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Volumn 50, Issue 8, 2009, Pages 1260-1266

Altered brain serotonin transporter and associated glucose metabolism in Alzheimer Disease

Author keywords

Alzheimer's disease; Depression; Glucose metabolism; Positron emission tomography; Serotonin transporter

Indexed keywords

3 AMINO 4 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL)BENZONITRILE C 11; BENZONITRILE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

EID: 68249152023     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.063008     Document Type: Article
Times cited : (76)

References (40)
  • 2
    • 0020673936 scopus 로고
    • Serotonin nerve cells in Alzheimer's disease [letter]
    • Mann DM, Yates PO. Serotonin nerve cells in Alzheimer's disease [letter]. J Neurol Neurosurg Psychiatry. 1983;46:96.
    • (1983) J Neurol Neurosurg Psychiatry , vol.46 , pp. 96
    • Mann, D.M.1    Yates, P.O.2
  • 3
    • 0023151640 scopus 로고
    • Presynaptic serotonergic dysfunction in patients with Alzheimer's disease
    • Palmer AM, Francis PT, Benton JS, et al. Presynaptic serotonergic dysfunction in patients with Alzheimer's disease. J Neurochem. 1987;48:8-15.
    • (1987) J Neurochem , vol.48 , pp. 8-15
    • Palmer, A.M.1    Francis, P.T.2    Benton, J.S.3
  • 4
    • 4043174258 scopus 로고    scopus 로고
    • Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
    • Assal F, Alarcón M, Solomon EC, Masterman D, Geschwind DH, Cummings JL. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch Neurol. 2004;61:1249-1253.
    • (2004) Arch Neurol , vol.61 , pp. 1249-1253
    • Assal, F.1    Alarcón, M.2    Solomon, E.C.3    Masterman, D.4    Geschwind, D.H.5    Cummings, J.L.6
  • 5
    • 0021139170 scopus 로고
    • Nucleus raphe dorsalis in dementia of the Alzheimer type: Neurofibrillary changes and neuronal packing density
    • Curcio CA, Kemper T. Nucleus raphe dorsalis in dementia of the Alzheimer type: neurofibrillary changes and neuronal packing density. J Neuropathol Exp Neurol. 1984;43:359-368.
    • (1984) J Neuropathol Exp Neurol , vol.43 , pp. 359-368
    • Curcio, C.A.1    Kemper, T.2
  • 6
    • 0025782754 scopus 로고
    • Neuropathologic and neurochemical correlates of psychosis in primary dementia
    • Zubenko GS, Moossy J, Martinez AJ, et al. Neuropathologic and neurochemical correlates of psychosis in primary dementia. Arch Neurol. 1991;48:619-624.
    • (1991) Arch Neurol , vol.48 , pp. 619-624
    • Zubenko, G.S.1    Moossy, J.2    Martinez, A.J.3
  • 7
    • 0025244327 scopus 로고
    • The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders: A Nordic multicentre study
    • Nyth AL, Gottfries CG. The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders: a Nordic multicentre study. Br J Psychiatry. 1990;157:894-901.
    • (1990) Br J Psychiatry , vol.157 , pp. 894-901
    • Nyth, A.L.1    Gottfries, C.G.2
  • 9
    • 31444449245 scopus 로고    scopus 로고
    • Serotonin 1A receptors in the living brain of Alzheimer's disease patients
    • Kepe V, Barrio JR, Huang SC, et al. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci USA. 2006;103:702-707.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 702-707
    • Kepe, V.1    Barrio, J.R.2    Huang, S.C.3
  • 10
    • 0031944188 scopus 로고    scopus 로고
    • Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging
    • Meltzer CC, Smith G, DeKosky ST, et al. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology. 1998;18:407-430.
    • (1998) Neuropsychopharmacology , vol.18 , pp. 407-430
    • Meltzer, C.C.1    Smith, G.2    DeKosky, S.T.3
  • 11
    • 40849097282 scopus 로고    scopus 로고
    • 18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease
    • 18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease. Neuroimage. 2008;40:1251-1256.
    • (2008) Neuroimage , vol.40 , pp. 1251-1256
    • Truchot, L.1    Costes, N.2    Zimmer, L.3
  • 12
    • 0025050481 scopus 로고
    • Immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey
    • Lavoie B, Parent A. Immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey. J Comp Neurol. 1990;299:1-16.
    • (1990) J Comp Neurol , vol.299 , pp. 1-16
    • Lavoie, B.1    Parent, A.2
  • 13
    • 0025936538 scopus 로고
    • Serotoninergic innervation of the thalamus in the primate: An immunohistochemical study
