Brain Structure and Function Related to Depression in Alzheimer's Disease: Contributions from Neuroimaging Research

Journal of Alzheimer's Disease

Volumn 45, Issue 3, 2015, Pages 689-703

  Brommelhoff, Jessica A ^a   Sultzer, David L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; depression; late life depression; neuroimaging

Indexed keywords

ALZHEIMER DISEASE; APATHY; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN PERFUSION; CONNECTOME; DEPRESSION; FRONTAL LOBE; GRAY MATTER; HISTOPATHOLOGY; HUMAN; MOOD DISORDER; NERVE CELL NETWORK; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROIMAGING; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL LOBE; WHITE MATTER LESION; ANIMAL; BRAIN; COMPLICATION; MEDICAL RESEARCH; PATHOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; ANIMALS; BIOMEDICAL RESEARCH; BRAIN; DEPRESSION; HUMANS; NEUROIMAGING;

EID: 84925778124     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-148007     Document Type: Review

References (96)

1. Blazer DG (2003) Depression in late life: Review and commentary. J Gerontol A Biol Sci Med Sci 58, 249-265.
2. Li X, Hu N, Tan MS, Yu JT, Tan L (2014) Behavioral and psychological symptoms in Alzheimer's disease. Biomed Res Int 2014, 927804.
3. Olin JT, Katz IR, Meyers BS, Schneider LS, Lebowitz BD (2002) Provisional diagnostic criteria for depression of Alzheimer disease: Rationale and background. Am J Geriatr Psychiatry 10, 129-141.
4. Lupien SJ, Nair NP, Briere S, Maheu F, Tu MT, Lemay M, McEwen BS, Meaney MJ (1999) Increased cortisol levels and impaired cognition in human aging: Implication for depression in later life. Rev Neurosci 10, 117-139.
5. Jorm AF (2001) History of depression as a risk factor for dementia: An updated review. Aust N Z J Psychiatry 35, 776-781.
6. Son JH, Han DH, Min KJ, Kee BS (2013) Correlation between gray matter volume in the temporal lobe and depressive symptoms in patients with Alzheimer's disease. Neurosci Lett 548, 15-20.
7. Zahodne LB, Gongvatana A, Cohen RA, Ott BR, Tremont G (2013) Are apathy and depression independently associated with longitudinal trajectories of cortical atrophy in mild cognitive impairment? Am J Geriatr Psychiatry 21, 1098-1106.
8. Xie C, Li W, Chen G, Ward BD, Franczak MB, Jones JL, Antuono PG, Li SJ, Goveas JS (2012) The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: Voxel-based morphology study. Behav Brain Res 235, 244-250.
9. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR Jr, Schuff N, Weiner MW, Thompson PM (2009) Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Hum Brain Mapp 30, 2766-2788.
10. Bruen PD, McGeown WJ, Shanks MF, Venneri A (2008) Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. Brain 131, 2455-2463.
11. MacQueen GM, Campbell S, McEwen BS, Macdonald K, Smano S, Joffe RT, Nahmias C, Young LT (2003) Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci U S A 100, 1387-1392.
12. Steffens DC, Payne ME, Greenberg DL, Byrum CE, Welsh-Bohmer KA, Wagner HR, MacFall JR (2002) Hippocampal volume and incident dementia in geriatric depression. Am J Geriatr Psychiatry 10, 62-71.
13. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63, 530-538.
14. Brommelhoff JA, Gatz M, Johansson B, McArdle JJ, Fratiglioni L, Pedersen NL (2009) Depression as a risk factor for dementia? Findings in a population-based sample of Swedish twins. Psychol Aging 24, 373-384.
15. Geerlings MI, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM (2008) History of depression, depressive symptoms, and medial temporal lobe atrophy and risk of Alzheimer disease. Neurology 70, 1258-1264.
16. Hsieh MH, McQuoid DR, Levy RM, Payne ME, MacFall JR, Steffens DC (2002) Hippocampal volume and antidepressant response in geriatric depression. Int J Geriatr Psychiatry 17, 519-525.
17. Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, Bentham P, Fox C, Holmes C, Katona C, Knapp M, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, Orrell M, O'Brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Burns A (2011) Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomized multicenter, double-blind, placebo-controlled trial. Lancet 378, 403-411.
18. Nelson JC, Devanand DP (2011) A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc 59, 577-585.
19. Alexopoulos GS, Young RC, Shindledecker RD (1992) Brain computed tomography findings in geriatric depression and primary degenerative dementia. Biol Psychiatry 31, 591-599.
20. Shima S, Shikano T, Kitamura T, Masuda Y, Tsukumo T, Kanba S, Asai M (1984) Depression and ventricular enlargement. Acta Psychiat Scand 70, 275-277.
21. Lavretsky H, Kurbanyan K, Ballmeier M, Mintz J, Toga A, Kumar A (2004) Sex differences in brain structure in geriatric depression. Am J Geriatr Psychiatry 12, 653-657.
22. Taki Y, Kinomura S, Awata S, Inoue K, Sato K, Ito H, Goto R, Uchida S, Tsuji I, Arai H, Kawashima R, Fukuda H (2005) Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: A voxel-based morphometry. J Affect Disord 88, 313-320.
23. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, Pham D, Kumar A (2004) Anterior cingulate gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 161, 99-108.
24. Elderkin-Thompson V, Hellemann G, Pham D, Kumar A (2009) Prefrontal morphology and executive function in healthy and depressed elderly. Int J Geriatr Psychiatry 24, 459-468.
25. Lee SH, Payne ME, Steffans DC, McQuoid DR, Lai TJ, Provenzale JM, Krishnan KR (2003) Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry 54, 529-533.
26. Lee JY, Park S, Mackin S, Ewers M, Chui H, Jagust W, Insel PS, Weiner MW (2014) Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression. PLoS One 9, e87747.
27. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 149, 351-356.
28. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJP, Vermersch P, Steinling M, Valk J (1993) A semiquantitative rating-scale for the assessment of signal hyperintensities on magnetic-resonance-imaging. J Neurol Sci 114, 7-12.
29. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjorgren M, Wallin A, Ader H, Leys D, Pantoni L, Pasquier F, Erkinjutti T, Scheltens P (2001) A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 32, 1318-1322.
30. Brommelhoff JA, Spann BM, Go JL, Mack WJ, Gatz M (2011) Striatal hypodensities, not white matter hypodensities on CT, are associated with late-onset depression in Alzheimer's disease. J Aging Res 2011, 187219.
31. Palmqvist S, Sarwai A, Wattmo C, Bronge L, Zhang Y, Wahlund LO, Nagga K (2011) Association between subcortical lesions and behavioral and psychological symptoms in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 32, 417-423.
32. Soennesyn H, Oppedal K, Grev OJ, Fritze F, Auestad BH, Nore SP, Beyer MK, Aarsland D (2012) White matter hyperintensities and the course of depressive symptoms in elderly people with mild dementia. Dement Geriatr Cogn Disord Extra 2, 97-111.
33. Mueller SG, Mack WJ, Mungas D, Kramer JH, Cardenas-Nicolson V, Lavretsky H, Greene M, Schuff N, Chui H, Weiner MW (2010) Influences of lobar gray matter and white matter lesion load on cognition and mood. Psychiatry Res 181, 90-96.
34. Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, Jagust W, Chui H, Mack WJ (2008) The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int J Geriatr Psychiatry 23, 1040-1050.
35. Starkstein SE, Mizrahi R, Capizzano AA, Acion L, Brockman S, Power BD (2009) Neuroimaging correlates of apathy and depression in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 21, 259-265.
36. Berlow YA, Wells WM, Ellison JM, Sung YH, Renshaw PF, Harper DG (2010) Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease. Int J Geriatr Psychiatry 25, 780-788.
37. Clark M, McDonald WM, Welsh-Bohner KA, Siegler IC, Dawson DV, Tupler LA, Krishnan KRR (1998) Magnetic resonance imaging correlates of depression in early- and lateonset Alzheimer's disease. Biol Psychiatry 44, 592-599.
