Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK–ERK–β-catenin pathway

Molecular and Cellular Biochemistry

Volumn 402, Issue 1-2, 2015, Pages 243-252

  Ku, Min Jung ^a   Kim, Ji Hyun ^a   Lee, Jongsung ^b   Cho, Jae Youl ^c   Chun, Taehoon ^d   Lee, Sang Yeol ^a  

^a Gachon University College of Medicine   (South Korea)

^b Eulji University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Korea University   (South Korea)

Author keywords

Maclurin; Matrix metalloproteinases; Metastasis; Non small cell lung cancer; Reactive oxygen species

Indexed keywords

ANTIMETASTATIC AGENT; BETA CATENIN; GELATINASE A; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROGEN PEROXIDE; MACLURIN; MITOGEN ACTIVATED PROTEIN KINASE; MULBERRY EXTRACT; PHENOL DERIVATIVE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CTNNB1 PROTEIN, HUMAN; FOCAL ADHESION KINASE 1; PLANT LECTIN; PTK2 PROTEIN, HUMAN;

A549 CELL LINE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; METASTASIS INHIBITION; MULBERRY; NON SMALL CELL LUNG CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR INVASION; CARCINOMA, NON-SMALL-CELL LUNG; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; LUNG NEOPLASMS; METABOLISM; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BETA CATENIN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; DRUG SCREENING ASSAYS, ANTITUMOR; FOCAL ADHESION KINASE 1; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; NEOPLASM INVASIVENESS; PLANT LECTINS; SRC-FAMILY KINASES; WNT SIGNALING PATHWAY;

EID: 84925536270     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2331-4     Document Type: Article

References (29)

1. Basset P, Okada A, Chenard MP, Kannanb R, Stoll I, Anglard P, Bellocq JP, Rio MC (1997) Matrix metalloproteinases as stromal effectors of human carcinoma progression: therapeutic implications. Matrix Biol 15:535–541
2. Johnsen M, Lund LR, Rømer J, Almholt K, Danø K (1998) Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr Opin Cell Biol 10:667–671
3. Sahai E (2007) Illuminating the metastatic process. Nat Rev Cancer 7:737–749
4. Stetler-Stevenson WG, Liotta LA, Kleiner DE Jr. (1993) Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J 7:1434–1441
5. Bierbaum S, Hintze V, Scharnweber D (2012) Functionalization of biomaterial surfaces using artificial extracellular matrices. Biomatter 2:132–141
6. Yodkeeree S, Ampasavate C, Sung B, Aggarwal BB, Limtrakul P (2010) Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. Eur J Pharmacol 627:8–15
7. Deryugina EI, Quigley JP (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25:9–34
8. Nyberg P, Salo T, Kalluri R (2008) Tumor microenvironment and angiogenesis. Front Biosci 13:6537–6553
9. Bae IH, Park MJ, Yoon SH, Kang SW, Lee SS, Choi KM, Um HD (2006) Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. Cancer Res 66:4991–4995
10. Westermarck J, Kähäri VM (1999) Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13:781–792
11. Hamaguchi M, Yamagata S, Thant AA, Xiao H, Iwata H, Mazaki T, Hanafusa H (1995) Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src. Oncogene 10:1037–1043
12. Szatrowski TP, Nathan CF (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51:794–798
13. Nishikawa M (2008) Reactive oxygen species in tumor metastasis. Cancer Lett 266:53–59
14. Nelson KK, Melendez JA (2004) Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med 37:768–784
15. Giannoni E, Buricchi F, Raugei G, Ramponi G, Chiarugi P (2005) Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol 25:6391–6403
16. Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, Hung WJ, Chen YJ, Huang MH (2011) Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food Chem Toxicol 49:785–790
17. Li X, Gao Y, Li F, Liang A, Xu Z, Bai Y, Mai W, Han L, Chen D (2014) Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: antioxidant evaluation and mechanistic insight. Chem Biol Interact 219C:221–228
18. Kofujita H, Yaguchi M, Doi N, Suzuki K (2004) A novel cytotoxic prenylated flavonoid from the root of Morus alba. J Insect Biotechnol Sericology 73:113–116
19. Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL, Hsieh YS (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235:248–259
20. Dulak J (2005) Nutraceuticals as anti-angiogenic agents: hopes and reality. J Physiol Pharmacol 56:51–67
21. Yadav M, Jain S, Bhardwaj A, Nagpal R, Puniya M, Tomar R, Singh V, Parkash O, Prasad GB, Marotta F, Yadav H (2009) Biological and medicinal properties of grapes and their bioactive constituents: an update. J Med Food 12:473–484
22. Meeran SM, Katiyar SK (2008) Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci 13:2191–2202
23. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480–481:243–268
24. 4hydrolase. Cancer Res 70:9755–9764
25. Kim MH, Son YJ, Lee SY, Yang WS, Yi YS, Yoon DH, Yang Y, Kim SH, Lee D, Rhee MH, Kang H, Kim TW, Sung GH, Cho JY (2013) JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide. Biochem Pharmacol 86:1747–1761
26. Yeh CH, Yang JJ, Yang ML, Li YC, Kuan YH (2014) Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK–NF-κB pathway. Free Radic Biol Med 69:249–257
27. Giannoni E, Taddei ML, Chiarugi P (2010) Src redox regulation: again in the front line. Free Radic Biol Med 49:516–527
28. Son YO, Pratheeshkumar P, Wang L, Wang X, Fan J, Kim DH, Lee JY, Zhang Z, Lee JC, Shi X (2013) Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3 K/AKT-dependent activation of GSK-3b/b-catenin signaling. Toxicol Appl Pharmacol 271(2):239–248
29. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC (2005) Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 19:159–170