Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(α)i/o/RhoA/ROCK signaling pathway

Journal of Cellular Physiology

Volumn 230, Issue 7, 2015, Pages 1640-1650

  Mai, Ping ^a   Tian, Lei ^a   Yang, Le ^a   Wang, Lin ^a   Yang, Lin ^a   Li, Liying ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; EXOENZYME C3; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MESSENGER RNA; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; CNR2 PROTEIN, MOUSE; GNAO1 PROTEIN, MOUSE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PHAGOCYTOSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE SILENCING; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; GENETICS; METABOLISM; PHAGOCYTOSIS; PHYSIOLOGY;

MURINAE;

ANIMALS; CELLS, CULTURED; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MACROPHAGES; MICE; PHAGOCYTOSIS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES;

EID: 84925665127     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24911     Document Type: Article

References (37)

1. Asplund MB, Coelho C, Cordero RJ, Martinez LR. 2013. Alcohol impairs J774.16 macrophage-like cell antimicrobial functions in Acinetobacter baumannii infection. Virulence 4:467-472.
2. Bishop AL, Hall A. 2000. Rho GTPases and their effector proteins. Biochem J 348:241-255.
3. Caron E, Hall A. 1998. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282:1717-1721.
4. Castellano F, Montcourrier P, Chavrier P. 2000. Membrane recruitment of Rac1 triggers phagocytosis. J Cell Sci 113:2955-2961.
5. Castellano F, Montcourrier P, Guillemot JC, Gouin E, Machesky L, Cossart P, Chavrier P. 1999. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation. Curr Biol 9:351-360.
6. Chen XP, Yang W, Fan Y, Luo JS, Hong K, Wang Z, Yan JF, Chen X, Lu JX, Benovic JL, Zhou NM. 2010. Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i). Br J Pharmacol 161:1817-1834.
7. Chimini G, Chavrier P. 2000. Function of Rho family proteins in actin dynamics during phagocytosis and engulfment. Nat Cell Biol 2:E191-E196.
8. Fonseca BM, Costa MA, Almada M, Correia-da-Silva G, Teixeira NA. 2013. Endogenous cannabinoids revisited: A biochemistry perspective. Prostaglandins Other Lipid Mediat 102-103:13-30.
9. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. 2010. Development of monocytes, macrophages, and dendritic cells. Science 327:656-661.
10. Gui H, Sun Y, Luo ZM, Su DF, Dai SM, Liu X. 2013. Cannabinoid receptor 2 protects against acute experimental sepsis in mice. Mediators Inflamm 2013:741303.
11. Han KH, Lim S, Ryu J, Lee CW, Kim Y, Kang JH, Kang SS, Ahn YK, Park CS, Kim JJ. 2009. CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Cardiovasc Res 84:378-386.
12. Hanna S, El-Sibai M. 2013. Signaling networks of Rho GTPases in cell motility. Cell Signal 25:1955-1961.
13. Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. 2004. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 47:345-358.
14. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. 2013. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med 19:1132-1140.
15. Kaplan BL. 2013. The role of CB1 in immune modulation by cannabinoids. Pharmacol Ther 137:365-374.
16. Klein TW, Newton C, Friedman H. 1998. Cannabinoid receptors and immunity. Immunol Today 19:373-381.
17. Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L. 2011. Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol 54:1205-1213.
18. Liu J, Batkai S, Pacher P, Harvey-White J, Wagner JA, Cravatt BF, Gao B, Kunos G. 2003. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem 278:45034-45039.
19. Martín-Moreno AM, Ramírez RD, Mechoulam BG, Innamorato R, Cuadrado N, de Ceballos A. 2011. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Mol Pharmacol 79:964-973.
20. Massol P, Montcourrier P, Guillemot JC, Chavrier P. 1998. Fc receptor-mediated phagocytosis requires CDC42 and Rac1. EMBO J 17:6219-6229.
21. Matias I, Pochard P, Orlando P, Salzet M, Pestel J, Di Marzo V. 2002. Presence and regulation of the endocannabinoid system in human dendritic cells. Eur J Biochem 269:3771-3778.
22. Mizutani T, Kawabata K, Koyama Y, Takahashi M, Haga H. 2009. Regulation of cellular contractile force in response to mechanical stretch by diphosphorylation of myosin regulatory light chain via RhoA signaling cascade. Cell Motil Cytoskeleton 66:389-397.
23. Morris AC, Brittan M, Wilkinson TS, McAuley DF, Antonelli J, McCulloch C, Barr LC, McDonald NA, Dhaliwal K, Jones RO, Mackellar A, Haslett C, Hay AW, Swann DG, Anderson N, Laurenson IF, Davidson DJ, Rossi AG, Walsh TS, Simpson AJ. 2011. C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients. Blood 117:5178-5188.
24. Niedergang F, Chavrier P. 2005. Regulation of phagocytosis by Rho GTPases. Curr Top Microbiol Immunol 291:43-60.
25. Pandey R, Mousawy K, Nagarkatti M, Nagarkatti P. 2009. Endocannabinoids and immune regulation. Pharmacol Res 60:85-92.
26. Pryce G, Ahmed Z, Hankey DJ, Jackson SJ, Croxford JL, Pocock JM, Ledent C, Petzold A, Thompson AJ, Giovannoni G, Cuzner ML, Baker D. 2003. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 126:2191-2202.
27. Qu G, Zhang C, Yuan L, He J, Wang Z, Wang L, Liu S, Jiang G. 2012. Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling. Nanoscale 4:2239-2244.
28. Raborn ES, Marciano-Cabral F, Buckley NE, Martin BR, Cabral GA. 2008. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor. J Neuroimmune Pharmacol 3:117-129.
29. Ramirez SH, Reichenbach NL, Fan S, Rom S, Merkel SF, Wang X, Ho WZ, Persidsky Y. 2013. Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists. J Leukoc Biol 93:801-810.
30. Ross RA, Brockie HC, Pertwee RG. 2000. Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide. Eur J Pharmacol 401:121-130.
31. Sacerdote P, Martucci C, Vaccani A, Bariselli F, Panerai AE, Colombo A, Parolaro D, Massi P. 2005. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol 159:97-105.
32. Shiratsuchi A, Watanabe I, Yoshida H, Nakanishi Y. 2008. Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. Immunol Cell Biol 86:179-184.
33. Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y, Izumiya Y, Miyata K, Nakayama M, Kaikita K, Obata T, Takeya M, Ogawa H. 2009. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation 119:28-36.
34. Tanasescu R, Constantinescu CS. 2010. Cannabinoids and the immune system: An overview. Immunobiology 215:588-597.
35. Varga K, Wagner JA, Bridgen DT, Kunos G. 1998. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 12:1035-1044.
36. Zhao Y, Yuan Z, Liu Y, Xue J, Tian Y, Liu W, Zhang W, Shen Y, Xu W, Liang X, Chen T. 2010. Activation of cannabinoid CB2 receptor ameliorates atherosclerosis associated with suppression of adhesion molecules. J Cardiovasc Pharmacol 55:292-298.
37. Zimmerman NP, Roy I, Hauser AD, Wilson JM, Williams CL, Dwinell MB. 2013. Sep 24 Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells. Mol Carcinog. DOI: 10.1002/mc.22091