메뉴 건너뛰기




Volumn 64, Issue 3, 2015, Pages 389-399

Tumor-induced CD14+HLA-DR−/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients

Author keywords

Bortezomib; Immunosuppression; Multiple myeloma; Myeloid derived suppressor cells; Tumor progressive

Indexed keywords

ARGINASE 1; BORTEZOMIB; CD14 ANTIGEN; DEXAMETHASONE; DOXORUBICIN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; VINCRISTINE; BORONIC ACID DERIVATIVE; CYTOKINE; PYRAZINE DERIVATIVE;

EID: 84925534592     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1646-4     Document Type: Article
Times cited : (80)

References (43)
  • 1
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • COI: 1:CAS:528:DC%2BD1MXltFSqtr8%3D, PID: 19009291
    • Galustian C, Meyer B, Labarthe MC et al (2009) The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol Immunother 58:1033–1045. doi:10.1007/s00262-008-0620-4
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1033-1045
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 2
    • 84892620823 scopus 로고    scopus 로고
    • Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial
    • COI: 1:CAS:528:DC%2BC2cXhvFGqtbzO, PID: 23996482
    • Scheid C, Sonneveld P, Schmidt-Wolf IG et al (2014) Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial. Haematologica 99:148–154. doi:10.3324/haematol.2013.087585
    • (2014) Haematologica , vol.99 , pp. 148-154
    • Scheid, C.1    Sonneveld, P.2    Schmidt-Wolf, I.G.3
  • 3
    • 84882624372 scopus 로고    scopus 로고
    • Immunomodulatory agents changing the landscape of multiple myeloma treatment
    • PID: 23769452
    • Niesvizky R (2013) Immunomodulatory agents changing the landscape of multiple myeloma treatment. Crit Rev Oncol Hematol 88(Suppl 1):S1–S4. doi:10.1016/j.critrevonc.2012.12.011
    • (2013) Crit Rev Oncol Hematol , vol.88 , pp. 1-4
    • Niesvizky, R.1
  • 4
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXhtVKgsr7O, PID: 17686051
    • Pratt G, Goodyear O, Moss P (2007) Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 138:563–579. doi:10.1111/j.1365-2141.2007.06705.x
    • (2007) Br J Haematol , vol.138 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 5
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BC3cXis1yitrs%3D, PID: 20142361
    • Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI (2010) Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J Immunol 184:3106–3116. doi:10.4049/jimmunol.0902661
    • (2010) J Immunol , vol.184 , pp. 3106-3116
    • Nagaraj, S.1    Schrum, A.G.2    Cho, H.I.3    Celis, E.4    Gabrilovich, D.I.5
  • 6
    • 42349094504 scopus 로고    scopus 로고
    • Tumor escape mechanism governed by myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BD1cXks1Git7s%3D, PID: 18413722
    • Nagaraj S, Gabrilovich DI (2008) Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer Res 68:2561–2563. doi:10.1158/0008-5472.CAN-07-6229
    • (2008) Cancer Res , vol.68 , pp. 2561-2563
    • Nagaraj, S.1    Gabrilovich, D.I.2
  • 7
    • 84863991235 scopus 로고    scopus 로고
    • Myeloid suppressor cell depletion augments antitumor activity in lung cancer
    • COI: 1:CAS:528:DC%2BC38XhtVyisLzP, PID: 22815789
    • Srivastava MK, Zhu L, Harris-White M et al (2012) Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS One 7:e40677. doi:10.1371/journal.pone.0040677
    • (2012) PLoS One , vol.7 , pp. 40677
    • Srivastava, M.K.1    Zhu, L.2    Harris-White, M.3
  • 8
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • COI: 1:CAS:528:DC%2BD1MXhsFeqsbw%3D, PID: 19197294
    • Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162–174. doi:10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 9
