ARTICLE;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG RESEARCH;
DRUG SYNTHESIS;
GENOTOXICITY;
HUMAN;
IN VITRO STUDY;
MYCOBACTERIUM TUBERCULOSIS;
TUBERCULOSIS;
ANIMALS;
ANTITUBERCULAR AGENTS;
CELL PROLIFERATION;
COMET ASSAY;
DNA DAMAGE;
DRUG DESIGN;
DRUG RESISTANCE, MULTIPLE;
MACROPHAGES;
MICE;
MICROBIAL SENSITIVITY TESTS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
MYCOBACTERIUM TUBERCULOSIS;
PHENANTHRIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
TUBERCULOSIS;
Significance of the identification in the Horn of Africa of an exceptionally deep branching Mycobacterium tuberculosis clade
Blouin, Y.; Hauck, Y.; Soler, C.; Fabre, M.; Vong, R.; Dehan, C.; Cazajous, G.; Massoure, P.; Kraemer, P.; Jenkins, A.; Garnotel, E.; Pourcel, C.; Vergnaud, G. Significance of the identification in the Horn of Africa of an exceptionally deep branching Mycobacterium tuberculosis clade PLoS One 2012, 7, 3484-3493
Transcriptional adaptation of Mycobacterium tuberculosis within macrophages insights into the phagosomal environment
Schnappinger, D.; Ehrt, S.; Voskuil, M. I.; Liu, Y.; Mangan, A. J.; Monahan, M. I.; Dolganov, G.; Efron, B.; Butcher, P. D.; Nathan, C.; Schoolnik, G. K. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages insights into the phagosomal environment JEM 2003, 198, 693-704
Emergence of new forms of totally drug-resistant tuberculosis bacilli: Super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran
Velayati, A. A.; Masjedi, M. R.; Farnia, P.; Tabarsi, P.; Ghanavi, J.; Ziazarifi, A. H.; Hoffner, S. E. Emergence of new forms of totally drug-resistant tuberculosis bacilli: Super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran CHEST. 2009, 136, 420-425
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Gandi, N. R.; Moll, A.; Strum, W. A.; Pawinski, R.; Govender, T.; Lallo, U.; Zeller, K.; Andrew, J.; Friedland, G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa Lancet 2006, 4, 1575-1580
The Growing Burden of Tuberculosis Global Trends and Interactions with the HIV Epidemic
Corbett, E. L.; Watt, C. J.; Walker, N.; Maher, D.; William, B. G.; Raviglione, M. C.; Dye, C the Growing Burden of Tuberculosis Global Trends and Interactions With the HIV Epidemic JAMA. 2003, 163, 1009-1021
Studies on quinones. Part 21. Regioselective synthesis of tetracyclic quinones related to rabelomycin
Valderrama, J. A.; Araya-Maturana, R.; Gonzáles, F.; Tapia, R.; Fariña, F.; Paredes, M. C. Studies on quinones. Part 21. Regioselective synthesis of tetracyclic quinones related to rabelomycin J. Chem. Soc., Perkin Trans. 1 1991, 555-559
Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity
Valderrama, J. A.; Colonelli, P.; Vásquez, D.; Florencia González, M.; Rodríguez, J. A.; Theoduloz, C. Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity Bioorg. Med. Chem. 2008, 16, 10172-10181
Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity
Collet, S. C.; Rémi, J.-F.; Cariou, C.; Laïb, S.; Guingant, A. Y.; Quang Vu, N.; Dujardin, G. Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity Tetrahedron Lett. 2004, 45, 4911-4915
One-pot preparation of 1H-naphtho[2,3-c]pyran-5,10-diones and its application to concise total synthesis of (±)-eleutherin and (±)-isoeleutherin
Kobayashi, K.; Uchida, M.; Uneda, T.; Tanmatsu, M.; Morikawa, O.; Konishi, H. One-pot preparation of 1H-naphtho[2,3-c]pyran-5,10-diones and its application to concise total synthesis of (±)-eleutherin and (±)-isoeleutherin Tetrahedron Lett. 1998, 7725-7728
An efficient method for the one-pot construction of the 1H-naphtho[2,3- c ]pyran-5,10-dione system
Kobayashi, K.; Uchida, M.; Uneda, T.; Yoneda, K.; Tanmatsu, M.; Morikawa, O.; Konishi, H. An efficient method for the one-pot construction of the 1H-naphtho[2,3- c ]pyran-5,10-dione system J. Chem. Soc., Perkin Trans. 1 2001, 2977-2982
Short synthesis of functionalized pentalongin derivatives using pyridinium ylid chemistry
Claes, P.; Jacobs, J.; Claessens, S.; De Kimpe, N. Short synthesis of functionalized pentalongin derivatives using pyridinium ylid chemistry Tetrahedron 2010, 66, 7088-7096
One-pot synthesis of isoquinoline-5,8-dione derivatives from acylquinones and enamines
Kobayashi, K.; Takanohashi, A.; Watanabe, T.; Morikawa, O.; Konishi, H. One-pot synthesis of isoquinoline-5,8-dione derivatives from acylquinones and enamines Tetrahedron Lett. 2000, 7657-7660
2,4-dialkyl-8,9,10,11-tetrahydrobenzo[ g ]pyrimido[4,5- c ]isoquinoline-1,3,7,12(2 H,4 H)-tetraones as new leads against Mycobacterium tuberculosis
EJMECH 6807, accepted for publication.
