. 2002. I-PLA[2] activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J Exp Med 196: 655-665
    • (2002) J Exp Med , vol.196 , pp. 655-665
    • Kim, S.J.1    Gershov, D.2    Ma, X.3    Brot, N.4    Elkon, K.B.5
  • 100
    • 22144437349 scopus 로고    scopus 로고
    • IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo
    • Ogden, C. A., R. Kowalewski, Y. Peng, V. Montenegro, and K. B. Elkon. 2005. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity 38: 259-264
    • (2005) Autoimmunity , vol.38 , pp. 259-264
    • Ogden, C.A.1    Kowalewski, R.2    Peng, Y.3    Montenegro, V.4    Elkon, K.B.5
  • 101
    • 79955045667 scopus 로고    scopus 로고
    • Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells
    • Notley, C. A., M. A. Brown, G. P. Wright, and M. R. Ehrenstein. 2011. Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells. J. Immunol 186: 4967-4972
    • (2011) J. Immunol , vol.186 , pp. 4967-4972
    • Notley, C.A.1    Brown, M.A.2    Wright, G.P.3    Ehrenstein, M.R.4
  • 102
    • 70449710443 scopus 로고    scopus 로고
    • IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
    • Chen, Y., Y. B. Park, E. Patel, andG. J. Silverman. 2009. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J. Immunol 182: 6031-6043
    • (2009) J. Immunol , vol.182 , pp. 6031-6043
    • Chen, Y.1    Park, Y.B.2    Patel, E.3    Silverman, A.J.4
  • 103
    • 0030929611 scopus 로고    scopus 로고
    • Human polyreactive IgM monoclonal antibodies with blocking activity against self-reactive IgG
    • Melero, J., D. Tarrago, A. Nunez-Roldan, and B. Sanchez. 1997. Human polyreactive IgM monoclonal antibodies with blocking activity against self-reactive IgG. Scand. J. Immunol 45: 393-400
    • (1997) Scand. J. Immunol , vol.45 , pp. 393-400
    • Melero, J.1    Tarrago, D.2    Nunez-Roldan, A.3    Sanchez, B.4
  • 104
    • 0029043457 scopus 로고
    • Active systemic lupus erythematosus is associated with depletion of the natural generic anti-idiotype [anti-F[ab']2] system
    • R. C. Williams, Jr, C. C. Malone, G. R. Huffman, et al. 1995. Active systemic lupus erythematosus is associated with depletion of the natural generic anti-idiotype [anti-F[ab']2] system. J. Rheumatol 22: 1075-1085
    • (1995) J. Rheumatol , vol.22 , pp. 1075-1085
    • Williams Jr., R.C.1    Malone, C.C.2    Huffman, G.R.3
  • 105
    • 0024472593 scopus 로고
    • Anti-idiotypes against autoantibodies in normal immunoglobulins: Evidence for network regulation of human autoimmune responses
    • Rossi, F., G. Dietrich, and M. D. Kazatchkine. 1989. Anti-idiotypes against autoantibodies in normal immunoglobulins: evidence for network regulation of human autoimmune responses. Immunol. Rev 110: 135-149
    • (1989) Immunol. Rev , vol.110 , pp. 135-149
    • Rossi, F.1    Dietrich, G.2    Kazatchkine, M.D.3
  • 106
    • 0021956416 scopus 로고
    • Antigen-specific interactions between Tand B cells
    • Lanzavecchia, A. 1985. Antigen-specific interactions between Tand B cells. Nature 314: 537
    • (1985) Nature , vol.314 , pp. 537
    • Lanzavecchia, A.1
  • 108
    • 0141678822 scopus 로고    scopus 로고
    • Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting
    • Tumanov, A. V., S. I. Grivennikov, A. N. Shakhov, et al. 2003. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol. Rev 195: 106-116
    • (2003) Immunol. Rev , vol.195 , pp. 106-116
    • Tumanov, A.V.1    Grivennikov, S.I.2    Shakhov, A.N.3
  • 109
    • 0034568991 scopus 로고    scopus 로고
    • Reciprocal regulation of polarized cytokine production by effector B and T cells
    • Harris, D. P., L. Haynes, P. C. Sayles, et al. 2000. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat. Immunol 1: 475-482
