Phenotypic plasticity of MDSC in cancers

Immunological Investigations

Volumn 41, Issue 6-7, 2012, Pages 711-721

  Manjili, Masoud H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Breast cancer relapse; Myeloid derived suppressor cells; Tumor immunoediting

Indexed keywords

ALPHA INTERFERON; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 18; PEROXYNITRITE; RETINOIC ACID; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 9;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; BREAST CANCER; CANCER INHIBITION; CANCER MORPHOLOGY; CELL DIFFERENTIATION; HUMAN; LIVER CELL CARCINOMA; MYELOID DERIVED SUPPRESSOR CELL; NATURAL KILLER T CELL; NEOPLASM; NITRATION; NONHUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPRESSOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

ANIMALS; BREAST NEOPLASMS; CARCINOMA; CYTOKINES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC HETEROGENEITY; HUMANS; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; MICE; MYELOID PROGENITOR CELLS; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 84866933880     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2012.673670     Document Type: Article

References (48)

1. Bronte, V. , Apolloni, E. , Cabrelle, A. , Ronca, R. , Serafini, P. , Zamboni, P. , Restifo, N. P. ,Zanovello, P. (2000). Identification of a CD11b( +)/Gr-1( +)/CD31( +) myeloid progenitorcapable of activating or suppressing CD8( +) T cells. Blood 96(12): 3838-3846.
2. Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S. (2009). Inflammation enhances myeloid-derived suppressor cell cross-talk by signalingthrough Toll-like receptor 4. J. Leukoc. Biol. 85(6): 996-1004.
3. Daud, A. I. , Mirza, N. , Lenox, B. , Andrews, S. , Urbas, P. , Gao, G. X. , Lee, J. H. , Sondak,V. K. , Riker, A. I. , Deconti, R. C. , Gabrilovich, D. (2008). Phenotypic and functionalanalysis of dendritic cells and clinical outcome in patients with high-risk melanomatreated with adjuvant granulocyte macrophage colony-stimulating factor. J. Clin. Oncol. 26(19): 3235-3241.
4. Delahaye, N. F. , Rusakiewicz, S. , Martins, I. , Ménard, C. , Roux, S. , Lyonnet, L. , Paul, P. ,Sarabi, M. , Chaput, N. , Semeraro, M. , Minard-Colin, V. , Poirier-Colame, V. , Chaba,K. , Flament, C. , Baud, V. , Authier, H. , Kerdine-Römer, S. , Pallardy, M. , Cremer, I. ,Peaudecerf, L. , Rocha, B. , Valteau-Couanet, D. , Gutierrez, J. C. , Nunès, J. A. , Commo,F. , Bonvalot, S. , Ibrahim, N. , Terrier, P. , Opolon, P. , Bottino, C. , Moretta, A. ,Tavernier, J. , Rihet, P. , Coindre, J. M. , Blay, J. Y. , Isambert, N. , Emile, J. F. , Vivier,E. , Lecesne, A. , Kroemer, G. , Zitvogel, L. (2011). Alternatively spliced NKp30 isoformsaffect the prognosis of gastrointestinal stromal tumors. Nat. Med. 17: 700-707.
5. Diaz-Montero, C. M. , Salem, M. L. , Nishimura, M. I. , Garrett-Mayer, E. , Cole, D. J. ,Montero, A. J. (2009). Increased circulating myeloid-derived suppressor cells correlatewith clinical cancer stage, metastatic tumor burden, and doxorubicincyclophosphamidechemotherapy. Cancer Immunol. Immunother. 58(1): 49-59.
6. Dolcetti, L. , Peranzoni, E. , Ugel, S. , Marigo, I. , Fernandez Gomez, A. , Mesa, C. , Geilich,M. , Winkels, G. , Traggiai, E. , Casati, A. , Grassi, F. , Bronte, V. (2009). Hierarchy ofimmunosuppressive strength among myeloid-derived suppressor cell subsets isdetermined by GM-CSF. Immunol. 40 (1): 22-35.
7. Elkabets,M. ,Ribeiro,V. S. , Dinarello, C. A. ,Ostrand-Rosenberg,S. , Di Santo, J. P. ,Apte,R. N. , Vosshenrich CA. (2010). IL-1β regulates a novel myeloid-derived suppressorcell subset that impairs NK cell development and function. Eur. J. Immunol. 40(12): 3347-3357.
8. Filipazzi, P. , Huber, V. , Rivoltini, L. (2012). Phenotype, function and clinical implicationsof myeloid-derived suppressor cells in cancer patients. Cancer Immunol. Immunother. 61(2): 255-263.