38. Holthoff VA, Beuthien-Baumann B, Kalbe E, Ludecke S, Lenz O, Zundorf G, Spirling S, Schierz K, Winiecki P, Sorbi S, Herholz K. (2005) Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry 57, 412-421.
39. Lind K, Jonsson M, Karlsson I, Sjogren M, Wallin A, Edman A. (2006) Depressive symptoms and white matter changes in patients with dementia. Int J Geriatr Psychiatry 21, 119-125.
40. Jellinger KA (2002) Alzheimer's disease and cerebrovascular pathology: An update. J Neural Transm 109, 813-836.
41. Alexopoulos GS, Meyers BS, Young RC, Kakuma T, Silbersweig D, Charlson M (1997) Clinically defined vascular depression. Am J Psychiatry 154, 562-565.
42. Alexopoulos GS, Kiosses DN, Klimstra S, Kalayam B, Bruce ML (2002) Clinical presentation of the "depression-executive dysfunction syndrome" of late life. Am J Geriatr Psychiatry 10, 98-106.
43. Shah PJ, Glabus MF, Goodwin GM, Ebmeier KP (2002) Chronic, treatment-resistant depression and right frontostriatal atrophy. Br J Psychiatry 180, 434-440.
44. Krishnan KR, Taylor WD, McQuoid DR, MacFall JR, Payne ME, Provenzale JM, Steffens DC (2004) Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biol Psychiatry 55, 390-397.
45. Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF III (2013) Late-life depression and risk of vascular dementia and Alzheimer's disease: Systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry 202, 329-335.
46. Brickman AM, Provenzano FA, Muraskin J, Manly JJ, Blum S, Apa Z, Stern Y, Brown TR, Luchsinger JA, Mayeux R (2012) Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community. Arch Neurol 69, 1621-1627.
47. Totso G, Zimmerman ME, Carmichael OT, Brickman AM (2014) Predicting aggressive decline in mild cognitive impairment. The importance of white matter hyperintensities. JAMA Neurol 71, 872-877.
48. Tighe SK, Oishi K, Mori S, Smith GS, Albert M, Lyketsos CG, Mielke MM (2012) Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and dementia. J Neuropsychiatry Clin Neurosci 24, 484-488.
49. Li W, Muftuler LT, Chen G, Ward BD, Budde MD, Jones JL, Franczak MB, Antuono PG, Li SJ, Goveas JS (2014) Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure. J Neurol Sci 338, 46-56.
50. Zhuang L, Sachdev PS, Trollor JN, Reppermund S, Kochan NA, Brodaty H, Wen W (2013) Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment. PLoS One 8, e58887.
51. Alves GS, Karakaya T, Fusser F, Kordulla M, O'Dwyer L, Christl J, Magerkurth J, Oertel-Knochel V, Knochel C, Prvulovic D, Jurcoane A, Laks J, Engelhardt E, Hampel H, Pantel J (2012) Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression. Psychiatry Res 203, 194-200.
52. Bae JN, MacFall JR, Krishnan KR, Payne ME, Steffens DC, Taylor WD (2006) Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 60, 1356-1363.
53. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KR (2004) Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry 161, 1293-1296.
54. Charlton RA, Lamar M, Zhang A, Yang S, Ajilore O, Kumar A (2014) White matter tract integrity in late-life depression: Associations with severity and cognition. Psychol Med 44, 1427-1437.
55. Alexopoulos GS, Hoptman MJ, Kanellopoulos D, Murphy CF, Lim KO, Gunning FM (2012) Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord 139, 56-65.
56. Wu M, Andreescu C, Butters MA, Tamburo R, Reynolds CF, 3rd, Aizenstein H (2011) Default-mode network connectivity and white matter burden in late-life depression. Psychiatry Res 194, 39-46.
57. Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K (2002) Depression: Perspectives from affective neuroscience. Annu Rev Psychol 53, 545-574.
58. Tadayonnejad R, Yang S, Kumar A, Ajilore O (2014) Multimodal brain connectivity analysis in unmedicated late-life depression. PLoS One 9, e96033.
59. Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Hashimoto M, Yamashita H, Sasaki M (1998) Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 50, 380-383.