    • (2000) Nat. Immunol , vol.1 , pp. 475-482
    • Harris, D.P.1    Haynes, L.2    Sayles, P.C.3
  • 110
    • 45449099469 scopus 로고    scopus 로고
    • Cytokine-producing B lymphocytes-key regulators of immunity
    • Lund, F. E. 2008. Cytokine-producing B lymphocytes-key regulators of immunity. Curr. Opin. Immunol 20: 332-338
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 332-338
    • Lund, F.E.1
  • 111
    • 0026593440 scopus 로고
    • Small B cells as antigen presenting cells in the induction of tolerance to soluble protein antigens
    • Eynon, E. E., andD. C. Parker. 1992. Small B cells as antigen presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med 175: 131
    • (1992) J. Exp. Med , vol.175 , pp. 131
    • Eynon, E.E.1    Parker, A.C.2
  • 112
    • 0036569428 scopus 로고    scopus 로고
    • Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases
    • Melo,M. E., J. Qian, M. El-Amine, et al. 2002. Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J. Immunol 168: 4788-4795
    • (2002) J. Immunol , vol.168 , pp. 4788-4795
    • Qian, J.E.M.M.1    El-Amine, M.2
  • 114
    • 54049107281 scopus 로고    scopus 로고
    • Tolerance without clonal expansion: Selfantigen-expressing B cells program self-reactive T cells for future deletion
    • Frommer, F., T. J. Heinen, F. T. Wunderlich, et al. 2008. Tolerance without clonal expansion: selfantigen-expressing B cells program self-reactive T cells for future deletion. J. Immunol 181: 5748-5759
    • (2008) J. Immunol , vol.181 , pp. 5748-5759
    • Frommer, F.1    Heinen, T.J.2    Wunderlich, F.T.3
  • 115
    • 0033764102 scopus 로고    scopus 로고
    • Polyreactive antibodies and polyreactive antigen-binding B [PAB] Cells
    • Notkins, A. L. 2000. Polyreactive antibodies and polyreactive antigen-binding B [PAB] Cells. Curr. Top. Microbiol. Immunol 252: 241-249
    • (2000) Curr. Top. Microbiol. Immunol , vol.252 , pp. 241-249
    • Notkins, A.L.1
  • 116
    • 30744458329 scopus 로고    scopus 로고
    • A case for regulatory B cells
    • Mizoguchi, A., and A. K. Bhan. 2006. A case for regulatory B cells. J Immunol 176: 705-710
    • (2006) J Immunol , vol.176 , pp. 705-710
    • Mizoguchi, A.1    Bhan, A.K.2
  • 117
    • 37849044394 scopus 로고    scopus 로고
    • The 'short' history of regulatory B cells
    • Mauri, C., and M. R. Ehrenstein. 2008. The 'short' history of regulatory B cells. Trends Immunol 29: 34-40
    • (2008) Trends Immunol , vol.29 , pp. 34-40
    • Mauri, C.1    Ehrenstein, M.R.2
  • 118
    • 42649124913 scopus 로고    scopus 로고
    • Not always the bad guys: B cells as regulators of autoimmune pathology
    • Fillatreau, S., D. Gray, and S. M. Anderton. 2008. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol 8: 391-397
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 391-397
    • Fillatreau, S.1    Gray, D.2    Anderton, S.M.3
  • 119
    • 49249136452 scopus 로고    scopus 로고
    • Regulatory B cells as inhibitors of immune responses and inflammation
    • Bouaziz, J. D., K. Yanaba, and T. F. Tedder. 2008. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol. Rev 224: 201-214
    • (2008) Immunol. Rev , vol.224 , pp. 201-214
    • Bouaziz, J.D.1    Yanaba, K.2    Tedder, T.F.3
  • 120
    • 47249159429 scopus 로고    scopus 로고
    • Regulatory B lymphocytes in humans: A potential role in autoimmunity
    • Jamin, C., A. Morva, S. Lemoine, et al. 2008. Regulatory B lymphocytes in humans: a potential role in autoimmunity. Arthritis Rheum 58: 1900-1906
    • (2008) Arthritis Rheum , vol.58 , pp. 1900-1906
    • Jamin, C.1    Morva, A.2    Lemoine, S.3
  • 121
    • 74649083783 scopus 로고    scopus 로고