9. Filipazzi, P. , Valenti, R. , Huber, V. , Pilla, L. , Canese, P. , Iero, M. , Castelli, C. , Mariani, L. ,Parmiani, G. , Rivoltini, L. (2007). Identification of a new subset of myeloid suppressorcells in peripheral blood of melanoma patients with modulation by a granulocytemacrophagecolony-stimulation factor-based antitumor vaccine. J. Clin. Oncol. 25(18): 2546-2553.
10. Giermasz, A. S. , Urban, J. A. , Nakamura, Y. , Watchmaker, P. , Cumberland, R. L. ,Gooding, W. , Kalinski P. (2009). Type-1 polarized dendritic cells primed for highIL-12 production show enhanced activity as cancer vaccines. Cancer Immunol. Immunother. 58(8): 1329-1336.
11. Hillen, F. , Baeten, C. I. , van de Winkel, A. , Creytens, D. , van der Schaft, D. W. ,Winnepenninckx, V. , Griffioen, A. W. (2008). Leukocyte infiltration and tumor cellplasticity are parameters of aggressiveness in primary cutaneous melanoma. CancerImmunol. Immunother. 57(1): 97-106.
12. Hoechst, B. , Voigtlaender, T. , Ormandy, L. , Gamrekelashvili, J. , Zhao, F. , Wedemeyer,H. , Lehner, F. , Manns, M. P. , Greten, T. F. , Korangy, F. (2009). Myeloid derivedsuppressor cells inhibit natural killer cells in patients with hepatocellular carcinomavia the NKp30 receptor. Hepatology. 50(3): 799-807.
13. Kalinski, P. , Mailliard, R. B. , Giermasz, A. , Zeh, H. J. , Basse, P. , Bartlett, D. L. , Kirkwood,J. M. , Lotze, M. T. , Herberman, R. B. (2005). Natural killer-dendritic cell cross-talk incancer immunotherapy. Expert Opin. Biol. Ther. 5(10): 1303-1315.
14. Kerkar, S. P. , Goldszmid, R. S. , Muranski, P. , Chinnasamy, D. , Yu, Z. , Reger, R. N. ,Leonardi, A. J. , Morgan, R. A. , Wang, E. , Marincola, F. M. , Trinchieri, G. , Rosenberg,S. A. , Restifo, N. P. (2011). IL-12 triggers a programmatic change in dysfunctionalmyeloid-derived cells within mouse tumors. J. Clin. Invest. 121(12): 4746-4757.
15. Kimpfler, S. , Sevko, A. , Ring, S. , Falk, C. , Osen, W. , Frank, K. , Kato, M. , Mahnke, K. ,Schadendorf, D. , Umansky, V. (2009). Skin melanoma development in ret transgenicmice despite the depletion of CD25 +Foxp3 + regulatory T cells in lymphoid organs. J. Immunol. 183(10): 6330-6337.
16. Kmieciak, M. , Basu, D. , Payne, K. K. , Toor, A. , Yacoub, A. , Wang, X. Y. , Smith, L. , Bear,H. D. , Manjili, M. H. (2011). Activated NKT cells and NK cells render T cells resistantto myeloid-derived suppressor cells and result in an effective adoptive cellulartherapy against breast cancer in the FVBN202 transgenic mouse. J. Immunol. 187(2): 708-717.
17. Kmieciak, M. , Morales, J. K. , Morales, J. , Bolesta, E. , Grimes, M. , Manjili, M. H. (2008). Danger signals and nonself entity of tumor antigen are both required for elicitingeffective immune responses against HER-2/neu positive mammary carcinoma: implications for vaccine design. Cancer Immunol. Immunother. 57(9): 1391-1398.
18. Ko, H. J. , Lee, J. M. , Kim, Y. J. , Kim, Y. S. , Lee, K. A. , Kang, C. Y. (2009). Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenicAPCs with the help of activated NKT cells: an alternative cell-based antitumorvaccine. J. Immunol. 182(4): 1818-1828.
19. Ko, J. S. , Zea, A. H. , Rini, B. I. , Ireland, J. L. , Elson, P. , Cohen, P. , Golshayan, A. , Rayman,P. A. , Wood, L. , Garcia, J. , Dreicer, R. , Bukowski, R. , Finke, J. H. (2009). Sunitinibmediates reversal of myeloid-derived suppressor cell accumulation in renal cellcarcinoma patients. Clin. Cancer Res. 15(6): 2148-2157.
20. Kusmartsev, S. , Su, Z. , Heiser, A. , Dannull, J. , Eruslanov, E. , Kübler, H. , Yancey, D. ,Dahm, P. , Vieweg, J. (2008). Reversal of myeloid cell-mediated immunosuppressionin patients with metastatic renal cell carcinoma. Clin Cancer Res 14(24): 8270-82788
