Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion

Cellular and Molecular Life Sciences

Volumn 64, Issue 22, 2007, Pages 2985-2993

  Sharoyko, V V ^a   Zaitseva, I I ^a,b   Leibiger, B ^a   Efendic S ^a   Berggren, P O ^a   Zaitsev, S V ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Arachidonic acid; BL11282; Calcium independent phospholipase A2; Cytochrome P 450; Imidazolines; Insulin secretion

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA 2 ADRENERGIC RECEPTOR; ARACHIDONIC ACID; BL 11282; IMIDAZOLE; IMIDAZOLINE RECEPTOR; INSULIN DERIVATIVE; PHOSPHOLIPASE A; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; INSULIN LIKE ACTIVITY; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ARACHIDONIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; CYTOCHROME P-450 ENZYME SYSTEM; IMIDAZOLES; IMIDAZOLINE RECEPTORS; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHOLIPASES A2; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES; YOHIMBINE;

MUS;

EID: 38549122935     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-7308-3     Document Type: Article

References (36)

1. Robertson, R. P. and Porte, D. Jr. (1973) Adrenergic modulation of basal insulin secretion in man. Diabetes 22, 1-8.
2. Efendic, S., Cerasi, E. and Luft, R. (1975) Effect of phentolamine and preperfusion with glucose on insulin release from the isolated perfused pancreas from fasted and fed rats. Diabetologia 11, 407-410.
3. Ostenson, C. G., Pigon, J., Doxey, J. C. and Efendic, S. (1988) Alpha 2-adrenoceptor blockade does not enhance glucose-induced insulin release in normal subjects or patients with noninsulin-dependent diabetes. J. Clin. Endocrinol. Metab. 67, 1054-1059.
4. Ostenson, C. G., Cattaneo, A. G., Doxey, J. C. and Efendic, S. (1989) Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats. Am. J. Physiol. 257, E439-443.
5. Schulz, A. and Hasselblatt, A. (1989) Dual action of clonidine on insulin release: Suppression, but stimulation when alpha 2-adrenoceptors are blocked. Naunyn Schmiedebergs Arch. Pharmacol. 340, 712-714.
6. + channels in pancreatic beta-cells. Br. J. Pharmacol. 107, 8-14.
7. ATP channels is mediated by Kir6.2. Proc. Natl. Acad. Sci. USA 94, 11716-11720.
8. ATP channels and interaction with the exocytotic machinery. Diabetes 45, 1610-1618.
9. Efanov, A. M., Zaitsev, S. V., Efanova, I. B., Zhu, S., Ostenson, C. G., Berggren, P. O. and Efendic, S. (1998) Signaling and sites of interaction for RX871024 and sulfonylurea in the stimulation of insulin release. Am. J. Physiol. 274, E751-757.
10. 2+ from endoplasmic reticulum, and interaction with exocytotic machinery. Ann. N. Y. Acad. Sci. 881, 241-252.
11. ATP channel activity. Diabetes 50, 797-802.
12. Efendic, S., Efanov, A. M., Berggren, P. O. and Zaitsev, S. V. (2002) Two generations of insulinotropic imidazoline compounds. Diabetes 51 Suppl 3, S448-454.
13. Shiota, C., Larsson, O., Shelton, K. D., Shiota, M., Efanov, A. M., Hoy, M., Lindner, J., Kooptiwut, S., Juntti-Berggren, L., Gromada, J., Berggren, P. O. and Magnuson, M. A. (2002) Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J. Biol. Chem. 277, 37176-37183.
14. 2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets. Proc. Natl. Acad. Sci. USA 92, 9712-9716.
15. Sharoyko, V. V., Zaitseva, II, Varsanyi, M., Portwood, N., Leibiger, B., Leibiger, I., Berggren, P. O., Efendic, S. and Zaitsev, S. V. (2005) Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 338, 1455-1459.
16. 2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: Dissociation from the mechanism of carbachol. Diabetes 47, 1436-1443.
17. Guenifi, A., Simonsson, E., Karlsson, S., Ahren, B. and Abdel-Halim, S. M. (2001) Carbachol restores insulin release in diabetic GK rat islets by mechanisms largely involving hydrolysis of diacylglycerol and direct interaction with the exocytotic machinery. Pancreas 22, 164-171.
18. Munk, S. A., Lai, R. K., Burke, J. E., Arasasingham, P. N., Kharlamb, A. B., Manlapaz, C. A., Padillo, E. U., Wijono, M. K., Hasson, D. W., Wheeler, L. A. and Garst, M. E. (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropyl bicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J. Med. Chem. 39, 1193-1195.
19. Efanov, A. M., Zaitsev, S. V., Berggren, P. O., Mest, H. J. and Efendic, S. (2001) Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets. Biochem. Biophys. Res. Commun. 281, 1070-1073.
20. 2+ in beta-cells. Diabetes 47, 365-373.
21. 2 results in insufficient insulin secretion and impaired glucose tolerance. Mol. Endocrinol. 19, 504-515.
22. 2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270, 445-450.
23. 2. Annu. Rev. Pharmacol. Toxicol. 39, 175-189.
24. Falck, J. R., Manna, S., Moltz, J., Chacos, N. and Capdevila, J. (1983) Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochem. Biophys. Res. Commun. 114, 743-749.
25. Woodcroft, K. J., Szczepan, E. W., Knickle, L. C. and Bend, J. R. (1990) Three N-aralkylated derivatives of 1-aminobenzotriazole as potent and isozyme-selective, mechanism-based inhibitors of guinea pig pulmonary cytochrome P-450 in vitro. Drug. Metab. Dispos. 18, 1031-1037.
26. ATP channels. Neuron 22, 537-548.
27. ATP channel-independent regulation of insulin secretion. J. Biol. Chem. 275, 9270-9277.
28. 1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla. Brain Res. 749, 335-339.
29. 1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Mol. Pharmacol. 49, 668-675.
30. 2+ concentration. Endocrinology 139, 4073-4085.
31. Needleman, P., Turk, J., Jakschik, B. A., Morrison, A. R. and Lefkowith, J. B. (1986) Arachidonic acid metabolism. Annu. Rev. Biochem. 55, 69-102.
32. Jones, P. M. and Persaud, S. J. (1993) Arachidonic acid as a second messenger in glucose-induced insulin secretion from pancreatic beta-cells. J. Endocrinol. 137, 7-14.
33. 2 regulation of arachidonic acid mobilization. FEBS Lett. 531, 2-6.
34. 2 isoforms: A perspective. Cell. Signal. 15, 637-665.
35. 2 beta transcript. Biochemistry 42, 13929-13940.
36. Efanov, A. M., Appelskog, I. B., Abdel-Halim, S. M., Khan, A., Branstrom, R., Larsson, O., Ostenson, C. G., Mest, H. J., Berggren, P. O., Efendic, S. and Zaitsev, S. V. (2002) Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat. Am. J. Physiol. Endocrinol. Metab. 282, E117-124.