    • 84865760928 scopus 로고    scopus 로고
    • Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC)
    • COI: 1:CAS:528:DC%2BC38XhtVOhtL%2FI, PID: 22546994
    • Ostrand-Rosenberg S, Sinha P, Chornoguz O, Ecker C (2012) Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC). Cancer Immunol Immunother 61:1319–1325. doi:10.1007/s00262-012-1269-6
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1319-1325
    • Ostrand-Rosenberg, S.1    Sinha, P.2    Chornoguz, O.3    Ecker, C.4
  • 10
    • 0036301973 scopus 로고    scopus 로고
    • Immature myeloid cells and cancer-associated immune suppression
    • COI: 1:CAS:528:DC%2BD38XmvVSqs7g%3D, PID: 12111117
    • Kusmartsev S, Gabrilovich DI (2002) Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol Immunother 51:293–298. doi:10.1007/s00262-002-0280-8
    • (2002) Cancer Immunol Immunother , vol.51 , pp. 293-298
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 11
    • 84866933880 scopus 로고    scopus 로고
    • Phenotypic plasticity of MDSC in cancers
    • COI: 1:CAS:528:DC%2BC38XhsVeiur3L
    • Manjili MH (2012) Phenotypic plasticity of MDSC in cancers. Immunol Investig 41:711–721. doi:10.3109/08820139.2012.673670
    • (2012) Immunol Investig , vol.41 , pp. 711-721
    • Manjili, M.H.1
  • 12
    • 79955723632 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells in human diseases
    • COI: 1:CAS:528:DC%2BC3MXntVyjurk%3D, PID: 21237299
    • Greten TF, Manns MP, Korangy F (2011) Myeloid derived suppressor cells in human diseases. Int Immunopharmacol 11:802–807. doi:10.1016/j.intimp.2011.01.003
    • (2011) Int Immunopharmacol , vol.11 , pp. 802-807
    • Greten, T.F.1    Manns, M.P.2    Korangy, F.3
  • 14
    • 71449127523 scopus 로고    scopus 로고
    • Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14(−)/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BD1MXhsVertrjI, PID: 19572148
    • Liu CY, Wang YM, Wang CL et al (2010) Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14(−)/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer. J Cancer Res Clin Oncol 136:35–45. doi:10.1007/s00432-009-0634-0
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 35-45
    • Liu, C.Y.1    Wang, Y.M.2    Wang, C.L.3
  • 15
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • COI: 1:CAS:528:DC%2BD1MXhslynsb4%3D, PID: 19201693
    • Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC (2009) Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res 69:1553–1560. doi:10.1158/0008-5472.CAN-08-1921
    • (2009) Cancer Res , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1    Ernstoff, M.S.2    Hernandez, C.3    Atkins, M.4    Zabaleta, J.5    Sierra, R.6    Ochoa, A.C.7
  • 16
    • 46049098560 scopus 로고    scopus 로고
    • A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
    • COI: 1:CAS:528:DC%2BD1cXps1Wltb0%3D, PID: 18485901
    • Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Kruger C, Manns MP, Greten TF, Korangy F (2008) A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology 135:234–243. doi:10.1053/j.gastro.2008.03.020
    • (2008) Gastroenterology , vol.135 , pp. 234-243
    • Hoechst, B.1    Ormandy, L.A.2    Ballmaier, M.3    Lehner, F.4    Kruger, C.5    Manns, M.P.6    Greten, T.F.7    Korangy, F.8
  • 18
    • 20644460600 scopus 로고    scopus 로고
    • International staging system for multiple myeloma
    • PID: 15809451
    • Greipp PR, San Miguel J, Durie BG et al (2005) International staging system for multiple myeloma. J Clin Oncol 23:3412–3420. doi:10.1200/JCO.2005.04.242
    • (2005) J Clin Oncol , vol.23 , pp. 3412-3420