21. Lechner, M. G. , Megiel, C. , Russell, S. M. , Bingham, B. , Arger, N. , Woo, T. , Epstein, A. L. (2011) Functional characterization of human Cd33 + and Cd11b + myeloid-derivedsuppressor cell subsets induced from peripheral blood mononuclear cells co-culturedwith a diverse set of human tumor cell lines. J. Transl. Med. 9: 90.
22. Lee, J. M. , Seo, J. H. , Kim, Y. J. , Kim, Y. S. , Ko, H. J. , Kang, C. Y. (2011) The restoration ofmyeloid-derived suppressor cells as functional antigen-presenting cells by NKT cellhelp and all-trans-retinoic acid treatment. Int. J. Cancer. doi: 10. 1002/ijc. 26411.
23. Li, H. , Han, Y. , Guo, Q. , Zhang, M. , Cao, X. (2009). Cancer-expanded myeloid-derivedsuppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J. Immunol. 182(1): 240-249.
24. Liu, C. Y. , Wang, Y. M. , Wang, C. L. , Feng, P. H. , Ko, H. W. , Liu, Y. H. , Wu, Y. C. , Chu, Y. ,Chung, F. T. , Kuo, C. H. , Lee, K. Y. , Lin, S. M. , Lin, H. C. , Wang, C. H. , Yu, C. T. , Kuo,H. P. (2010). Population alterations of L-arginase-and inducible nitric oxidesynthase-expressed CD11b +CD14/CD15 +CD33 + myeloid-derived suppressorcells and CD8 + T lymphocytes in patients with advanced-stage non-small cell lungcancer. J. Cancer Res. Clin. Oncol. 136(1): 35-45.
25. Mamessier, E. , Sylvain, A. , Bertucci, F. , Castellano, R. , Finetti, P. , Houvenaeghel, G. ,Charaffe-Jaufret, E. , Birnbaum, D. , Moretta, A. , Olive, D. (2011). Human breasttumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated andDNAM-mediated NK cell recognition. Cancer Res. 71(21): 6621-6632.
26. Mamessier, E. , Sylvain, A. , Thibult, M. L. , Houvenaeghel, G. , Jacquemier, J. , Castellano,R. , Gonçalves, A. , André, P. , Romagné, F. , Thibault, G. , Viens, P. , Birnbaum, D. ,Bertucci, F. , Moretta, A. , Olive, D. (2011). Human breast cancer cells enhance selftolerance by promoting evasion from NK cell antitumor immunity. J. Clin. Invest. 121: 3609-3622.
27. Mandruzzato, S. , Solito, S. , Falisi, E. , Francescato, S. , Chiarion-Sileni, V. , Mocellin, S. ,Zanon, A. , Rossi, C. R. , Nitti, D. , Bronte, V. , Zanovello, P. (2009). IL4Ralpha + myeloid-derived suppressor cell expansion in cancer patients. J. Immunol. 182(10): 6562-6568.
28. Mantovani, A. (2010). Molecular pathways linking inflammation and cancer. Curr. Mol. Med. 10: 369-373.
29. Marigo, I. , Bosio, E. , Solito, S. , Mesa, C. , Fernandez, A. , Dolcetti, L. , Ugel, S. , Sonda, N. ,Bicciato, S. , Falisi, E. , Calabrese, F. , Basso, G. , Zanovello, P. , Cozzi, E. ,Mandruzzato, S. , Bronte, V. (2010). Tumor-induced tolerance and immune suppressiondepend on the C/EBPbeta transcription factor. Immunity 32(6): 790-802.
30. Meyer, C. , Sevko, A. , Ramacher, M. , Bazhin, A. V. , Falk, C. S. , Osen, W. , Borrello, I. ,Kato, M. , Schadendorf, D. , Baniyash, M. , Umansky, V. (2011). Chronic inflammationpromotes myeloid-derived suppressor cell activation blocking antitumorimmunity in transgenic mouse melanoma model. Proc, Natl. Acad, Sci. USA108(41): 17111-17116.
31. Mirza, N. , Fishman, M. , Fricke, I. , Dunn, M. , Neuger, A. M. , Frost, T. J. , Lush, R. M. ,Antonia, S. , Gabrilovich, D. I. (2006). All-trans-retinoic acid improves differentiationof myeloid cells and immune response in cancer patients. Cancer Res. 66(18): 9299-9307.
32. Morales, J. K. , Kmieciak, M. , Knutson, K. L. , Bear, H. D. , Manjili, M. H. (2010). GM-CSF isone of the main breast tumor-derived soluble factors involved in the differentiation ofCD11b-Gr1-bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res. Treat. 123(1): 39-49.
33. Movahedi, K. , Guilliams, M. , Van den Bossche, J. , Van den Bergh, R. , Gysemans, C. ,Beschin, A. , De Baetselier, P. , Van Ginderachter, J. A. (2008). Identification of discretetumor-induced myeloid-derived suppressor cell subpopulations with distinct Tcell-suppressive activity. Blood 111: 4233-4244.
