AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant

Hormone and Metabolic Research

Volumn 47, Issue 4, 2015, Pages 265-272

  Ramdas, M ^a   Harel, C ^a   Armoni, M ^a   Karnieli, E ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

Author keywords

insulin resistance; metabolic syndrome; obesity

Indexed keywords

ACYL COENZYME A DESATURASE; AHNAK PROTEIN; CD36 ANTIGEN; FAT; FATTY ACID BINDING PROTEIN 4; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE TRANSPORTER 4; INSULIN; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOPROTEIN; PROTEIN; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AHNAK PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; MEMBRANE PROTEIN; SLC2A4 PROTEIN, MOUSE; TUMOR PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; COMPARATIVE STUDY; CONTROLLED STUDY; DIET INDUCED OBESITY; ENDOCRINE FUNCTION TEST; ENERGY METABOLISM; EPIDIDYMIS FAT; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN METABOLISM; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPID DIET; LIPID METABOLISM; LIVER; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WEIGHT CONTROL; ANALYSIS; ANIMAL; BODY WEIGHT; CHEMISTRY; DEFICIENCY; OBESITY; PHYSIOLOGY;

MUS;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIET, HIGH-FAT; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORTER TYPE 4; INSULIN RESISTANCE; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; OBESITY;

EID: 84925746952     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1387736     Document Type: Article

References (50)