    • Greipp, P.R.1    San Miguel, J.2    Durie, B.G.3
  • 19
    • 84988241358 scopus 로고    scopus 로고
    • International uniform response criteria for multiple myeloma
    • COI: 1:STN:280:DC%2BD28rgt1aqtA%3D%3D, PID: 16855634
    • Durie BG, Harousseau JL, Miguel JS et al (2006) International uniform response criteria for multiple myeloma. Leukemia 20:1467–1473. doi:10.1038/sj.leu.2404284
    • (2006) Leukemia , vol.20 , pp. 1467-1473
    • Durie, B.G.1    Harousseau, J.L.2    Miguel, J.S.3
  • 20
    • 84897692701 scopus 로고    scopus 로고
    • Increased frequencies of CD11b(+) CD33(+) CD14(+) HLA-DR(low) myeloid-derived suppressor cells are an early event in melanoma patients
    • COI: 1:CAS:528:DC%2BC2cXkt12gsb8%3D, PID: 24495013
    • Rudolph BM, Loquai C, Gerwe A, Bacher N, Steinbrink K, Grabbe S, Tuettenberg A (2014) Increased frequencies of CD11b(+) CD33(+) CD14(+) HLA-DR(low) myeloid-derived suppressor cells are an early event in melanoma patients. Exp Dermatol 23:202–204. doi:10.1111/exd.12336
    • (2014) Exp Dermatol , vol.23 , pp. 202-204
    • Rudolph, B.M.1    Loquai, C.2    Gerwe, A.3    Bacher, N.4    Steinbrink, K.5    Grabbe, S.6    Tuettenberg, A.7
  • 21
    • 84883447186 scopus 로고    scopus 로고
    • Increased CD14(+)HLA-DR (−/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
    • COI: 1:CAS:528:DC%2BC3sXhsFKjsbrI, PID: 23760662
    • Huang A, Zhang B, Wang B, Zhang F, Fan KX, Guo YJ (2013) Increased CD14(+)HLA-DR (−/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother 62:1439–1451. doi:10.1007/s00262-013-1450-6
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1439-1451
    • Huang, A.1    Zhang, B.2    Wang, B.3    Zhang, F.4    Fan, K.X.5    Guo, Y.J.6
  • 22
    • 78751689059 scopus 로고    scopus 로고
    • Immunosuppressive CD14+ HLA-DR(low)/− monocytes in B-cell non-Hodgkin lymphoma
    • COI: 1:CAS:528:DC%2BC3MXhslKks7g%3D, PID: 21063024
    • Lin Y, Gustafson MP, Bulur PA, Gastineau DA, Witzig TE, Dietz AB (2011) Immunosuppressive CD14+ HLA-DR(low)/− monocytes in B-cell non-Hodgkin lymphoma. Blood 117:872–881. doi:10.1182/blood-2010-05-283820
    • (2011) Blood , vol.117 , pp. 872-881
    • Lin, Y.1    Gustafson, M.P.2    Bulur, P.A.3    Gastineau, D.A.4    Witzig, T.E.5    Dietz, A.B.6
  • 24
    • 84880924329 scopus 로고    scopus 로고
    • Increase in CD14+ HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
    • COI: 1:CAS:528:DC%2BC3sXht1CrtrvI, PID: 23764929
    • Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S (2013) Increase in CD14+ HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. Cancer Immunol Immunother 62:1421–1430. doi:10.1007/s00262-013-1447-1
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1421-1430
    • Arihara, F.1    Mizukoshi, E.2    Kitahara, M.3    Takata, Y.4    Arai, K.5    Yamashita, T.6    Nakamoto, Y.7    Kaneko, S.8
  • 25
    • 84888286401 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BC3sXhs1OrtLzI, PID: 24197563
    • Payne KK, Zoon CK, Wan W, Marlar K, Keim RC, Kenari MN, Kazim AL, Bear HD, Manjili MH (2013) Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells. Breast Cancer Res Treat 142:45–57. doi:10.1007/s10549-013-2733-5
    • (2013) Breast Cancer Res Treat , vol.142 , pp. 45-57
    • Payne, K.K.1    Zoon, C.K.2    Wan, W.3    Marlar, K.4    Keim, R.C.5    Kenari, M.N.6    Kazim, A.L.7    Bear, H.D.8    Manjili, M.H.9
  • 26
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • COI: 1:CAS:528:DC%2BD1cXht1yqs7bN, PID: 18446337
    • Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 58:49–59. doi:10.1007/s00262-008-0523-4