34. Nagaraj, S. , Schrum, A. G. , Cho, H. I. , Celis, E. , Gabrilovich, D. I. (2010). Mechanism of Tcell tolerance induced by myeloid-derived suppressor cells. J. Immunol. 184(6): 3106-3116.
35. Nausch, N. , Galani, I. E. , Schlecker, E. , Cerwenka, A. (2008). Mononuclear myeloidderived"suppressor" cells express RAE-1 and activate natural killer cells. Blood112: 4080-4089.
36. Peláez, B. , Campillo, J. A. , López-Asenjo, J. A. , Subiza, J. L. (2001). Cyclophosphamideinduces the development of early myeloid cells suppressing tumor cell growth by anitric oxide-dependent mechanism. J. Immunol. 166: 6608-6615.
37. Rodriguez, P. C. , Ernstoff, M. S. , Hernandez, C. , Atkins, M. , Zabaleta, J. , Sierra, R. ,Ochoa, A. C. (2009). Arginase I-producing myeloid-derived suppressor cells inrenal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69(4): 1553-1560.
38. Schmielau, J. , Finn, O. J. (2001). Activated granulocytes and granulocyte-derived hydrogenperoxide are the underlying mechanism of suppression of t-cell function inadvanced cancer patients. Cancer Res. 61(12): 4756-4760.
39. Shirota, Y. , Shirota, H. , Klinman, D. M. (2012). Intratumoral injection of CpG oligonucleotidesinduces the differentiation and reduces the immunosuppressive activity ofmyeloid-derived suppressor cells. J. Immunol. 2012 Jan 9. [Epub ahead of print].
40. Srivastava, M. K. , Bosch, J. J. , Thompson, J. A. , Ksander, B. R. , Edelman, M. J. , Ostrand-Rosenberg, S. (2008). Lung cancer patients' CD4( +) T cells are activated in vitro byMHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells. Cancer Immunol. Immunother. 57(10): 1493-1504.
41. Steding, C. E. , Wu, S. T. , Zhang, Y. , Jeng, M. H. , Elzey, B. D. , Kao, C. (2011). The role ofinterleukin-12 on modulating myeloid-derived suppressor cells, increasing overallsurvival and reducing metastasis. Immunology 133(2): 221-238.
42. van Cruijsen, H. , van der Veldt, A. A. , Vroling, L. , Oosterhoff, D. , Broxterman, H. J. ,Scheper, R. J. , Giaccone, G. , Haanen, J. B. , van den Eertwegh, A. J. , Boven, E. ,Hoekman, K. , de Gruijl, T. D. (2008). Sunitinib-induced myeloid lineage redistributionin renal cell cancer patients: CD1c + dendritic cell frequency predictsprogression-free survival. Clin. Cancer Res 14(18): 5884-5892.
43. Vuk-Pavlović, S, Bulur, P. A. , Lin, Y. , Qin, R. , Szumlanski, C. L. , Zhao, X. , Dietz, A. B. (2010) Immunosuppressive CD14 +HLA-DRlow/monocytes in prostate cancer. Prostate 70(4): 443-455.
44. Wright, S. E. , Rewers-Felkins, K. A. , Quinlin, I. S. , Phillips, C. A. , Townsend, M. , Philip, R. ,Zorsky, P. , Klug, P. , Dai, L. , Hussain, M. , Thomas, A. A. , Sundaramurthy, C. (2009). Tumor burden influences cytotoxic T cell development in metastatic breast cancerpatient-a phase I/II study. Immunol. Invest. 38(8): 820-838.
45. Wong, J. L. , Mailliard, R. B. , Moschos, S. J. , Edington, H. , Lotze, M. T. , Kirkwood, J. M. ,Kalinski, P. (2011). Helper activity of natural killer cells during the dendritic cellmediatedinduction of melanoma-specific cytotoxic T cells. J. Immunother. 34(3): 270-278.
46. Youn, J. I. , Gabrilovich, D. I. (2010). The biology of myeloid-derived suppressor cells: theblessing and the curse of morphological and functional heterogeneity. Eur. J. Immunol. 40(11): 2969-2675.
47. Youn, J. I. , Nagaraj, S. , Collazo, M. , Gabrilovich, D. I. (2008). Subsets of myeloid-derivedsuppressor cells in tumor-bearing mice. J. Immunol. 181: 5791-5802.
48. Zea, A. H. , Rodriguez, P. C. , Atkins, M. B. , Hernandez, C. , Signoretti, S. , Zabaleta, J. ,McDermott, D. , Quiceno, D. , Youmans, A. , O'Neill, A. , Mier, J. , Ochoa, A. C. (2005)Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: amechanism of tumor evasion. Cancer Res. 65(8): 3044-3048.