1. McArdle M. A., Finucane O. M., Connaughton R. M., McMorrow A. M., Roche H. M. Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne): 2013; 4 52
2. Bays H. E. Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obes Res: 2004; 12 1197 1211
3. Eckel R. H., Kahn S. E., Ferrannini E., Goldfine A. B., Nathan D. M., Schwartz M. W., Smith R. J., Smith R. S. Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab: 2011; 96 1654 1663
4. Armoni M., Harel C., Bar-Yoseph F., Milo S., Karnieli E. Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements. J Biol Chem: 2005; 280 34786 34795
5. Shtivelman E., Bishop J. M. The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus. J Cell Biol: 1993; 120 625 630
6. Shtivelman E., Cohen F. E., Bishop J. M. A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. Proc Natl Acad Sci USA: 1992; 89 5472 5476
7. Gentil B. J., Delphin C., Benaud C., Baudier J. Expression of the giant protein AHNAK (desmoyokin) in muscle and lining epithelial cells. J Histochem Cytochem: 2003; 51 339 348
8. Marg A., Haase H., Neumann T., Kouno M., Morano I. AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness. Biochem Biophys Res Commun: 2010; 401 143 148
9. Benaud C., Gentil B. J., Assard N., Court M., Garin J., Delphin C., Baudier J. AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J Cell Biol: 2004; 164 133 144
10. Nie Z., Ning W., Amagai M., Hashimoto T. C-Terminus of desmoyokin/AHNAK protein is responsible for its translocation between the nucleus and cytoplasm. J Invest Dermatol: 2000; 114 1044 1049
11. Alvarez J. L., Petzhold D., Pankonien I., Behlke J., Kouno M., Vassort G., Morano I., Haase H. Ahnak1 modulates L-type Ca(2+) channel inactivation of rodent cardiomyocytes. Pflugers Arch: 2010; 460 719 730
12. Haase H. Ahnak, a new player in beta-adrenergic regulation of the cardiac L-type Ca2+ channel. Cardiovasc Res: 2007; 73 19 25
13. Haase H., Podzuweit T., Lutsch G., Hohaus A., Kostka S., Lindschau C., Kott M., Kraft R., Moraqno I. Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK. FASEB J: 1999; 13 2161 2172
14. Hohaus A., Person V., Behlke J., Schaper J., Morano I., Haase H. The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton. FASEB J: 2002; 16 1205 1216
15. Matza D., Badou A., Jha M. K., Willinger T., Antov A., Sanjabi S., Kobayashi K. S., Marchesi V. T., Flavell R. A. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proc Natl Acad Sci USA: 2009; 106 9785 9790
16. Matza D., Badou A., Kobayashi K. S., Goldsmith-Pestana K., Masuda Y., Komuro A., McMahon-Pratt D., Marches V. T., Flavell R. A. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity: 2008; 28 64 74
17. Matza D., Flavell RA. Roles of Ca(v) channels and AHNAK1 in T cells: the beauty and the beast. Immunol Rev: 2009; 231 257 264
18. Pankonien I., Alvarez J. L., Doller A., Kohncke C., Rotte D., Regitz-Zagrosek V., Morano I., Haase H. Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity. J Muscle Res Cell Motil: 2011; 32 281 290
19. Sekiya F., Bae Y. S., Jhon D. Y., Hwang S. C., Rhee S. G. AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid. J Biol Chem: 1999; 274 13900 13907
20. Alli A. A., Gower W. R. Jr. The C type natriuretic peptide receptor tethers AHNAK1 at the plasma membrane to potentiate arachidonic acid-induced calcium mobilization. Am J Physiol: 2009; 297 C1157 C1167
21. Parikh H., Nilsson E., Ling C., Poulsen P., Almgren P., Nittby H., Erlksson K-F, Vaag A. Molecular correlates for maximal oxygen uptake and type 1 fibers. Am J Physiol: 2008; 294 E1152 E1159
22. 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice. Biochem Biophys Res Commun: 2010; 403 428 434
23. Kouno M., Kondoh G., Horie K., Komazawa N., Ishii N., Takahashi Y., Takeda J., Hashimoto T. Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis. J Invest Dermatol: 2004; 123 700 707
24. Hemi R., Yochananov Y., Barhod E., Kasher-Meron M., Karasik A., Tirosh A., Kanety H. p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. Diabetes: 2011; 60 1134 1145
25. Freidenberg G. R., Reichart D., Olefsky J. M., Henry R. R. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest: 1988; 82 1398 1406
26. Cho H., Mu J., Kim J. K., Thorvaldsen J., Chu Q., Crenshaw E. B. III, Kaestner KI H., Bartolmei M. S., Shulman G. I., Birnbaum M. J. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science: 2001; 292 1728 1731
27. Graham T. E., Yang Q., Bluher M., Hammarstedt A., Ciaraldi T. P., Henry R. R., Wason C. J., Oberbach A., Jansson P-A, Smith U., Kahn B. B. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Eng J Med: 2006; 354 2552 2563
28. Ruan W., Lai M. Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome? Acta Diabetol: 2010; 47 5 14
29. Wheatcroft S. B., Kearney M. T. IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis. Trends Endocrinol Metab: 2009; 20 153 162
30. Bak J. F., Moller N., Schmitz O., Saaek A., Pedersen O. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia: 1992; 35 777 784
31. Li J., Yu X., Pan W., Unger R. H. Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Am J Physiol: 2002; 282 E1334 E1341
32. Zierath J. R., Houseknecht K. L., Gnudi L., Kahn B. B. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes: 1997; 46 215 223
33. Muoio D. M., Koves T. R. Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. Appl Physiol Nutr Metab: 2007; 32 874 883
34. Pedersen M. G., Sherman A. Newcomer insulin secretory granules as a highly calcium-sensitive pool. Proc Natl Acad Sci USA: 2009; 106 7432 7436
35. Jacobson D. A., Weber C. R., Bao S., Turk J., Philipson L. H. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem: 2007; 282 7442 7449
36. Ramanadham S., Gross R., Turk J. Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cells. Biochem Biophys Res Commun: 1992; 184 647 653
37. Sharoyko V. V., Zaitseva I. I., Leibiger B., Efendic S., Berggren P-O, Zaitsev S. V. Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion. Cell Mol Life Sci: 2007; 64 2985 2993
38. Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes: 1999; 48 1198 1214
39. Edgerton D. S., Lautz M., Scott M., Everett C. A., Stettler K. M., Neal D. W., Chu C. A., Cherrington A. D. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest: 2006; 116 521 527
40. Gutierrez-Juarez R., Pocai A., Mulas C., Ono H., Bhanot S., Monia B. P., Rossetti L. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest: 2006; 116 1686 1695
41. Ntambi J. M., Miyazaki M., Stoehr J. P., Lan H., Kendiziorskis C. M., Song Y., Cohen P., Friedman J. M., Attie A. D. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA: 2002; 99 11482 11486
42. Jiang G., Li Z., Liu F., Ellsworth K., Dallas-Yan Q., Wu M., Ronan J., Esau C., Murphy C., Szalkowski D., Bergeron R., Doebber T., Zhang B. B. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest: 2005; 115 1030 1038
43. Austin S., St-Pierre J. PGC1alpha and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci: 2012; 125 4963 4971
44. Kleiner S., Mepani R. J., Laznik D., Ye L., Jurczak M. J., Jornayvaz F. R., Estall J. L., Bhowmick D. C., Shulman G. I., Spiegelman B. M. Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues. Proc Natl Acad Sci USA: 2012; 109 9635 9640
45. Frystyk J., Vestbo E., Skjaerbaek C., Mogensen C. E., Orskov H. Free insulin-like growth factors in human obesity. Metab Clin Exp: 1995; 44 37 44
46. Crossey P. A., Jones J. S., Miell J. P. Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. Diabetes: 2000; 49 457 465
47. Rajkumar K., Krsek M., Dheen S. T., Murphy L. J. Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice. J Clin Invest: 1996; 98 1818 1825
48. Rajkumar K., Modric T., Murphy L. J. Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice. J Endocrinol: 1999; 162 457 465
49. Rajwani A., Ezzat V., Smith J., Yuldasheva N. Y., Duncan E. R., Gage M., Cubbon R. M., Kahn M. B., Imrie H., Abbas A., Viswambharan H., Azziz A., Sukumar P., Vidal-Puig A., Sethi J. K., Xuan S., Shah A. M., Grant P. J., Porter K. E., Kearny M. T., Wheatcroft S. B. Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes: 2012; 61 915 924
50. Yang Q., Graham T. E., Mody N., Preitner F., Peroni O. D., Zabolotny J. M., Kotani K., Quadro L., Kahn B. B. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature: 2005; 436 356 362