Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging

Hypertension

Volumn 63, Issue 2, 2014, Pages 390-396

  Oelze, Matthias ^a   Kröller Schön, Swenja ^a   Steven, Sebastian ^a   Lubos, Edith ^c   Doppler, Christopher ^a   Hausding, Michael ^a   Tobias, Silke ^a   Brochhausen, Christoph ^a   Li, Huige ^a   Torzewski, Michael ^b   Wenzel, Philip ^a   Bachschmid, Markus ^d   Lackner, Karl J ^b   Schulz, Eberhard ^a   Münzel, Thomas ^a   Daiber, Andreas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b ROBERT BOSCH HOSPITAL   (Germany)

^c UNIVERSITY HEART CENTER HAMBURG   (Germany)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

aging; oxidative stress; vascular function

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ADENYLATE CYCLASE; CHLORDANE; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE PEROXIDASE 1; GUANYLATE CYCLASE; GUANYLATE CYCLASE ALPHA1; GUANYLATE CYCLASE BETA1; HYDROETHIDINE; LUCIGENIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; C57BL 6 MOUSE; CELL CULTURE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME DEFICIENCY; ENZYME MODIFICATION; FLUORESCENCE MICROSCOPY; FLUORESCENCE MICROTOPOGRAPHY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INFLAMMATORY CELL; LEUKOCYTE ADHERENCE; MACROPHAGE; MALE; MONOCYTE; MOUSE; NITRATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION ASSAY; PROTEIN PHOSPHORYLATION; RESPIRATORY BURST; SIGNAL TRANSDUCTION; STAINING; VASCULAR DISEASE; VASCULAR RING; VASODILATATION; WESTERN BLOTTING;

EID: 84892916146     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.01602     Document Type: Article

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