    • Lavoie B, Parent A. Serotoninergic innervation of the thalamus in the primate: an immunohistochemical study. J Comp Neurol. 1991;312:1-18.
    • (1991) J Comp Neurol , vol.312 , pp. 1-18
    • Lavoie, B.1    Parent, A.2
  • 14
    • 33646084617 scopus 로고    scopus 로고
    • A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression
    • Thomas AJ, Hendriksen M, Piggott M, et al. A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. Neuropathol Appl Neurobiol. 2006;32:296-303.
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 296-303
    • Thomas, A.J.1    Hendriksen, M.2    Piggott, M.3
  • 15
    • 43749121625 scopus 로고    scopus 로고
    • Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease
    • Levy-Cooperman N, Burhan AM, Rafi-Tari S, et al. Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease. J Psychiatry Neurosci. 2008;33:218-226.
    • (2008) J Psychiatry Neurosci , vol.33 , pp. 218-226
    • Levy-Cooperman, N.1    Burhan, A.M.2    Rafi-Tari, S.3
  • 17
    • 0024981394 scopus 로고
    • Rapidly progressive Alzheimer's disease [letter]
    • Mann UM, Mohr E, Chase TN. Rapidly progressive Alzheimer's disease [letter]. Lancet. 1989;2:799.
    • (1989) Lancet , vol.2 , pp. 799
    • Mann, U.M.1    Mohr, E.2    Chase, T.N.3
  • 18
    • 33947518883 scopus 로고    scopus 로고
    • In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus
    • Ouchi Y, Nakayama T, Kanno T, Yoshikawa E, Shinke T, Torizuka T. In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus. J Cereb Blood Flow Metab. 2007;27:803-810.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 803-810
    • Ouchi, Y.1    Nakayama, T.2    Kanno, T.3    Yoshikawa, E.4    Shinke, T.5    Torizuka, T.6
  • 19
    • 35448989394 scopus 로고    scopus 로고
    • Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: Evidence from the 15-item Geriatric Depression Scale (GDS-15)
    • Weintraub D, Xie S, Karlawish J, Siderowf A. Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: evidence from the 15-item Geriatric Depression Scale (GDS-15). Int J Geriatr Psychiatry. 2007;22:1025-1030.
    • (2007) Int J Geriatr Psychiatry , vol.22 , pp. 1025-1030
    • Weintraub, D.1    Xie, S.2    Karlawish, J.3    Siderowf, A.4
  • 20
    • 0032963916 scopus 로고    scopus 로고
    • Alterations in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: Compartment analysis for beta-CFT binding with positron emission tomography
    • Ouchi Y, Yoshikawa E, Okada H, et al. Alterations in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: compartment analysis for beta-CFT binding with positron emission tomography. Ann Neurol. 1999;45:601-610.
    • (1999) Ann Neurol , vol.45 , pp. 601-610
    • Ouchi, Y.1    Yoshikawa, E.2    Okada, H.3
  • 21
    • 29844450918 scopus 로고    scopus 로고
    • Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    • Sekine Y, Ouchi Y, Takei N, et al. Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Arch Gen Psychiatry. 2006;63:90-100.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 90-100
    • Sekine, Y.1    Ouchi, Y.2    Takei, N.3
  • 22
    • 0018582265 scopus 로고
    • Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: Validation of method
    • Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol. 1979;6:371-388.
    • (1979) Ann Neurol , vol.6 , pp. 371-388
    • Phelps, M.E.1    Huang, S.C.2    Hoffman, E.J.3    Selin, C.4    Sokoloff, L.5    Kuhl, D.E.6
  • 25
    • 0028051572 scopus 로고
    • 11C]raclopride binding in the brain: Model simulations and kinetic analysis of PET data
    • 11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data. J Cereb Blood Flow Metab. 1994;14:995-1010.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 995-1010
    • Logan, J.1    Volkow, N.D.2    Fowler, J.S.3
  • 26
    • 0023838439 scopus 로고
    • Topographical distribution of neurochemical changes in Alzheimer's disease
    • Procter AW, Lowe SL, Palmer AM, et al. Topographical distribution of neurochemical changes in Alzheimer's disease. J Neurol Sci. 1988;84:125-140.
    • (1988) J Neurol Sci , vol.84 , pp. 125-140
    • Procter, A.W.1    Lowe, S.L.2    Palmer, A.M.3
  • 27
    • 1942521246 scopus 로고    scopus 로고
    • Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: Relevance of reduction in posterior cingulate metabolism
    • Ouchi Y, Yoshikawa E, Futatsubashi M, Okada H, Torizuka T, Kaneko M. Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: relevance of reduction in posterior cingulate metabolism. Neuroimage. 2004;22:155-163.