    • CD19[]-CD24[hi]CD38[hi] B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    • Blair, P. A., L. Y. Norena, F. Flores-Borja, et al. CD19[]-CD24[hi] CD38[hi] B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 32: 129-140
    • Immunity , vol.32 , pp. 129-140
    • Blair, P.A.1    Norena, L.Y.2    Flores-Borja, F.3
  • 122
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • Wolf, S.D.,B.N.Dittel, F.Hardardottir, and C. A. Janeway, Jr. 1996. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J. Exp. Med 184: 2271-2278
    • (1996) J. Exp. Med 184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway Jr., C.A.4
  • 124
    • 0030666959 scopus 로고    scopus 로고
    • Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
    • Mizoguchi, A., E. Mizoguchi, R. N. Smith, F. I. Preffer, and A. K. Bhan. 1997. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J. Exp. Med 186: 1749-1756
    • (1997) J. Exp. Med , vol.186 , pp. 1749-1756
    • Mizoguchi, A.1    Mizoguchi, E.2    Smith, R.N.3    Preffer, F.I.4    Bhan, A.K.5
  • 125
    • 13844320401 scopus 로고    scopus 로고
    • Mesenteric B cells centrally inhibit CD4 T cell colitis through interaction with regulatory T cell subsets
    • Wei, B., P. Velazquez, O. Turovskaya, et al. 2005. Mesenteric B cells centrally inhibit CD4 T cell colitis through interaction with regulatory T cell subsets. Proc. Natl. Acad. Sci. USA 102: 2010-2015
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2010-2015
    • Wei, B.1    Velazquez, P.2    Turovskaya, O.3
  • 126
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med 197: 489-501
    • (2003) J. Exp. Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 127
    • 34250179766 scopus 로고    scopus 로고
    • Novel suppressive function of transitional 2 B cells in experimental arthritis
    • Evans, J. G., K. A. Chavez-Rueda, A. Eddaoudi, et al. 2007. Novel suppressive function of transitional 2 B cells in experimental arthritis. J. Immunol 178: 7868-7878
    • (2007) J. Immunol , vol.178 , pp. 7868-7878
    • Evans, J.G.1    Chavez-Rueda, K.A.2    Eddaoudi, A.3
  • 128
    • 38849192507 scopus 로고    scopus 로고
    • Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner
    • Hussain, S., and T. L. Delovitch. 2007. Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner. J. Immunol 179: 7225-7232
    • (2007) J. Immunol , vol.179 , pp. 7225-7232
    • Hussain, S.1    Delovitch, T.L.2
  • 129
    • 65449188259 scopus 로고    scopus 로고
    • Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
    • Blair, P. A., K. A. Chavez-Rueda, J. G. Evans, et al. 2009. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J. Immunol 182: 3492-3502
    • (2009) J. Immunol , vol.182 , pp. 3492-3502
    • Blair, P.A.1    Chavez-Rueda, K.A.2    Evans, J.G.3
  • 130
    • 0028136767 scopus 로고
    • Interleukin-10 and its receptor
    • Ho, A. S., and K. W. Moore. 1994. Interleukin-10 and its receptor. Ther. Immunol 1: 173-185
    • (1994) Ther. Immunol , vol.1 , pp. 173-185
    • Ho, A.S.1    Moore, K.W.2
  • 131
    • 0035879105 scopus 로고    scopus 로고
    • Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice
    • Tian, J., D. Zekzer, L. Hanssen, et al. 2001. Lipopolysaccharide- activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J. Immunol 167: 1081-1089
    • (2001) J. Immunol , vol.167 , pp. 1081-1089
    • Tian, J.1    Zekzer, D.2    Hanssen, L.3
  • 132
    • 42649111367 scopus 로고    scopus 로고
    • TLRactivated B cells suppress T cell-mediated autoimmunity
    • Lampropoulou, V., K. Hoehlig, T. Roch, et al. 2008. TLRactivated B cells suppress T cell-mediated autoimmunity. J. Immunol 180: 4763-4773
    • (2008) J. Immunol , vol.180 , pp. 4763-4773
    • Lampropoulou, V.1    Hoehlig, K.2    Roch, T.3
  • 133