60. Lee DY, Choo IH, Jhoo JH, Kim KW, Youn JC, Lee DS, Kang EJ, Lee JS, Kang WJ, Woo JI (2006) Frontal dysfunction underlies depressive syndrome in Alzheimer's disease: A FDG-PET study. Am J Geriatr Psychiatry 14, 625-628.
61. Lee HS, Choo IH, Lee DY, Kim JW, Seo EH, Kim SG, Park SY, Shin JH, Kim KW, Woo JI (2010) Frontal dysfunction underlies depression in mild cognitive impairment: A FDG-PET study. Psychiatry Investig 7, 208-214.
62. Sultzer DL, Mahler ME, Mandelkern MA, Cummings JL, Van Gorp WG, Hinkin CH, Berisford MA (1995) The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 7, 476-484.
63. Smith GS, Kramer E, Ma Y, Kingsley P, Dhawan V, Chaly T, Eidelberg D (2009) The functional neuroanatomy of geriatric depression. Int J Geriatr Psychiatry 24, 798-808.
64. Levy-Cooperman N, Burhan AM, Rafi-Tari S, Kusano M, Ramirez J, Caldwell C, Black SE (2008) Frontal lobe hypoperfusion and depressive symptoms in Alzheimer's disease. J Psychiatry Neurosci 33, 218-226.
65. Liao YC, Liu RS, Lee YC, Sun CM, Liu CY, Wang PS, Wang PN, Liu HC (2003) Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: A brain SPECT finding by statistical parametric mapping. Dement Geriatr Cogn Disord 16, 238-244.
66. Ritchie K, Gillham C, Ledesert B, Touchon J, Kotzki P-O (1999) Depressive illness, depressive symptomatology and regional cerebral blood flow in elderly people with subclinical cognitive impairment. Age Ageing 28, 385-391.
67. Wu KY, Hsiao IT, Chen CS, Chen CH, Hsieh CJ, Wai YY, Chang CJ, Tseng HJ, Yen TC, Liu CY, Lin KJ (2014) Increased brain amyloid deposition in patients with a lifetime history of major depression: Evidence on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging 41, 714-722.
68. Marano C, Workman C, Lyman C, Narrow T, Zhou Y, Munro C, Dannals R, Holt D, Leoutsakos JM, Lyketsos C, Wong D, Smith G (2013) Cortical beta-amyloid deposition in late-life depression. Am J Geriatr Psychiatry 21, 1.
69. Lavretsky H, Siddarth P, Kepe V, Ercoli LM, Miller KJ, Burggren AC, Bookheimer SY, Huang SC, Barrio JR, Small GW (2009) Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. Am J Geriatr Psychiatry 17, 493-502.
70. Meltzer CC, Smith G, DeKosky ST, Pollock BG, Mathis CA, Moore RY, Kupfer DJ, Reynolds CF III (1998) Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging. Neuropsychopharmacology 18, 407-430.
71. Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT (2004) Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. Am J Psychiatry 161, 1096-1102.
72. Hirao K, Smith GS (2014) Positron emission tomography molecular imaging in late-life depression. J Geriatric Psychiatry Neurol 27, 13-23.
73. Ouchi Y, Yoshikawa E, Futatsubashi M, Yagi S, Ueki T, Nakamura K (2009) Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease. J Nucl Med 50, 1260-1266.
74. Guimaraes HC, Levy R, Teixeira AL, Beato RG, Caramelli P (2008) Neurobiology of apathy in Alzheimer's disease. Arq Neuropsiquiatr 66, 436-443.
75. Lanctot KL, Moosa S, Herrmann N, Leibovitch FS, Rothenburg L, Cotter A, Black SE (2007)ASPECTstudy of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord 24, 65-72.
76. Migneco O, Benoit M, Koulibaly PM, Dygai I, Bertogliati C, Desvignes P, Robert PH, Malandain G, Bussiere F, Darcourt J (2001) Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: A study in Alzheimer's disease and nondemented patients. Neuroimage 13, 896-902.
77. Robert PH, Darcourt G, Koulibaly MP, Clariet S, Benoit M, Garcia R, Dechaux O, Darcourt J (2006) Lack of initiative and interest in Alzheimer's disease: A single photon emission computed tomography study. Eur J Neurol 13, 729-735.