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 27
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BC3sXhsV2jsbfL, PID: 24060865
    • Talmadge JE, Gabrilovich DI (2013) History of myeloid-derived suppressor cells. Nat Rev Cancer 13:739–752. doi:10.1038/nrc3581
    • (2013) Nat Rev Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 28
    • 77955549860 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity
    • PID: 20414655
    • Ostrand-Rosenberg S (2010) Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother 59:1593–1600. doi:10.1007/s00262-010-0855-8
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1593-1600
    • Ostrand-Rosenberg, S.1
  • 29
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • COI: 1:CAS:528:DC%2BC3cXltVaj, PID: 20028852
    • Srivastava MK, Sinha P, Clements VK, Rodriguez P, Ostrand-Rosenberg S (2010) Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res 70:68–77. doi:10.1158/0008-5472.CAN-09-2587
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 30
    • 25144493776 scopus 로고    scopus 로고
    • Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model
    • COI: 1:CAS:528:DC%2BD2MXmvFensLg%3D, PID: 16052222
    • Schmidt H, Bastholt L, Geertsen P, Christensen IJ, Larsen S, Gehl J, von der Maase H (2005) Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer 93:273–278. doi:10.1038/sj.bjc.6602702
    • (2005) Br J Cancer , vol.93 , pp. 273-278
    • Schmidt, H.1    Bastholt, L.2    Geertsen, P.3    Christensen, I.J.4    Larsen, S.5    Gehl, J.6    von der Maase, H.7
  • 31
    • 84894257778 scopus 로고    scopus 로고
    • The lower peripheral blood lymphocyte/monocyte ratio assessed during routine follow-up after standard first-line chemotherapy is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma
    • PID: 24439567
    • Yan-Li L, Kang-Sheng G, Yue-Yin P, Yang J, Zhi-Min Z (2014) The lower peripheral blood lymphocyte/monocyte ratio assessed during routine follow-up after standard first-line chemotherapy is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma. Leuk Res 38:323–328. doi:10.1016/j.leukres.2013.12.005
    • (2014) Leuk Res , vol.38 , pp. 323-328
    • Yan-Li, L.1    Kang-Sheng, G.2    Yue-Yin, P.3    Yang, J.4    Zhi-Min, Z.5
  • 32
    • 84879452593 scopus 로고    scopus 로고
    • Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans
    • COI: 1:CAS:528:DC%2BC3sXmsFehtLs%3D, PID: 23321256
    • Gorgun GT, Whitehill G, Anderson JL et al (2013) Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans. Blood 121:2975–2987. doi:10.1182/blood-2012-08-448548
    • (2013) Blood , vol.121 , pp. 2975-2987
    • Gorgun, G.T.1    Whitehill, G.2    Anderson, J.L.3
  • 33
    • 84903623517 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma
    • Favaloro J, Liyadipitiya T, Brown R et al (2014) Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma. Leuk Lymphoma. doi:10.3109/10428194.2014.904511
    • (2014) Leuk Lymphoma
    • Favaloro, J.1    Liyadipitiya, T.2    Brown, R.3
  • 34
    • 80052194777 scopus 로고    scopus 로고
    • Increased circulating immunosuppressive CD14(+)HLA-DR(−/low) cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhtlKktLbO, PID: 21986138
    • Yuan XK, Zhao XK, Xia YC, Zhu X, Xiao P (2011) Increased circulating immunosuppressive CD14(+)HLA-DR(−/low) cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma. J Int Med Res 39:1381–1391
    • (2011) J Int Med Res , vol.39 , pp. 1381-1391
    • Yuan, X.K.1    Zhao, X.K.2    Xia, Y.C.3    Zhu, X.4    Xiao, P.5
  • 35
    • 77956920766 scopus 로고    scopus 로고
    • Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