    • 13544254614 scopus 로고    scopus 로고
    • Activation of marginal zone B cells from lupus mice with type A[D] CpGoligodeoxynucleotides
    • Brummel, R., and P. Lenert. 2005. Activation of marginal zone B cells from lupus mice with type A[D] CpGoligodeoxynucleotides. J. Immunol 174: 2429-2434
    • (2005) J. Immunol , vol.174 , pp. 2429-2434
    • Brummel, R.1    Lenert, P.2
  • 134
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter, E., I. Rifkin, A. Hohlbaum, et al. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.1    Rifkin, I.2    Hohlbaum, A.3
  • 135
    • 0347480224 scopus 로고    scopus 로고
    • Activation of autoreactive B cells by CpG dsDNA
    • Viglianti, G. A., C. M. Lau, T. M. Hanley, et al. 2003. Activation of autoreactive B cells by CpG dsDNA. Immunity 19: 837-847
    • (2003) Immunity , vol.19 , pp. 837-847
    • Viglianti, G.A.1    Lau, C.M.2    Hanley, T.M.3
  • 136
    • 34848922720 scopus 로고    scopus 로고
    • Cutting edge: Primary B lymphocytes preferentially expand allogeneic FoxP3 CD4 T cells
    • Chen, X., and P. E. Jensen. 2007. Cutting edge: primary B lymphocytes preferentially expand allogeneic FoxP3 CD4 T cells. J. Immunol 179: 2046-2050
    • (2007) J. Immunol , vol.179 , pp. 2046-2050
    • Chen, X.1    Jensen, P.E.2
  • 137
    • 0035818044 scopus 로고    scopus 로고
    • Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin
    • Kazatchkine, M. D., and S. V. Kaveri. 2001. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N. Engl. J. Med 345: 747-755
    • (2001) N. Engl. J. Med , vol.345 , pp. 747-755
    • Kazatchkine, M.D.1    Kaveri, S.V.2
  • 138
    • 67651027514 scopus 로고    scopus 로고
    • Intravenous immunoglobulin a natural regulator of immunity and inflammation
    • Jordan, S. C., M. Toyoda, and A. A. Vo. 2009. Intravenous immunoglobulin a natural regulator of immunity and inflammation. Transplantation 88: 1-6
    • (2009) Transplantation , vol.88 , pp. 1-6
    • Jordan, S.C.1    Toyoda, M.2    Vo, A.A.3
  • 139
    • 0030831738 scopus 로고    scopus 로고
    • Pooled normal human polyspecific IgM contains neutralizing antiidiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease
    • Hurez, V.,M. D. Kazatchkine, T. Vassilev, et al. 1997. Pooled normal human polyspecific IgM contains neutralizing antiidiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease. Blood 90: 4004-4013
    • (1997) Blood , vol.90 , pp. 4004-4013
    • Hurez, V.1    Kazatchkine, M.D.2    Vassilev, T.3
  • 140
    • 0032938501 scopus 로고    scopus 로고
    • Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation
    • Rieben, R., A. Roos, Y. Muizert, et al. 1999. Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation. Blood 93: 942-951
    • (1999) Blood , vol.93 , pp. 942-951
    • Rieben, R.1    Roos, A.2    Muizert, Y.3
  • 141
    • 0032905094 scopus 로고    scopus 로고
    • Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow
    • Zander, A. R., T. Zabelina, N. Kroger, et al. 1999. Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow. Bone Marrow Transplant 23: 889-893
    • (1999) Bone Marrow Transplant , vol.23 , pp. 889-893
    • Zander, A.R.1    Zabelina, T.2    Kroger, N.3
  • 142
    • 0036849054 scopus 로고    scopus 로고
    • Efficacy of IVIG affinity-purified anti-double-stranded DNA antiidiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus
    • Shoenfeld, Y., L. Rauova, B. Gilburd, et al. 2002. Efficacy of IVIG affinity-purified anti-double-stranded DNA antiidiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus. Int. Immunol 14: 1303-1311
    • (2002) Int. Immunol , vol.14 , pp. 1303-1311
    • Shoenfeld, Y.1    Rauova, L.2    Gilburd, B.3


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