78. Marshall GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer DL (2007) Positron emission tomography metabolic correlates of apathy in Alzheimer's disease. Arch Neurol 64, 1015-1020.
79. Mori T, Shimada H, Shinotoh H, Hirano S, Eguchi Y, Yamada M, Fukuhara R, Tanimukai S, Zhang MR, Kuwabara S, Ueno S, Suhara T (2014) Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease. J Neurol Neurosurg Psychiatry 85, 449-455.
80. Apostolova LG, Akopyan GG, Partiali N, Steiner CA, Dutton RA, Hayashi KM, Dinov ID, Toga AW, Cummings JL, Thompson PM (2007) Structural correlates of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord 24, 91-97.
81. Sultzer DL, Leskin LP, Jacobs ZM, Melrose RJ, Harwood DG, Narvaez TA, Ando TK, Mandelkern MA (2013) Cognitive, behavioral, and emotional domains of apathy in Alzheimer's disease: Clinical and neurobiological features. Am J Geriatr Psychiatry 21, S144-S145.
82. Benoit M, Clairet S, Koulibaly PM, Darcourt J, Robert PH (2004) Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. Int J Geriatr Psychiatry 19, 864-869.
83. Alexopoulos GS, Hoptman MJ, Yuen G, Kanellopoulos D, Seirup JK, Lim KO, Gunning FM (2013) Functional connectivity in apathy of late-life depression: A preliminary study. J Affect Disord 149, 398-405.
84. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer O (1983) Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17, 37-49.
85. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56-62.
86. Montgomery SA, Åsberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134, 382-389.
87. Burke WJ, Houston MJ, Boust SJ, Roccaforte WH (1989) Use of the Geriatric Depression Scale in dementia of the Alzheimer type. J Am Geriatr Soc 37, 856-860.
88. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314.
89. Alexopoulos GS, Abrams RC, Young RC, Shamolan CA (1988) Cornell Scale for Depression in Dementia. Biol Psychiatry 23, 271-284.
90. Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JL (1992) Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: The Neurobehavioral Rating Scale. J Am Geriatr Soc 40, 549-555.
91. Lopez OL, Gonzalez MP, Becker JT, Reynolds CF III, Sudilovsky A, DeKosky ST (1995) Symptoms of depression in Alzheimer's disease, frontal lobe-type dementia, and subcortical dementia. Ann NY Acad Sci 769, 389-392.
92. Aarsland D, Ballard C, Larsen JP, McKeith I (2001) A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia. Int J Geriatr Psychiatry 16, 528-536.
93. Farina E, Baglio F, Caffarra P, Magnani G, Scarpini E, Appollonio I, Bascelli C, Cheldi A, Nemni R, Franceschi M, Italian Group for Lewy Body Dementia, Dementias Associated to Parkinsonism, Messa G, Mantovani F, Bellotti M, Olivotto F, Alberoni M, Isella V, Regazzoni R, Schiatti E, Vismara C, Falautano M, Barbieri A, Restelli I, Fetoni V, Donato M, Zuffi M, Castiglioni S (2009) Frequency and clinical features of Lewy body dementia in Italian Memory Clinics. Acta Biomed 80, 57-64.
94. Huang C, Ravdin LD, Nirenberg MJ, Piboolnurak P, Severt L, Maniscalco JS, Solnes L, Dorfman BJ, Henchcliffe C (2013) Neuroimaging markers of motor and nonmotor features of Parkinson's disease: An [18F]fluorodeoxyglucose positron emission computed tomography study. Dement Geriatr Cogn Disord 35, 183-196.
95. Nihonmatsu-Kikuchi N, Hayashi Y, Yu XJ, Tatebayashi Y (2013) Depression and Alzheimer's disease: Novel postmortem brain studies reveal a possible common mechanism. J Alzheimers Dis 37, 611-621.
96. Teipel SJ, Walter M, Likitjaroen Y, Schonknect P, Gruber O (2014) Diffusion tensor imaging in Alzheimer's disease and affective disorders. Eur Arch Psychiatry Clin Neurosci 264, 467-483.