    • COI: 1:CAS:528:DC%2BC3cXpslWnu7g%3D, PID: 20644162
    • Lechner MG, Liebertz DJ, Epstein AL (2010) Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol 185:2273–2284. doi:10.4049/jimmunol.1000901
    • (2010) J Immunol , vol.185 , pp. 2273-2284
    • Lechner, M.G.1    Liebertz, D.J.2    Epstein, A.L.3
  • 36
    • 84868125342 scopus 로고    scopus 로고
    • Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells
    • COI: 1:CAS:528:DC%2BC38XhsFKgtb%2FJ
    • Wu CT, Hsieh CC, Lin CC, Chen WC, Hong JH, Chen MF (2012) Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells. J Mol Med (Berl) 90:1343–1355. doi:10.1007/s00109-012-0916-x
    • (2012) J Mol Med (Berl) , vol.90 , pp. 1343-1355
    • Wu, C.T.1    Hsieh, C.C.2    Lin, C.C.3    Chen, W.C.4    Hong, J.H.5    Chen, M.F.6
  • 37
    • 36849017497 scopus 로고    scopus 로고
    • IL-6 involvement in epithelial cancers
    • COI: 1:CAS:528:DC%2BD2sXhsVals7fJ, PID: 18060028
    • Schafer ZT, Brugge JS (2007) IL-6 involvement in epithelial cancers. J Clin Investig 117:3660–3663. doi:10.1172/JCI34237
    • (2007) J Clin Investig , vol.117 , pp. 3660-3663
    • Schafer, Z.T.1    Brugge, J.S.2
  • 38
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • COI: 1:CAS:528:DyaK1cXislyhsrk%3D, PID: 9597127
    • Letterio JJ, Roberts AB (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol 16:137–161. doi:10.1146/annurev.immunol.16.1.137
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 39
    • 84861697428 scopus 로고    scopus 로고
    • Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck
    • COI: 1:CAS:528:DC%2BC38XnslKhtrs%3D, PID: 22360618
    • Chikamatsu K, Sakakura K, Toyoda M, Takahashi K, Yamamoto T, Masuyama K (2012) Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck. Cancer Sci 103:976–983. doi:10.1111/j.1349-7006.2012.02248.x
    • (2012) Cancer Sci , vol.103 , pp. 976-983
    • Chikamatsu, K.1    Sakakura, K.2    Toyoda, M.3    Takahashi, K.4    Yamamoto, T.5    Masuyama, K.6
  • 40
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • COI: 1:CAS:528:DC%2BD1cXhsFCis7bI, PID: 19109155
    • Li H, Han Y, Guo Q, Zhang M, Cao X (2009) Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol 182:240–249
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 41
    • 0037077192 scopus 로고    scopus 로고
    • Regulation of T cell receptor CD3zeta chain expression by l-arginine
    • COI: 1:CAS:528:DC%2BD38Xkslyqsbw%3D, PID: 11950832
    • Rodriguez PC, Zea AH, Culotta KS, Zabaleta J, Ochoa JB, Ochoa AC (2002) Regulation of T cell receptor CD3zeta chain expression by l-arginine. J Biol Chem 277:21123–21129. doi:10.1074/jbc.M110675200
    • (2002) J Biol Chem , vol.277 , pp. 21123-21129
    • Rodriguez, P.C.1    Zea, A.H.2    Culotta, K.S.3    Zabaleta, J.4    Ochoa, J.B.5    Ochoa, A.C.6
  • 42
    • 84866916560 scopus 로고    scopus 로고
    • Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives
    • COI: 1:CAS:528:DC%2BC38XhsVeiurrF
    • Raber P, Ochoa AC, Rodriguez PC (2012) Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives. Immunol Investig 41:614–634. doi:10.3109/08820139.2012.680634
    • (2012) Immunol Investig , vol.41 , pp. 614-634
    • Raber, P.1    Ochoa, A.C.2    Rodriguez, P.C.3
  • 43
    • 84874852282 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXjslGmuro%3D, PID: 23477520
    • McBride A, Ryan PY (2013) Proteasome inhibitors in the treatment of multiple myeloma. Expert Rev Anticancer Ther 13:339–358. doi:10.1586/era.13.9
    • (2013) Expert Rev Anticancer Ther , vol.13 , pp. 339-358
    • McBride, A.1    Ryan, P.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.