Claes, P.; Cappoen, D.; Uythethofken, C.; Jacobs, J.; Mertens, B.; Mathys, V.; Verschaeve, L.; Huygen, K.; De Kimpe, N. 2,4-dialkyl-8,9,10,11- tetrahydrobenzo[ g ]pyrimido[4,5- c ]isoquinoline-1,3,7,12(2 H,4 H)-tetraones as new leads against Mycobacterium tuberculosis. Eur. J. Med. Chem. 2014, EJMECH 6807, accepted for publication.
Assessment of immunity to mycobacterial infection with luciferase reporter construct
Snewin, V. A.; Gares, M. P.; Gaora, P. O.; Hasan, Z.; Brown, D.; Young, D. B. Assessment of immunity to mycobacterial infection with luciferase reporter construct Infect. Immun. 1999, 67, 4586-4593
Biological evaluation of bisbenzaldehydes against four Mycobacterium species
Cappoen, D.; Forge, D.; Vercammen, F.; Mathys, V.; Kiass, M.; Roupie, V.; Anthonissen, R.; Verschaeve, L.; Vanden, E. J.; Huygen, K. Biological evaluation of bisbenzaldehydes against four Mycobacterium species Eur. J. Med. Chem. 2013, 63, 231-738
Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine
Claes, P.; Cappoen, D.; Mbala, B.; Jacobs, J.; Mertens, B.; Mathys, V.; Verschaeve, L.; Huygen, K.; De Kimpe, N. Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine Eur. J. Med. Chem. 2013, 67C, 98-110
Mediastinitis and pericardial effusion in a patient with AIDS and disseminated Mycobacterium avium infection: A case report
Cortez-Escalante, J. J.; Santos, A. M.; Garnica, C.; Sarmento, A. L.; Castro, C. N.; Romero, G. A. Mediastinitis and pericardial effusion in a patient with AIDS and disseminated Mycobacterium avium infection: A case report Rev. Soc. Bras. Med. Trop. 2012, 45, 407-409
Crohn's disease and the mycobacterioses: A quarter century later. Causation or simple association?
Chiodini, R. J.; Chamberlin, W. M.; Sarosiek, J.; McCallum, R. W. Crohn's disease and the mycobacterioses: a quarter century later. Causation or simple association? Crit. Rev. Microbiol. 2012, 38, 52-93
Multicenter evaluation of the BACTEC MGIT 960 system for recovery of mycobacteria
Hanna, B. A.; Ebrahimzadeh, A.; Elliot, B. L.; Morgan, M. A.; Novak, S. M.; Vannier, A. M. Multicenter evaluation of the BACTEC MGIT 960 system for recovery of mycobacteria J. Clin. Microbiol. 1999, 37, 748-752
VITOTOX® bacterial genotoxicity and toxicity test for the rapid screening of chemicals
Verschaeve, L.; Van Gompel, J.; Thilemans, L.; Regniers, L.; P. Vanparys, P.; Van der Lelie, D. VITOTOX® bacterial genotoxicity and toxicity test for the rapid screening of chemicals Environ. Mol. Mutagen. 1999, 33, 240-248
Evaluation of the Vitotox and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development
Westerink, W. M.; Stevenson, J. C.; Lauwers, A.; Griffioen, G.; Horbach, J. G.; Schoonen, W. G. Evaluation of the Vitotox and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development Environ. Mutagen. 2009, 1, 113-130
Single Cell Gel/ Comet Assay: Guidelines for in Vitro and in Vivo Genetic Toxicology Testing
Tice, R. R.; Agurell, E.; Anderson, D.; Burlinson, B.; Hartmann, A.; Kobayashi, H.; Miyamae, Y.; Rojas, E.; Ryu, J. C.; Sasaki, Y. F. Single Cell Gel/ Comet Assay: Guidelines for In Vitro and In Vivo Genetic Toxicology Testing Environ. Mol. Mutagen. 2000, 35, 206-211
The Enamine Alkylation and Acylation of Carbonyl Compounds
Stork, G.; Brizzolara, A.; Landesman, H.; Szmuszkovicz, J.; Terrell, R the Enamine Alkylation and Acylation of Carbonyl Compounds J. Am. Chem. Soc. 1963, 85, 207-222
A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization
Evano, G.; Schaus, J. V.; Panek, J. S. A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization Org. Lett. 2004, 6, 525-528