    • (2004) Neuroimage , vol.22 , pp. 155-163
    • Ouchi, Y.1    Yoshikawa, E.2    Futatsubashi, M.3    Okada, H.4    Torizuka, T.5    Kaneko, M.6
  • 28
    • 0021801018 scopus 로고
    • Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons
    • Yamamoto T, Hirano A. Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Ann Neurol. 1985;17:573-577.
    • (1985) Ann Neurol , vol.17 , pp. 573-577
    • Yamamoto, T.1    Hirano, A.2
  • 29
    • 2942565912 scopus 로고    scopus 로고
    • Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression
    • Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. Am J Psychiatry. 2004;161:1096-1102.
    • (2004) Am J Psychiatry , vol.161 , pp. 1096-1102
    • Hendricksen, M.1    Thomas, A.J.2    Ferrier, I.N.3    Ince, P.4    O'Brien, J.T.5
  • 31
    • 14444278967 scopus 로고    scopus 로고
    • Li T, Holmes C, Sham PC, et al. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport. 1997;8:683-686.
    • Li T, Holmes C, Sham PC, et al. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport. 1997;8:683-686.
  • 32
    • 15044357074 scopus 로고    scopus 로고
    • Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease
    • Aucoin JS, Jiang P, Aznavour N, et al. Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. Neuroscience. 2005;132:73-86.
    • (2005) Neuroscience , vol.132 , pp. 73-86
    • Aucoin, J.S.1    Jiang, P.2    Aznavour, N.3
  • 33
    • 13444282255 scopus 로고    scopus 로고
    • Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression
    • Holthoff VA, Beuthien-Baumann B, Kalbe E, et al. Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry. 2005;57:412-421.
    • (2005) Biol Psychiatry , vol.57 , pp. 412-421
    • Holthoff, V.A.1    Beuthien-Baumann, B.2    Kalbe, E.3
  • 34
    • 0032944684 scopus 로고    scopus 로고
    • Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness
    • Mayberg HS, Liotti M, Brannan SK, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry. 1999;156:675-682.
    • (1999) Am J Psychiatry , vol.156 , pp. 675-682
    • Mayberg, H.S.1    Liotti, M.2    Brannan, S.K.3
  • 35
    • 0034975128 scopus 로고    scopus 로고
    • Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression
    • Kennedy SH, Evans KR, Krüger S, et al. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Am J Psychiatry. 2001;158:899-905.
    • (2001) Am J Psychiatry , vol.158 , pp. 899-905
    • Kennedy, S.H.1    Evans, K.R.2    Krüger, S.3
  • 36
    • 0029975463 scopus 로고    scopus 로고
    • Frontal lobe injuries, violence, and aggression: A report of the Vietnam Head Injury Study
    • Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology. 1996;46:1231-1238.
    • (1996) Neurology , vol.46 , pp. 1231-1238
    • Grafman, J.1    Schwab, K.2    Warden, D.3    Pridgen, A.4    Brown, H.R.5    Salazar, A.M.6
  • 37
    • 3142583464 scopus 로고    scopus 로고
    • In the course of time': A PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease
    • Eustache F, Piolino P, Giffard B, et al. 'In the course of time': a PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease. Brain. 2004;127:1549-1560.
    • (2004) Brain , vol.127 , pp. 1549-1560
    • Eustache, F.1    Piolino, P.2    Giffard, B.3
  • 38
    • 4544328810 scopus 로고    scopus 로고
    • BDNF and 5-HT: A dynamic duo in agerelated neuronal plasticity and neurodegenerative disorders
    • Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in agerelated neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004;27:589-594.
    • (2004) Trends Neurosci , vol.27 , pp. 589-594
    • Mattson, M.P.1    Maudsley, S.2    Martin, B.3
  • 39
    • 34247211763 scopus 로고    scopus 로고
    • Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice
    • Nelson RL, Guo Z, Halagappa VM, et al. Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol. 2007;205:166-176.
    • (2007) Exp Neurol , vol.205 , pp. 166-176
    • Nelson, R.L.1    Guo, Z.2    Halagappa, V.M.3
  • 40
    • 0025142124 scopus 로고
    • Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease
    • Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psychiatry. 1990; 147:1049-1051.
    • (1990) Am J Psychiatry , vol.147 , pp. 1049-1051
    • Steele, C.1    Rovner, B.2    Chase, G.A.3    Folstein, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.