A novel cytotoxic prenylated flavonoid from the root of Morus alba

Journal of Insect Biotechnology and Sericology

Volumn 73, Issue 3, 2004, Pages 113-116

  Kofujita, Hisayoshi ^a   Yaguchi, Masashi ^a   Doi, Noroi ^b   Suzuki, Koichi ^a  

^a IWATE UNIVERSITY   (Japan)

^b Fukushima Agric Research Center   (Japan)

Author keywords

Cytotoxic activity; Morus alba; Novel prenylated flavanone; Root

Indexed keywords

CYTOTOXIC; CYTOTOXIC ACTIVITIES; ETHYL ACETATES; MORUS ALBA; NOVEL PRENYLATED FLAVANONE; PRENYLATED FLAVONOIDS; ROOT;

CYTOTOXICITY; FLAVONOIDS; SPECTRUM ANALYSIS;

PLANTS (BOTANY);

MORUS (PLANT); MORUS ALBA;

SERICULTURE;

EID: 13244278417     PISSN: 13468073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ahluwalia, V.K., Singh, M., and Singh, R.P. (1984) A facile synthesis of crotylacetophenones and acetyl substituted 2-methylchromans. Syn. Commun. 14, 127-137.
2. Asano, N., Oseki, K., Tomika, E., Kizu, H., and Matsui, K. (1994) N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohyr. Res. 259, 243-255.
3. Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H., Kameda, Y., Kato, A., Nash, R.J., Lee, H.S., and Ryu, K.S. (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric. Food Chem. 49, 4208-4213.
4. Bhanumati, S., Chhabra, S.C., and Gupta, S.R. (1979) Cajaisoflavone, a new prenylated isoflavone from Cajanus cajan. Phytochemistry 18 1254.
5. Chi, Y.S., Jong, H.G., Son, K.H., Chang, H.W., Kang, S.S., and Kim, H.P. (2001) Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cyclooxygenases and lipoxygenases. Biochem. Pharmacol. 62, 1185-1191.
6. Doi, K., Kojima, T., Makino, M., Kimura, Y., and Fujimoto, Y. (2001a) Studies on the constituents of the leaves of Morus alba L. Chem. Pharm. Bul. 49, 151-153.
7. Doi, N., Koyama, A., and Fujita, S. (2001b) Breeding of new mulberry cultivator "Kinuyutaka". Bull. Fukushima Seric. Exp. Stat. 32 23-34 (in Japanese).
8. Du, J., He, Z.D., Jiang, R.W., Ye, W.C., Xu, H.X., and But, P.P. H. (2003) Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 62, 1235-1238.
9. Dufall, K.G., Ngadjui, B.T., Simeon, K.F., Abegaz, B.M., and Croft, K.D. (2003) Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii. J. Ethnopharmacol. 87 67-72.
10. Hatano, T., Fukuda, T., Miyase, T., Noro, T., and Okuda, T. (1991) Phenolic constituents of Licorice. III. Structures of glicoricone and licofranone, and inhibitory effect of Licorice constituents on monoamine oxidase. Chem. Pharm. Bull. 39, 1238.
11. Iinuma, M., Ohyama, M., Tanaka, T., Mizuno, M., and Hong, S.K. (1992a) Three 2', 4', 6'-trioxygenated flavanones in roots of Echinosophorakoreensis. Phytochemistry 31, 665-669.
12. Iinuma, M., Ohyama, M., Tanaka, T., Mizuno, M., and Hong, S. K. (1992b) Three 2', 4', 6'-trioxygenated flavanones in roots of Echinosophorakoreensis. Phytochemistry 31, 2855-2858.
13. Kaneda, M., Saitoh, T., Iitaka, Y., and Shibata, S. (1973) Chemical studies on the oriental plant drugs. XXXVI. Structure of licoricone, a new isoflavone from Licorice root. Chem. Pharm. Bull. 21, 1338.
14. Nomura, T., Fukai, T., Hano, Y, Yoshizawa, S., Suganuma, M., and Fujiki, H. (1988) Chemistry and anti-tumor promoting activity of Morus flavonoids. Prog. Clin. Bio. Res. 280, 267-281.
15. Oka, M., Maeda, S., Kago, N., Kato, K., and Saito, T. (1992) A modified colorimetric MTT assay adapted for primary cultured hapatocytes.: Application to ploriferation and cytotoxicity assays. Biosci. Biotech. Biochem. 56, 1472-1473.
16. Oshima, Y., Konno, C., Hikino, H., and Matsushita, K. (1980) Structure of Moracenin A, a hypotensive principle of Morus root barks. Heterocycles 14, 1287-1290.
17. Ryu, K.S., Lee, H.S., and Kim, I. (2002) Effects and mechanisms of shilkworm powder as blood glucose-lowering agent. Int. J. Indust. Entomol. 4, 93-100.
18. Shi, Y.Q., Fukai, T., Sakagami, H., Chang, W.J., Yang, P.Q., Wang, F.P., and Nomura, T. (2001) Cytotoxic flavonoids with isoprenoid groups from Morus mongolica. J. Nat. Prod. 64, 181-188.
19. Son, J.K., Park, J.S., Kim, J.A., Kim, Y., Chung, S.R., and Lee, S.H. (2003) Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 69, 559-61.
20. Yagi, M., Kouno, T., Aoyagi, Y, and Murai, H. (1976) The structure of moranoline, a piperidine alkaloid from Morus species. Nippon Nogei Kagaku Kaishi 50, 571-572 (in Japanese).
21. Yamamoto, H., Yatou, A., and Inoue, K. (2001) 8-Dimethylallylnaringenin 20-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells. Phytochemistry 58, 671-676.